Project name: 73268194b5d990d

Chain sequence(s)	A: PRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSSRWKLYPRMLRNVAETDLSTSVLGQRVSMPICVGATAMQRMAHVVDGELATVRACQSLGTGMMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVTKKLVRQAEKMGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQLRMKNFETSTLSFSPEENFGDDSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIVWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.9586
• Maximal score value: 1.6181
• Average score: -0.7631
• Total score value: -274.7165

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
3	P	A	-0.9285
4	R	A	-1.4470
5	L	A	-0.2936
6	I	A	1.3909
7	C	A	0.2081
8	I	A	0.0000
9	N	A	-1.7496
10	D	A	-1.4850
11	Y	A	0.0000
12	E	A	-2.1962
13	Q	A	-2.3948
14	H	A	-1.5777
15	A	A	0.0000
16	K	A	-2.3012
17	S	A	-0.9158
18	V	A	0.4995
19	L	A	-0.3365
20	P	A	-1.0356
21	K	A	-2.1019
22	S	A	-1.9809
23	I	A	0.0000
24	Y	A	0.0000
25	D	A	-1.3624
26	Y	A	0.0000
27	Y	A	0.0000
28	R	A	-0.8144
29	S	A	0.0000
30	G	A	0.0000
31	A	A	0.0000
32	N	A	-2.7724
33	D	A	-3.2985
34	E	A	-2.4757
35	E	A	-2.8892
36	T	A	0.0000
37	L	A	-1.0576
38	A	A	-0.6049
39	D	A	-0.6834
40	N	A	0.0000
41	I	A	0.8587
42	A	A	0.1547
43	A	A	0.0000
44	F	A	0.0000
45	S	A	-0.9745
46	R	A	-2.0035
47	W	A	0.0000
48	K	A	-2.5003
49	L	A	-0.7191
50	Y	A	0.4332
51	P	A	0.4874
52	R	A	0.2779
53	M	A	1.3300
54	L	A	1.2978
55	R	A	-0.4416
56	N	A	-1.2541
57	V	A	-0.6207
58	A	A	-1.2698
59	E	A	-2.3965
60	T	A	-1.7584
61	D	A	-2.1247
62	L	A	0.0000
63	S	A	-1.0344
64	T	A	0.0000
65	S	A	-1.3137
66	V	A	0.0000
67	L	A	-0.8405
68	G	A	-1.2218
69	Q	A	-1.8194
70	R	A	-2.2815
71	V	A	0.0000
72	S	A	-0.8563
73	M	A	0.0000
74	P	A	0.0000
75	I	A	0.0000
76	C	A	0.0000
77	V	A	0.0000
78	G	A	0.0000
79	A	A	-0.0653
80	T	A	-0.1016
81	A	A	0.0000
82	M	A	0.0000
83	Q	A	0.0000
84	R	A	-0.2654
85	M	A	0.0000
86	A	A	0.0000
87	H	A	-0.1535
88	V	A	0.8819
89	D	A	-0.7183
90	G	A	0.0000
91	E	A	0.0000
92	L	A	-0.7935
93	A	A	0.0000
94	T	A	0.0000
95	V	A	0.0000
96	R	A	-2.4609
97	A	A	0.0000
98	C	A	0.0000
99	Q	A	-1.6323
100	S	A	-1.2409
101	L	A	0.0000
102	G	A	-1.1616
103	T	A	0.0000
104	G	A	0.0000
105	M	A	0.0000
106	M	A	0.0000
107	L	A	0.0000
108	S	A	0.0000
109	S	A	0.0000
110	W	A	0.0000
111	A	A	0.0000
112	T	A	0.0000
113	S	A	0.0000
114	S	A	-1.2486
115	I	A	0.0000
116	E	A	-2.2543
117	E	A	-1.7815
118	V	A	0.0000
119	A	A	0.0000
120	E	A	-2.6690
121	A	A	0.0000
122	G	A	0.0000
123	P	A	-2.0977
124	E	A	-2.4837
125	A	A	0.0000
126	L	A	-1.0780
127	R	A	0.0000
128	W	A	0.0000
129	L	A	0.0000
130	Q	A	0.0000
131	L	A	0.0000
132	Y	A	0.0000
133	I	A	0.0000
134	Y	A	0.0000
135	K	A	-2.2812
136	D	A	-2.5204
137	R	A	-2.4825
138	E	A	-3.0074
139	V	A	-2.2035
140	T	A	0.0000
141	K	A	-2.3238
142	K	A	-2.4400
143	L	A	0.0000
144	V	A	0.0000
145	R	A	-2.1007
146	Q	A	-2.0169
147	A	A	0.0000
148	E	A	-2.0734
149	K	A	-2.3582
150	M	A	-1.8234
151	G	A	-1.4442
152	Y	A	0.0000
153	K	A	-1.3384
154	A	A	0.0000
155	I	A	0.0000
156	F	A	0.0000
157	V	A	0.0000
158	T	A	0.0000
159	V	A	0.4188
160	D	A	0.4845
161	T	A	0.0000
162	P	A	0.5207
163	Y	A	0.9079
164	L	A	0.5869
165	G	A	-0.1872
166	N	A	-1.3831
167	R	A	0.0000
168	L	A	-1.5984
169	D	A	-1.8077
170	D	A	0.0000
171	V	A	-2.5190
172	R	A	-3.0312
173	N	A	-2.9567
174	R	A	-3.9586
175	F	A	0.0000
176	K	A	-2.7271
177	L	A	0.0000
178	P	A	-1.2490
179	P	A	-1.5114
180	Q	A	-1.4700
181	L	A	0.0000
182	R	A	-1.2101
183	M	A	0.0000
184	K	A	-1.8026
185	N	A	0.0000
186	F	A	-1.2330
187	E	A	-1.9296
188	T	A	-1.0297
189	S	A	-1.1880
190	T	A	-1.0993
191	L	A	-0.6182
192	S	A	0.0000
193	F	A	0.0000
194	S	A	0.0000
195	P	A	-2.2482
196	E	A	-2.8104
197	E	A	-2.6526
198	N	A	-2.5062
199	F	A	0.0000
200	G	A	-2.6010
201	D	A	-3.6740
202	D	A	-3.8462
203	S	A	0.0000
204	G	A	0.0000
205	L	A	0.0000
206	A	A	-0.7893
207	A	A	-1.0099
208	Y	A	0.0000
209	V	A	0.0000
210	A	A	-0.4918
211	K	A	-1.5130
212	A	A	0.0000
213	I	A	0.0000
214	D	A	-0.9174
215	P	A	-0.0537
216	S	A	-0.2383
217	I	A	-0.2827
218	S	A	-0.6328
219	W	A	-1.0384
220	E	A	-2.0798
221	D	A	-1.4067
222	I	A	0.0000
223	K	A	-2.0848
224	W	A	-1.3735
225	L	A	0.0000
226	R	A	-1.7166
227	R	A	-2.1595
228	L	A	-1.1325
229	T	A	0.0000
230	S	A	-0.5867
231	L	A	-0.4099
232	P	A	-0.5138
233	I	A	0.0000
234	V	A	0.0000
235	A	A	0.0000
236	K	A	0.0000
237	G	A	0.0000
238	I	A	0.0000
239	L	A	-1.2665
240	R	A	-3.0289
241	G	A	-3.0343
242	D	A	-3.3650
243	D	A	-2.8161
244	A	A	0.0000
245	R	A	-3.3007
246	E	A	-2.7460
247	A	A	0.0000
248	V	A	0.0000
249	K	A	-2.4255
250	H	A	-1.9264
251	G	A	-1.5413
252	L	A	0.0000
253	N	A	-0.9157
254	G	A	0.0000
255	I	A	0.0000
256	L	A	0.0000
257	V	A	0.0000
258	S	A	0.0000
259	N	A	0.0000
260	H	A	-0.0229
261	G	A	-0.2764
262	A	A	0.0000
263	R	A	-0.4892
264	Q	A	0.0000
265	L	A	0.5297
266	D	A	-1.3645
267	G	A	-1.2979
268	V	A	-0.0917
269	P	A	-0.4265
270	A	A	0.0000
271	T	A	0.0000
272	I	A	0.0000
273	D	A	-0.9692
274	V	A	-0.8301
275	L	A	0.0000
276	P	A	-1.3738
277	E	A	-2.8716
278	I	A	0.0000
279	V	A	-1.8412
280	E	A	-3.0339
281	A	A	-3.0636
282	V	A	0.0000
283	E	A	-3.1613
284	G	A	-2.4424
285	K	A	-2.6123
286	V	A	-1.5428
287	E	A	-1.1217
288	V	A	0.0000
289	F	A	0.0000
290	L	A	0.0000
291	D	A	0.0000
292	G	A	-0.0179
293	G	A	0.0000
294	V	A	0.0000
295	R	A	-0.4955
296	K	A	-0.9503
297	G	A	0.0000
298	T	A	-0.3635
299	D	A	0.0000
300	V	A	0.0000
301	L	A	0.0000
302	K	A	0.0000
303	A	A	0.0000
304	L	A	0.0000
305	A	A	0.0000
306	L	A	0.0000
307	G	A	-1.1582
308	A	A	0.0000
309	K	A	-0.9751
310	A	A	0.0000
311	V	A	0.0000
312	F	A	0.0000
313	V	A	0.0000
314	G	A	-0.2971
315	R	A	-0.4404
316	P	A	0.0000
317	I	A	0.0000
318	V	A	0.0000
319	W	A	0.0000
320	G	A	0.0000
321	L	A	0.0000
322	A	A	-0.2255
323	F	A	-0.6942
324	Q	A	-1.8586
325	G	A	0.0000
326	E	A	-2.6590
327	K	A	-2.7211
328	G	A	0.0000
329	V	A	0.0000
330	Q	A	-1.9630
331	D	A	-1.1944
332	V	A	0.0000
333	L	A	0.0000
334	E	A	-1.8034
335	I	A	-0.8593
336	L	A	0.0000
337	K	A	-1.8988
338	E	A	-2.0167
339	E	A	-1.3088
340	F	A	0.0000
341	R	A	-1.1634
342	L	A	0.6575
343	A	A	0.0000
344	M	A	0.0000
345	A	A	0.3053
346	L	A	1.6181
347	S	A	0.0000
348	G	A	0.0000
349	C	A	0.0000
350	Q	A	-1.7584
351	N	A	-1.5953
352	V	A	-1.1306
353	K	A	-1.8365
354	V	A	-0.8140
355	I	A	0.0000
356	D	A	-1.6738
357	K	A	-2.1453
358	T	A	-1.1658
359	L	A	0.0000
360	V	A	0.0000
361	R	A	-2.9802
362	K	A	-3.1692