Project name: model 3 TAU

Chain sequence(s)	A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.3358
• Maximal score value: 1.8418
• Average score: -1.2862
• Total score value: -567.1967

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	-0.0962
2	A	A	-0.8995
3	E	A	-2.3252
4	P	A	-2.0151
5	R	A	-1.7845
6	Q	A	-1.7897
7	E	A	-2.3969
8	F	A	-1.2164
9	E	A	-1.4626
10	V	A	0.0000
11	M	A	-0.4753
12	E	A	-2.2169
13	D	A	-2.5841
14	H	A	-2.2067
15	A	A	-1.2244
16	G	A	-0.9998
17	T	A	-0.5321
18	Y	A	-0.4139
19	G	A	-0.9505
20	L	A	-0.0291
21	G	A	-1.3038
22	D	A	-2.9232
23	R	A	-4.0702
24	K	A	-4.3358
25	D	A	-4.0900
26	Q	A	-3.1365
27	G	A	-2.9356
28	G	A	-1.4129
29	Y	A	-0.6936
30	T	A	0.1990
31	M	A	0.1570
32	H	A	-1.0208
33	Q	A	-1.8391
34	D	A	-2.7110
35	Q	A	-3.1786
36	E	A	-3.5955
37	G	A	-3.1794
38	D	A	-3.2189
39	T	A	-2.8368
40	D	A	-3.3838
41	A	A	-2.4236
42	G	A	-2.0521
43	L	A	-1.6415
44	K	A	-2.8243
45	E	A	-2.3762
46	S	A	-1.6142
47	P	A	-0.9760
48	L	A	-0.2914
49	Q	A	-1.6271
50	T	A	-1.0008
51	P	A	-1.0797
52	T	A	-1.8976
53	E	A	-3.3198
54	D	A	-3.6139
55	G	A	-3.0069
56	S	A	-2.5863
57	E	A	-2.8716
58	E	A	-3.2738
59	P	A	-2.3734
60	G	A	-1.9744
61	S	A	-1.8640
62	E	A	-2.6385
63	T	A	-2.0092
64	S	A	-2.0341
65	D	A	-2.8394
66	A	A	-1.7936
67	K	A	-2.3995
68	S	A	-1.8402
69	T	A	-1.3062
70	P	A	-0.9346
71	T	A	-1.2292
72	A	A	-1.5061
73	E	A	-2.2277
74	D	A	-1.8870
75	V	A	0.8001
76	T	A	0.5782
77	A	A	0.6063
78	P	A	0.6989
79	L	A	1.8418
80	V	A	1.0308
81	D	A	-1.9311
82	E	A	-2.3012
83	G	A	-1.1867
84	A	A	-1.6438
85	P	A	-2.1724
86	G	A	-2.6447
87	K	A	-2.8005
88	Q	A	-2.2231
89	A	A	-1.3777
90	A	A	-1.0161
91	A	A	-0.9129
92	Q	A	-1.5355
93	P	A	-1.2767
94	H	A	-1.7238
95	T	A	-1.3670
96	E	A	-2.0644
97	I	A	-0.5799
98	P	A	-1.4673
99	E	A	-2.1992
100	G	A	-1.2705
101	T	A	-0.9352
102	T	A	-0.9842
103	A	A	-1.0352
104	E	A	-2.6717
105	E	A	-2.4659
106	A	A	-1.0930
107	G	A	-1.2172
108	I	A	0.3041
109	G	A	-0.7632
110	D	A	-1.6172
111	T	A	-0.8144
112	P	A	-0.6663
113	S	A	-0.8360
114	L	A	-0.4335
115	E	A	-2.2865
116	D	A	-2.5930
117	E	A	-1.5760
118	A	A	-1.0646
119	A	A	-0.7468
120	G	A	-0.9376
121	H	A	-0.6943
122	V	A	0.7490
123	T	A	-0.2426
124	Q	A	-1.2264
125	A	A	0.0000
126	R	A	-2.3442
127	M	A	-0.8444
128	V	A	-1.1371
129	S	A	0.0000
130	K	A	-2.6664
131	S	A	-2.1904
132	K	A	-3.3926
133	D	A	-3.4055
134	G	A	-2.3732
135	T	A	-2.5361
136	G	A	-2.5260
137	S	A	-2.9644
138	D	A	-3.7291
139	D	A	-4.1739
140	K	A	-4.2252
141	K	A	-3.7338
142	A	A	-2.4824
143	K	A	-3.1516
144	G	A	-2.5977
145	A	A	-2.3194
146	D	A	-3.2489
147	G	A	-2.5944
148	K	A	-2.8861
149	T	A	-1.9578
150	K	A	-1.5815
151	I	A	0.8764
152	A	A	0.0970
153	T	A	-0.3983
154	P	A	-1.0730
155	R	A	-2.1454
156	G	A	-1.4201
157	A	A	-1.3279
158	A	A	-1.1060
159	P	A	-1.1234
160	P	A	-1.3031
161	G	A	-2.0144
162	Q	A	-2.5801
163	K	A	-2.8809
164	G	A	-2.0888
165	Q	A	-2.0386
166	A	A	-1.2386
167	N	A	-1.8226
168	A	A	-0.5919
169	T	A	-0.4813
170	R	A	-0.7101
171	I	A	-0.2504
172	P	A	-1.1363
173	A	A	-1.3969
174	K	A	-2.3855
175	T	A	-1.3124
176	P	A	-1.3545
177	P	A	-1.6381
178	A	A	-1.2603
179	P	A	-1.2586
180	K	A	-2.1223
181	T	A	-1.3301
182	P	A	-0.9197
183	P	A	-0.9979
184	S	A	-0.9775
185	S	A	-1.4356
186	G	A	-1.9534
187	E	A	-3.0144
188	P	A	-3.1789
189	P	A	-2.4972
190	K	A	-3.6013
191	S	A	-3.1093
192	G	A	-2.6639
193	D	A	-3.7712
194	R	A	-3.6504
195	S	A	-2.0870
196	G	A	-1.8239
197	Y	A	-0.0852
198	S	A	-0.5791
199	S	A	-0.1350
200	P	A	-0.5116
201	G	A	-1.0515
202	S	A	-0.6322
203	P	A	-0.8772
204	G	A	-1.2979
205	T	A	-1.3471
206	P	A	-2.0864
207	G	A	-1.8484
208	S	A	-1.9829
209	R	A	-3.2871
210	S	A	-2.7162
211	R	A	-3.1436
212	T	A	-1.5428
213	P	A	-1.0333
214	S	A	-0.6114
215	L	A	-0.3168
216	P	A	-0.5347
217	T	A	-0.3771
218	P	A	-0.6156
219	P	A	-0.8934
220	T	A	-1.3750
221	R	A	-2.1264
222	E	A	-1.7833
223	P	A	-1.4304
224	K	A	-1.5532
225	K	A	-1.8834
226	V	A	-0.2375
227	A	A	-0.2951
228	V	A	0.4174
229	V	A	-0.1154
230	R	A	-0.4548
231	T	A	-0.7950
232	P	A	-1.1573
233	P	A	-1.5588
234	K	A	-2.1164
235	S	A	-1.3556
236	P	A	-1.3661
237	S	A	-1.4611
238	S	A	-1.0919
239	A	A	-0.9193
240	K	A	-1.1249
241	S	A	-1.3497
242	R	A	-2.4394
243	L	A	-1.5292
244	Q	A	-2.0521
245	T	A	-1.0678
246	A	A	-0.8018
247	P	A	-0.1764
248	V	A	0.0000
249	P	A	-0.7539
250	M	A	-0.6694
251	P	A	-1.4236
252	D	A	-2.3317
253	L	A	-1.2163
254	K	A	-2.4451
255	N	A	-1.9634
256	V	A	-0.2189
257	K	A	-1.6522
258	S	A	-0.8630
259	K	A	-1.2851
260	I	A	0.3451
261	G	A	-0.4940
262	S	A	-1.0064
263	T	A	-1.2165
264	E	A	-2.1523
265	N	A	-1.7222
266	L	A	-1.5330
267	K	A	-2.4062
268	H	A	-1.8368
269	Q	A	-2.1753
270	P	A	-1.6724
271	G	A	-1.4797
272	G	A	-1.4230
273	G	A	-1.2714
274	K	A	-1.5780
275	V	A	0.0140
276	Q	A	-0.9884
277	I	A	-0.4645
278	I	A	0.0000
279	N	A	-1.5364
280	K	A	-2.6717
281	K	A	-2.7771
282	L	A	-1.9100
283	D	A	-2.4979
284	L	A	-1.7506
285	S	A	-1.3660
286	N	A	-2.1676
287	V	A	-1.5391
288	Q	A	-1.8871
289	S	A	-1.4866
290	K	A	-2.2653
291	C	A	-1.3891
292	G	A	-1.9578
293	S	A	-1.7468
294	K	A	-2.3748
295	D	A	-2.6654
296	N	A	-1.5459
297	I	A	-0.2640
298	K	A	-1.5505
299	H	A	-1.5854
300	V	A	-0.8252
301	P	A	-0.7728
302	G	A	-0.7502
303	G	A	-1.1370
304	G	A	-0.8407
305	S	A	-0.2846
306	V	A	0.7894
307	Q	A	0.4010
308	I	A	0.5243
309	V	A	1.6401
310	Y	A	0.2686
311	K	A	-0.5689
312	P	A	-0.0223
313	V	A	0.8991
314	D	A	-0.5194
315	L	A	0.3963
316	S	A	-0.6628
317	K	A	-1.5666
318	V	A	-1.1751
319	T	A	-1.0422
320	S	A	-1.4566
321	K	A	-1.6316
322	C	A	-0.3043
323	G	A	-0.2786
324	S	A	0.1401
325	L	A	1.3663
326	G	A	0.0141
327	N	A	-0.4538
328	I	A	0.8595
329	H	A	-1.2543
330	H	A	-1.7183
331	K	A	-2.5854
332	P	A	-1.9330
333	G	A	-1.4381
334	G	A	-1.3207
335	G	A	-0.8064
336	Q	A	-0.8032
337	V	A	0.7549
338	E	A	-0.7577
339	V	A	0.6637
340	K	A	-1.5418
341	S	A	-1.6128
342	E	A	-2.8896
343	K	A	-2.7712
344	L	A	-0.9700
345	D	A	-1.3073
346	F	A	-0.2086
347	K	A	-2.1937
348	D	A	-2.8274
349	R	A	-2.3778
350	V	A	-0.4431
351	Q	A	-1.2731
352	S	A	-0.6902
353	K	A	-1.2832
354	I	A	0.8413
355	G	A	0.4041
356	S	A	0.0741
357	L	A	0.2306
358	D	A	-1.2834
359	N	A	-1.2388
360	I	A	0.7801
361	T	A	0.5866
362	H	A	0.1285
363	V	A	1.6071
364	P	A	-0.1477
365	G	A	-0.6388
366	G	A	-1.5410
367	G	A	-1.8168
368	N	A	-2.7123
369	K	A	-2.4771
370	K	A	-1.7540
371	I	A	0.1293
372	E	A	-1.2664
373	T	A	-0.4410
374	H	A	-1.2881
375	K	A	-1.1352
376	L	A	-0.7798
377	T	A	-1.3874
378	F	A	-1.4734
379	R	A	-2.7906
380	E	A	-2.9198
381	N	A	-2.1587
382	A	A	-1.0473
383	K	A	-1.9537
384	A	A	-1.2961
385	K	A	-2.0654
386	T	A	-2.0408
387	D	A	-2.2756
388	H	A	-2.1649
389	G	A	-1.6939
390	A	A	-0.9806
391	E	A	-1.0921
392	I	A	0.7803
393	V	A	0.0539
394	Y	A	0.3495
395	K	A	-0.7363
396	S	A	-0.1734
397	P	A	0.1301
398	V	A	0.2875
399	V	A	0.8365
400	S	A	-0.4893
401	G	A	-1.0649
402	D	A	-2.3915
403	T	A	-1.1400
404	S	A	-1.7139
405	P	A	-1.0329
406	R	A	-1.0295
407	H	A	-0.6963
408	L	A	0.7687
409	S	A	0.2437
410	N	A	-0.3400
411	V	A	1.2180
412	S	A	0.0504
413	S	A	-0.2550
414	T	A	-0.0525
415	G	A	-0.5008
416	S	A	0.1152
417	I	A	0.7727
418	D	A	-0.2843
419	M	A	0.4933
420	V	A	-0.2669
421	D	A	-1.6028
422	S	A	-0.9409
423	P	A	-0.6684
424	Q	A	-0.5148
425	L	A	1.5194
426	A	A	1.0970
427	T	A	0.7084
428	L	A	1.0362
429	A	A	0.0516
430	D	A	-1.7598
431	E	A	-1.4304
432	V	A	1.0156
433	S	A	0.8034
434	A	A	-0.0282
435	S	A	-0.4156
436	L	A	1.0756
437	A	A	-0.1751
438	K	A	-1.7728
439	Q	A	-0.7517
440	G	A	-0.1719
441	L	A	0.9911