Project name: 7619c415ed420a

Chain sequence(s)	H: QVQLVESGGGVVQPGRSLRLSCAASGFAFSSYGMHWVRQAPGKGLEWVAVIWFDGTKKYYTDSVKGRFTISRDNSKNTLYLQMNTLRAEDTAVYYCARDRGIGARRGPYYMDVWGKGTTVTVSSASTKGPSVFPLAPSSTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.0352
• Maximal score value: 2.4898
• Average score: -0.5838
• Total score value: -127.8444

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.2857
2	V	H	-0.5109
3	Q	H	-0.6095
4	L	H	0.0000
5	V	H	1.1046
6	E	H	0.0650
7	S	H	-0.4930
8	G	H	-0.8335
9	G	H	-0.4036
10	G	H	0.2067
11	V	H	0.8658
12	V	H	-0.2523
13	Q	H	-1.2615
14	P	H	-1.6562
15	G	H	-1.8066
16	R	H	-2.3435
17	S	H	-1.6832
18	L	H	-0.9552
19	R	H	-1.4953
20	L	H	0.0000
21	S	H	-0.2595
22	C	H	0.0000
23	A	H	-0.0747
24	A	H	0.0000
25	S	H	-0.5900
26	G	H	-0.8151
27	F	H	-0.1763
28	A	H	0.0511
29	F	H	0.0000
30	S	H	-0.8355
31	S	H	-0.5039
32	Y	H	-0.5685
33	G	H	-0.5536
34	M	H	0.0000
35	H	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	0.0000
39	Q	H	-0.6837
40	A	H	-1.2107
41	P	H	-1.1385
42	G	H	-1.4408
43	K	H	-2.1420
44	G	H	-1.0444
45	L	H	0.3921
46	E	H	-0.5275
47	W	H	0.2385
48	V	H	0.0000
49	A	H	0.0000
50	V	H	0.0000
51	I	H	0.0000
52	W	H	-1.2660
53	F	H	-0.9329
54	D	H	-1.8051
55	G	H	-1.4959
56	T	H	-1.4249
57	K	H	-1.9270
58	K	H	-0.9282
59	Y	H	-0.1450
60	Y	H	-0.4520
61	T	H	-1.0988
62	D	H	-2.3186
63	S	H	-1.7767
64	V	H	0.0000
65	K	H	-2.4657
66	G	H	-1.7093
67	R	H	-1.2855
68	F	H	0.0000
69	T	H	-0.7019
70	I	H	0.0000
71	S	H	-0.4252
72	R	H	-1.1100
73	D	H	-1.7816
74	N	H	-1.8926
75	S	H	-1.6203
76	K	H	-2.3925
77	N	H	-1.7356
78	T	H	-0.9577
79	L	H	0.0000
80	Y	H	-0.4009
81	L	H	0.0000
82	Q	H	-0.8983
83	M	H	0.0000
84	N	H	-1.5712
85	T	H	-1.4554
86	L	H	0.0000
87	R	H	-2.2693
88	A	H	-1.5697
89	E	H	-2.1991
90	D	H	0.0000
91	T	H	-0.7164
92	A	H	0.0000
93	V	H	0.0173
94	Y	H	0.0000
95	Y	H	0.1823
96	C	H	0.0000
97	A	H	0.0000
98	R	H	-0.2532
99	D	H	0.0000
100	R	H	-0.9400
101	G	H	0.0000
102	I	H	0.8527
103	G	H	-0.5389
104	A	H	-0.8957
105	R	H	-1.9093
106	R	H	-0.9234
107	G	H	-0.4939
108	P	H	0.3840
109	Y	H	1.4830
110	Y	H	1.2434
111	M	H	0.1609
112	D	H	-0.9694
113	V	H	-0.2878
114	W	H	0.0210
115	G	H	0.0000
116	K	H	-1.3369
117	G	H	-0.6316
118	T	H	-0.3724
119	T	H	-0.0104
120	V	H	0.0000
121	T	H	-0.1743
122	V	H	0.0000
123	S	H	-0.5710
124	S	H	-0.5706
125	A	H	-0.3458
126	S	H	-0.4478
127	T	H	-0.6789
128	K	H	-1.2616
129	G	H	-1.5163
130	P	H	0.0000
131	S	H	-0.0439
132	V	H	0.0000
133	F	H	1.0982
134	P	H	-0.0139
135	L	H	0.3780
136	A	H	-0.8677
137	P	H	0.0000
138	S	H	-0.8518
139	S	H	-0.5469
146	T	H	-0.2809
147	A	H	-0.2330
148	A	H	0.0739
149	L	H	0.0000
150	G	H	0.0000
151	C	H	0.0000
152	L	H	0.8766
153	V	H	0.0000
154	K	H	-0.1540
155	D	H	-0.5856
156	Y	H	0.0000
157	F	H	0.0000
158	P	H	-0.9744
159	E	H	-1.3469
160	P	H	-1.4290
161	V	H	-1.1464
162	T	H	-0.9027
163	V	H	-0.3462
164	S	H	-0.4670
165	W	H	0.0000
166	N	H	-0.8386
167	S	H	-0.6935
168	G	H	-0.5750
169	A	H	-0.2363
170	L	H	0.0163
171	T	H	-0.2762
172	S	H	-0.3593
173	G	H	-0.4542
174	V	H	-0.0191
175	H	H	-0.5288
176	T	H	0.1199
177	F	H	0.8032
178	P	H	0.6537
179	A	H	1.0908
180	V	H	2.4898
181	L	H	2.0554
182	Q	H	0.7056
183	S	H	0.1168
184	S	H	-0.1997
185	G	H	0.2069
186	L	H	0.1014
187	Y	H	0.0000
188	S	H	0.0000
189	L	H	0.9296
190	S	H	0.7032
191	S	H	0.0000
192	V	H	0.3689
193	V	H	0.0000
194	T	H	-0.2365
195	V	H	0.0000
196	P	H	-0.4301
197	S	H	-0.5439
198	S	H	-0.6234
199	S	H	-0.7148
200	L	H	-0.9695
201	G	H	-1.0615
202	T	H	-0.8418
203	Q	H	-1.4892
204	T	H	-1.2423
205	Y	H	0.0000
206	I	H	-1.4047
207	C	H	0.0000
208	N	H	-1.6873
209	V	H	0.0000
210	N	H	-2.5960
211	H	H	0.0000
212	K	H	-3.0352
213	P	H	-1.8612
214	S	H	-1.9190
215	N	H	-2.6668
216	T	H	-2.2420
217	K	H	-2.9878
218	V	H	-1.9450
219	D	H	-2.7731
220	K	H	-2.2801
221	R	H	-2.6741
222	V	H	0.0000
223	E	H	-2.9752
224	P	H	-2.0015
225	K	H	-2.3148