| Chain sequence(s) |
A: TCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP B: TCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1A | T | A | -0.3337 | |
| 1 | C | A | -0.1657 | |
| 2 | G | A | 0.0000 | |
| 3 | L | A | -0.0593 | |
| 4 | R | A | -0.6860 | |
| 5 | Q | A | -1.1217 | |
| 6 | Y | A | -0.5240 | |
| 7 | S | A | -1.0867 | |
| 8 | Q | A | -1.3219 | |
| 9 | P | A | 0.0000 | |
| 10 | Q | A | -1.0555 | |
| 11 | F | A | 0.4742 | |
| 15 | R | A | -1.4594 | |
| 16 | I | A | 0.0000 | |
| 17 | K | A | -2.5933 | |
| 18 | G | A | -1.7448 | |
| 19 | G | A | 0.0000 | |
| 20 | L | A | -0.7095 | |
| 21 | F | A | -0.2449 | |
| 22 | A | A | 0.0000 | |
| 23 | D | A | -1.1640 | |
| 24 | I | A | 0.0000 | |
| 25 | A | A | -0.6815 | |
| 26 | S | A | 0.0000 | |
| 27 | H | A | 0.0000 | |
| 28 | P | A | 0.0000 | |
| 29 | W | A | 0.0000 | |
| 30 | Q | A | 0.0000 | |
| 31 | A | A | 0.0000 | |
| 32 | A | A | 0.0000 | |
| 33 | I | A | 0.0000 | |
| 34 | F | A | 0.0000 | |
| 35 | A | A | 0.0000 | |
| 36 | K | A | -3.3431 | |
| 37 | H | A | -3.3121 | |
| 37A | R | A | -3.4101 | |
| 37B | R | A | -3.2780 | |
| 37C | S | A | -2.5233 | |
| 37D | P | A | -2.2857 | |
| 37E | G | A | -2.5684 | |
| 38 | E | A | -3.2242 | |
| 39 | R | A | -2.7596 | |
| 40 | F | A | 0.0000 | |
| 41 | L | A | -0.6965 | |
| 42 | C | A | 0.0000 | |
| 43 | G | A | 0.0000 | |
| 44 | G | A | 0.0000 | |
| 45 | I | A | 0.0000 | |
| 46 | L | A | 0.0000 | |
| 47 | I | A | 0.0000 | |
| 48 | S | A | -0.7970 | |
| 49 | S | A | -1.4024 | |
| 50 | C | A | 0.0000 | |
| 51 | W | A | 0.0000 | |
| 52 | I | A | 0.0000 | |
| 53 | L | A | 0.0000 | |
| 54 | S | A | 0.0000 | |
| 55 | A | A | 0.0000 | |
| 56 | A | A | 0.0000 | |
| 57 | H | A | -1.3211 | |
| 58 | C | A | 0.0000 | |
| 59 | F | A | 0.0000 | |
| 60 | Q | A | -2.8987 | |
| 60A | E | A | -3.2718 | |
| 60B | R | A | -2.9964 | |
| 60C | F | A | -1.8975 | |
| 60D | P | A | -1.2990 | |
| 61 | P | A | -1.6303 | |
| 62 | H | A | -2.0449 | |
| 63 | H | A | -2.0141 | |
| 64 | L | A | 0.0000 | |
| 65 | T | A | -1.9725 | |
| 66 | V | A | 0.0000 | |
| 67 | I | A | 0.0000 | |
| 68 | L | A | 0.0000 | |
| 69 | G | A | 0.0000 | |
| 70 | R | A | 0.0000 | |
| 71 | T | A | -0.6579 | |
| 72 | Y | A | 0.0623 | |
| 73 | R | A | -0.0323 | |
| 74 | V | A | -0.0517 | |
| 75 | V | A | 0.2402 | |
| 76 | P | A | -0.6309 | |
| 77 | G | A | -1.5419 | |
| 78 | E | A | -2.8607 | |
| 79 | E | A | -3.1098 | |
| 80 | E | A | -2.2180 | |
| 81 | Q | A | -2.1625 | |
| 82 | K | A | -2.4519 | |
| 83 | F | A | 0.0000 | |
| 84 | E | A | -3.0475 | |
| 85 | V | A | 0.0000 | |
| 86 | E | A | -2.5524 | |
| 87 | K | A | -1.8410 | |
| 88 | Y | A | -0.2448 | |
| 89 | I | A | 0.1896 | |
| 90 | V | A | -0.3712 | |
| 91 | H | A | -1.4307 | |
| 92 | K | A | -2.6231 | |
| 93 | E | A | -3.2894 | |
| 94 | F | A | -2.9372 | |
| 95 | D | A | -3.9266 | |
| 96 | D | A | -3.8955 | |
| 97 | D | A | -3.3786 | |
| 98 | T | A | -2.1937 | |
| 99 | Y | A | -1.6494 | |
| 100 | D | A | -2.0439 | |
| 101 | N | A | -1.8453 | |
| 102 | D | A | 0.0000 | |
| 103 | I | A | 0.0000 | |
| 104 | A | A | 0.0000 | |
| 105 | L | A | 0.0000 | |
| 106 | L | A | 0.0000 | |
| 107 | Q | A | -1.1145 | |
| 108 | L | A | 0.0000 | |
| 109 | K | A | -2.8622 | |
| 110 | S | A | -2.2667 | |
| 110A | D | A | -2.4890 | |
| 110B | S | A | -1.9197 | |
| 110C | S | A | -1.7246 | |
| 110D | R | A | -2.6335 | |
| 111 | C | A | 0.0000 | |
| 112 | A | A | 0.0000 | |
| 113 | Q | A | -2.5537 | |
| 114 | E | A | -2.6703 | |
| 115 | S | A | -1.8167 | |
| 116 | S | A | -1.1612 | |
| 117 | V | A | 0.0000 | |
| 118 | V | A | 0.0000 | |
| 119 | R | A | -1.2993 | |
| 120 | T | A | -0.4630 | |
| 121 | V | A | 0.0000 | |
| 122 | C | A | 0.1201 | |
| 123 | L | A | 0.4029 | |
| 124 | P | A | 0.0000 | |
| 125 | P | A | -0.6807 | |
| 126 | A | A | -1.2995 | |
| 127 | D | A | -1.9438 | |
| 128 | L | A | -1.2104 | |
| 129 | Q | A | -1.7036 | |
| 130 | L | A | -0.9811 | |
| 131 | P | A | -1.4427 | |
| 132 | D | A | -2.1128 | |
| 133 | W | A | -1.1156 | |
| 134 | T | A | -1.2429 | |
| 135 | E | A | -2.0022 | |
| 136 | C | A | 0.0000 | |
| 137 | E | A | 0.0000 | |
| 138 | L | A | 0.0000 | |
| 139 | S | A | 0.0000 | |
| 140 | G | A | 0.0000 | |
| 141 | Y | A | 0.0000 | |
| 142 | G | A | 0.0000 | |
| 143 | K | A | -1.0074 | |
| 144 | H | A | -1.4785 | |
| 145 | E | A | -2.0817 | |
| 146 | A | A | -0.5105 | |
| 147 | L | A | 0.8183 | |
| 148 | S | A | 0.0245 | |
| 149 | P | A | 0.1464 | |
| 150 | F | A | 0.1600 | |
| 151 | Y | A | -0.2634 | |
| 152 | S | A | 0.0000 | |
| 153 | E | A | -0.2079 | |
| 154 | R | A | -0.4307 | |
| 155 | L | A | 0.0000 | |
| 156 | K | A | 0.0000 | |
| 157 | E | A | 0.0000 | |
| 158 | A | A | 0.0000 | |
| 159 | H | A | -0.9698 | |
| 160 | V | A | 0.0000 | |
| 161 | R | A | -1.5578 | |
| 162 | L | A | 0.0000 | |
| 163 | Y | A | -1.0652 | |
| 164 | P | A | -1.2069 | |
| 165 | S | A | -1.2473 | |
| 166 | S | A | -1.2706 | |
| 167 | R | A | -2.2304 | |
| 168 | C | A | -1.2032 | |
| 169 | T | A | -1.4907 | |
| 169A | S | A | -1.6192 | |
| 169B | Q | A | -1.9509 | |
| 170 | H | A | -1.5877 | |
| 171 | L | A | 0.0000 | |
| 172 | L | A | -0.0176 | |
| 173 | N | A | -1.8863 | |
| 174 | R | A | -2.3884 | |
| 175 | T | A | -1.3536 | |
| 176 | V | A | -0.9629 | |
| 177 | T | A | -0.8615 | |
| 178 | D | A | -2.1284 | |
| 179 | N | A | -1.5596 | |
| 180 | M | A | 0.0000 | |
| 181 | L | A | -0.5244 | |
| 182 | C | A | 0.0000 | |
| 183 | A | A | 0.0000 | |
| 184 | G | A | 0.0000 | |
| 185 | D | A | -1.8719 | |
| 186 | T | A | -1.7378 | |
| 186A | R | A | -2.7078 | |
| 186B | S | A | -2.5223 | |
| 186C | G | A | -1.6588 | |
| 186D | G | A | -1.3960 | |
| 186E | P | A | -1.1553 | |
| 186F | Q | A | -1.7681 | |
| 186G | A | A | -1.6848 | |
| 186H | N | A | -1.8897 | |
| 187 | L | A | -1.5870 | |
| 188 | H | A | -1.0791 | |
| 189 | D | A | -1.0040 | |
| 190 | A | A | -0.7400 | |
| 191 | C | A | 0.0000 | |
| 192 | Q | A | -1.3455 | |
| 193 | G | A | 0.0000 | |
| 194 | D | A | 0.0000 | |
| 195 | S | A | 0.0000 | |
| 196 | G | A | 0.0000 | |
| 197 | G | A | 0.0000 | |
| 198 | P | A | 0.0000 | |
| 199 | L | A | 0.0000 | |
| 200 | V | A | 0.0000 | |
| 201 | C | A | 0.0000 | |
| 202 | L | A | 0.4100 | |
| 203 | N | A | -0.7558 | |
| 204 | D | A | -2.0233 | |
| 205 | G | A | -1.3042 | |
| 206 | R | A | -1.0486 | |
| 207 | M | A | 0.0000 | |
| 208 | T | A | 0.0000 | |
| 209 | L | A | 0.0000 | |
| 210 | V | A | 0.0000 | |
| 211 | G | A | 0.0000 | |
| 212 | I | A | 0.0000 | |
| 213 | I | A | 0.0000 | |
| 214 | S | A | 0.0000 | |
| 215 | W | A | -0.1183 | |
| 216 | G | A | -0.6226 | |
| 217 | L | A | -0.1806 | |
| 219 | G | A | -0.7743 | |
| 220 | C | A | -1.3592 | |
| 221 | G | A | -1.8769 | |
| 221A | Q | A | -2.3190 | |
| 222 | K | A | -3.4876 | |
| 223 | D | A | -3.2977 | |
| 224 | V | A | -1.5956 | |
| 225 | P | A | 0.0000 | |
| 226 | G | A | 0.0000 | |
| 227 | V | A | 0.0000 | |
| 228 | Y | A | 0.0000 | |
| 229 | T | A | 0.0000 | |
| 230 | K | A | -1.3174 | |
| 231 | V | A | 0.0000 | |
| 232 | T | A | -1.2960 | |
| 233 | N | A | -1.7899 | |
| 234 | Y | A | 0.0000 | |
| 235 | L | A | 0.0000 | |
| 236 | D | A | -3.1253 | |
| 237 | W | A | -2.1364 | |
| 238 | I | A | 0.0000 | |
| 239 | R | A | -3.6613 | |
| 240 | D | A | -3.6362 | |
| 241 | N | A | -2.3970 | |
| 242 | M | A | -2.0904 | |
| 243 | R | A | -2.6320 | |
| 244 | P | A | -1.1386 | |
| 1A | T | B | -0.3579 | |
| 1 | C | B | -0.2258 | |
| 2 | G | B | 0.0000 | |
| 3 | L | B | -0.2496 | |
| 4 | R | B | -0.9096 | |
| 5 | Q | B | -1.2448 | |
| 6 | Y | B | -0.6785 | |
| 7 | S | B | -1.1957 | |
| 8 | Q | B | -1.3602 | |
| 9 | P | B | -0.9433 | |
| 10 | Q | B | -1.0406 | |
| 11 | F | B | 0.4948 | |
| 15 | R | B | -1.3352 | |
| 16 | I | B | -1.1572 | |
| 17 | K | B | -2.2964 | |
| 18 | G | B | -1.4512 | |
| 19 | G | B | 0.0000 | |
| 20 | L | B | -0.5169 | |
| 21 | F | B | -0.2977 | |
| 22 | A | B | 0.0000 | |
| 23 | D | B | -1.1881 | |
| 24 | I | B | 0.0000 | |
| 25 | A | B | -0.6988 | |
| 26 | S | B | 0.0000 | |
| 27 | H | B | 0.0000 | |
| 28 | P | B | 0.0000 | |
| 29 | W | B | 0.0000 | |
| 30 | Q | B | 0.0000 | |
| 31 | A | B | 0.0000 | |
| 32 | A | B | 0.0000 | |
| 33 | I | B | 0.0000 | |
| 34 | F | B | 0.0000 | |
| 35 | A | B | 0.0000 | |
| 36 | K | B | -2.8458 | |
| 37 | H | B | -3.1516 | |
| 37A | R | B | -3.5475 | |
| 37B | R | B | -3.2363 | |
| 37C | S | B | -2.6602 | |
| 37D | P | B | -2.0580 | |
| 37E | G | B | -2.3015 | |
| 38 | E | B | -2.9165 | |
| 39 | R | B | -1.8607 | |
| 40 | F | B | 0.0000 | |
| 41 | L | B | 0.0000 | |
| 42 | C | B | 0.0000 | |
| 43 | G | B | 0.0000 | |
| 44 | G | B | 0.0000 | |
| 45 | I | B | 0.0000 | |
| 46 | L | B | 0.0000 | |
| 47 | I | B | 0.2152 | |
| 48 | S | B | -0.5676 | |
| 49 | S | B | -1.2827 | |
| 50 | C | B | -1.0010 | |
| 51 | W | B | 0.0000 | |
| 52 | I | B | 0.0000 | |
| 53 | L | B | 0.0000 | |
| 54 | S | B | 0.0000 | |
| 55 | A | B | 0.0000 | |
| 56 | A | B | 0.0000 | |
| 57 | H | B | -1.1319 | |
| 58 | C | B | 0.0000 | |
| 59 | F | B | 0.0000 | |
| 60 | Q | B | -2.8137 | |
| 60A | E | B | -3.2801 | |
| 60B | R | B | -3.1298 | |
| 60C | F | B | 0.0000 | |
| 60D | P | B | -1.3955 | |
| 61 | P | B | -2.0210 | |
| 62 | H | B | -2.0563 | |
| 63 | H | B | -2.0279 | |
| 64 | L | B | 0.0000 | |
| 65 | T | B | -1.5901 | |
| 66 | V | B | 0.0000 | |
| 67 | I | B | 0.0000 | |
| 68 | L | B | 0.0000 | |
| 69 | G | B | 0.0000 | |
| 70 | R | B | 0.0000 | |
| 71 | T | B | -0.4710 | |
| 72 | Y | B | 0.0715 | |
| 73 | R | B | 0.0398 | |
| 74 | V | B | 0.1853 | |
| 75 | V | B | 0.2869 | |
| 76 | P | B | -0.6120 | |
| 77 | G | B | -1.5246 | |
| 78 | E | B | -2.8560 | |
| 79 | E | B | -3.0970 | |
| 80 | E | B | -2.2040 | |
| 81 | Q | B | 0.0000 | |
| 82 | K | B | -2.1033 | |
| 83 | F | B | -1.7772 | |
| 84 | E | B | -2.7440 | |
| 85 | V | B | 0.0000 | |
| 86 | E | B | -3.3337 | |
| 87 | K | B | -2.4115 | |
| 88 | Y | B | -0.5337 | |
| 89 | I | B | 0.1594 | |
| 90 | V | B | -0.1164 | |
| 91 | H | B | -1.2824 | |
| 92 | K | B | -2.5196 | |
| 93 | E | B | -3.0865 | |
| 94 | F | B | -2.5561 | |
| 95 | D | B | -3.2499 | |
| 96 | D | B | -3.5370 | |
| 97 | D | B | -3.1393 | |
| 98 | T | B | -1.9235 | |
| 99 | Y | B | -1.3626 | |
| 100 | D | B | -1.7237 | |
| 101 | N | B | -1.6867 | |
| 102 | D | B | 0.0000 | |
| 103 | I | B | 0.0000 | |
| 104 | A | B | 0.0000 | |
| 105 | L | B | 0.0000 | |
| 106 | L | B | 0.0000 | |
| 107 | Q | B | -1.4294 | |
| 108 | L | B | 0.0000 | |
| 109 | K | B | -3.3261 | |
| 110 | S | B | -2.5004 | |
| 110A | D | B | -2.5051 | |
| 110B | S | B | -1.9556 | |
| 110C | S | B | -1.7822 | |
| 110D | R | B | -2.8655 | |
| 111 | C | B | -2.3278 | |
| 112 | A | B | 0.0000 | |
| 113 | Q | B | -2.5494 | |
| 114 | E | B | -2.7700 | |
| 115 | S | B | -1.6921 | |
| 116 | S | B | -1.1189 | |
| 117 | V | B | 0.0000 | |
| 118 | V | B | 0.0000 | |
| 119 | R | B | -1.0651 | |
| 120 | T | B | -0.3266 | |
| 121 | V | B | 0.0000 | |
| 122 | C | B | 0.1518 | |
| 123 | L | B | 0.3733 | |
| 124 | P | B | 0.0000 | |
| 125 | P | B | -0.8351 | |
| 126 | A | B | -1.3611 | |
| 127 | D | B | -2.0741 | |
| 128 | L | B | 0.0000 | |
| 129 | Q | B | -1.7690 | |
| 130 | L | B | -0.9885 | |
| 131 | P | B | -1.4607 | |
| 132 | D | B | -2.1720 | |
| 133 | W | B | -1.2814 | |
| 134 | T | B | -1.3529 | |
| 135 | E | B | -2.1221 | |
| 136 | C | B | 0.0000 | |
| 137 | E | B | -0.6904 | |
| 138 | L | B | 0.0000 | |
| 139 | S | B | 0.0000 | |
| 140 | G | B | 0.0000 | |
| 141 | Y | B | 0.0000 | |
| 142 | G | B | 0.0000 | |
| 143 | K | B | -0.5421 | |
| 144 | H | B | -0.7551 | |
| 145 | E | B | -0.6109 | |
| 146 | A | B | 0.1360 | |
| 147 | L | B | 1.1933 | |
| 148 | S | B | 0.4711 | |
| 149 | P | B | 0.3355 | |
| 150 | F | B | 0.4311 | |
| 151 | Y | B | -0.1472 | |
| 152 | S | B | 0.0000 | |
| 153 | E | B | -0.2090 | |
| 154 | R | B | -0.4628 | |
| 155 | L | B | 0.0000 | |
| 156 | K | B | 0.0000 | |
| 157 | E | B | 0.0000 | |
| 158 | A | B | 0.0000 | |
| 159 | H | B | -1.0358 | |
| 160 | V | B | 0.0000 | |
| 161 | R | B | -1.7686 | |
| 162 | L | B | 0.0000 | |
| 163 | Y | B | -1.0577 | |
| 164 | P | B | -1.2142 | |
| 165 | S | B | -1.2096 | |
| 166 | S | B | -1.1036 | |
| 167 | R | B | -1.9554 | |
| 168 | C | B | -1.1687 | |
| 169 | T | B | -1.5139 | |
| 169A | S | B | -1.6738 | |
| 169B | Q | B | -2.0383 | |
| 170 | H | B | -1.8610 | |
| 171 | L | B | 0.0000 | |
| 172 | L | B | -0.1172 | |
| 173 | N | B | -1.9008 | |
| 174 | R | B | -2.4027 | |
| 175 | T | B | -1.2891 | |
| 176 | V | B | -0.9140 | |
| 177 | T | B | -0.8780 | |
| 178 | D | B | -2.0428 | |
| 179 | N | B | -1.4075 | |
| 180 | M | B | 0.0000 | |
| 181 | L | B | -0.3843 | |
| 182 | C | B | 0.0000 | |
| 183 | A | B | 0.0000 | |
| 184 | G | B | 0.0000 | |
| 185 | D | B | -1.9106 | |
| 186 | T | B | -1.6816 | |
| 186A | R | B | -2.7732 | |
| 186B | S | B | -2.3438 | |
| 186C | G | B | -1.3910 | |
| 186D | G | B | -1.3515 | |
| 186E | P | B | -1.1591 | |
| 186F | Q | B | -1.8188 | |
| 186G | A | B | -1.5789 | |
| 186H | N | B | -2.2054 | |
| 187 | L | B | -1.6995 | |
| 188 | H | B | -1.2120 | |
| 189 | D | B | -0.9048 | |
| 190 | A | B | -0.5470 | |
| 191 | C | B | 0.0000 | |
| 192 | Q | B | -1.1320 | |
| 193 | G | B | 0.0000 | |
| 194 | D | B | 0.0000 | |
| 195 | S | B | -0.3014 | |
| 196 | G | B | 0.0000 | |
| 197 | G | B | 0.0000 | |
| 198 | P | B | 0.0000 | |
| 199 | L | B | 0.0000 | |
| 200 | V | B | 0.0000 | |
| 201 | C | B | 0.0000 | |
| 202 | L | B | 0.2183 | |
| 203 | N | B | -1.0013 | |
| 204 | D | B | -2.1994 | |
| 205 | G | B | -1.5638 | |
| 206 | R | B | -1.5573 | |
| 207 | M | B | 0.0000 | |
| 208 | T | B | 0.0000 | |
| 209 | L | B | 0.0000 | |
| 210 | V | B | 0.0000 | |
| 211 | G | B | 0.0000 | |
| 212 | I | B | 0.0000 | |
| 213 | I | B | 0.0000 | |
| 214 | S | B | 0.0000 | |
| 215 | W | B | -0.0979 | |
| 216 | G | B | -0.4332 | |
| 217 | L | B | -0.1930 | |
| 219 | G | B | -0.6152 | |
| 220 | C | B | -0.9061 | |
| 221 | G | B | -1.6614 | |
| 221A | Q | B | -2.3262 | |
| 222 | K | B | -2.9705 | |
| 223 | D | B | -2.9356 | |
| 224 | V | B | -1.5692 | |
| 225 | P | B | 0.0000 | |
| 226 | G | B | 0.0000 | |
| 227 | V | B | 0.0000 | |
| 228 | Y | B | 0.0000 | |
| 229 | T | B | 0.0000 | |
| 230 | K | B | -0.9584 | |
| 231 | V | B | 0.0000 | |
| 232 | T | B | -1.1264 | |
| 233 | N | B | -1.4585 | |
| 234 | Y | B | 0.0000 | |
| 235 | L | B | -1.5926 | |
| 236 | D | B | -2.9821 | |
| 237 | W | B | -1.9720 | |
| 238 | I | B | 0.0000 | |
| 239 | R | B | -3.5350 | |
| 240 | D | B | -3.3455 | |
| 241 | N | B | -2.0796 | |
| 242 | M | B | -1.7284 | |
| 243 | R | B | -2.5898 | |
| 244 | P | B | -1.1208 |