| Chain sequence(s) |
A: FRDCADVYQAGFNKSGIYTIYINNMPEPKKVFCNMDVNGGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRRFHIGNEKQNYRLYYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLD B: FRDCADVYQAGFNKSGIYTIYINNMPEPKKVFCNMDVNGGGWTVIQHREDGSLDFQRGWKEYKMGFGNPSGEYWLGNEFIFAITSQRQYMLRIELMDWEGNRAYSQYDRRFHIGNEKQNYRLYYLKGHTGTAGKQSSLILHGADFSTKDADNDNCMCKCALMLTGGWWFDACGPSNLNGMFYTAGQNHGKLNGIKWHYFKGPSYSLRSTTMMIRPLD |
| Distance of aggregation | 5 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 283 | F | A | 1.8050 | |
| 284 | R | A | -0.3675 | |
| 285 | D | A | 0.0000 | |
| 286 | C | A | 0.0000 | |
| 287 | A | A | 0.0096 | |
| 288 | D | A | 0.0000 | |
| 289 | V | A | 0.0000 | |
| 290 | Y | A | 0.4076 | |
| 291 | Q | A | -1.1048 | |
| 292 | A | A | -0.2732 | |
| 293 | G | A | -0.1899 | |
| 294 | F | A | 1.2283 | |
| 295 | N | A | -1.1767 | |
| 296 | K | A | -1.9218 | |
| 297 | S | A | -0.4206 | |
| 298 | G | A | 0.0116 | |
| 299 | I | A | 0.6694 | |
| 300 | Y | A | 0.3521 | |
| 301 | T | A | -0.2489 | |
| 302 | I | A | 0.0000 | |
| 303 | Y | A | 1.3000 | |
| 304 | I | A | 0.0000 | |
| 305 | N | A | -1.5066 | |
| 306 | N | A | -1.4783 | |
| 307 | M | A | -0.1256 | |
| 308 | P | A | -0.5641 | |
| 309 | E | A | -1.8927 | |
| 310 | P | A | -0.3776 | |
| 311 | K | A | -0.6004 | |
| 312 | K | A | -1.7552 | |
| 313 | V | A | 0.0000 | |
| 314 | F | A | 0.5588 | |
| 315 | C | A | 0.0000 | |
| 316 | N | A | -0.1873 | |
| 317 | M | A | 0.0000 | |
| 318 | D | A | -1.7555 | |
| 319 | V | A | -0.3786 | |
| 320 | N | A | -1.3252 | |
| 321 | G | A | -0.7020 | |
| 322 | G | A | 0.0000 | |
| 323 | G | A | 0.0000 | |
| 324 | W | A | 0.0000 | |
| 325 | T | A | 0.0000 | |
| 326 | V | A | 0.0000 | |
| 327 | I | A | 0.0000 | |
| 328 | Q | A | 0.0000 | |
| 329 | H | A | -0.1990 | |
| 330 | R | A | 0.0000 | |
| 331 | E | A | -2.1501 | |
| 332 | D | A | -2.1555 | |
| 333 | G | A | -0.5511 | |
| 334 | S | A | -0.2017 | |
| 335 | L | A | -0.0354 | |
| 336 | D | A | -1.2574 | |
| 337 | F | A | 0.0000 | |
| 338 | Q | A | -0.8265 | |
| 339 | R | A | -0.6080 | |
| 340 | G | A | -0.1263 | |
| 341 | W | A | -0.1803 | |
| 342 | K | A | -1.8405 | |
| 343 | E | A | -1.0650 | |
| 344 | Y | A | 0.0000 | |
| 345 | K | A | -0.3779 | |
| 346 | M | A | 0.3152 | |
| 347 | G | A | -0.0021 | |
| 348 | F | A | 0.1222 | |
| 349 | G | A | -0.5276 | |
| 350 | N | A | -1.3398 | |
| 351 | P | A | -0.2982 | |
| 352 | S | A | -0.2577 | |
| 353 | G | A | -0.2515 | |
| 354 | E | A | 0.0000 | |
| 355 | Y | A | 0.0000 | |
| 356 | W | A | 0.0000 | |
| 357 | L | A | 0.0000 | |
| 358 | G | A | 0.0000 | |
| 359 | N | A | 0.0000 | |
| 360 | E | A | -0.3211 | |
| 361 | F | A | 0.0000 | |
| 362 | I | A | 0.0000 | |
| 363 | F | A | 0.4632 | |
| 364 | A | A | 0.0000 | |
| 365 | I | A | 0.0000 | |
| 366 | T | A | 0.0000 | |
| 367 | S | A | -0.0419 | |
| 368 | Q | A | 0.0000 | |
| 369 | R | A | -0.3838 | |
| 370 | Q | A | -0.3307 | |
| 371 | Y | A | 0.0000 | |
| 372 | M | A | -0.0720 | |
| 373 | L | A | 0.0000 | |
| 374 | R | A | 0.0000 | |
| 375 | I | A | 0.0000 | |
| 376 | E | A | 0.0000 | |
| 377 | L | A | 0.0000 | |
| 378 | M | A | 0.0102 | |
| 379 | D | A | 0.0000 | |
| 380 | W | A | -0.1076 | |
| 381 | E | A | -1.8645 | |
| 382 | G | A | -1.0087 | |
| 383 | N | A | -1.5440 | |
| 384 | R | A | -1.9498 | |
| 385 | A | A | 0.0000 | |
| 386 | Y | A | 0.4592 | |
| 387 | S | A | 0.0000 | |
| 388 | Q | A | -0.1945 | |
| 389 | Y | A | 0.0000 | |
| 390 | D | A | -1.8147 | |
| 391 | R | A | 0.0000 | |
| 392 | F | A | 0.0000 | |
| 393 | H | A | 0.0000 | |
| 394 | I | A | 0.0000 | |
| 395 | G | A | 0.0000 | |
| 396 | N | A | -0.2911 | |
| 397 | E | A | -0.9771 | |
| 398 | K | A | -1.8120 | |
| 399 | Q | A | 0.0000 | |
| 400 | N | A | -0.2667 | |
| 401 | Y | A | 0.0000 | |
| 402 | R | A | 0.0000 | |
| 403 | L | A | 0.0000 | |
| 404 | Y | A | 0.0000 | |
| 405 | L | A | 0.0000 | |
| 406 | K | A | -0.4823 | |
| 407 | G | A | -0.6574 | |
| 408 | H | A | -0.2584 | |
| 409 | T | A | -0.1548 | |
| 410 | G | A | -0.3118 | |
| 411 | T | A | -0.1241 | |
| 412 | A | A | 0.0000 | |
| 413 | G | A | -0.2848 | |
| 414 | K | A | -1.9330 | |
| 415 | Q | A | -1.5111 | |
| 416 | S | A | 0.0000 | |
| 417 | S | A | 0.0000 | |
| 418 | L | A | 0.0000 | |
| 419 | I | A | 0.3115 | |
| 420 | L | A | 0.2572 | |
| 421 | H | A | -0.5214 | |
| 422 | G | A | 0.0000 | |
| 423 | A | A | 0.0000 | |
| 424 | D | A | 0.0000 | |
| 425 | F | A | 0.0000 | |
| 426 | S | A | 0.0000 | |
| 427 | T | A | 0.0000 | |
| 428 | K | A | -1.3652 | |
| 429 | D | A | -1.9784 | |
| 430 | A | A | -0.6545 | |
| 431 | D | A | -1.8351 | |
| 432 | N | A | -0.6298 | |
| 433 | D | A | -0.4046 | |
| 434 | N | A | -0.7198 | |
| 435 | C | A | 0.2018 | |
| 436 | M | A | 1.1043 | |
| 437 | C | A | 0.1047 | |
| 438 | K | A | -1.3158 | |
| 439 | C | A | 0.0000 | |
| 440 | A | A | 0.0000 | |
| 441 | L | A | 1.4062 | |
| 442 | M | A | 1.0108 | |
| 443 | L | A | 0.0000 | |
| 444 | T | A | -0.0080 | |
| 445 | G | A | 0.0000 | |
| 446 | G | A | 0.0000 | |
| 447 | W | A | 0.0000 | |
| 448 | W | A | 0.0000 | |
| 449 | F | A | 0.0000 | |
| 450 | D | A | -0.5375 | |
| 451 | A | A | 0.0107 | |
| 452 | C | A | 0.0122 | |
| 453 | G | A | -0.1701 | |
| 454 | P | A | -0.0628 | |
| 455 | S | A | 0.0000 | |
| 456 | N | A | 0.0000 | |
| 457 | L | A | 0.0000 | |
| 458 | N | A | 0.0000 | |
| 459 | G | A | 0.0000 | |
| 460 | M | A | 0.3791 | |
| 461 | F | A | 0.4225 | |
| 462 | Y | A | 0.2862 | |
| 463 | T | A | -0.0159 | |
| 464 | A | A | 0.0455 | |
| 465 | G | A | 0.0000 | |
| 466 | Q | A | -0.7182 | |
| 467 | N | A | -1.5456 | |
| 468 | H | A | -1.2721 | |
| 469 | G | A | -0.9518 | |
| 470 | K | A | -1.4909 | |
| 471 | L | A | 1.1808 | |
| 472 | N | A | 0.1072 | |
| 473 | G | A | 0.0000 | |
| 474 | I | A | 0.0000 | |
| 475 | K | A | 0.0000 | |
| 476 | W | A | 0.0000 | |
| 477 | H | A | -0.1485 | |
| 478 | Y | A | 0.5095 | |
| 479 | F | A | 0.2818 | |
| 480 | K | A | -0.5453 | |
| 481 | G | A | -0.2603 | |
| 482 | P | A | -0.3040 | |
| 483 | S | A | -0.0645 | |
| 484 | Y | A | 0.0921 | |
| 485 | S | A | 0.0000 | |
| 486 | L | A | 0.0000 | |
| 487 | R | A | -0.5139 | |
| 488 | S | A | -0.3576 | |
| 489 | T | A | 0.0000 | |
| 490 | T | A | -0.0338 | |
| 491 | M | A | 0.0000 | |
| 492 | M | A | 0.0000 | |
| 493 | I | A | 0.0000 | |
| 494 | R | A | -0.2711 | |
| 495 | P | A | 0.0000 | |
| 496 | L | A | 0.2980 | |
| 497 | D | A | -1.6768 | |
| 283 | F | B | 1.8175 | |
| 284 | R | B | -0.2977 | |
| 285 | D | B | 0.0000 | |
| 286 | C | B | 0.0000 | |
| 287 | A | B | 0.0094 | |
| 288 | D | B | 0.0000 | |
| 289 | V | B | 0.0000 | |
| 290 | Y | B | 0.4020 | |
| 291 | Q | B | -1.1044 | |
| 292 | A | B | -0.2746 | |
| 293 | G | B | -0.2079 | |
| 294 | F | B | 1.1276 | |
| 295 | N | B | -1.2184 | |
| 296 | K | B | -1.9264 | |
| 297 | S | B | -0.4199 | |
| 298 | G | B | 0.0321 | |
| 299 | I | B | 0.8012 | |
| 300 | Y | B | 0.3831 | |
| 301 | T | B | -0.2377 | |
| 302 | I | B | 0.0000 | |
| 303 | Y | B | 1.3006 | |
| 304 | I | B | 0.0000 | |
| 305 | N | B | -1.5063 | |
| 306 | N | B | -1.4784 | |
| 307 | M | B | -0.1284 | |
| 308 | P | B | -0.5645 | |
| 309 | E | B | -1.8917 | |
| 310 | P | B | -0.3775 | |
| 311 | K | B | -0.6193 | |
| 312 | K | B | -1.7000 | |
| 313 | V | B | 0.0000 | |
| 314 | F | B | 0.5889 | |
| 315 | C | B | 0.0000 | |
| 316 | N | B | -0.1721 | |
| 317 | M | B | 0.0000 | |
| 318 | D | B | -1.7493 | |
| 319 | V | B | -0.3454 | |
| 320 | N | B | -1.3189 | |
| 321 | G | B | -0.7016 | |
| 322 | G | B | 0.0000 | |
| 323 | G | B | 0.0000 | |
| 324 | W | B | 0.0000 | |
| 325 | T | B | 0.0000 | |
| 326 | V | B | 0.0000 | |
| 327 | I | B | 0.0000 | |
| 328 | Q | B | 0.0000 | |
| 329 | H | B | -0.1609 | |
| 330 | R | B | 0.0000 | |
| 331 | E | B | -1.8109 | |
| 332 | D | B | -2.0953 | |
| 333 | G | B | -0.5573 | |
| 334 | S | B | -0.2070 | |
| 335 | L | B | -0.1417 | |
| 336 | D | B | -1.7208 | |
| 337 | F | B | 0.0000 | |
| 338 | Q | B | -0.9623 | |
| 339 | R | B | -0.5786 | |
| 340 | G | B | 0.0000 | |
| 341 | W | B | -0.1620 | |
| 342 | K | B | -1.8890 | |
| 343 | E | B | -1.3474 | |
| 344 | Y | B | 0.0000 | |
| 345 | K | B | -0.3326 | |
| 346 | M | B | 0.3867 | |
| 347 | G | B | -0.0274 | |
| 348 | F | B | 0.0000 | |
| 349 | G | B | -0.5843 | |
| 350 | N | B | -1.3423 | |
| 351 | P | B | -0.2929 | |
| 352 | S | B | -0.2474 | |
| 353 | G | B | -0.2012 | |
| 354 | E | B | 0.0000 | |
| 355 | Y | B | 0.0000 | |
| 356 | W | B | 0.0000 | |
| 357 | L | B | 0.0000 | |
| 358 | G | B | 0.0000 | |
| 359 | N | B | 0.0000 | |
| 360 | E | B | -0.3657 | |
| 361 | F | B | 0.0000 | |
| 362 | I | B | 0.0000 | |
| 363 | F | B | 0.4443 | |
| 364 | A | B | 0.0000 | |
| 365 | I | B | 0.0000 | |
| 366 | T | B | 0.0000 | |
| 367 | S | B | -0.0318 | |
| 368 | Q | B | 0.0000 | |
| 369 | R | B | -0.3995 | |
| 370 | Q | B | -0.3593 | |
| 371 | Y | B | 0.0000 | |
| 372 | M | B | 0.0000 | |
| 373 | L | B | 0.0000 | |
| 374 | R | B | 0.0000 | |
| 375 | I | B | 0.0000 | |
| 376 | E | B | 0.0000 | |
| 377 | L | B | 0.0000 | |
| 378 | M | B | -0.0600 | |
| 379 | D | B | 0.0000 | |
| 380 | W | B | -0.0581 | |
| 381 | E | B | -1.8553 | |
| 382 | G | B | -0.9727 | |
| 383 | N | B | -1.3635 | |
| 384 | R | B | -1.9891 | |
| 385 | A | B | 0.0000 | |
| 386 | Y | B | 0.4291 | |
| 387 | S | B | 0.0000 | |
| 388 | Q | B | -0.1905 | |
| 389 | Y | B | 0.0000 | |
| 390 | D | B | -1.8467 | |
| 391 | R | B | -0.5198 | |
| 392 | F | B | 0.0000 | |
| 393 | H | B | 0.0000 | |
| 394 | I | B | 0.0000 | |
| 395 | G | B | 0.0000 | |
| 396 | N | B | -0.2928 | |
| 397 | E | B | -0.9224 | |
| 398 | K | B | -1.8017 | |
| 399 | Q | B | 0.0000 | |
| 400 | N | B | -0.2564 | |
| 401 | Y | B | 0.0000 | |
| 402 | R | B | 0.0000 | |
| 403 | L | B | 0.0000 | |
| 404 | Y | B | 0.0000 | |
| 405 | L | B | 0.0000 | |
| 406 | K | B | -0.4401 | |
| 407 | G | B | -0.5724 | |
| 408 | H | B | -0.5776 | |
| 409 | T | B | -0.2055 | |
| 410 | G | B | -0.2354 | |
| 411 | T | B | -0.1099 | |
| 412 | A | B | 0.0000 | |
| 413 | G | B | -0.3123 | |
| 414 | K | B | -1.9144 | |
| 415 | Q | B | -1.3578 | |
| 416 | S | B | -0.2161 | |
| 417 | S | B | 0.0000 | |
| 418 | L | B | 0.0000 | |
| 419 | I | B | 0.2932 | |
| 420 | L | B | 0.1564 | |
| 421 | H | B | -0.5765 | |
| 422 | G | B | 0.0000 | |
| 423 | A | B | 0.0000 | |
| 424 | D | B | 0.0000 | |
| 425 | F | B | 0.0000 | |
| 426 | S | B | 0.0000 | |
| 427 | T | B | 0.0000 | |
| 428 | K | B | -1.9585 | |
| 429 | D | B | -2.0867 | |
| 430 | A | B | -0.6534 | |
| 431 | D | B | -1.8355 | |
| 432 | N | B | -0.6333 | |
| 433 | D | B | -0.4033 | |
| 434 | N | B | -0.7054 | |
| 435 | C | B | 0.2372 | |
| 436 | M | B | 1.1035 | |
| 437 | C | B | 0.1103 | |
| 438 | K | B | -1.0817 | |
| 439 | C | B | 0.0000 | |
| 440 | A | B | 0.0000 | |
| 441 | L | B | 1.6247 | |
| 442 | M | B | 1.0752 | |
| 443 | L | B | 0.0000 | |
| 444 | T | B | -0.0090 | |
| 445 | G | B | 0.0000 | |
| 446 | G | B | 0.0000 | |
| 447 | W | B | 0.0000 | |
| 448 | W | B | 0.0000 | |
| 449 | F | B | 0.0000 | |
| 450 | D | B | -0.5209 | |
| 451 | A | B | 0.0201 | |
| 452 | C | B | 0.0165 | |
| 453 | G | B | -0.1713 | |
| 454 | P | B | -0.0630 | |
| 455 | S | B | 0.0000 | |
| 456 | N | B | 0.0000 | |
| 457 | L | B | 0.0000 | |
| 458 | N | B | 0.0000 | |
| 459 | G | B | 0.0000 | |
| 460 | M | B | 0.3751 | |
| 461 | F | B | 0.4217 | |
| 462 | Y | B | 0.3035 | |
| 463 | T | B | -0.0132 | |
| 464 | A | B | 0.0393 | |
| 465 | G | B | 0.0000 | |
| 466 | Q | B | -0.7364 | |
| 467 | N | B | -1.5490 | |
| 468 | H | B | -1.2669 | |
| 469 | G | B | -0.9652 | |
| 470 | K | B | -1.4802 | |
| 471 | L | B | 1.1860 | |
| 472 | N | B | 0.0594 | |
| 473 | G | B | 0.0000 | |
| 474 | I | B | 0.0000 | |
| 475 | K | B | 0.0000 | |
| 476 | W | B | 0.0000 | |
| 477 | H | B | -0.1041 | |
| 478 | Y | B | 0.7430 | |
| 479 | F | B | 0.3026 | |
| 480 | K | B | -0.7563 | |
| 481 | G | B | -0.2840 | |
| 482 | P | B | -0.2391 | |
| 483 | S | B | -0.2181 | |
| 484 | Y | B | 0.0949 | |
| 485 | S | B | 0.0000 | |
| 486 | L | B | 0.0000 | |
| 487 | R | B | -0.5894 | |
| 488 | S | B | -0.3576 | |
| 489 | T | B | 0.0000 | |
| 490 | T | B | -0.0286 | |
| 491 | M | B | 0.0000 | |
| 492 | M | B | 0.0000 | |
| 493 | I | B | 0.0000 | |
| 494 | R | B | -0.2697 | |
| 495 | P | B | 0.0000 | |
| 496 | L | B | 0.3124 | |
| 497 | D | B | -1.6749 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine