Project name: R111C

Chain sequence(s)	A: MAGIRVTKVDWQRSRNGAAHHTQEYPCPELVVRRGQSFSLTLELSRALDCEEILIFTMETGPRASEALHTKAVFQTSELERGEGWTAAREAQMEKTLTVSLASPPSAVIGRYLLSIRLSSHRKHSNRRLGEFVLLFNPWCAEDDVFLASEEERQEYVLSDSGIIFRGVEKHIRAQGWNYGQFEEDILNICLSILDRSPGHQNNPATDVSCRHNPIYVTRVISAMVNSNNDRGVVQGQWQGKYGGGTSPLHWRGSVAILQKWLKGRYKPVKYGQCWVFAGVLCTVLRCLGIATRVVSNFNSAHDTDQNLSVDKYVDSFGRTLEDLTEDSMWNFHVWNESWFARQDLGPSYNGWQVLDATPQEESEGVFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWHEDESRERVYSNTKKIGRCISTKAVGSDSRVDITDLYKYPEGSRKERQVYSKAVNRLFGVEASGRRIWIRRAGGRCLWRDDLLEPATKPSIAGKFKVLEPPMLGHDLRLALCLANLTSRAQRVRVNLSGATILYTRKPVAEILHESHAVRLGPQEEKRIPITISYSKYKEDLTEDKKILLAAMCLVTKGEKLLVEKDITLEDFITIKVLGPAMVGVAVTVEVTVVNPLIERVKDCALMVEGSGLLQEQLSIDVPTLEPQERASVQFDITPSKSGPRQLQVDLVSPHFPDIKGFVIVH
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.1242
• Maximal score value: 2.0403
• Average score: -0.9323
• Total score value: -653.5709

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	-0.1399
2	A	A	-0.8573
3	G	A	-1.4822
4	I	A	0.0000
5	R	A	-2.3080
6	V	A	-1.4914
7	T	A	-1.7462
8	K	A	-2.1942
9	V	A	-1.3039
10	D	A	-1.9048
11	W	A	-1.8530
12	Q	A	-1.9500
13	R	A	-2.5432
14	S	A	-1.8485
15	R	A	-2.5225
16	N	A	0.0000
17	G	A	0.0000
18	A	A	-1.4710
19	A	A	-0.9069
20	H	A	0.0000
21	H	A	-1.0229
22	T	A	0.0000
23	Q	A	-2.3968
24	E	A	-2.6693
25	Y	A	-2.1285
26	P	A	0.0000
27	C	A	-0.9968
28	P	A	-1.0954
29	E	A	-2.2489
30	L	A	0.0000
31	V	A	0.0000
32	V	A	0.0000
33	R	A	0.0000
34	R	A	0.0000
35	G	A	-1.1458
36	Q	A	-0.7991
37	S	A	-0.3709
38	F	A	0.0000
39	S	A	0.0000
40	L	A	0.0000
41	T	A	-1.2839
42	L	A	0.0000
43	E	A	-2.3412
44	L	A	-2.1389
45	S	A	-2.1300
46	R	A	-2.8993
47	A	A	-2.2162
48	L	A	-1.9422
49	D	A	-2.0114
50	C	A	-1.4578
51	E	A	-1.9843
52	E	A	-0.9228
53	I	A	0.6590
54	L	A	0.0000
55	I	A	0.0833
56	F	A	0.0000
57	T	A	-0.2670
58	M	A	0.0000
59	E	A	-1.9154
60	T	A	0.0000
61	G	A	-1.5384
62	P	A	-1.4342
63	R	A	-2.3093
64	A	A	-1.9610
65	S	A	-1.8712
66	E	A	-2.1111
67	A	A	-1.0427
68	L	A	-0.9661
69	H	A	-1.7646
70	T	A	0.0000
71	K	A	-1.7645
72	A	A	-0.3839
73	V	A	0.9349
74	F	A	0.0000
75	Q	A	-0.5257
76	T	A	-0.8163
77	S	A	-1.1092
78	E	A	-2.4019
79	L	A	-0.8779
80	E	A	-2.8048
81	R	A	-3.2206
82	G	A	-2.5862
83	E	A	-3.1036
84	G	A	-1.9268
85	W	A	-0.7967
86	T	A	-1.2349
87	A	A	0.0000
88	A	A	-1.8815
89	R	A	-2.6810
90	E	A	-2.8563
91	A	A	-1.5619
92	Q	A	-1.9673
93	M	A	-0.9706
94	E	A	-2.5974
95	K	A	-2.9455
96	T	A	-1.7220
97	L	A	0.0000
98	T	A	-1.3097
99	V	A	0.0000
100	S	A	-0.8688
101	L	A	0.0000
102	A	A	-0.9559
103	S	A	0.0000
104	P	A	-1.3404
105	P	A	0.0000
106	S	A	-1.1321
107	A	A	0.0000
108	V	A	0.0000
109	I	A	0.0000
110	G	A	0.0000
111	R	A	-1.6896
112	Y	A	0.0000
113	L	A	-1.4644
114	L	A	0.0000
115	S	A	-1.5953
116	I	A	0.0000
117	R	A	-1.7097
118	L	A	0.0000
119	S	A	0.0000
120	S	A	0.0000
121	H	A	-2.5366
122	R	A	-3.2281
123	K	A	-3.2576
124	H	A	-2.6738
125	S	A	-2.1313
126	N	A	-2.5330
127	R	A	-2.3984
128	R	A	-2.7447
129	L	A	-1.8215
130	G	A	-1.7566
131	E	A	-2.6086
132	F	A	0.0000
133	V	A	0.0000
134	L	A	0.0000
135	L	A	0.0000
136	F	A	0.0000
137	N	A	0.0000
138	P	A	0.0000
139	W	A	-0.1589
140	C	A	0.0000
141	A	A	-0.7040
142	E	A	-2.0838
143	D	A	0.0000
144	D	A	-0.9472
145	V	A	0.0000
146	F	A	0.1795
147	L	A	0.0000
148	A	A	-0.2810
149	S	A	-1.1275
150	E	A	-2.0149
151	E	A	-2.6673
152	E	A	-1.8104
153	R	A	-1.3946
154	Q	A	-1.8411
155	E	A	0.0000
156	Y	A	0.0000
157	V	A	0.0000
158	L	A	-0.9098
159	S	A	-1.0551
160	D	A	-2.0242
161	S	A	-1.5453
162	G	A	-1.1988
163	I	A	-1.0170
164	I	A	0.0000
165	F	A	0.0000
166	R	A	-1.0744
167	G	A	-1.2343
168	V	A	-1.0277
169	E	A	-1.3791
170	K	A	-2.1729
171	H	A	-1.9395
172	I	A	-1.3705
173	R	A	-2.1267
174	A	A	-1.4419
175	Q	A	-1.0744
176	G	A	-1.4570
177	W	A	0.0000
178	N	A	-2.1866
179	Y	A	0.0000
180	G	A	0.0000
181	Q	A	0.0000
182	F	A	-1.9750
183	E	A	-2.9957
184	E	A	-3.1458
185	D	A	-2.1855
186	I	A	0.0000
187	L	A	0.0000
188	N	A	-1.3189
189	I	A	0.0000
190	C	A	0.0000
191	L	A	0.0000
192	S	A	-0.7032
193	I	A	0.0000
194	L	A	0.0000
195	D	A	-1.6290
196	R	A	-1.8770
197	S	A	0.0000
198	P	A	-1.3518
199	G	A	-1.2778
200	H	A	-2.0581
201	Q	A	-2.6234
202	N	A	-2.4673
203	N	A	-2.3757
204	P	A	-2.0078
205	A	A	-1.4309
206	T	A	-0.8499
207	D	A	0.0000
208	V	A	0.0000
209	S	A	0.0000
210	C	A	-0.0110
211	R	A	0.0000
212	H	A	-0.4811
213	N	A	-0.5825
214	P	A	0.0000
215	I	A	0.0000
216	Y	A	0.1784
217	V	A	0.0000
218	T	A	0.0000
219	R	A	0.0124
220	V	A	0.0000
221	I	A	0.0000
222	S	A	0.0000
223	A	A	0.0000
224	M	A	0.0000
225	V	A	0.0000
226	N	A	-1.2661
227	S	A	-1.6780
228	N	A	-2.6734
229	N	A	-2.8203
230	D	A	-3.4485
231	R	A	-3.0830
232	G	A	0.0000
233	V	A	0.0000
234	V	A	0.0000
235	Q	A	-1.7875
236	G	A	0.0000
237	Q	A	-0.9443
238	W	A	-0.4513
239	Q	A	-1.1901
240	G	A	-1.6104
241	K	A	-2.3143
242	Y	A	-1.5649
243	G	A	-1.4435
244	G	A	-1.3343
245	G	A	-1.2813
246	T	A	-0.9000
247	S	A	-0.7857
248	P	A	0.0000
249	L	A	0.0656
250	H	A	-0.9967
251	W	A	0.0000
252	R	A	-2.2262
253	G	A	-1.6945
254	S	A	0.0000
255	V	A	-1.0535
256	A	A	-0.6669
257	I	A	0.0000
258	L	A	0.0000
259	Q	A	-1.6400
260	K	A	-2.5928
261	W	A	0.0000
262	L	A	-2.0739
263	K	A	-3.0150
264	G	A	-2.7793
265	R	A	-3.1071
266	Y	A	-2.7022
267	K	A	-3.5801
268	P	A	-2.3482
269	V	A	-1.3517
270	K	A	-1.7700
271	Y	A	-1.1229
272	G	A	0.0000
273	Q	A	-0.2310
274	C	A	0.0000
275	W	A	0.0000
276	V	A	0.0000
277	F	A	0.0000
278	A	A	0.0000
279	G	A	0.0000
280	V	A	0.0000
281	L	A	0.0000
282	C	A	0.0000
283	T	A	0.0000
284	V	A	0.0000
285	L	A	0.0000
286	R	A	0.0000
287	C	A	0.0000
288	L	A	0.0000
289	G	A	0.0000
290	I	A	0.0000
291	A	A	0.0000
292	T	A	0.0000
293	R	A	0.0000
294	V	A	0.0000
295	V	A	0.0000
296	S	A	0.0000
297	N	A	0.0000
298	F	A	0.0000
299	N	A	0.0000
300	S	A	0.0000
301	A	A	-1.3826
302	H	A	-2.1440
303	D	A	-3.0140
304	T	A	-2.6059
305	D	A	-2.9473
306	Q	A	-2.7076
307	N	A	-1.7314
308	L	A	-0.7215
309	S	A	0.0000
310	V	A	-0.6006
311	D	A	-1.3125
312	K	A	-0.7270
313	Y	A	-0.0667
314	V	A	0.5612
315	D	A	-1.5007
316	S	A	-1.1283
317	F	A	0.0420
318	G	A	-1.4687
319	R	A	-2.3077
320	T	A	-1.7288
321	L	A	-0.9786
322	E	A	-2.3350
323	D	A	-2.2382
324	L	A	-0.1849
325	T	A	-0.7704
326	E	A	-0.5864
327	D	A	-1.1176
328	S	A	0.0000
329	M	A	0.0000
330	W	A	-0.6207
331	N	A	-1.0640
332	F	A	0.0000
333	H	A	0.0000
334	V	A	0.0000
335	W	A	0.0000
336	N	A	0.0000
337	E	A	0.0000
338	S	A	0.0000
339	W	A	0.1180
340	F	A	0.0000
341	A	A	-1.0526
342	R	A	0.0000
343	Q	A	-2.2943
344	D	A	-2.2119
345	L	A	-1.3029
346	G	A	-1.0375
347	P	A	-1.0642
348	S	A	-0.8194
349	Y	A	-0.9860
350	N	A	-1.4663
351	G	A	0.0000
352	W	A	0.0126
353	Q	A	0.0000
354	V	A	0.0000
355	L	A	0.0000
356	D	A	0.0000
357	A	A	0.0000
358	T	A	0.0000
359	P	A	-1.0675
360	Q	A	-1.5083
361	E	A	-2.2900
362	E	A	-2.8399
363	S	A	-2.0530
364	E	A	-2.4584
365	G	A	-1.0675
366	V	A	0.4139
367	F	A	0.0000
368	R	A	-1.0470
369	C	A	0.0000
370	G	A	0.0000
371	P	A	0.0000
372	A	A	0.0000
373	S	A	0.0000
374	V	A	0.0000
375	T	A	-0.4232
376	A	A	0.0000
377	I	A	0.0000
378	R	A	-1.0787
379	E	A	-1.3905
380	G	A	0.0000
381	D	A	-0.9155
382	V	A	0.0000
383	H	A	-1.1492
384	L	A	-0.5411
385	A	A	-0.6530
386	H	A	-0.6490
387	D	A	-0.8413
388	G	A	0.0000
389	P	A	-0.2821
390	F	A	-0.0517
391	V	A	0.0000
392	F	A	-0.0775
393	A	A	0.0000
394	E	A	-0.2557
395	V	A	0.0000
396	N	A	-0.4592
397	A	A	-0.3881
398	D	A	-0.2573
399	Y	A	0.0000
400	I	A	0.2894
401	T	A	-0.0618
402	W	A	-0.5496
403	L	A	-0.5953
404	W	A	-1.8695
405	H	A	-2.0642
406	E	A	-3.2773
407	D	A	-3.5118
408	E	A	-3.5371
409	S	A	-3.4562
410	R	A	-4.1242
411	E	A	-3.5965
412	R	A	-2.2253
413	V	A	-0.1815
414	Y	A	0.7752
415	S	A	-0.3941
416	N	A	-1.6509
417	T	A	0.0000
418	K	A	-1.3768
419	K	A	-1.3788
420	I	A	0.0000
421	G	A	0.0000
422	R	A	-0.8959
423	C	A	-0.6152
424	I	A	0.0000
425	S	A	0.0000
426	T	A	0.0000
427	K	A	-0.8602
428	A	A	-0.7555
429	V	A	-0.7924
430	G	A	-1.3247
431	S	A	-1.2070
432	D	A	-2.1168
433	S	A	-1.5207
434	R	A	-1.2826
435	V	A	-0.5793
436	D	A	-1.5004
437	I	A	0.0000
438	T	A	-1.1766
439	D	A	-1.9655
440	L	A	-0.7604
441	Y	A	0.0000
442	K	A	-1.5415
443	Y	A	-2.2943
444	P	A	-2.3214
445	E	A	-2.9175
446	G	A	-2.4395
447	S	A	-2.9355
448	R	A	-3.9369
449	K	A	-3.9202
450	E	A	-3.7377
451	R	A	-4.0904
452	Q	A	-3.3345
453	V	A	0.0000
454	Y	A	-1.7746
455	S	A	-1.8212
456	K	A	-1.4144
457	A	A	0.0000
458	V	A	0.0000
459	N	A	-1.3169
460	R	A	-1.1375
461	L	A	-0.3202
462	F	A	-0.5844
463	G	A	-1.0647
464	V	A	-1.2222
465	E	A	-2.0649
466	A	A	-1.0483
467	S	A	-1.0419
468	G	A	-0.7384
469	R	A	0.0000
470	R	A	-0.9805
471	I	A	0.0000
472	W	A	0.0000
473	I	A	0.0000
474	R	A	-0.6433
475	R	A	0.0000
476	A	A	-0.5513
477	G	A	-1.2606
478	G	A	-1.6789
479	R	A	-2.0397
480	C	A	-1.2319
481	L	A	-1.4356
482	W	A	-1.0703
483	R	A	-2.0219
484	D	A	-1.6832
485	D	A	-1.6667
486	L	A	0.3455
487	L	A	0.7269
488	E	A	-1.2220
489	P	A	-0.8210
490	A	A	-0.9537
491	T	A	-1.3340
492	K	A	-1.9900
493	P	A	-1.1769
494	S	A	0.0000
495	I	A	-1.0065
496	A	A	-0.8780
497	G	A	-0.9930
498	K	A	-1.0501
499	F	A	-0.3862
500	K	A	-1.1348
501	V	A	0.0890
502	L	A	0.9207
503	E	A	-0.6633
504	P	A	-0.5419
505	P	A	0.0000
506	M	A	-0.6275
507	L	A	-0.7549
508	G	A	0.0000
509	H	A	-1.2169
510	D	A	-2.4761
511	L	A	0.0000
512	R	A	-2.4941
513	L	A	0.0000
514	A	A	0.0000
515	L	A	0.0000
516	C	A	0.0000
517	L	A	0.0000
518	A	A	0.0000
519	N	A	0.0000
520	L	A	-0.8044
521	T	A	0.0000
522	S	A	-1.3125
523	R	A	-1.4712
524	A	A	-1.5883
525	Q	A	0.0000
526	R	A	-2.8776
527	V	A	0.0000
528	R	A	-1.8917
529	V	A	0.0000
530	N	A	0.0000
531	L	A	0.0000
532	S	A	0.0000
533	G	A	-0.2524
534	A	A	0.0000
535	T	A	0.0000
536	I	A	0.0000
537	L	A	-0.7241
538	Y	A	0.0769
539	T	A	-0.7271
540	R	A	-2.1252
541	K	A	-2.2958
542	P	A	-1.3426
543	V	A	-0.8462
544	A	A	-1.2083
545	E	A	-1.4038
546	I	A	0.3305
547	L	A	0.8029
548	H	A	-0.2735
549	E	A	-1.2401
550	S	A	-1.4527
551	H	A	-1.9458
552	A	A	-1.7754
553	V	A	0.0000
554	R	A	-2.8724
555	L	A	0.0000
556	G	A	-1.7553
557	P	A	-1.5789
558	Q	A	-1.9191
559	E	A	-2.0323
560	E	A	-1.5654
561	K	A	-1.4811
562	R	A	-0.8879
563	I	A	-0.4050
564	P	A	-0.9050
565	I	A	0.0000
566	T	A	-1.3095
567	I	A	0.0000
568	S	A	-1.9170
569	Y	A	0.0000
570	S	A	-1.8640
571	K	A	-2.9590
572	Y	A	0.0000
573	K	A	-2.7769
574	E	A	-3.3738
575	D	A	-3.2563
576	L	A	-1.9954
577	T	A	-1.4421
578	E	A	-2.3100
579	D	A	-1.1133
580	K	A	-1.1878
581	K	A	-0.9387
582	I	A	0.0000
583	L	A	-0.7926
584	L	A	0.0000
585	A	A	0.0000
586	A	A	0.0000
587	M	A	0.0000
588	C	A	0.0000
589	L	A	0.0000
590	V	A	0.0000
591	T	A	-0.6766
592	K	A	-0.4242
593	G	A	0.0000
594	E	A	0.0000
595	K	A	0.0000
596	L	A	0.0000
597	L	A	0.0000
598	V	A	0.0000
599	E	A	-0.7903
600	K	A	0.0000
601	D	A	-1.1909
602	I	A	0.0000
603	T	A	-0.8452
604	L	A	0.0000
605	E	A	-0.5857
606	D	A	0.3023
607	F	A	1.5961
608	I	A	1.1275
609	T	A	0.5479
610	I	A	-0.0255
611	K	A	-1.4209
612	V	A	-0.1597
613	L	A	-0.3858
614	G	A	-0.0623
615	P	A	0.4642
616	A	A	0.8435
617	M	A	1.4781
618	V	A	1.6684
619	G	A	1.2746
620	V	A	2.0403
621	A	A	0.4756
622	V	A	0.0000
623	T	A	-1.1136
624	V	A	0.0000
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