| Chain sequence(s) |
A: KHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKP B: HIGNYRLLKTIGAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGWMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGY |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 267 | K | A | -2.6551 | |
| 268 | H | A | -2.6800 | |
| 269 | Q | A | -0.9444 | |
| 270 | P | A | -0.7637 | |
| 271 | G | A | -1.4134 | |
| 272 | G | A | -1.2838 | |
| 273 | G | A | -1.7342 | |
| 274 | K | A | -1.6826 | |
| 275 | V | A | 0.4347 | |
| 276 | Q | A | -0.2522 | |
| 277 | I | A | 1.6866 | |
| 278 | I | A | 1.9045 | |
| 279 | N | A | 1.0429 | |
| 280 | K | A | -0.5961 | |
| 281 | K | A | -0.6749 | |
| 282 | L | A | 1.3549 | |
| 283 | D | A | 0.0000 | |
| 284 | L | A | 1.0522 | |
| 285 | S | A | -0.4150 | |
| 286 | N | A | -0.9195 | |
| 287 | V | A | 0.9244 | |
| 288 | Q | A | 0.0000 | |
| 289 | S | A | -0.9946 | |
| 290 | K | A | -2.2811 | |
| 291 | C | A | -0.5854 | |
| 292 | G | A | 0.0000 | |
| 293 | S | A | -1.4764 | |
| 294 | K | A | -2.9742 | |
| 295 | D | A | -3.5276 | |
| 296 | N | A | -2.7895 | |
| 297 | I | A | -1.8945 | |
| 298 | K | A | -2.7218 | |
| 299 | H | A | -1.0933 | |
| 300 | V | A | 0.0000 | |
| 301 | P | A | 0.3387 | |
| 302 | G | A | 0.6423 | |
| 303 | G | A | -0.7714 | |
| 304 | G | A | -0.9676 | |
| 305 | S | A | -0.0210 | |
| 306 | V | A | 2.0445 | |
| 307 | Q | A | 0.8446 | |
| 308 | I | A | 1.9315 | |
| 309 | V | A | 2.5818 | |
| 310 | Y | A | 1.6907 | |
| 311 | K | A | -0.7940 | |
| 312 | P | A | -0.5386 | |
| 49 | H | B | -1.5586 | |
| 50 | I | B | -0.7974 | |
| 51 | G | B | -0.9195 | |
| 52 | N | B | -0.9312 | |
| 53 | Y | B | 0.0000 | |
| 54 | R | B | -2.3400 | |
| 55 | L | B | -1.4123 | |
| 56 | L | B | -1.1067 | |
| 57 | K | B | -1.2859 | |
| 58 | T | B | -0.8887 | |
| 59 | I | B | -0.1370 | |
| 60 | G | B | -0.7697 | |
| 65 | A | B | -0.9809 | |
| 66 | K | B | -1.6032 | |
| 67 | V | B | -0.9330 | |
| 68 | K | B | -1.1602 | |
| 69 | L | B | 0.0000 | |
| 70 | A | B | 0.0000 | |
| 71 | R | B | -2.6710 | |
| 72 | H | B | 0.0000 | |
| 73 | I | B | -0.0898 | |
| 74 | L | B | 0.6768 | |
| 75 | T | B | -0.0885 | |
| 76 | G | B | -0.9338 | |
| 77 | K | B | -1.3798 | |
| 78 | E | B | -2.4933 | |
| 79 | V | B | 0.0000 | |
| 80 | A | B | 0.0000 | |
| 81 | V | B | 0.0000 | |
| 82 | K | B | -0.8283 | |
| 83 | I | B | 0.0000 | |
| 84 | I | B | -1.2317 | |
| 85 | D | B | -2.1227 | |
| 86 | K | B | -2.2681 | |
| 87 | T | B | -1.9408 | |
| 88 | Q | B | -1.8512 | |
| 89 | L | B | -1.1666 | |
| 90 | N | B | -1.6503 | |
| 91 | S | B | -1.3801 | |
| 92 | S | B | -1.3525 | |
| 93 | S | B | -1.4809 | |
| 94 | L | B | -1.3413 | |
| 95 | Q | B | -2.0621 | |
| 96 | K | B | -2.4966 | |
| 97 | L | B | 0.0000 | |
| 98 | F | B | -1.2119 | |
| 99 | R | B | -2.4695 | |
| 100 | E | B | -1.9176 | |
| 101 | V | B | 0.0000 | |
| 102 | R | B | -2.4850 | |
| 103 | I | B | 0.0000 | |
| 104 | M | B | 0.0000 | |
| 105 | K | B | -1.5272 | |
| 106 | V | B | -0.3535 | |
| 107 | L | B | 0.0000 | |
| 108 | N | B | -1.5430 | |
| 109 | H | B | 0.0000 | |
| 110 | P | B | -0.6828 | |
| 111 | N | B | 0.0000 | |
| 112 | I | B | 0.0000 | |
| 113 | V | B | 0.0000 | |
| 114 | K | B | -0.7817 | |
| 115 | L | B | 0.0000 | |
| 116 | F | B | 0.0000 | |
| 117 | E | B | 0.0000 | |
| 118 | V | B | -0.6630 | |
| 119 | I | B | -0.7562 | |
| 120 | E | B | -2.3685 | |
| 121 | T | B | -2.4419 | |
| 122 | E | B | -3.2816 | |
| 123 | K | B | -3.4581 | |
| 124 | T | B | -2.1907 | |
| 125 | L | B | 0.0000 | |
| 126 | Y | B | -0.3525 | |
| 127 | L | B | 0.0000 | |
| 128 | V | B | 0.0000 | |
| 129 | M | B | -0.1592 | |
| 130 | E | B | 0.0000 | |
| 131 | Y | B | -0.3201 | |
| 132 | A | B | 0.0000 | |
| 133 | S | B | -0.6424 | |
| 134 | G | B | -1.0881 | |
| 135 | G | B | -0.8313 | |
| 136 | E | B | -1.3045 | |
| 137 | V | B | 0.0000 | |
| 138 | F | B | 0.1127 | |
| 139 | D | B | -1.1306 | |
| 140 | Y | B | -0.3997 | |
| 141 | L | B | 0.0000 | |
| 142 | V | B | 1.0903 | |
| 143 | A | B | 0.1152 | |
| 144 | H | B | -0.7270 | |
| 145 | G | B | -0.7071 | |
| 146 | W | B | -0.2651 | |
| 147 | M | B | 0.0000 | |
| 148 | K | B | -1.8984 | |
| 149 | E | B | -1.5904 | |
| 150 | K | B | -2.1780 | |
| 151 | E | B | -1.4794 | |
| 152 | A | B | 0.0000 | |
| 153 | R | B | 0.0000 | |
| 154 | A | B | -0.6682 | |
| 155 | K | B | 0.0000 | |
| 156 | F | B | 0.0000 | |
| 157 | R | B | -0.6928 | |
| 158 | Q | B | -0.4339 | |
| 159 | I | B | 0.0000 | |
| 160 | V | B | 0.0000 | |
| 161 | S | B | -0.5603 | |
| 162 | A | B | 0.0000 | |
| 163 | V | B | 0.0000 | |
| 164 | Q | B | 0.0000 | |
| 165 | Y | B | 0.0000 | |
| 166 | C | B | 0.0000 | |
| 167 | H | B | -0.5160 | |
| 168 | Q | B | -0.5054 | |
| 169 | K | B | -0.6816 | |
| 170 | F | B | 0.0211 | |
| 171 | I | B | 0.0000 | |
| 172 | V | B | 0.0000 | |
| 173 | H | B | 0.0000 | |
| 174 | R | B | 0.0000 | |
| 175 | D | B | 0.0000 | |
| 176 | L | B | 0.0000 | |
| 177 | K | B | -0.5408 | |
| 178 | A | B | 0.0000 | |
| 179 | E | B | -1.0543 | |
| 180 | N | B | 0.0000 | |
| 181 | L | B | 0.0000 | |
| 182 | L | B | -0.5788 | |
| 183 | L | B | 0.0000 | |
| 184 | D | B | -0.9179 | |
| 185 | A | B | -0.9964 | |
| 186 | D | B | -1.8050 | |
| 187 | M | B | -0.7330 | |
| 188 | N | B | -0.8202 | |
| 189 | I | B | 0.0000 | |
| 190 | K | B | 0.0000 | |
| 191 | I | B | 0.0000 | |
| 192 | A | B | -0.9097 | |
| 193 | D | B | -1.4449 | |
| 194 | F | B | 0.0000 | |
| 195 | G | B | -0.7514 | |
| 196 | F | B | 0.1355 | |
| 197 | S | B | 0.0000 | |
| 198 | N | B | -1.3907 | |
| 199 | E | B | -2.0370 | |
| 200 | F | B | 0.0000 | |
| 201 | T | B | -0.3797 | |
| 202 | F | B | 0.7047 | |
| 203 | G | B | -0.7094 | |
| 204 | N | B | -2.4457 | |
| 205 | K | B | -3.7349 | |
| 206 | L | B | -2.9731 | |
| 207 | D | B | -3.0514 | |
| 208 | T | B | -0.8694 | |
| 209 | F | B | 0.2948 | |
| 210 | C | B | 0.6069 | |
| 211 | G | B | 0.2564 | |
| 212 | S | B | -0.0660 | |
| 213 | P | B | -0.3765 | |
| 214 | P | B | -0.5805 | |
| 215 | Y | B | 0.0000 | |
| 216 | A | B | 0.0000 | |
| 217 | A | B | 0.0000 | |
| 218 | P | B | 0.0000 | |
| 219 | E | B | 0.0000 | |
| 220 | L | B | 0.0000 | |
| 221 | F | B | -0.5333 | |
| 222 | Q | B | -1.4635 | |
| 223 | G | B | -1.8918 | |
| 224 | K | B | -3.1250 | |
| 225 | K | B | -3.9962 | |
| 226 | Y | B | 0.0000 | |
| 227 | D | B | -3.1662 | |
| 228 | G | B | 0.0000 | |
| 229 | P | B | -0.4919 | |
| 230 | E | B | -1.2996 | |
| 231 | V | B | 0.0000 | |
| 232 | D | B | 0.0000 | |
| 233 | V | B | 0.0000 | |
| 234 | W | B | 0.0000 | |
| 235 | S | B | 0.0000 | |
| 236 | L | B | 0.0000 | |
| 237 | G | B | 0.0000 | |
| 238 | V | B | 0.0000 | |
| 239 | I | B | 0.0000 | |
| 240 | L | B | 0.0000 | |
| 241 | Y | B | 0.0000 | |
| 242 | T | B | 0.0000 | |
| 243 | L | B | 0.0000 | |
| 244 | V | B | 0.0000 | |
| 245 | S | B | 0.0000 | |
| 246 | G | B | -0.1174 | |
| 247 | S | B | -0.3295 | |
| 248 | L | B | -0.1991 | |
| 249 | P | B | 0.0000 | |
| 250 | F | B | 0.0000 | |
| 251 | D | B | -2.7070 | |
| 252 | G | B | -2.8869 | |
| 253 | Q | B | -2.4263 | |
| 254 | N | B | -2.3933 | |
| 255 | L | B | -2.1496 | |
| 256 | K | B | -3.5625 | |
| 257 | E | B | -4.0279 | |
| 258 | L | B | 0.0000 | |
| 259 | R | B | -3.4577 | |
| 260 | E | B | -3.9886 | |
| 261 | R | B | -3.3031 | |
| 262 | V | B | 0.0000 | |
| 263 | L | B | -1.5933 | |
| 264 | R | B | -2.5886 | |
| 265 | G | B | -1.7451 | |
| 266 | K | B | -2.2516 | |
| 267 | Y | B | -1.0784 | |
| 268 | R | B | -0.3338 | |
| 269 | I | B | 0.6205 | |
| 270 | P | B | 0.0000 | |
| 271 | F | B | 2.2839 | |
| 272 | Y | B | 1.3591 | |
| 273 | M | B | 0.0000 | |
| 274 | S | B | -0.3566 | |
| 275 | T | B | -0.7933 | |
| 276 | D | B | -2.0494 | |
| 277 | C | B | 0.0000 | |
| 278 | E | B | -1.8906 | |
| 279 | N | B | -2.7837 | |
| 280 | L | B | 0.0000 | |
| 281 | L | B | 0.0000 | |
| 282 | K | B | -2.5222 | |
| 283 | K | B | -2.2623 | |
| 284 | F | B | 0.0000 | |
| 285 | L | B | 0.0000 | |
| 286 | I | B | -0.6590 | |
| 287 | L | B | -0.0834 | |
| 288 | N | B | -1.0742 | |
| 289 | P | B | -1.2638 | |
| 290 | S | B | -1.5343 | |
| 291 | K | B | -2.0818 | |
| 292 | R | B | 0.0000 | |
| 293 | G | B | -1.5435 | |
| 294 | T | B | -1.2705 | |
| 295 | L | B | 0.0000 | |
| 296 | E | B | -2.1601 | |
| 297 | Q | B | -2.3173 | |
| 298 | I | B | 0.0000 | |
| 299 | M | B | 0.0000 | |
| 300 | K | B | -2.8268 | |
| 301 | D | B | -2.3996 | |
| 302 | R | B | -2.7246 | |
| 303 | W | B | 0.0000 | |
| 304 | M | B | 0.0000 | |
| 305 | N | B | -2.1418 | |
| 306 | V | B | -0.8553 | |
| 307 | G | B | -1.7169 | |
| 308 | H | B | -3.0040 | |
| 309 | E | B | -3.8823 | |
| 310 | D | B | -4.1902 | |
| 311 | D | B | -4.4009 | |
| 312 | E | B | -4.5304 | |
| 313 | L | B | 0.0000 | |
| 314 | K | B | -2.6861 | |
| 315 | P | B | -0.9118 | |
| 316 | Y | B | 0.2754 | |
| 317 | V | B | 1.2399 | |
| 318 | E | B | -0.1059 | |
| 319 | P | B | 0.0424 | |
| 320 | L | B | 0.8810 | |
| 321 | P | B | -0.5200 | |
| 322 | D | B | -1.9469 | |
| 323 | Y | B | -1.6106 | |
| 324 | K | B | -3.1817 | |
| 325 | D | B | -2.7712 | |
| 326 | P | B | -2.5115 | |
| 327 | R | B | -2.9988 | |
| 328 | R | B | -2.0192 | |
| 329 | T | B | -2.3796 | |
| 330 | E | B | -2.5094 | |
| 331 | L | B | -0.8011 | |
| 332 | M | B | 0.0000 | |
| 333 | V | B | -0.5590 | |
| 334 | S | B | -0.2310 | |
| 335 | M | B | 0.1516 | |
| 336 | G | B | -0.4554 | |
| 337 | Y | B | -0.8349 | |
| 338 | T | B | -1.9952 | |
| 339 | R | B | -3.9167 | |
| 340 | E | B | -3.8859 | |
| 341 | E | B | -3.0199 | |
| 342 | I | B | 0.0000 | |
| 343 | Q | B | -3.2750 | |
| 344 | D | B | -3.3122 | |
| 345 | S | B | 0.0000 | |
| 346 | L | B | 0.0000 | |
| 347 | V | B | -0.4585 | |
| 348 | G | B | -1.4107 | |
| 349 | Q | B | -2.1811 | |
| 350 | R | B | -2.8628 | |
| 351 | Y | B | 0.0000 | |
| 352 | N | B | -1.8812 | |
| 353 | E | B | -1.7223 | |
| 354 | V | B | 0.0000 | |
| 355 | M | B | 0.0000 | |
| 356 | A | B | 0.0000 | |
| 357 | T | B | 0.0000 | |
| 358 | Y | B | 0.0000 | |
| 359 | L | B | 0.2967 | |
| 360 | L | B | 0.0000 | |
| 361 | L | B | 0.0000 | |
| 362 | G | B | -0.1083 | |
| 363 | Y | B | 0.9140 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine