| Chain sequence(s) |
A: DIQMTQSPSSLSASVGDRVTITCRSSQRIVHSNGNTYLEWYQQTPGKAPKLLIYKVSNRFSGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCFQGSHVPFTFGQGTKLQITRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFN B: EVQLVESGGGVVQPGRSLRLSCSTSGFTFSDYYMYWVRQAPGKGLEWVAYMSNVGAITDYPDTVKGRFTISRDNSKNTLFLQMDSLRPEDTGVYFCARGTRDGSWFAYWGQGTPVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPQPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVE |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | D | A | -1.8417 | |
| 2 | I | A | -1.6097 | |
| 3 | Q | A | -2.2182 | |
| 4 | M | A | 0.0000 | |
| 5 | T | A | -1.4198 | |
| 6 | Q | A | 0.0000 | |
| 7 | S | A | -0.8568 | |
| 8 | P | A | -0.6077 | |
| 9 | S | A | -0.8442 | |
| 10 | S | A | -0.6733 | |
| 11 | L | A | -0.2706 | |
| 12 | S | A | -0.3916 | |
| 13 | A | A | -0.5807 | |
| 14 | S | A | -0.5228 | |
| 15 | V | A | 0.2149 | |
| 16 | G | A | -1.1222 | |
| 17 | D | A | -2.5512 | |
| 18 | R | A | -2.7163 | |
| 19 | V | A | 0.0000 | |
| 20 | T | A | -0.4873 | |
| 21 | I | A | 0.0000 | |
| 22 | T | A | -0.7257 | |
| 23 | C | A | 0.0000 | |
| 24 | R | A | -2.8721 | |
| 25 | S | A | -2.3270 | |
| 26 | S | A | -2.2387 | |
| 27 | Q | A | -2.7105 | |
| 28 | R | A | -2.8188 | |
| 29 | I | A | 0.0000 | |
| 30 | V | A | -0.9062 | |
| 31 | H | A | -1.1623 | |
| 32 | S | A | -1.1212 | |
| 33 | N | A | -1.7329 | |
| 34 | G | A | -1.3136 | |
| 35 | N | A | -1.0864 | |
| 36 | T | A | -0.8220 | |
| 37 | Y | A | -0.4274 | |
| 38 | L | A | 0.0000 | |
| 39 | E | A | 0.0000 | |
| 40 | W | A | 0.0000 | |
| 41 | Y | A | 0.0000 | |
| 42 | Q | A | 0.0000 | |
| 43 | Q | A | -1.0547 | |
| 44 | T | A | -1.1371 | |
| 45 | P | A | -1.1925 | |
| 46 | G | A | -1.4526 | |
| 47 | K | A | -2.3111 | |
| 48 | A | A | -1.5112 | |
| 49 | P | A | 0.0000 | |
| 50 | K | A | -1.4376 | |
| 51 | L | A | 0.0000 | |
| 52 | L | A | 0.0000 | |
| 53 | I | A | 0.0000 | |
| 54 | Y | A | -0.6297 | |
| 55 | K | A | -1.2798 | |
| 56 | V | A | -0.7720 | |
| 57 | S | A | -1.1148 | |
| 58 | N | A | -1.6778 | |
| 59 | R | A | -1.5907 | |
| 60 | F | A | -0.6194 | |
| 61 | S | A | -0.5145 | |
| 62 | G | A | -0.5674 | |
| 63 | V | A | -0.5211 | |
| 64 | P | A | -0.5320 | |
| 65 | S | A | -0.6640 | |
| 66 | R | A | -1.0548 | |
| 67 | F | A | 0.0000 | |
| 68 | S | A | -0.6987 | |
| 69 | G | A | -0.6608 | |
| 70 | S | A | -0.7431 | |
| 71 | G | A | -1.0004 | |
| 72 | S | A | -1.0133 | |
| 73 | G | A | 0.0000 | |
| 74 | T | A | -2.0522 | |
| 75 | D | A | -2.1977 | |
| 76 | F | A | 0.0000 | |
| 77 | T | A | -0.7015 | |
| 78 | F | A | 0.0000 | |
| 79 | T | A | -0.5843 | |
| 80 | I | A | 0.0000 | |
| 81 | S | A | -1.6342 | |
| 82 | S | A | -1.5783 | |
| 83 | L | A | 0.0000 | |
| 84 | Q | A | -1.3394 | |
| 85 | P | A | -1.6745 | |
| 86 | E | A | -2.5633 | |
| 87 | D | A | 0.0000 | |
| 88 | I | A | -1.0670 | |
| 89 | A | A | 0.0000 | |
| 90 | T | A | -0.7108 | |
| 91 | Y | A | 0.0000 | |
| 92 | Y | A | 0.0000 | |
| 93 | C | A | 0.0000 | |
| 94 | F | A | 0.0000 | |
| 95 | Q | A | 0.0000 | |
| 96 | G | A | 0.0000 | |
| 97 | S | A | -0.2253 | |
| 98 | H | A | 0.3866 | |
| 99 | V | A | 1.3166 | |
| 100 | P | A | 0.1835 | |
| 101 | F | A | 0.3396 | |
| 102 | T | A | -0.2192 | |
| 103 | F | A | -0.4361 | |
| 104 | G | A | 0.0000 | |
| 105 | Q | A | -1.5827 | |
| 106 | G | A | -1.2885 | |
| 107 | T | A | 0.0000 | |
| 108 | K | A | -1.0685 | |
| 109 | L | A | 0.0000 | |
| 110 | Q | A | -0.8775 | |
| 111 | I | A | 0.0000 | |
| 112 | T | A | -0.0291 | |
| 113 | R | A | -0.2610 | |
| 114 | T | A | 0.1005 | |
| 115 | V | A | 0.4356 | |
| 116 | A | A | -0.1113 | |
| 117 | A | A | -0.1970 | |
| 118 | P | A | 0.0000 | |
| 119 | S | A | -0.2892 | |
| 120 | V | A | 0.0000 | |
| 121 | F | A | 0.0000 | |
| 122 | I | A | 0.0000 | |
| 123 | F | A | 0.0000 | |
| 124 | P | A | -0.5857 | |
| 125 | P | A | -0.6666 | |
| 126 | S | A | 0.0000 | |
| 127 | D | A | -3.0745 | |
| 128 | E | A | -3.3399 | |
| 129 | Q | A | 0.0000 | |
| 130 | L | A | -2.1520 | |
| 131 | K | A | -2.9993 | |
| 132 | S | A | -1.7834 | |
| 133 | G | A | -1.4411 | |
| 134 | T | A | -1.1385 | |
| 135 | A | A | 0.0000 | |
| 136 | S | A | 0.0000 | |
| 137 | V | A | 0.0000 | |
| 138 | V | A | 0.0000 | |
| 139 | C | A | 0.0000 | |
| 140 | L | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | N | A | 0.0000 | |
| 143 | N | A | -1.1193 | |
| 144 | F | A | 0.0000 | |
| 145 | Y | A | -1.0146 | |
| 146 | P | A | -1.4610 | |
| 147 | R | A | -3.0480 | |
| 148 | E | A | -3.2561 | |
| 149 | A | A | -2.4165 | |
| 150 | K | A | -2.7363 | |
| 151 | V | A | -1.3349 | |
| 152 | Q | A | -1.2893 | |
| 153 | W | A | 0.0000 | |
| 154 | K | A | -1.1317 | |
| 155 | V | A | 0.0000 | |
| 156 | D | A | -2.6248 | |
| 157 | N | A | -2.0492 | |
| 158 | A | A | -0.8034 | |
| 159 | L | A | -0.1975 | |
| 160 | Q | A | -0.6781 | |
| 161 | S | A | -0.6347 | |
| 162 | G | A | -0.8720 | |
| 163 | N | A | -0.8209 | |
| 164 | S | A | -1.1413 | |
| 165 | Q | A | -1.3071 | |
| 166 | E | A | -2.1672 | |
| 167 | S | A | -0.9577 | |
| 168 | V | A | -0.8296 | |
| 169 | T | A | 0.0000 | |
| 170 | E | A | -1.6794 | |
| 171 | Q | A | 0.0000 | |
| 172 | D | A | -1.9922 | |
| 173 | S | A | -2.3495 | |
| 174 | K | A | -2.7344 | |
| 175 | D | A | -1.9038 | |
| 176 | S | A | 0.0000 | |
| 177 | T | A | 0.0000 | |
| 178 | Y | A | -1.2089 | |
| 179 | S | A | 0.0000 | |
| 180 | L | A | 0.0000 | |
| 181 | S | A | 0.0000 | |
| 182 | S | A | 0.0000 | |
| 183 | T | A | -0.6532 | |
| 184 | L | A | 0.0000 | |
| 185 | T | A | -0.2492 | |
| 186 | L | A | -0.5864 | |
| 187 | S | A | -0.9797 | |
| 188 | K | A | -1.8283 | |
| 189 | A | A | -1.6053 | |
| 190 | D | A | -2.0204 | |
| 191 | Y | A | -2.0857 | |
| 192 | E | A | -3.3199 | |
| 193 | K | A | -3.4828 | |
| 194 | H | A | -3.1610 | |
| 195 | K | A | -3.2274 | |
| 196 | V | A | -2.0224 | |
| 197 | Y | A | 0.0000 | |
| 198 | A | A | 0.0000 | |
| 199 | C | A | 0.0000 | |
| 200 | E | A | -0.9006 | |
| 201 | V | A | 0.0000 | |
| 202 | T | A | -1.2026 | |
| 203 | H | A | 0.0000 | |
| 204 | Q | A | -1.6291 | |
| 205 | G | A | -0.4851 | |
| 206 | L | A | -0.2120 | |
| 207 | S | A | -0.3999 | |
| 208 | S | A | -0.3865 | |
| 209 | P | A | -0.5139 | |
| 210 | V | A | 0.1831 | |
| 211 | T | A | -0.3492 | |
| 212 | K | A | -0.5856 | |
| 213 | S | A | -0.8110 | |
| 214 | F | A | 0.0000 | |
| 215 | N | A | -1.8062 | |
| 1 | E | B | -1.9770 | |
| 2 | V | B | -1.1272 | |
| 3 | Q | B | -0.8976 | |
| 4 | L | B | 0.0000 | |
| 5 | V | B | 0.9375 | |
| 6 | E | B | 0.0000 | |
| 7 | S | B | -0.5323 | |
| 8 | G | B | -1.0199 | |
| 9 | G | B | -0.7535 | |
| 10 | G | B | -0.4939 | |
| 11 | V | B | -0.0734 | |
| 12 | V | B | -1.0328 | |
| 13 | Q | B | -2.1404 | |
| 14 | P | B | -2.2139 | |
| 15 | G | B | -2.4481 | |
| 16 | R | B | -3.0761 | |
| 17 | S | B | -2.3623 | |
| 18 | L | B | -1.6404 | |
| 19 | R | B | -2.3814 | |
| 20 | L | B | 0.0000 | |
| 21 | S | B | -0.6227 | |
| 22 | C | B | 0.0000 | |
| 23 | S | B | -0.2556 | |
| 24 | T | B | 0.0000 | |
| 25 | S | B | -0.8922 | |
| 26 | G | B | -1.0627 | |
| 27 | F | B | -0.6366 | |
| 28 | T | B | -0.7928 | |
| 29 | F | B | 0.0000 | |
| 30 | S | B | -0.8547 | |
| 31 | D | B | -1.7181 | |
| 32 | Y | B | -0.6338 | |
| 33 | Y | B | -0.2321 | |
| 34 | M | B | 0.0000 | |
| 35 | Y | B | 0.0000 | |
| 36 | W | B | 0.0000 | |
| 37 | V | B | 0.0000 | |
| 38 | R | B | 0.0000 | |
| 39 | Q | B | -0.7634 | |
| 40 | A | B | -1.1499 | |
| 41 | P | B | -1.0308 | |
| 42 | G | B | -1.4775 | |
| 43 | K | B | -2.3937 | |
| 44 | G | B | -1.6714 | |
| 45 | L | B | 0.0000 | |
| 46 | E | B | -0.8605 | |
| 47 | W | B | 0.0000 | |
| 48 | V | B | 0.0000 | |
| 49 | A | B | 0.0000 | |
| 50 | Y | B | 0.3951 | |
| 51 | M | B | 0.0000 | |
| 52 | S | B | 0.6000 | |
| 53 | N | B | 0.1233 | |
| 54 | V | B | 1.5713 | |
| 55 | G | B | 0.9321 | |
| 56 | A | B | 1.1908 | |
| 57 | I | B | 2.1102 | |
| 58 | T | B | 0.7212 | |
| 59 | D | B | 0.0817 | |
| 60 | Y | B | -0.8137 | |
| 61 | P | B | -1.1167 | |
| 62 | D | B | -2.3496 | |
| 63 | T | B | -1.6128 | |
| 64 | V | B | 0.0000 | |
| 65 | K | B | -2.2680 | |
| 66 | G | B | -1.6839 | |
| 67 | R | B | -1.7809 | |
| 68 | F | B | 0.0000 | |
| 69 | T | B | -1.1343 | |
| 70 | I | B | 0.0000 | |
| 71 | S | B | -0.3555 | |
| 72 | R | B | -1.3644 | |
| 73 | D | B | -2.2330 | |
| 74 | N | B | -2.5512 | |
| 75 | S | B | -2.0534 | |
| 76 | K | B | -2.6576 | |
| 77 | N | B | -2.0904 | |
| 78 | T | B | -1.3338 | |
| 79 | L | B | 0.0000 | |
| 80 | F | B | 0.0000 | |
| 81 | L | B | 0.0000 | |
| 82 | Q | B | -1.8635 | |
| 83 | M | B | 0.0000 | |
| 84 | D | B | -2.8142 | |
| 85 | S | B | -2.0831 | |
| 86 | L | B | 0.0000 | |
| 87 | R | B | -2.8651 | |
| 88 | P | B | -1.9917 | |
| 89 | E | B | -2.3829 | |
| 90 | D | B | 0.0000 | |
| 91 | T | B | -0.8357 | |
| 92 | G | B | 0.0000 | |
| 93 | V | B | -0.0380 | |
| 94 | Y | B | 0.0000 | |
| 95 | F | B | 0.0000 | |
| 96 | C | B | 0.0000 | |
| 97 | A | B | 0.0000 | |
| 98 | R | B | 0.0513 | |
| 99 | G | B | 0.0000 | |
| 100 | T | B | -1.5036 | |
| 101 | R | B | -2.8894 | |
| 102 | D | B | -2.7708 | |
| 103 | G | B | -1.5559 | |
| 104 | S | B | 0.0000 | |
| 105 | W | B | -0.2785 | |
| 106 | F | B | 0.0000 | |
| 107 | A | B | 0.0206 | |
| 108 | Y | B | 0.0535 | |
| 109 | W | B | 0.0000 | |
| 110 | G | B | -0.2737 | |
| 111 | Q | B | -1.0083 | |
| 112 | G | B | 0.0000 | |
| 113 | T | B | 0.0000 | |
| 114 | P | B | 0.0000 | |
| 115 | V | B | 0.0000 | |
| 116 | T | B | -0.5255 | |
| 117 | V | B | 0.0000 | |
| 118 | S | B | -0.7816 | |
| 119 | S | B | -0.6780 | |
| 120 | A | B | -0.4674 | |
| 121 | S | B | -0.5223 | |
| 122 | T | B | -0.6703 | |
| 123 | K | B | -1.2580 | |
| 124 | G | B | -1.2568 | |
| 125 | P | B | -0.6356 | |
| 126 | S | B | -0.3462 | |
| 127 | V | B | 0.0000 | |
| 128 | F | B | 0.0000 | |
| 129 | P | B | -1.2786 | |
| 130 | L | B | 0.0000 | |
| 131 | A | B | -0.8002 | |
| 132 | P | B | -0.5645 | |
| 133 | S | B | -0.6017 | |
| 134 | S | B | -0.6150 | |
| 135 | K | B | -0.9739 | |
| 136 | S | B | 0.0000 | |
| 137 | T | B | -0.5611 | |
| 138 | S | B | -0.6518 | |
| 139 | G | B | -0.8074 | |
| 140 | G | B | -0.8307 | |
| 141 | T | B | -0.4987 | |
| 142 | A | B | 0.0000 | |
| 143 | A | B | 0.0000 | |
| 144 | L | B | 0.0000 | |
| 145 | G | B | 0.0000 | |
| 146 | C | B | 0.0000 | |
| 147 | L | B | 0.0000 | |
| 148 | V | B | 0.0000 | |
| 149 | K | B | 0.0000 | |
| 150 | D | B | -0.5245 | |
| 151 | Y | B | 0.0000 | |
| 152 | F | B | -0.1870 | |
| 153 | P | B | 0.0000 | |
| 154 | Q | B | -0.3857 | |
| 155 | P | B | -0.4604 | |
| 156 | V | B | -0.2432 | |
| 157 | T | B | -0.4887 | |
| 158 | V | B | 0.0000 | |
| 159 | S | B | -0.4884 | |
| 160 | W | B | 0.0000 | |
| 161 | N | B | -0.6792 | |
| 162 | S | B | -0.6384 | |
| 163 | G | B | -0.4849 | |
| 164 | A | B | -0.0995 | |
| 165 | L | B | 0.1225 | |
| 166 | T | B | -0.0727 | |
| 167 | S | B | -0.4042 | |
| 168 | G | B | -0.2048 | |
| 169 | V | B | 0.0743 | |
| 170 | H | B | -0.3562 | |
| 171 | T | B | -0.2242 | |
| 172 | F | B | 0.0000 | |
| 173 | P | B | -0.4444 | |
| 174 | A | B | 0.0038 | |
| 175 | V | B | 0.3230 | |
| 176 | L | B | 0.9502 | |
| 177 | Q | B | 0.0685 | |
| 178 | S | B | -0.2033 | |
| 179 | S | B | -0.3379 | |
| 180 | G | B | -0.1785 | |
| 181 | L | B | 0.0430 | |
| 182 | Y | B | 0.3454 | |
| 183 | S | B | 0.0000 | |
| 184 | L | B | 0.0000 | |
| 185 | S | B | 0.0000 | |
| 186 | S | B | 0.0000 | |
| 187 | V | B | 0.0000 | |
| 188 | V | B | 0.0000 | |
| 189 | T | B | -0.1083 | |
| 190 | V | B | 0.0021 | |
| 191 | P | B | -0.4218 | |
| 192 | S | B | -0.5041 | |
| 193 | S | B | -0.3609 | |
| 194 | S | B | -0.3229 | |
| 195 | L | B | -0.4517 | |
| 196 | G | B | -1.1094 | |
| 197 | T | B | -1.0058 | |
| 198 | Q | B | -1.5509 | |
| 199 | T | B | -1.5448 | |
| 200 | Y | B | 0.0000 | |
| 201 | I | B | -1.4638 | |
| 202 | C | B | 0.0000 | |
| 203 | N | B | -1.6538 | |
| 204 | V | B | 0.0000 | |
| 205 | N | B | -1.5662 | |
| 206 | H | B | 0.0000 | |
| 207 | K | B | -1.7301 | |
| 208 | P | B | 0.0000 | |
| 209 | S | B | -1.4415 | |
| 210 | N | B | -2.1932 | |
| 211 | T | B | -1.7942 | |
| 212 | K | B | -2.5103 | |
| 213 | V | B | -1.6755 | |
| 214 | D | B | -2.7687 | |
| 215 | K | B | -2.4919 | |
| 216 | K | B | -2.7709 | |
| 217 | V | B | 0.0000 | |
| 218 | E | B | -2.5371 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine