Project name: AT8_200

Chain sequence(s)	A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKEPPEEGEPPKEGDRSGYSSPGEPGEPGSREREPELPEPPTREPKKVAVVREPPKEPEEAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGEVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVEKEPVVEGDEEPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.8465
• Maximal score value: 2.7171
• Average score: -1.1871
• Total score value: -523.5331

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	0.0000
2	A	A	0.0000
3	E	A	-3.4419
4	P	A	-2.6808
5	R	A	-2.9555
6	Q	A	-2.0030
7	E	A	-1.7042
8	F	A	0.4729
9	E	A	0.0335
10	V	A	0.8622
11	M	A	0.0000
12	E	A	-0.3633
13	D	A	-0.6522
14	H	A	-0.4406
15	A	A	-0.4146
16	G	A	-0.2793
17	T	A	0.2129
18	Y	A	1.1228
19	G	A	0.1814
20	L	A	-0.3128
21	G	A	-1.3698
22	D	A	-3.2173
23	R	A	-3.8465
24	K	A	-3.4031
25	D	A	-3.4382
26	Q	A	-2.4392
27	G	A	0.0000
28	G	A	0.0000
29	Y	A	-1.2754
30	T	A	-0.5753
31	M	A	-0.1394
32	H	A	-1.3904
33	Q	A	-1.9657
34	D	A	-2.8310
35	Q	A	-2.6267
36	E	A	-2.2535
37	G	A	-2.3364
38	D	A	-2.7917
39	T	A	-2.1927
40	D	A	-2.5228
41	A	A	-1.4474
42	G	A	-0.5580
43	L	A	-0.0441
44	K	A	-1.4287
45	E	A	-1.7962
46	S	A	-1.0145
47	P	A	-0.1492
48	L	A	0.3426
49	Q	A	-0.7146
50	T	A	-0.4601
51	P	A	-1.3855
52	T	A	-2.0246
53	E	A	-3.4558
54	D	A	-3.1393
55	G	A	-2.2267
56	S	A	-2.1153
57	E	A	-2.6552
58	E	A	-2.5661
59	P	A	-1.5582
60	G	A	-1.2690
61	S	A	-1.2404
62	E	A	-1.5081
63	T	A	-0.8778
64	S	A	-1.5920
65	D	A	-2.5054
66	A	A	0.0000
67	K	A	-2.6789
68	S	A	0.0000
69	T	A	-2.2854
70	P	A	-1.4551
71	T	A	-1.0024
72	A	A	-0.9997
73	E	A	-2.3945
74	D	A	-1.8640
75	V	A	0.5039
76	T	A	0.1355
77	A	A	-0.1248
78	P	A	0.3783
79	L	A	1.5951
80	V	A	0.2304
81	D	A	-2.0339
82	E	A	-2.7594
83	G	A	-1.7915
84	A	A	-1.1299
85	P	A	-1.4649
86	G	A	-2.1869
87	K	A	-2.4457
88	Q	A	-2.5179
89	A	A	-1.4836
90	A	A	0.0000
91	A	A	-1.1946
92	Q	A	-1.7716
93	P	A	-1.5230
94	H	A	-1.2487
95	T	A	-0.6729
96	E	A	-0.6886
97	I	A	0.7756
98	P	A	-0.8212
99	E	A	-2.0419
100	G	A	-1.2124
101	T	A	-1.4926
102	T	A	-1.5908
103	A	A	0.0000
104	E	A	-3.7420
105	E	A	-3.4045
106	A	A	-2.3501
107	G	A	-1.7051
108	I	A	0.0000
109	G	A	-2.0253
110	D	A	-1.7139
111	T	A	-0.8804
112	P	A	-0.1031
113	S	A	0.0441
114	L	A	0.1474
115	E	A	-1.8946
116	D	A	-2.9150
117	E	A	-2.9801
118	A	A	-1.3992
119	A	A	-0.9040
120	G	A	-0.7866
121	H	A	-0.9440
122	V	A	-1.1404
123	T	A	-1.2750
124	Q	A	-2.0706
125	A	A	0.0000
126	R	A	-2.2406
127	M	A	-0.8975
128	V	A	0.3810
129	S	A	-1.0096
130	K	A	-2.2620
131	S	A	-1.8061
132	K	A	-1.5306
133	D	A	-2.7275
134	G	A	-1.4658
135	T	A	-1.5369
136	G	A	-2.3211
137	S	A	-1.9952
138	D	A	0.0000
139	D	A	-2.0083
140	K	A	-2.4759
141	K	A	0.0000
142	A	A	-2.6086
143	K	A	-3.4359
144	G	A	-2.6487
145	A	A	-1.9872
146	D	A	-2.8985
147	G	A	-2.3993
148	K	A	-3.0388
149	T	A	-1.9937
150	K	A	-1.4516
151	I	A	-0.8119
152	A	A	0.0000
153	T	A	-0.5279
154	P	A	-1.1378
155	R	A	-2.0620
156	G	A	-1.3962
157	A	A	-0.7135
158	A	A	-0.5550
159	P	A	0.0000
160	P	A	-0.7115
161	G	A	-1.5212
162	Q	A	0.0000
163	K	A	-2.3538
164	G	A	-1.8524
165	Q	A	-2.1057
166	A	A	-1.4110
167	N	A	-1.8432
168	A	A	-1.0689
169	T	A	-1.3563
170	R	A	-2.5554
171	I	A	-1.4969
172	P	A	0.0000
173	A	A	-0.9664
174	K	A	-1.4554
175	T	A	-0.8713
176	P	A	-0.7140
177	P	A	-1.1267
178	A	A	-1.2216
179	P	A	-1.9408
180	K	A	-3.5152
181	E	A	-3.5134
182	P	A	-3.0525
183	P	A	-2.3687
184	E	A	-3.1656
185	E	A	-3.0839
186	G	A	-2.3013
187	E	A	-2.5402
188	P	A	-2.1835
189	P	A	-2.1044
190	K	A	-2.2857
191	E	A	-2.6507
192	G	A	-2.8712
193	D	A	-2.8718
194	R	A	-2.4515
195	S	A	-1.6539
196	G	A	-2.2163
197	Y	A	0.0000
198	S	A	0.0000
199	S	A	-1.2586
200	P	A	-0.9832
201	G	A	-1.1432
202	E	A	0.0000
203	P	A	-1.2327
204	G	A	-1.1448
205	E	A	-1.2575
206	P	A	-0.8947
207	G	A	-0.8557
208	S	A	-1.1904
209	R	A	-2.0028
210	E	A	-2.9245
211	R	A	-3.0561
212	E	A	-2.5364
213	P	A	-2.5260
214	E	A	-3.3639
215	L	A	-2.6151
216	P	A	0.0000
217	E	A	-2.8904
218	P	A	0.0000
219	P	A	-1.3590
220	T	A	-1.1419
221	R	A	-1.2417
222	E	A	-1.4177
223	P	A	0.0000
224	K	A	-2.4569
225	K	A	-2.4185
226	V	A	-1.2287
227	A	A	-0.1579
228	V	A	0.8164
229	V	A	1.2392
230	R	A	-0.6452
231	E	A	-2.1415
232	P	A	-1.8506
233	P	A	-2.1141
234	K	A	-2.9876
235	E	A	-3.0125
236	P	A	-2.0728
237	E	A	-1.9890
238	E	A	-2.4947
239	A	A	-1.6164
240	K	A	-1.7210
241	S	A	-0.5481
242	R	A	0.6335
243	L	A	2.0308
244	Q	A	0.0000
245	T	A	-0.2177
246	A	A	0.2758
247	P	A	-0.4417
248	V	A	-0.3244
249	P	A	-0.9234
250	M	A	-0.8142
251	P	A	-1.0339
252	D	A	-0.7651
253	L	A	-1.4621
254	K	A	-1.8144
255	N	A	-1.4843
256	V	A	0.0000
257	K	A	-1.7514
258	S	A	-0.9845
259	K	A	-1.3548
260	I	A	-1.6969
261	G	A	-1.4747
262	S	A	-1.4565
263	T	A	-1.4075
264	E	A	-2.0159
265	N	A	-1.7371
266	L	A	-0.7369
267	K	A	-1.6226
268	H	A	-1.8618
269	Q	A	-1.4354
270	P	A	-0.7950
271	G	A	-1.0777
272	G	A	0.0000
273	G	A	0.0000
274	K	A	-0.8050
275	V	A	1.6719
276	Q	A	0.0000
277	I	A	2.7171
278	I	A	1.9454
279	N	A	-0.9680
280	K	A	-2.3356
281	K	A	-2.7604
282	L	A	0.0000
283	D	A	-1.8907
284	L	A	0.0974
285	S	A	-0.7405
286	N	A	0.0000
287	V	A	-0.6732
288	Q	A	-1.0808
289	S	A	-0.5841
290	K	A	0.0000
291	C	A	0.0000
292	G	A	-1.2384
293	S	A	-1.5958
294	K	A	-1.8262
295	D	A	-2.5182
296	N	A	-1.8253
297	I	A	-1.0061
298	K	A	-2.0689
299	H	A	0.0000
300	V	A	0.0000
301	P	A	-0.4829
302	G	A	-0.0335
303	G	A	0.0000
304	G	A	-1.4439
305	E	A	-2.4418
306	V	A	-0.5662
307	Q	A	-0.4126
308	I	A	0.2832
309	V	A	1.6591
310	Y	A	0.2208
311	K	A	-1.5868
312	P	A	0.0000
313	V	A	-0.6425
314	D	A	-0.6533
315	L	A	-0.4808
316	S	A	-0.4746
317	K	A	-1.3722
318	V	A	-1.8952
319	T	A	0.0000
320	S	A	-2.1497
321	K	A	-2.0160
322	C	A	-1.0563
323	G	A	0.0000
324	S	A	-1.2403
325	L	A	-0.3560
326	G	A	0.0000
327	N	A	0.0000
328	I	A	0.6888
329	H	A	0.1433
330	H	A	0.1572
331	K	A	0.0000
332	P	A	-0.9469
333	G	A	-1.5704
334	G	A	-1.3623
335	G	A	-1.2591
336	Q	A	-2.0563
337	V	A	-1.7474
338	E	A	-2.2145
339	V	A	-0.9670
340	K	A	-1.2166
341	S	A	-1.6508
342	E	A	-1.4426
343	K	A	-2.3194
344	L	A	-1.0995
345	D	A	-1.1488
346	F	A	-0.7549
347	K	A	-1.2895
348	D	A	-2.0706
349	R	A	-1.9048
350	V	A	-1.7497
351	Q	A	-1.5499
352	S	A	-0.3767
353	K	A	-0.2517
354	I	A	1.0850
355	G	A	-0.3016
356	S	A	-0.6816
357	L	A	-1.0971
358	D	A	-1.3373
359	N	A	-1.8558
360	I	A	-0.9016
361	T	A	-1.3446
362	H	A	-1.7721
363	V	A	-1.2099
364	P	A	-0.5605
365	G	A	-0.6495
366	G	A	0.1682
367	G	A	-0.3978
368	N	A	0.0000
369	K	A	-1.0006
370	K	A	-1.1199
371	I	A	0.0000
372	E	A	-0.8201
373	T	A	0.0000
374	H	A	-0.6914
375	K	A	-1.3925
376	L	A	-0.9335
377	T	A	-0.7039
378	F	A	-0.4493
379	R	A	-1.9434
380	E	A	-1.7251
381	N	A	-1.7373
382	A	A	-1.4583
383	K	A	-1.4055
384	A	A	0.0000
385	K	A	-1.7064
386	T	A	-1.3826
387	D	A	-1.0805
388	H	A	-1.5936
389	G	A	-1.1480
390	A	A	-0.8458
391	E	A	-1.5632
392	I	A	-0.2994
393	V	A	0.4055
394	E	A	-1.3747
395	K	A	-2.4613
396	E	A	-2.5595
397	P	A	-1.7517
398	V	A	-0.7794
399	V	A	-0.9283
400	E	A	-1.5428
401	G	A	-1.4793
402	D	A	-2.1938
403	E	A	-2.8410
404	E	A	-3.1006
405	P	A	-2.1598
406	R	A	0.0000
407	H	A	-1.4658
408	L	A	-0.3605
409	S	A	-0.5938
410	N	A	-1.5795
411	V	A	-0.6089
412	S	A	0.0000
413	S	A	0.0000
414	T	A	-1.3269
415	G	A	-1.1243
416	S	A	-0.7466
417	I	A	0.0000
418	D	A	-0.8697
419	M	A	0.0000
420	V	A	-0.7653
421	D	A	-1.3624
422	S	A	-1.1217
423	P	A	-0.7094
424	Q	A	-0.3612
425	L	A	1.0537
426	A	A	0.8116
427	T	A	0.7248
428	L	A	1.0113
429	A	A	-0.3613
430	D	A	-1.8735
431	E	A	-1.6981
432	V	A	0.5070
433	S	A	0.1164
434	A	A	0.5805
435	S	A	0.4711
436	L	A	0.8162
437	A	A	-0.9173
438	K	A	-2.5371
439	Q	A	-2.4279
440	G	A	-1.8367
441	L	A	-0.9490