Project name: 2000034

Chain sequence(s)	A: SQSNRELVVDFLSYKLSQKGYSWSQMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNN; C: SQSNRELVVDFLSYKLSQKGYSWSQMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNN; B: GSGTMENLSRRLKVTGDLFDIMSG
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.5537
• Maximal score value: 2.2008
• Average score: -0.9109
• Total score value: -278.7219

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	S	A	-1.9278
3	Q	A	-2.5962
4	S	A	-1.9102
5	N	A	0.0000
6	R	A	-3.1446
7	E	A	-2.7599
8	L	A	0.0000
9	V	A	0.0000
10	V	A	-0.9070
11	D	A	-0.7987
12	F	A	0.0000
13	L	A	0.0000
14	S	A	0.0010
15	Y	A	-0.2791
16	K	A	0.0000
17	L	A	0.0000
18	S	A	-1.2701
19	Q	A	-1.9880
20	K	A	-2.5539
21	G	A	-1.7557
22	Y	A	-0.9101
23	S	A	-0.5907
24	W	A	-0.1453
25	S	A	-0.5360
26	Q	A	-1.4714
83	M	A	-0.8878
84	A	A	-0.4601
85	A	A	-1.1121
86	V	A	0.0000
87	K	A	-0.8348
88	Q	A	-1.1812
89	A	A	0.0000
90	L	A	0.0000
91	R	A	-0.9784
92	E	A	-1.6123
93	A	A	0.0000
94	G	A	0.0000
95	D	A	-1.4286
96	E	A	-1.7559
97	F	A	0.0000
98	E	A	-1.7186
99	L	A	-1.7693
100	R	A	-2.2679
101	Y	A	0.0000
102	R	A	-3.0452
103	R	A	-2.9510
104	A	A	-1.5809
105	F	A	-1.0538
106	S	A	-1.3373
107	D	A	-1.7386
108	L	A	0.0000
109	T	A	-0.6983
110	S	A	-1.5271
111	Q	A	-1.7285
112	L	A	0.0000
113	H	A	-1.4400
114	I	A	0.0000
115	T	A	-0.6652
116	P	A	-0.5064
117	G	A	-0.6913
118	T	A	-0.7213
119	A	A	0.0000
120	Y	A	-0.6072
121	Q	A	-1.4897
122	S	A	0.0000
123	F	A	0.0000
124	E	A	-1.6410
125	Q	A	-1.7447
126	V	A	0.0000
127	V	A	0.0000
128	N	A	-2.1431
129	E	A	-2.2993
130	L	A	0.0000
131	F	A	-1.7077
132	R	A	-2.9373
133	D	A	-2.7893
134	G	A	-1.4480
135	V	A	-0.5840
136	N	A	-0.0477
137	W	A	0.0000
138	G	A	0.0000
139	R	A	0.0000
140	I	A	0.0000
141	V	A	0.0000
142	A	A	0.0000
143	F	A	0.0000
144	F	A	0.0000
145	S	A	0.0000
146	F	A	0.0000
147	G	A	0.0000
148	G	A	0.0000
149	A	A	0.0000
150	L	A	0.0000
151	C	A	0.0000
152	V	A	0.0000
153	E	A	0.0000
154	S	A	0.0000
155	V	A	-2.0927
156	D	A	-3.3746
157	K	A	-3.5537
158	E	A	-3.1395
159	M	A	-1.5174
160	Q	A	-1.4056
161	V	A	0.6712
162	L	A	0.0000
163	V	A	0.0000
164	S	A	-0.5176
165	R	A	-1.1480
166	I	A	0.0000
167	A	A	0.0000
168	A	A	-0.7471
169	W	A	-0.4213
170	M	A	0.0000
171	A	A	0.0000
172	T	A	-1.0400
173	Y	A	-1.1225
174	L	A	0.0000
175	N	A	-2.1587
176	D	A	-2.5945
177	H	A	-2.0811
178	L	A	0.0000
179	E	A	-1.9511
180	P	A	-1.9026
181	W	A	-1.4450
182	I	A	0.0000
183	Q	A	-2.5543
184	E	A	-2.9204
185	N	A	-2.4094
186	G	A	-2.0210
187	G	A	-1.8397
188	W	A	-1.4454
189	D	A	-2.3423
190	T	A	-1.5834
191	F	A	0.0000
192	V	A	-1.4828
193	E	A	-1.9085
194	L	A	-0.6578
195	Y	A	0.0000
196	G	A	-1.7381
197	N	A	-2.5091
198	N	A	-2.1385
105	G	B	-1.0152
106	S	B	-1.0961
107	G	B	-1.1721
108	T	B	-1.4745
109	M	B	-1.6179
110	E	B	-2.1212
111	N	B	-2.1474
112	L	B	0.0000
113	S	B	0.0000
114	R	B	-2.2035
115	R	B	-1.2636
116	L	B	0.0000
117	K	B	-0.2432
118	V	B	1.0111
119	T	B	0.0000
120	G	B	0.0000
121	D	B	1.0830
122	L	B	1.8771
123	F	B	0.0000
124	D	B	1.1220
125	I	B	2.2008
126	M	B	1.6235
127	S	B	0.7115
128	G	B	0.3895
2	S	C	-1.5369
3	Q	C	-2.3631
4	S	C	-1.8482
5	N	C	0.0000
6	R	C	-2.9311
7	E	C	-2.4811
8	L	C	0.0000
9	V	C	0.0000
10	V	C	-0.7541
11	D	C	-0.7484
12	F	C	0.0000
13	L	C	0.0000
14	S	C	0.0058
15	Y	C	-0.3312
16	K	C	0.0000
17	L	C	0.0000
18	S	C	-1.1504
19	Q	C	-1.8057
20	K	C	-2.2842
21	G	C	-1.5992
22	Y	C	-0.7815
23	S	C	-0.5136
24	W	C	-0.0790
25	S	C	-0.5046
26	Q	C	-1.3284
83	M	C	-0.8255
84	A	C	-0.5665
85	A	C	-0.8034
86	V	C	0.0000
87	K	C	-0.7470
88	Q	C	-0.8580
89	A	C	0.0000
90	L	C	0.0000
91	R	C	0.0000
92	E	C	-1.3904
93	A	C	0.0000
94	G	C	0.0000
95	D	C	-1.2585
96	E	C	-1.7456
97	F	C	-1.0431
98	E	C	-1.2222
99	L	C	-1.5035
100	R	C	-2.4031
101	Y	C	-1.4021
102	R	C	-2.3036
103	R	C	-2.5787
104	A	C	-0.8764
105	F	C	0.3503
106	S	C	-0.5006
107	D	C	-1.2211
108	L	C	-0.3266
109	T	C	-0.6497
110	S	C	-1.3855
111	Q	C	-1.4565
112	L	C	-0.6888
113	H	C	-1.1442
114	I	C	0.0000
115	T	C	-0.5557
116	P	C	-0.2569
117	G	C	-0.6175
118	T	C	-0.6529
119	A	C	0.0000
120	Y	C	-0.5974
121	Q	C	-1.5273
122	S	C	-1.0761
123	F	C	0.0000
124	E	C	-1.8108
125	Q	C	-2.1786
126	V	C	-1.3071
127	V	C	0.0000
128	N	C	-2.4879
129	E	C	-3.1106
130	L	C	-1.7936
131	F	C	0.0000
132	R	C	-3.3234
133	D	C	-3.0241
134	G	C	-1.8506
135	V	C	-1.0137
136	N	C	-1.0616
137	W	C	0.0000
138	G	C	-0.6745
139	R	C	-0.9000
140	I	C	0.0000
141	V	C	0.0000
142	A	C	-0.1881
143	F	C	0.0000
144	F	C	0.0000
145	S	C	0.0000
146	F	C	0.2993
147	G	C	0.0000
148	G	C	0.0000
149	A	C	0.0000
150	L	C	0.0000
151	C	C	0.0000
152	V	C	0.0000
153	E	C	0.0000
154	S	C	0.0000
155	V	C	-2.0181
156	D	C	-3.0737
157	K	C	-3.4147
158	E	C	-3.0733
159	M	C	-1.5360
160	Q	C	-1.4492
161	V	C	0.6305
162	L	C	0.0000
163	V	C	0.0000
164	S	C	-0.5553
165	R	C	-1.1062
166	I	C	0.0000
167	A	C	0.0000
168	A	C	-0.6947
169	W	C	-0.3882
170	M	C	0.0000
171	A	C	0.0000
172	T	C	-1.0085
173	Y	C	-1.0607
174	L	C	0.0000
175	N	C	-2.1511
176	D	C	-2.5978
177	H	C	-2.0466
178	L	C	0.0000
179	E	C	-1.9343
180	P	C	-1.8922
181	W	C	-1.5648
182	I	C	0.0000
183	Q	C	-2.5694
184	E	C	-2.9067
185	N	C	-2.4209
186	G	C	-1.9359
187	G	C	-1.6659
188	W	C	-1.0966
189	D	C	-1.7310
190	T	C	-1.1086
191	F	C	0.0000
192	V	C	-0.7980
193	E	C	-1.3029
194	L	C	0.4772
195	Y	C	-0.0247
196	G	C	-1.2334
197	N	C	-2.0885
198	N	C	-1.9841