Project name: 7af0a05d37bba5a

Chain sequence(s)	A: GVTEEQVHHIVKQALQQRYSEDRIGLADYALESGGASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVILQPDVHPGNCWAFQGPQGFAVVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAIFGFDEDLQQEGTLLGKFTYDQDGEPIQTFHFQAPTMATYQVVELRILTNWGHPEYTCCIYRFRVHGEPAH
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.3383
• Maximal score value: 3.2662
• Average score: -0.6597
• Total score value: -129.3071

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
522	G	A	0.1992
523	V	A	0.8834
524	T	A	-0.8763
525	E	A	-2.5774
526	E	A	-2.6005
527	Q	A	-1.3046
528	V	A	-0.1977
529	H	A	-1.8263
530	H	A	-1.4603
531	I	A	0.9093
532	V	A	0.3924
533	K	A	-1.5320
534	Q	A	-1.4824
535	A	A	-0.7111
536	L	A	-0.1770
537	Q	A	-2.1437
538	R	A	-2.6828
539	Y	A	-1.3418
540	S	A	-1.7247
541	E	A	-2.5795
542	D	A	-2.2272
543	R	A	-2.3031
544	I	A	-1.2496
545	G	A	-1.4154
546	L	A	-0.0848
547	A	A	-0.0691
548	D	A	-0.0551
549	Y	A	-0.4888
550	A	A	0.0000
551	L	A	-0.3672
552	E	A	-1.1586
553	S	A	-0.7593
554	G	A	-0.8102
555	G	A	-1.0178
556	A	A	0.0000
557	S	A	-0.9423
558	V	A	-0.4791
559	I	A	0.0039
560	S	A	0.0615
561	T	A	-0.2954
562	R	A	-0.5698
563	C	A	-0.2536
564	S	A	-1.1886
565	E	A	-2.4125
566	T	A	-1.6756
567	Y	A	-2.1346
568	E	A	-2.7745
569	T	A	-1.7762
570	K	A	-1.9716
571	T	A	-0.9064
572	A	A	0.0015
573	L	A	1.5251
574	L	A	2.3582
575	S	A	2.6968
576	L	A	2.9541
577	F	A	2.8631
578	G	A	2.0143
579	I	A	3.2662
580	P	A	2.3837
581	L	A	2.6864
582	W	A	2.2899
583	Y	A	0.8593
584	H	A	-0.4983
585	S	A	-1.2124
586	Q	A	-1.4643
587	S	A	-1.1334
588	P	A	-0.9839
589	R	A	-1.8942
590	V	A	-1.3611
591	I	A	0.0000
592	L	A	0.0000
593	Q	A	-1.4906
594	P	A	-1.4434
595	D	A	-2.1765
596	V	A	-1.2308
597	H	A	-1.3833
598	P	A	-0.7602
599	G	A	-0.8648
600	N	A	-1.4236
601	C	A	0.0000
602	W	A	0.0000
603	A	A	-1.0755
604	F	A	0.0000
605	Q	A	-2.6284
606	G	A	-1.8032
607	P	A	-1.3002
608	Q	A	-1.4855
609	G	A	0.0000
610	F	A	-0.3231
611	A	A	0.0000
612	V	A	0.0000
613	V	A	0.0000
614	R	A	-1.6913
615	L	A	0.0000
616	S	A	-0.9724
617	A	A	-0.8951
618	R	A	-1.3428
619	I	A	0.0000
620	R	A	-0.5982
621	P	A	0.0000
622	T	A	-0.5999
623	A	A	0.0000
624	V	A	0.0000
625	T	A	0.0000
626	L	A	0.0000
627	E	A	0.0000
628	H	A	0.0000
629	V	A	0.0000
630	P	A	-0.6623
631	K	A	-1.1550
632	A	A	0.1021
633	L	A	0.8475
634	S	A	-0.1151
635	P	A	-0.7127
636	N	A	-1.3900
637	S	A	-0.8299
638	T	A	-0.8611
639	I	A	0.0000
640	S	A	-0.4185
641	S	A	-0.5125
642	A	A	0.0000
643	P	A	0.0000
644	K	A	-0.9125
645	D	A	-1.1806
646	F	A	0.0000
647	A	A	0.0000
648	I	A	0.0000
649	F	A	-0.0510
650	G	A	0.0000
651	F	A	0.0000
652	D	A	-3.2405
653	E	A	-3.3383
654	D	A	-2.8252
655	L	A	-1.9061
656	Q	A	-2.2626
657	Q	A	-2.7502
658	E	A	-2.5897
659	G	A	-1.5502
660	T	A	-0.3166
661	L	A	0.5205
662	L	A	0.1874
663	G	A	-0.7029
664	K	A	-1.5492
665	F	A	-1.0110
666	T	A	-0.9599
667	Y	A	0.0000
668	D	A	-2.6214
669	Q	A	-2.4112
670	D	A	-3.0609
671	G	A	-2.6131
672	E	A	-2.7091
673	P	A	-1.5780
674	I	A	-0.7243
675	Q	A	-0.7407
676	T	A	-0.2843
677	F	A	-0.6189
678	H	A	-1.1979
679	F	A	0.0000
680	Q	A	-1.5729
681	A	A	-0.5519
682	P	A	-0.3059
683	T	A	0.2856
684	M	A	0.8446
685	A	A	0.1657
686	T	A	-0.6290
687	Y	A	0.0000
688	Q	A	-1.9399
689	V	A	0.0000
690	V	A	0.0000
691	E	A	0.0000
692	L	A	0.0000
693	R	A	-0.6613
694	I	A	0.0000
695	L	A	-0.4778
696	T	A	-0.5654
697	N	A	0.0000
698	W	A	-0.5345
699	G	A	-0.7954
700	H	A	-0.9931
701	P	A	-1.4145
702	E	A	-2.1261
703	Y	A	-1.7480
704	T	A	0.0000
705	C	A	0.0000
706	I	A	0.0000
707	Y	A	0.0000
708	R	A	0.0000
709	F	A	0.0000
710	R	A	0.0000
711	V	A	0.0000
712	H	A	0.0000
713	G	A	-0.7738
714	E	A	-1.3495
715	P	A	-1.1011
716	A	A	-0.8941
717	H	A	-1.1703