| Chain sequence(s) |
A: KILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFRDFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIFDSYIMKELLACSHPFSKSATEHVQGHLGKKQVPPDLFQPYIEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSFILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPPLIPPRGEVNAADAFDIKLLDSDQELYRNFPLTISERWQQEVAETVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHGYMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTMEEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQWKKELRDAYREAQQLVQRVPKMKNKPRAP B: SELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICCFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICCGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN G: SIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREKKFFCA |
| Distance of aggregation | 5 Å |
| Dynamic mode | No |
| Mutated residues | IB80T |
| Energy difference between WT (input) and mutated protein (by FoldX) | 2.6348 kcal/mol
CAUTION: Your mutation/s can destabilize the protein structure Changes in protein stability upon mutation are calculated using the FoldX forcefield. Computational prediction of protein stability is used with the intention of preventing the experimental characterization of proteins bearing mutations that significantly destabilize their structure. Mutations resulting in a predicted reduction in protein stability ≥ 1 kcal/mol are considered disruptive. |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 31 | K | A | -1.7224 | |
| 32 | I | A | 0.2026 | |
| 33 | L | A | 1.5885 | |
| 34 | L | A | 0.0000 | |
| 35 | P | A | -0.1326 | |
| 36 | E | A | -0.5377 | |
| 37 | P | A | -0.1576 | |
| 38 | S | A | -0.0845 | |
| 39 | I | A | 0.0000 | |
| 40 | R | A | -0.3057 | |
| 41 | S | A | -0.0818 | |
| 42 | V | A | 0.0000 | |
| 43 | M | A | 0.0000 | |
| 44 | Q | A | -0.2804 | |
| 45 | K | A | -0.3805 | |
| 46 | Y | A | 0.0661 | |
| 47 | L | A | 0.0000 | |
| 48 | E | A | -2.0269 | |
| 49 | D | A | -2.2942 | |
| 50 | R | A | -1.4517 | |
| 51 | G | A | -0.7854 | |
| 52 | E | A | -0.7470 | |
| 53 | V | A | 0.1335 | |
| 54 | T | A | 0.0299 | |
| 55 | F | A | 0.0000 | |
| 56 | E | A | -1.1396 | |
| 57 | K | A | -1.2338 | |
| 58 | I | A | 0.0000 | |
| 59 | F | A | 0.1802 | |
| 60 | S | A | -0.2117 | |
| 61 | Q | A | -0.4020 | |
| 62 | K | A | -0.9975 | |
| 63 | L | A | 0.0000 | |
| 64 | G | A | 0.0000 | |
| 65 | Y | A | 0.2793 | |
| 66 | L | A | 0.3945 | |
| 67 | L | A | 0.0000 | |
| 68 | F | A | 0.0000 | |
| 69 | R | A | -0.7672 | |
| 70 | D | A | -0.6362 | |
| 71 | F | A | 0.0000 | |
| 72 | C | A | 0.0000 | |
| 73 | L | A | 0.0461 | |
| 74 | N | A | -1.3922 | |
| 75 | H | A | -1.1911 | |
| 76 | L | A | -0.3579 | |
| 77 | E | A | -2.1216 | |
| 78 | E | A | -2.1531 | |
| 79 | A | A | 0.0000 | |
| 80 | R | A | -0.3029 | |
| 81 | P | A | 0.0000 | |
| 82 | L | A | 0.0000 | |
| 83 | V | A | 0.0000 | |
| 84 | E | A | -0.5606 | |
| 85 | F | A | 0.0000 | |
| 86 | Y | A | 0.0000 | |
| 87 | E | A | -0.4114 | |
| 88 | E | A | -0.6485 | |
| 89 | I | A | 0.0000 | |
| 90 | K | A | -0.9239 | |
| 91 | K | A | -1.4979 | |
| 92 | Y | A | 0.0000 | |
| 93 | E | A | -1.8988 | |
| 94 | K | A | -1.9542 | |
| 95 | L | A | -0.3824 | |
| 96 | E | A | -1.2427 | |
| 97 | T | A | -0.5763 | |
| 98 | E | A | -2.1497 | |
| 99 | E | A | -2.3275 | |
| 100 | E | A | -1.3371 | |
| 101 | R | A | 0.0000 | |
| 102 | V | A | 0.2838 | |
| 103 | A | A | -0.1376 | |
| 104 | R | A | -1.3320 | |
| 105 | S | A | 0.0000 | |
| 106 | R | A | -2.1685 | |
| 107 | E | A | -2.2701 | |
| 108 | I | A | 0.0000 | |
| 109 | F | A | -0.0136 | |
| 110 | D | A | -1.7374 | |
| 111 | S | A | -0.0978 | |
| 112 | Y | A | 1.1363 | |
| 113 | I | A | 0.0000 | |
| 114 | M | A | 0.0000 | |
| 115 | K | A | -1.7016 | |
| 116 | E | A | -1.0734 | |
| 117 | L | A | 0.0000 | |
| 118 | L | A | 1.5377 | |
| 119 | A | A | 0.3005 | |
| 120 | C | A | 0.2565 | |
| 121 | S | A | -0.3373 | |
| 122 | H | A | -1.0578 | |
| 123 | P | A | -0.1237 | |
| 124 | F | A | 0.1488 | |
| 125 | S | A | -0.3528 | |
| 126 | K | A | -1.7514 | |
| 127 | S | A | -0.5181 | |
| 128 | A | A | 0.0000 | |
| 129 | T | A | -0.3441 | |
| 130 | E | A | -2.0096 | |
| 131 | H | A | -1.3327 | |
| 132 | V | A | 0.0000 | |
| 133 | Q | A | -0.8696 | |
| 134 | G | A | -0.6252 | |
| 135 | H | A | -0.5365 | |
| 136 | L | A | 0.0000 | |
| 137 | G | A | -0.7712 | |
| 138 | K | A | -2.0842 | |
| 139 | K | A | -2.2037 | |
| 140 | Q | A | -1.4454 | |
| 141 | V | A | 0.0000 | |
| 142 | P | A | -0.0637 | |
| 143 | P | A | -0.6171 | |
| 144 | D | A | -1.8051 | |
| 145 | L | A | 0.0000 | |
| 146 | F | A | 0.0000 | |
| 147 | Q | A | -0.7203 | |
| 148 | P | A | -0.2124 | |
| 149 | Y | A | 0.0000 | |
| 150 | I | A | -0.2059 | |
| 151 | E | A | -1.8676 | |
| 152 | E | A | -0.8012 | |
| 153 | I | A | 0.0000 | |
| 154 | C | A | -0.1048 | |
| 155 | Q | A | -1.2569 | |
| 156 | N | A | -0.6499 | |
| 157 | L | A | 0.0000 | |
| 158 | R | A | -1.1798 | |
| 159 | G | A | -0.9988 | |
| 160 | D | A | -1.9720 | |
| 161 | V | A | 0.0000 | |
| 162 | F | A | 0.0448 | |
| 163 | Q | A | -1.2532 | |
| 164 | K | A | -1.1609 | |
| 165 | F | A | 0.0000 | |
| 166 | I | A | 0.0000 | |
| 167 | E | A | -1.8259 | |
| 168 | S | A | -0.6943 | |
| 169 | D | A | -1.8501 | |
| 170 | K | A | -0.6261 | |
| 171 | F | A | 0.0000 | |
| 172 | T | A | 0.0000 | |
| 173 | R | A | 0.0000 | |
| 174 | F | A | 0.0000 | |
| 175 | C | A | 0.0000 | |
| 176 | Q | A | 0.0000 | |
| 177 | W | A | 0.0000 | |
| 178 | K | A | 0.0000 | |
| 179 | N | A | 0.0000 | |
| 180 | V | A | 0.3127 | |
| 181 | E | A | 0.0000 | |
| 182 | L | A | 0.4970 | |
| 183 | N | A | -0.2714 | |
| 184 | I | A | 0.1472 | |
| 185 | H | A | -0.8770 | |
| 186 | L | A | 0.0086 | |
| 187 | T | A | 0.0495 | |
| 188 | M | A | -0.0412 | |
| 189 | N | A | -1.3328 | |
| 190 | D | A | -0.7638 | |
| 191 | F | A | 0.0000 | |
| 192 | S | A | -0.0490 | |
| 193 | V | A | 0.6907 | |
| 194 | H | A | -1.1618 | |
| 195 | R | A | -1.7015 | |
| 196 | I | A | 1.5169 | |
| 197 | I | A | 0.6674 | |
| 198 | G | A | -0.2191 | |
| 199 | R | A | -1.6791 | |
| 200 | G | A | -0.5618 | |
| 201 | G | A | -0.4561 | |
| 202 | F | A | 0.1689 | |
| 203 | G | A | -0.0910 | |
| 204 | E | A | -0.6304 | |
| 205 | V | A | 0.2440 | |
| 206 | Y | A | 0.5300 | |
| 207 | G | A | 0.0000 | |
| 208 | C | A | 0.0000 | |
| 209 | R | A | -1.7806 | |
| 210 | K | A | 0.0000 | |
| 211 | A | A | -0.0227 | |
| 212 | D | A | -0.6665 | |
| 213 | T | A | 0.0000 | |
| 214 | G | A | -0.2453 | |
| 215 | K | A | -0.4116 | |
| 216 | M | A | 0.1713 | |
| 217 | Y | A | 0.2687 | |
| 218 | A | A | 0.0000 | |
| 219 | M | A | 0.0000 | |
| 220 | K | A | -0.1743 | |
| 221 | C | A | 0.0000 | |
| 222 | L | A | 0.0000 | |
| 223 | D | A | -0.6019 | |
| 224 | K | A | 0.0000 | |
| 225 | K | A | -1.2687 | |
| 226 | R | A | -1.1069 | |
| 227 | I | A | 0.0000 | |
| 228 | K | A | -0.3051 | |
| 229 | M | A | 0.0756 | |
| 230 | K | A | -1.8192 | |
| 231 | Q | A | -1.5182 | |
| 232 | G | A | -0.2922 | |
| 233 | E | A | -0.5268 | |
| 234 | T | A | -0.0472 | |
| 235 | L | A | 0.6139 | |
| 236 | A | A | 0.0000 | |
| 237 | L | A | 0.2114 | |
| 238 | N | A | -0.1954 | |
| 239 | E | A | 0.0000 | |
| 240 | R | A | -0.0356 | |
| 241 | I | A | 1.1271 | |
| 242 | M | A | 0.0000 | |
| 243 | L | A | 0.0000 | |
| 244 | S | A | 0.0281 | |
| 245 | L | A | 0.4807 | |
| 246 | V | A | 0.0000 | |
| 247 | S | A | 0.0000 | |
| 248 | T | A | -0.1120 | |
| 249 | G | A | -0.7886 | |
| 250 | D | A | -1.8722 | |
| 251 | C | A | 0.0000 | |
| 252 | P | A | -0.0383 | |
| 253 | F | A | 0.0000 | |
| 254 | I | A | 0.0000 | |
| 255 | V | A | 0.0000 | |
| 256 | C | A | 0.0000 | |
| 257 | M | A | 0.0000 | |
| 258 | S | A | 0.0000 | |
| 259 | Y | A | 0.0000 | |
| 260 | A | A | 0.0000 | |
| 261 | F | A | 0.0000 | |
| 262 | H | A | -0.2591 | |
| 263 | T | A | -0.1062 | |
| 264 | P | A | -0.5698 | |
| 265 | D | A | -1.9790 | |
| 266 | K | A | -1.1740 | |
| 267 | L | A | 0.0000 | |
| 268 | S | A | 0.0000 | |
| 269 | F | A | 0.0000 | |
| 270 | I | A | 0.0000 | |
| 271 | L | A | 0.0000 | |
| 272 | D | A | -0.2111 | |
| 273 | L | A | 0.3752 | |
| 274 | M | A | 0.0000 | |
| 275 | N | A | -0.5502 | |
| 276 | G | A | 0.0000 | |
| 277 | G | A | 0.0000 | |
| 278 | D | A | 0.0000 | |
| 279 | L | A | 0.0000 | |
| 280 | H | A | -0.3951 | |
| 281 | Y | A | 0.1568 | |
| 282 | H | A | 0.0000 | |
| 283 | L | A | 0.0000 | |
| 284 | S | A | -0.4223 | |
| 285 | Q | A | -1.3931 | |
| 286 | H | A | -1.1119 | |
| 287 | G | A | -0.1583 | |
| 288 | V | A | 1.0879 | |
| 289 | F | A | 0.0000 | |
| 290 | S | A | -0.2362 | |
| 291 | E | A | -0.3956 | |
| 292 | A | A | -0.0873 | |
| 293 | D | A | -0.4053 | |
| 294 | M | A | 0.0000 | |
| 295 | R | A | -0.3153 | |
| 296 | F | A | 0.0000 | |
| 297 | Y | A | 0.0000 | |
| 298 | A | A | 0.0000 | |
| 299 | A | A | 0.0000 | |
| 300 | E | A | 0.0000 | |
| 301 | I | A | 0.0000 | |
| 302 | I | A | 0.0000 | |
| 303 | L | A | 0.0000 | |
| 304 | G | A | 0.0000 | |
| 305 | L | A | 0.0000 | |
| 306 | E | A | -0.5480 | |
| 307 | H | A | -0.2134 | |
| 308 | M | A | 0.0000 | |
| 309 | H | A | -0.1723 | |
| 310 | N | A | -1.4117 | |
| 311 | R | A | -0.6126 | |
| 312 | F | A | 1.3626 | |
| 313 | V | A | 0.0000 | |
| 314 | V | A | 0.0000 | |
| 315 | Y | A | 0.0000 | |
| 316 | R | A | -0.2222 | |
| 317 | D | A | -0.2282 | |
| 318 | L | A | 0.0000 | |
| 319 | K | A | -0.3159 | |
| 320 | P | A | 0.0000 | |
| 321 | A | A | -0.0652 | |
| 322 | N | A | -0.1254 | |
| 323 | I | A | 0.0000 | |
| 324 | L | A | 0.1867 | |
| 325 | L | A | 0.0000 | |
| 326 | D | A | -0.7203 | |
| 327 | E | A | -2.0490 | |
| 328 | H | A | -1.3078 | |
| 329 | G | A | 0.0000 | |
| 330 | H | A | 0.0000 | |
| 331 | V | A | 0.0000 | |
| 332 | R | A | -0.2669 | |
| 333 | I | A | 0.0000 | |
| 334 | S | A | -0.1900 | |
| 335 | D | A | -0.9184 | |
| 336 | L | A | 0.0000 | |
| 337 | G | A | 0.0000 | |
| 338 | L | A | 0.5182 | |
| 339 | A | A | 0.0000 | |
| 340 | C | A | 0.0170 | |
| 341 | D | A | -0.2988 | |
| 342 | F | A | -0.0792 | |
| 343 | S | A | -0.4555 | |
| 344 | K | A | -2.0454 | |
| 345 | K | A | -2.3034 | |
| 346 | K | A | -1.8759 | |
| 347 | P | A | -0.5023 | |
| 348 | H | A | -1.0317 | |
| 349 | A | A | -0.1729 | |
| 350 | S | A | -0.0163 | |
| 351 | V | A | 0.2039 | |
| 352 | G | A | -0.0897 | |
| 353 | T | A | -0.0815 | |
| 354 | H | A | -0.2076 | |
| 355 | G | A | 0.0000 | |
| 356 | Y | A | 0.0000 | |
| 357 | M | A | 0.0000 | |
| 358 | A | A | 0.0000 | |
| 359 | P | A | 0.0000 | |
| 360 | E | A | 0.0000 | |
| 361 | V | A | 0.0000 | |
| 362 | L | A | 0.0000 | |
| 363 | Q | A | -1.1396 | |
| 364 | K | A | -1.9377 | |
| 365 | G | A | -0.7519 | |
| 366 | V | A | 0.6114 | |
| 367 | A | A | 0.0612 | |
| 368 | Y | A | 0.0000 | |
| 369 | D | A | -0.4790 | |
| 370 | S | A | -0.1130 | |
| 371 | S | A | 0.0000 | |
| 372 | A | A | 0.0000 | |
| 373 | D | A | 0.0000 | |
| 374 | W | A | 0.0000 | |
| 375 | F | A | 0.0000 | |
| 376 | S | A | 0.0000 | |
| 377 | L | A | 0.0000 | |
| 378 | G | A | 0.0000 | |
| 379 | C | A | 0.0000 | |
| 380 | M | A | 0.0000 | |
| 381 | L | A | 0.0000 | |
| 382 | F | A | 0.0000 | |
| 383 | K | A | -0.3087 | |
| 384 | L | A | 0.0000 | |
| 385 | L | A | 0.0000 | |
| 386 | R | A | -1.0514 | |
| 387 | G | A | -0.4984 | |
| 388 | H | A | -0.5008 | |
| 389 | S | A | 0.0000 | |
| 390 | P | A | 0.0000 | |
| 391 | F | A | 0.0000 | |
| 392 | R | A | -0.9541 | |
| 393 | Q | A | -1.5154 | |
| 394 | H | A | -1.5170 | |
| 395 | K | A | -1.8851 | |
| 396 | T | A | -0.6563 | |
| 397 | K | A | -1.9802 | |
| 398 | D | A | -2.1201 | |
| 399 | K | A | -2.1149 | |
| 400 | H | A | -1.5594 | |
| 401 | E | A | -1.8435 | |
| 402 | I | A | 0.0000 | |
| 403 | D | A | -0.6063 | |
| 404 | R | A | -2.0200 | |
| 405 | M | A | -0.1733 | |
| 406 | T | A | 0.0000 | |
| 407 | L | A | 0.2934 | |
| 408 | T | A | 0.0614 | |
| 409 | M | A | 0.3077 | |
| 410 | A | A | 0.1654 | |
| 411 | V | A | -0.0576 | |
| 412 | E | A | -1.7360 | |
| 413 | L | A | -0.1775 | |
| 414 | P | A | -0.3745 | |
| 415 | D | A | -1.8427 | |
| 416 | S | A | -0.5409 | |
| 417 | F | A | 0.0000 | |
| 418 | S | A | -0.0808 | |
| 419 | P | A | -0.4522 | |
| 420 | E | A | -0.8326 | |
| 421 | L | A | 0.0000 | |
| 422 | R | A | -0.4934 | |
| 423 | S | A | -0.1950 | |
| 424 | L | A | 0.0000 | |
| 425 | L | A | 0.0000 | |
| 426 | E | A | -1.8319 | |
| 427 | G | A | -0.3767 | |
| 428 | L | A | 0.0000 | |
| 429 | L | A | 0.1108 | |
| 430 | Q | A | -0.5608 | |
| 431 | R | A | -2.0603 | |
| 432 | D | A | -1.1966 | |
| 433 | V | A | -0.0169 | |
| 434 | N | A | -1.5287 | |
| 435 | R | A | -2.0695 | |
| 436 | R | A | 0.0000 | |
| 437 | L | A | 0.1991 | |
| 438 | G | A | 0.0000 | |
| 439 | C | A | 0.3617 | |
| 440 | L | A | 1.1969 | |
| 441 | G | A | -0.5751 | |
| 442 | R | A | -1.9593 | |
| 443 | G | A | -0.4978 | |
| 444 | A | A | 0.0000 | |
| 445 | Q | A | -1.3229 | |
| 446 | E | A | -0.6479 | |
| 447 | V | A | 0.0000 | |
| 448 | K | A | -0.9168 | |
| 449 | E | A | -1.9048 | |
| 450 | S | A | 0.0000 | |
| 451 | P | A | -0.1255 | |
| 452 | F | A | 0.0000 | |
| 453 | F | A | 0.0000 | |
| 454 | R | A | -1.8831 | |
| 455 | S | A | -0.5094 | |
| 456 | L | A | -0.1195 | |
| 457 | D | A | -1.5417 | |
| 458 | W | A | -0.3444 | |
| 459 | Q | A | -0.9496 | |
| 460 | M | A | 0.0136 | |
| 461 | V | A | 0.0000 | |
| 462 | F | A | 0.7375 | |
| 463 | L | A | 0.7012 | |
| 464 | Q | A | -0.6516 | |
| 465 | K | A | -1.6553 | |
| 466 | Y | A | -0.0148 | |
| 467 | P | A | -0.2003 | |
| 468 | P | A | -0.0918 | |
| 469 | P | A | -0.0674 | |
| 470 | L | A | 0.5437 | |
| 471 | I | A | 2.0475 | |
| 472 | P | A | 0.0000 | |
| 473 | P | A | -0.5937 | |
| 474 | R | A | -1.9750 | |
| 475 | G | A | -0.8767 | |
| 476 | E | A | -0.1857 | |
| 477 | V | A | 1.4651 | |
| 478 | N | A | -0.9567 | |
| 479 | A | A | 0.0000 | |
| 480 | A | A | -0.0936 | |
| 481 | D | A | -0.6701 | |
| 482 | A | A | 0.2847 | |
| 483 | F | A | 1.6316 | |
| 484 | D | A | -1.4467 | |
| 496 | I | A | 1.7085 | |
| 497 | K | A | -1.2611 | |
| 498 | L | A | 0.2394 | |
| 499 | L | A | 0.3779 | |
| 500 | D | A | -1.7409 | |
| 501 | S | A | -0.8036 | |
| 502 | D | A | -0.4223 | |
| 503 | Q | A | -0.9402 | |
| 504 | E | A | -1.7382 | |
| 505 | L | A | 0.6351 | |
| 506 | Y | A | 0.0000 | |
| 507 | R | A | -2.0770 | |
| 508 | N | A | -1.6104 | |
| 509 | F | A | 0.0000 | |
| 510 | P | A | -0.1428 | |
| 511 | L | A | 0.3436 | |
| 512 | T | A | 0.0525 | |
| 513 | I | A | 0.0000 | |
| 514 | S | A | -0.2944 | |
| 515 | E | A | -1.1354 | |
| 516 | R | A | -0.3981 | |
| 517 | W | A | 0.0000 | |
| 518 | Q | A | 0.0000 | |
| 519 | Q | A | -0.3717 | |
| 520 | E | A | 0.0000 | |
| 521 | V | A | 0.0000 | |
| 522 | A | A | -0.3036 | |
| 523 | E | A | -1.4712 | |
| 524 | T | A | -0.2790 | |
| 525 | V | A | 0.0000 | |
| 526 | F | A | 0.0000 | |
| 527 | D | A | -1.8024 | |
| 528 | T | A | -0.4055 | |
| 529 | I | A | 0.0000 | |
| 530 | N | A | -0.1835 | |
| 531 | A | A | -0.5267 | |
| 532 | E | A | -1.8163 | |
| 533 | T | A | 0.0000 | |
| 534 | D | A | -2.1102 | |
| 535 | R | A | -1.8018 | |
| 536 | L | A | 1.1900 | |
| 537 | E | A | 0.1029 | |
| 538 | A | A | -0.3169 | |
| 539 | R | A | -2.0420 | |
| 540 | K | A | -1.8009 | |
| 541 | K | A | -1.9030 | |
| 542 | A | A | -0.5540 | |
| 543 | K | A | -1.7485 | |
| 544 | N | A | -0.9340 | |
| 545 | K | A | -2.0248 | |
| 546 | Q | A | -1.2240 | |
| 547 | L | A | 1.2477 | |
| 548 | G | A | -0.4685 | |
| 549 | H | A | -0.9196 | |
| 550 | E | A | -2.1135 | |
| 551 | E | A | -1.6848 | |
| 552 | D | A | -1.5721 | |
| 553 | Y | A | -0.0247 | |
| 554 | A | A | 0.3299 | |
| 555 | L | A | 1.4595 | |
| 556 | G | A | -0.2279 | |
| 557 | K | A | -0.7817 | |
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| 562 | H | A | -0.1599 | |
| 563 | G | A | 0.0000 | |
| 564 | Y | A | 0.2548 | |
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| 566 | S | A | -0.3708 | |
| 567 | K | A | -0.2271 | |
| 568 | M | A | 0.0854 | |
| 569 | G | A | -0.1467 | |
| 570 | N | A | -0.6727 | |
| 571 | P | A | -0.0213 | |
| 572 | F | A | 2.1742 | |
| 573 | L | A | 1.8910 | |
| 574 | T | A | 0.0240 | |
| 575 | Q | A | -1.1503 | |
| 576 | W | A | -0.0125 | |
| 577 | Q | A | -0.7868 | |
| 578 | R | A | -2.0172 | |
| 579 | R | A | -0.7423 | |
| 580 | Y | A | 0.0000 | |
| 581 | F | A | 0.0000 | |
| 582 | Y | A | 0.0000 | |
| 583 | L | A | 0.0000 | |
| 584 | F | A | 0.0000 | |
| 585 | P | A | -0.0484 | |
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| 587 | R | A | 0.0000 | |
| 588 | L | A | 0.0000 | |
| 589 | E | A | 0.0000 | |
| 590 | W | A | 0.0000 | |
| 591 | R | A | 0.0000 | |
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| 595 | E | A | -0.9879 | |
| 596 | A | A | -0.1157 | |
| 597 | P | A | -0.2318 | |
| 598 | Q | A | -1.2203 | |
| 599 | S | A | -0.2833 | |
| 600 | L | A | 0.1627 | |
| 601 | L | A | 0.0000 | |
| 602 | T | A | 0.0000 | |
| 603 | M | A | 0.0000 | |
| 604 | E | A | -0.2955 | |
| 605 | E | A | -0.5368 | |
| 606 | I | A | 0.0000 | |
| 607 | Q | A | -1.2057 | |
| 608 | S | A | -0.2641 | |
| 609 | V | A | 0.0000 | |
| 610 | E | A | -1.6647 | |
| 611 | E | A | -0.7902 | |
| 612 | T | A | -0.3276 | |
| 613 | Q | A | -1.2285 | |
| 614 | I | A | -0.1449 | |
| 615 | K | A | -1.9585 | |
| 616 | E | A | -2.3520 | |
| 617 | R | A | -1.7502 | |
| 618 | K | A | -1.2113 | |
| 619 | C | A | 0.0000 | |
| 620 | L | A | 0.0000 | |
| 621 | L | A | 0.2817 | |
| 622 | L | A | 0.0000 | |
| 623 | K | A | -1.3737 | |
| 624 | I | A | 0.0000 | |
| 625 | R | A | -1.9319 | |
| 626 | G | A | -0.8989 | |
| 627 | G | A | -0.8572 | |
| 628 | K | A | -1.8641 | |
| 629 | Q | A | -0.8805 | |
| 630 | F | A | 0.0000 | |
| 631 | I | A | 0.0000 | |
| 632 | L | A | 0.0000 | |
| 633 | Q | A | -0.1571 | |
| 634 | C | A | 0.0000 | |
| 635 | D | A | -1.7894 | |
| 636 | S | A | 0.0000 | |
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| 638 | P | A | 0.0000 | |
| 639 | E | A | 0.0000 | |
| 640 | L | A | 0.0000 | |
| 641 | V | A | 0.5635 | |
| 642 | Q | A | 0.0000 | |
| 643 | W | A | 0.0000 | |
| 644 | K | A | -0.4410 | |
| 645 | K | A | -1.0300 | |
| 646 | E | A | -0.4492 | |
| 647 | L | A | 0.0000 | |
| 648 | R | A | -1.2400 | |
| 649 | D | A | -1.9594 | |
| 650 | A | A | 0.0000 | |
| 651 | Y | A | -0.1758 | |
| 652 | R | A | -2.1452 | |
| 653 | E | A | -2.1549 | |
| 654 | A | A | 0.0000 | |
| 655 | Q | A | -0.4387 | |
| 656 | Q | A | -1.1411 | |
| 657 | L | A | 0.1260 | |
| 658 | V | A | 0.0000 | |
| 659 | Q | A | -1.5337 | |
| 660 | R | A | -2.0620 | |
| 661 | V | A | 0.0000 | |
| 662 | P | A | -0.0837 | |
| 663 | K | A | -0.2792 | |
| 664 | M | A | 0.0000 | |
| 665 | K | A | -0.7747 | |
| 666 | N | A | -1.4341 | |
| 667 | K | A | -0.6170 | |
| 668 | P | A | -0.4989 | |
| 669 | R | A | -1.1059 | |
| 670 | A | A | -0.1766 | |
| 671 | P | A | -0.2448 | |
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| 3 | E | B | -1.7616 | |
| 4 | L | B | -0.1117 | |
| 5 | D | B | -1.8947 | |
| 6 | Q | B | -1.4522 | |
| 7 | L | B | 0.0000 | |
| 8 | R | B | -2.0632 | |
| 9 | Q | B | -1.6564 | |
| 10 | E | B | -0.9998 | |
| 11 | A | B | 0.0000 | |
| 12 | E | B | -2.0392 | |
| 13 | Q | B | -1.5699 | |
| 14 | L | B | -0.3428 | |
| 15 | K | B | -1.7728 | |
| 16 | N | B | -1.5848 | |
| 17 | Q | B | -1.4166 | |
| 18 | I | B | 0.0000 | |
| 19 | R | B | -2.2579 | |
| 20 | D | B | -2.2279 | |
| 21 | A | B | -0.3626 | |
| 22 | R | B | -0.5750 | |
| 23 | K | B | -1.7377 | |
| 24 | A | B | -0.2573 | |
| 25 | C | B | 0.0000 | |
| 26 | A | B | -0.2538 | |
| 27 | D | B | -1.5616 | |
| 28 | A | B | -0.2857 | |
| 29 | T | B | -0.0380 | |
| 30 | L | B | 0.0000 | |
| 31 | S | B | -0.3363 | |
| 32 | Q | B | -1.1352 | |
| 33 | I | B | 0.2409 | |
| 34 | T | B | 0.0000 | |
| 35 | N | B | -1.5160 | |
| 36 | N | B | -1.4732 | |
| 37 | I | B | -0.3405 | |
| 38 | D | B | -1.7933 | |
| 39 | P | B | -0.5209 | |
| 40 | V | B | 0.2077 | |
| 41 | G | B | -0.7443 | |
| 42 | R | B | -1.9303 | |
| 43 | I | B | 0.0000 | |
| 44 | Q | B | -1.1983 | |
| 45 | M | B | 0.0000 | |
| 46 | R | B | -1.8491 | |
| 47 | T | B | -0.4792 | |
| 48 | R | B | -0.5621 | |
| 49 | R | B | -0.3345 | |
| 50 | T | B | -0.1070 | |
| 51 | L | B | 0.0000 | |
| 52 | R | B | -1.8926 | |
| 53 | G | B | -0.6038 | |
| 54 | H | B | 0.0000 | |
| 55 | L | B | 0.3694 | |
| 56 | A | B | 0.0000 | |
| 57 | K | B | -0.2036 | |
| 58 | I | B | 0.0000 | |
| 59 | Y | B | 0.0000 | |
| 60 | A | B | 0.0000 | |
| 61 | M | B | 0.0000 | |
| 62 | H | B | -0.2064 | |
| 63 | W | B | 0.0000 | |
| 64 | G | B | 0.0000 | |
| 65 | T | B | -0.4052 | |
| 66 | D | B | -1.8026 | |
| 67 | S | B | 0.0000 | |
| 68 | R | B | 0.0000 | |
| 69 | L | B | 0.2808 | |
| 70 | L | B | 0.0000 | |
| 71 | V | B | 0.0000 | |
| 72 | S | B | 0.0000 | |
| 73 | A | B | 0.0000 | |
| 74 | S | B | 0.0000 | |
| 75 | Q | B | 0.0000 | |
| 76 | D | B | 0.0000 | |
| 77 | G | B | 0.0000 | |
| 78 | K | B | -0.2598 | |
| 79 | L | B | 0.0000 | |
| 80 | T | B | 0.0000 | mutated: IB80T |
| 81 | I | B | 0.0000 | |
| 82 | W | B | 0.0000 | |
| 83 | D | B | -0.1441 | |
| 84 | S | B | 0.0000 | |
| 85 | Y | B | 0.1617 | |
| 86 | T | B | -0.0057 | |
| 87 | T | B | -0.2684 | |
| 88 | N | B | -1.5002 | |
| 89 | K | B | -1.2274 | |
| 90 | V | B | 0.8672 | |
| 91 | H | B | -0.0083 | |
| 92 | A | B | 0.0168 | |
| 93 | I | B | 0.0000 | |
| 94 | P | B | -0.2218 | |
| 95 | L | B | 0.0000 | |
| 96 | R | B | -1.9004 | |
| 97 | S | B | -0.3752 | |
| 98 | S | B | 0.0000 | |
| 99 | W | B | 0.1156 | |
| 100 | V | B | 0.0000 | |
| 101 | M | B | 0.0000 | |
| 102 | T | B | 0.0000 | |
| 103 | C | B | 0.0000 | |
| 104 | A | B | 0.0000 | |
| 105 | Y | B | 0.0000 | |
| 106 | A | B | 0.0000 | |
| 107 | P | B | -0.1681 | |
| 108 | S | B | -0.2371 | |
| 109 | G | B | -0.2551 | |
| 110 | N | B | -0.5213 | |
| 111 | Y | B | 0.0905 | |
| 112 | V | B | 0.0000 | |
| 113 | A | B | 0.0000 | |
| 114 | C | B | 0.0000 | |
| 115 | G | B | 0.0000 | |
| 116 | G | B | 0.0000 | |
| 117 | L | B | 0.1043 | |
| 118 | D | B | -0.6308 | |
| 119 | N | B | -0.5094 | |
| 120 | I | B | 0.3342 | |
| 121 | C | B | 0.0000 | |
| 122 | S | B | -0.1539 | |
| 123 | I | B | 0.0000 | |
| 124 | Y | B | 0.0000 | |
| 125 | N | B | -0.2101 | |
| 126 | L | B | 0.0000 | |
| 127 | K | B | -1.7018 | |
| 128 | T | B | -0.7027 | |
| 129 | R | B | -2.1754 | |
| 130 | E | B | -2.2379 | |
| 131 | G | B | -1.0255 | |
| 132 | N | B | -1.2528 | |
| 133 | V | B | 0.0099 | |
| 134 | R | B | -1.6950 | |
| 135 | V | B | -0.1063 | |
| 136 | S | B | -0.1330 | |
| 137 | R | B | -0.9291 | |
| 138 | E | B | -1.1648 | |
| 139 | L | B | 0.0000 | |
| 140 | A | B | -0.0304 | |
| 141 | G | B | -0.4552 | |
| 142 | H | B | 0.0000 | |
| 143 | T | B | -0.0836 | |
| 144 | G | B | -0.1335 | |
| 145 | Y | B | 0.0000 | |
| 146 | L | B | 0.0000 | |
| 147 | S | B | 0.0000 | |
| 148 | C | B | 0.0000 | |
| 149 | C | B | 0.0000 | |
| 150 | R | B | -0.3088 | |
| 151 | F | B | 0.0000 | |
| 152 | L | B | 0.0496 | |
| 153 | D | B | -0.9244 | |
| 154 | D | B | -0.8595 | |
| 155 | N | B | -0.7440 | |
| 156 | Q | B | -0.4845 | |
| 157 | I | B | 0.0000 | |
| 158 | V | B | 0.0000 | |
| 159 | T | B | 0.0000 | |
| 160 | S | B | 0.0000 | |
| 161 | S | B | 0.0000 | |
| 162 | G | B | -0.1993 | |
| 163 | D | B | -0.3704 | |
| 164 | T | B | -0.1316 | |
| 165 | T | B | -0.0125 | |
| 166 | C | B | 0.0000 | |
| 167 | A | B | 0.0000 | |
| 168 | L | B | 0.0000 | |
| 169 | W | B | 0.0000 | |
| 170 | D | B | -0.4117 | |
| 171 | I | B | 0.0000 | |
| 172 | E | B | -1.8295 | |
| 173 | T | B | -0.3987 | |
| 174 | G | B | -0.3058 | |
| 175 | Q | B | -1.2883 | |
| 176 | Q | B | -0.6434 | |
| 177 | T | B | -0.1479 | |
| 178 | T | B | -0.0315 | |
| 179 | T | B | -0.0441 | |
| 180 | F | B | 0.0000 | |
| 181 | T | B | -0.1467 | |
| 182 | G | B | -0.4123 | |
| 183 | H | B | 0.0000 | |
| 184 | T | B | -0.0821 | |
| 185 | G | B | -0.1959 | |
| 186 | D | B | -0.4356 | |
| 187 | V | B | 0.0000 | |
| 188 | M | B | 0.0000 | |
| 189 | S | B | -0.0249 | |
| 190 | L | B | 0.0000 | |
| 191 | S | B | 0.0203 | |
| 192 | L | B | 0.2329 | |
| 193 | A | B | 0.0000 | |
| 194 | P | B | -0.5426 | |
| 195 | D | B | -1.6870 | |
| 196 | T | B | -0.6545 | |
| 197 | R | B | -1.8211 | |
| 198 | L | B | -0.2063 | |
| 199 | F | B | 0.0000 | |
| 200 | V | B | 0.0000 | |
| 201 | S | B | 0.0000 | |
| 202 | G | B | 0.0000 | |
| 203 | A | B | 0.0000 | |
| 204 | C | B | -0.0161 | |
| 205 | D | B | -0.5090 | |
| 206 | A | B | -0.1270 | |
| 207 | S | B | -0.0269 | |
| 208 | A | B | 0.0000 | |
| 209 | K | B | 0.0000 | |
| 210 | L | B | 0.0000 | |
| 211 | W | B | 0.0000 | |
| 212 | D | B | -0.2145 | |
| 213 | V | B | 0.0000 | |
| 214 | R | B | -2.1797 | |
| 215 | E | B | -2.1821 | |
| 216 | G | B | -0.3798 | |
| 217 | M | B | 0.3839 | |
| 218 | C | B | 0.0000 | |
| 219 | R | B | -0.7295 | |
| 220 | Q | B | 0.0000 | |
| 221 | T | B | -0.0130 | |
| 222 | F | B | 0.0000 | |
| 223 | T | B | -0.1132 | |
| 224 | G | B | -0.2331 | |
| 225 | H | B | 0.0000 | |
| 226 | E | B | -1.8348 | |
| 227 | S | B | -0.4795 | |
| 228 | D | B | -0.3225 | |
| 229 | I | B | 0.0000 | |
| 230 | N | B | -0.1543 | |
| 231 | A | B | 0.0000 | |
| 232 | I | B | 0.0000 | |
| 233 | C | B | 0.1219 | |
| 234 | F | B | 0.0000 | |
| 235 | F | B | 0.0000 | |
| 236 | P | B | -0.1654 | |
| 237 | N | B | -0.5824 | |
| 238 | G | B | -0.2094 | |
| 239 | N | B | -0.1664 | |
| 240 | A | B | 0.0000 | |
| 241 | F | B | 0.0000 | |
| 242 | A | B | 0.0000 | |
| 243 | T | B | 0.0000 | |
| 244 | G | B | 0.0000 | |
| 245 | S | B | 0.0000 | |
| 246 | D | B | -0.5276 | |
| 247 | D | B | -0.3855 | |
| 248 | A | B | 0.0000 | |
| 249 | T | B | -0.0071 | |
| 250 | C | B | 0.0000 | |
| 251 | R | B | -0.1918 | |
| 252 | L | B | 0.0000 | |
| 253 | F | B | 0.0000 | |
| 254 | D | B | 0.0000 | |
| 255 | L | B | 0.0000 | |
| 256 | R | B | -0.8754 | |
| 257 | A | B | 0.0000 | |
| 258 | D | B | 0.0000 | |
| 259 | Q | B | -0.2558 | |
| 260 | E | B | -0.5889 | |
| 261 | L | B | 0.0474 | |
| 262 | M | B | 0.0000 | |
| 263 | T | B | -0.0517 | |
| 264 | Y | B | 0.0000 | |
| 265 | S | B | -0.1987 | |
| 266 | H | B | -0.8461 | |
| 267 | D | B | -2.1109 | |
| 268 | N | B | -1.5961 | |
| 269 | I | B | 0.0000 | |
| 270 | I | B | 2.0126 | |
| 271 | C | B | 0.0000 | |
| 272 | G | B | -0.1284 | |
| 273 | I | B | 0.0000 | |
| 274 | T | B | -0.0090 | |
| 275 | S | B | 0.0000 | |
| 276 | V | B | 0.0000 | |
| 277 | S | B | -0.0235 | |
| 278 | F | B | 0.0000 | |
| 279 | S | B | 0.0000 | |
| 280 | K | B | -0.8636 | |
| 281 | S | B | 0.0000 | |
| 282 | G | B | 0.0000 | |
| 283 | R | B | -0.1796 | |
| 284 | L | B | 0.0000 | |
| 285 | L | B | 0.0000 | |
| 286 | L | B | 0.0000 | |
| 287 | A | B | 0.0000 | |
| 288 | G | B | 0.0000 | |
| 289 | Y | B | 0.0000 | |
| 290 | D | B | 0.0000 | |
| 291 | D | B | -0.7575 | |
| 292 | F | B | 0.3151 | |
| 293 | N | B | -0.1367 | |
| 294 | C | B | 0.0000 | |
| 295 | N | B | 0.0000 | |
| 296 | V | B | 0.0000 | |
| 297 | W | B | 0.0000 | |
| 298 | D | B | 0.0000 | |
| 299 | A | B | 0.0000 | |
| 300 | L | B | 0.0000 | |
| 301 | K | B | -0.4008 | |
| 302 | A | B | -0.3880 | |
| 303 | D | B | -1.8603 | |
| 304 | R | B | -0.7278 | |
| 305 | A | B | 0.0000 | |
| 306 | G | B | 0.0000 | |
| 307 | V | B | 0.6221 | |
| 308 | L | B | 0.0000 | |
| 309 | A | B | 0.0161 | |
| 310 | G | B | -0.1048 | |
| 311 | H | B | -0.4554 | |
| 312 | D | B | -1.8611 | |
| 313 | N | B | -0.5573 | |
| 314 | R | B | 0.0000 | |
| 315 | V | B | 0.0000 | |
| 316 | S | B | 0.0000 | |
| 317 | C | B | 0.0000 | |
| 318 | L | B | 0.0000 | |
| 319 | G | B | -0.0070 | |
| 320 | V | B | 0.2209 | |
| 321 | T | B | 0.0000 | |
| 322 | D | B | -1.9136 | |
| 323 | D | B | -1.0140 | |
| 324 | G | B | 0.0000 | |
| 325 | M | B | 0.1417 | |
| 326 | A | B | 0.0000 | |
| 327 | V | B | 0.0000 | |
| 328 | A | B | 0.0000 | |
| 329 | T | B | 0.0000 | |
| 330 | G | B | 0.0000 | |
| 331 | S | B | 0.0000 | |
| 332 | W | B | 0.0317 | |
| 333 | D | B | -0.2600 | |
| 334 | S | B | -0.0105 | |
| 335 | F | B | 0.5123 | |
| 336 | L | B | 0.0000 | |
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| 338 | I | B | 0.0000 | |
| 339 | W | B | 0.0000 | |
| 340 | N | B | -0.1881 | |
| 8 | S | G | -0.0119 | |
| 9 | I | G | 1.0954 | |
| 10 | A | G | 0.0472 | |
| 11 | Q | G | -1.1878 | |
| 12 | A | G | 0.0000 | |
| 13 | R | G | -2.0646 | |
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| 15 | L | G | 0.1199 | |
| 16 | V | G | 0.0000 | |
| 17 | E | G | -1.8427 | |
| 18 | Q | G | -0.4581 | |
| 19 | L | G | 0.0000 | |
| 20 | K | G | -1.2233 | |
| 21 | M | G | 0.0395 | |
| 22 | E | G | 0.0000 | |
| 23 | A | G | -0.2252 | |
| 24 | N | G | -1.1908 | |
| 25 | I | G | -0.1395 | |
| 26 | D | G | -1.7574 | |
| 27 | R | G | -0.5045 | |
| 28 | I | G | 0.2386 | |
| 29 | K | G | -0.6064 | |
| 30 | V | G | 0.0000 | |
| 31 | S | G | -0.3530 | |
| 32 | K | G | -1.7071 | |
| 33 | A | G | 0.0000 | |
| 34 | A | G | 0.0000 | |
| 35 | A | G | -0.2074 | |
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| 37 | L | G | 0.0000 | |
| 38 | M | G | 0.2032 | |
| 39 | A | G | 0.1373 | |
| 40 | Y | G | 0.2537 | |
| 41 | C | G | 0.0000 | |
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| 43 | A | G | -0.3380 | |
| 44 | H | G | -0.3120 | |
| 45 | A | G | -0.3551 | |
| 46 | K | G | -2.0303 | |
| 47 | E | G | -2.1302 | |
| 48 | D | G | 0.0000 | |
| 49 | P | G | -0.0302 | |
| 50 | L | G | 0.0000 | |
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| 52 | T | G | -0.0455 | |
| 53 | P | G | -0.1684 | |
| 54 | V | G | 0.4083 | |
| 55 | P | G | -0.1602 | |
| 56 | A | G | -0.0738 | |
| 57 | S | G | -0.5339 | |
| 58 | E | G | -1.8577 | |
| 59 | N | G | 0.0000 | |
| 60 | P | G | -0.0326 | |
| 61 | F | G | 0.0000 | |
| 62 | R | G | -1.5526 | |
| 63 | E | G | -2.3488 | |
| 64 | K | G | -2.3327 | |
| 65 | K | G | -1.6665 | |
| 66 | F | G | 1.7140 | |
| 67 | F | G | 0.8722 | |
| 68 | C | G | 0.8117 | |
| 69 | A | G | 0.1835 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine