Project name: telomerase

Chain sequence(s)	A: MVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRNIFEMLRIDEGLRLKIYKNTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCI
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.738
• Maximal score value: 3.6822
• Average score: -0.1556
• Total score value: -68.7888

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
65	M	A	2.2727
66	V	A	2.6307
67	T	A	1.8617
68	A	A	1.8104
69	I	A	2.2110
70	T	A	1.2614
71	I	A	0.0000
72	M	A	1.4509
73	A	A	1.0701
74	L	A	1.3279
75	Y	A	0.0000
76	S	A	1.6698
77	I	A	2.9808
78	V	A	0.0000
79	C	A	2.2123
80	V	A	3.4132
81	V	A	3.4009
82	G	A	0.0000
83	L	A	2.8950
84	F	A	3.4605
85	G	A	0.0000
86	N	A	0.0000
87	F	A	3.1561
88	L	A	2.5096
89	V	A	0.0000
90	M	A	1.8000
91	Y	A	1.9815
92	V	A	0.0000
93	I	A	0.0000
94	V	A	1.1068
95	R	A	-0.8887
96	Y	A	-0.8411
97	T	A	-1.1976
98	K	A	-2.0992
99	M	A	0.0000
100	K	A	-1.4163
101	T	A	-1.0611
102	A	A	0.0000
103	T	A	-0.1345
104	N	A	0.0000
105	I	A	0.0000
106	Y	A	0.0000
107	I	A	0.0000
108	F	A	0.9463
109	N	A	0.0000
110	L	A	0.0000
111	A	A	0.0000
112	L	A	0.9932
113	A	A	0.0000
114	D	A	0.0000
115	A	A	0.0000
116	L	A	0.5201
117	A	A	0.0000
118	T	A	0.0000
119	S	A	0.4199
120	T	A	0.0000
121	L	A	0.0000
122	P	A	0.3299
123	F	A	0.6313
124	Q	A	0.3880
125	S	A	0.7792
126	V	A	1.0522
127	N	A	0.4460
128	Y	A	1.1311
129	L	A	1.4919
130	M	A	1.0919
131	G	A	0.1241
132	T	A	0.0442
133	W	A	0.0000
134	P	A	0.0476
135	F	A	0.6236
136	G	A	0.1212
137	N	A	-0.0236
138	I	A	2.0364
139	L	A	1.3464
140	C	A	0.0000
141	K	A	1.2601
142	I	A	1.3596
143	V	A	0.0000
144	I	A	0.3930
145	S	A	0.0000
146	I	A	0.4487
147	D	A	-0.1961
148	Y	A	0.0000
149	Y	A	0.4968
150	N	A	0.0000
151	M	A	0.1001
152	F	A	0.0000
153	T	A	0.0000
154	S	A	0.0000
155	I	A	0.0000
156	F	A	0.9527
157	T	A	0.0000
158	L	A	0.0000
159	C	A	0.0000
160	T	A	0.4827
161	M	A	0.0000
162	S	A	0.0000
163	V	A	1.0649
164	D	A	0.2737
165	R	A	0.0000
166	Y	A	0.8690
167	I	A	0.5933
168	A	A	0.0000
169	V	A	0.0000
170	C	A	0.1827
171	H	A	0.1074
172	P	A	0.0832
173	V	A	0.3310
174	K	A	-0.3419
175	A	A	0.0000
176	L	A	0.8135
177	D	A	-0.7580
178	F	A	-0.1242
179	R	A	-0.5310
180	T	A	-1.0104
181	P	A	-1.2765
182	R	A	-2.0239
183	N	A	-0.6246
184	A	A	0.0000
185	K	A	-0.4660
186	I	A	1.6403
187	V	A	1.8398
188	N	A	0.0000
189	V	A	3.3046
190	C	A	3.1264
191	N	A	0.0000
192	W	A	2.7840
193	I	A	3.6822
194	L	A	3.0486
195	S	A	0.0000
196	S	A	1.7459
197	A	A	1.3709
198	I	A	1.0256
199	G	A	0.0000
200	L	A	1.5530
201	P	A	1.1861
202	V	A	0.0000
203	M	A	1.9090
204	F	A	2.5451
205	M	A	1.3448
206	A	A	0.0000
207	T	A	0.3615
208	T	A	-0.3726
209	K	A	-0.7551
210	Y	A	-0.3066
211	R	A	-2.1498
212	Q	A	-2.0269
213	G	A	-1.4391
214	S	A	-1.0090
215	I	A	-0.6004
216	D	A	-0.8646
217	C	A	-0.0753
218	T	A	-0.1350
219	L	A	0.2138
220	T	A	-0.1104
221	F	A	0.1535
222	S	A	-0.3582
223	H	A	-0.6211
224	P	A	-0.0566
225	T	A	0.3417
226	W	A	1.2562
227	Y	A	1.4707
228	W	A	0.8916
229	E	A	-0.0562
230	N	A	0.7039
231	L	A	1.0945
232	L	A	0.0000
233	K	A	0.6889
234	I	A	2.0535
235	C	A	1.7418
236	V	A	0.0000
237	F	A	2.1799
238	I	A	2.4937
239	F	A	2.8289
240	A	A	0.0000
241	F	A	1.8890
242	I	A	2.2112
243	M	A	2.4224
244	P	A	0.0000
245	V	A	2.3220
246	L	A	2.6282
247	I	A	2.7343
248	I	A	0.0000
249	T	A	1.7506
250	V	A	2.7261
251	C	A	0.0000
252	Y	A	1.9006
253	G	A	1.8425
254	L	A	1.8449
255	M	A	0.0000
256	I	A	2.6477
257	L	A	2.0013
258	R	A	0.1449
259	L	A	0.3201
260	K	A	-1.4327
261	S	A	-1.9869
262	V	A	0.0000
263	R	A	-2.4622
1002	N	A	-1.4392
1003	I	A	-0.4846
1004	F	A	-0.4091
1005	E	A	-0.9803
1006	M	A	0.0000
1007	L	A	0.0000
1008	R	A	-0.7929
1009	I	A	-0.1758
1010	D	A	-0.6694
1011	E	A	-0.7055
1012	G	A	0.0000
1013	L	A	-1.0926
1014	R	A	-1.2541
1015	L	A	-0.7861
1016	K	A	-1.5405
1017	I	A	-0.5949
1018	Y	A	-0.9289
1019	K	A	-1.9096
1020	N	A	-1.3288
1021	T	A	-1.3986
1022	E	A	-2.2421
1023	G	A	-1.7006
1024	Y	A	-1.1424
1025	Y	A	-0.7343
1026	T	A	0.0000
1027	I	A	0.0000
1028	G	A	0.0000
1029	I	A	0.0000
1030	G	A	-0.3040
1031	H	A	0.3443
1032	L	A	0.6236
1033	L	A	0.1408
1034	T	A	-0.5791
1035	K	A	-1.6900
1036	S	A	-0.9724
1037	P	A	-0.8500
1038	S	A	-0.5130
1039	L	A	-0.1558
1040	N	A	-1.4894
1041	A	A	-1.0663
1042	A	A	0.0000
1043	K	A	-1.7310
1044	S	A	-2.0238
1045	E	A	-1.8824
1046	L	A	0.0000
1047	D	A	-2.6933
1048	K	A	-2.7241
1049	A	A	-1.4320
1050	I	A	-1.3558
1051	G	A	-1.8200
1052	R	A	-2.3881
1053	N	A	-2.5449
1054	T	A	0.0000
1055	N	A	-1.9207
1056	G	A	0.0000
1057	V	A	-0.2549
1058	I	A	0.0000
1059	T	A	-1.7631
1060	K	A	-3.2567
1061	D	A	-3.6763
1062	E	A	-2.4467
1063	A	A	0.0000
1064	E	A	-3.5737
1065	K	A	-3.6454
1066	L	A	0.0000
1067	F	A	0.0000
1068	N	A	-2.5366
1069	Q	A	-2.7698
1070	D	A	-1.9854
1071	V	A	0.0000
1072	D	A	-2.7859
1073	A	A	-1.8792
1074	A	A	0.0000
1075	V	A	-1.6744
1076	R	A	-2.6621
1077	G	A	0.0000
1078	I	A	0.0000
1079	L	A	-1.7664
1080	R	A	-2.5065
1081	N	A	-1.9381
1082	A	A	-1.2712
1083	K	A	-1.8453
1084	L	A	0.0000
1085	K	A	-2.3330
1086	P	A	-1.4908
1087	V	A	0.0000
1088	Y	A	0.0000
1089	D	A	-2.3859
1090	S	A	-1.9130
1091	L	A	0.0000
1092	D	A	-1.6148
1093	A	A	-1.1735
1094	V	A	-0.8284
1095	R	A	-0.9790
1096	R	A	-1.0619
1097	A	A	0.0000
1098	A	A	0.0000
1099	L	A	0.0000
1100	I	A	0.0000
1101	N	A	0.0000
1102	M	A	0.0000
1103	V	A	0.0000
1104	F	A	-0.1550
1105	Q	A	-0.1321
1106	M	A	0.0253
1107	G	A	-0.2544
1108	E	A	-1.0173
1109	T	A	-0.5474
1110	G	A	-0.4417
1111	V	A	0.0000
1112	A	A	-0.6586
1113	G	A	-0.7894
1114	F	A	-0.8589
1115	T	A	-1.3366
1116	N	A	-2.2532
1117	S	A	0.0000
1118	L	A	0.0000
1119	R	A	-3.1169
1120	M	A	-3.1786
1121	L	A	0.0000
1122	Q	A	-2.5283
1123	Q	A	-2.6081
1124	K	A	-3.6624
1125	R	A	-4.0920
1126	W	A	-3.1071
1127	D	A	-3.2829
1128	E	A	-3.2183
1129	A	A	0.0000
1130	A	A	0.0000
1131	V	A	-0.1392
1132	N	A	-1.0760
1133	L	A	0.0000
1134	A	A	-1.1020
1135	K	A	-2.0541
1136	S	A	-2.0214
1137	R	A	-2.9803
1138	W	A	0.0000
1139	Y	A	-2.3459
1140	N	A	-2.9218
1141	Q	A	-2.5952
1142	T	A	-1.9479
1143	P	A	-2.1523
1144	N	A	-2.3672
1145	R	A	0.0000
1146	A	A	0.0000
1147	K	A	-2.3859
1148	R	A	-2.2805
1149	V	A	0.0000
1150	I	A	0.0000
1151	T	A	-1.8883
1152	T	A	0.0000
1153	F	A	0.0000
1154	R	A	-2.8502
1155	T	A	-1.4547
1156	G	A	-1.0878
1157	T	A	-1.2120
1158	W	A	0.0000
1159	D	A	-2.4274
1160	A	A	-1.8470
1161	Y	A	0.0000
270	E	A	-3.0671
271	K	A	-4.1046
272	D	A	-4.5576
273	R	A	-4.7380
274	N	A	-4.1673
275	L	A	-3.2903
276	R	A	-4.4543
277	R	A	-3.8921
278	I	A	-2.0190
279	T	A	-1.9786
280	R	A	-2.5689
281	M	A	0.0000
282	V	A	0.0000
283	L	A	-0.0396
284	V	A	0.2473
285	V	A	0.0000
286	V	A	0.0000
287	A	A	1.0446
288	V	A	1.3050
289	F	A	0.0000
290	I	A	1.5892
291	V	A	2.2096
292	C	A	0.0000
293	W	A	0.0000
294	T	A	0.9838
295	P	A	1.2020
296	I	A	1.4262
297	H	A	0.0000
298	I	A	1.3724
299	Y	A	1.0508
300	V	A	1.0509
301	I	A	1.8166
302	I	A	2.0025
303	K	A	0.9864
304	A	A	1.3223
305	L	A	2.5365
306	I	A	2.6926
307	T	A	0.9594
308	I	A	0.2231
309	P	A	-0.5985
310	E	A	-1.6069
311	T	A	-0.3293
312	T	A	0.4970
313	F	A	1.6380
314	Q	A	0.6573
315	T	A	0.6783
316	V	A	1.6365
317	S	A	1.5201
318	W	A	1.3453
319	H	A	1.3982
320	F	A	2.3389
321	C	A	1.6289
322	I	A	1.3114
323	A	A	0.0000
324	L	A	1.5572
325	G	A	1.0791
326	Y	A	0.6186
327	T	A	0.7790
328	N	A	0.0000
329	S	A	0.0000
330	C	A	0.0000
331	L	A	1.1170
332	N	A	0.0000
333	P	A	0.0000
334	V	A	1.9022
335	L	A	1.5554
336	Y	A	0.0000
337	A	A	0.0000
338	F	A	1.9787
339	L	A	0.5226
340	D	A	0.0000
341	E	A	-1.6008
342	N	A	-2.2232
343	F	A	0.0000
344	K	A	-2.2667
345	R	A	-3.3469
346	C	A	0.0000
347	F	A	-1.2648
348	R	A	-2.0903
349	E	A	-1.5059
350	F	A	1.0426
351	C	A	1.2271
352	I	A	1.5850