Project name: 7d74c43b66319bd

Chain sequence(s)	A: DHHEGQPRSVCALEENAKRALISCVQTHLTADTTQKLSAVKDQLHCDDVYCVFVRICDRNNGTLEHPSNEFFSNAEKTDIRSAVVTCRENLQRQAEAAKTSGGGGSFRFPLICHLFGKKCVPKADCPTENVSWILGCGAKSVCCNTAKMPFCSTLGGTCQAVCGGNIQRNVTCSGIKTCCIYTSKSNQATASNHVRRHSNKFIRNGFEGGGGSGIQTEALYPGLFQSCLYGAGLGGAGLYGGSLSPLGSFSSLGGIGYLGGLSPFGGLGNPLSSLGYPGLLGGQGGKFPGDLRLITEPTSGLPVSEAVYVGLERQRLVPAPYRVPRPAPVPVPHVVPQPFTVDVPIPQPFEVPVPQPVPIHTLTEVTDTALIEPVTTAYVTEHGPMINQFQTQVPFMVYGGGGSSEIKYHNYNSNGFNPKGPGPGILFGDAFIPAIVQPVSQIFPGPGPGILFNSLQYTNVVKDYWGNDLGPGPGKETVLRVAVTAQHPKPASLMGPGPGYDAGIELAHLLAFNKYGPGPGHDKKQFAALMLYEEDGTLRVEGVGPGPGKRHGKRLRVTKVIPHAKYNEKSEAAAKFYPSYHSTPQRPGTP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.5094
• Maximal score value: 2.1145
• Average score: -0.6464
• Total score value: -382.0389

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	A	-3.0985
2	H	A	-2.9179
3	H	A	-3.1900
4	E	A	-3.5094
5	G	A	-2.4653
6	Q	A	-2.8049
7	P	A	-1.5784
8	R	A	-1.2573
9	S	A	0.2963
10	V	A	1.4561
11	C	A	0.7377
12	A	A	-0.4988
13	L	A	0.0000
14	E	A	-1.5632
15	E	A	-2.3367
16	N	A	-2.1896
17	A	A	0.0000
18	K	A	-2.2303
19	R	A	-2.7240
20	A	A	0.0000
21	L	A	0.0000
22	I	A	-0.4593
23	S	A	0.0000
24	C	A	0.0000
25	V	A	0.0000
26	Q	A	-0.0600
27	T	A	0.0000
28	H	A	-0.6039
29	L	A	-0.1083
30	T	A	-0.6760
31	A	A	-1.1477
32	D	A	-2.3805
33	T	A	0.0000
34	T	A	-1.4195
35	Q	A	-2.2974
36	K	A	-2.2190
37	L	A	-1.3917
38	S	A	-1.6202
39	A	A	-1.7398
40	V	A	0.0000
41	K	A	-2.2227
42	D	A	-3.1392
43	Q	A	-2.2332
44	L	A	0.0000
45	H	A	-2.3644
46	C	A	-1.8140
47	D	A	-1.8442
48	D	A	-1.4603
49	V	A	-1.0320
50	Y	A	-0.7208
51	C	A	0.0000
52	V	A	0.0000
53	F	A	0.0000
54	V	A	0.0000
55	R	A	-0.8943
56	I	A	0.0000
57	C	A	0.0000
58	D	A	-3.3114
59	R	A	-3.2393
60	N	A	-3.0735
61	N	A	-2.9306
62	G	A	-2.4455
63	T	A	-2.0009
64	L	A	0.0000
65	E	A	-2.0805
66	H	A	-1.6406
67	P	A	-0.8369
68	S	A	-0.6314
69	N	A	-1.0253
70	E	A	0.0000
71	F	A	0.1591
72	F	A	0.9219
73	S	A	-0.4510
74	N	A	0.0000
75	A	A	-0.9493
76	E	A	-2.4837
77	K	A	-2.5544
78	T	A	-1.5442
79	D	A	-1.9279
80	I	A	0.0317
81	R	A	-1.0492
82	S	A	0.0000
83	A	A	-0.5367
84	V	A	-0.0429
85	V	A	0.0000
86	T	A	0.0000
87	C	A	0.0000
88	R	A	-1.5018
89	E	A	-1.5478
90	N	A	0.0000
91	L	A	-1.5188
92	Q	A	-2.3003
93	R	A	-2.3980
94	Q	A	0.0000
95	A	A	-1.9394
96	E	A	-2.6020
97	A	A	0.0000
98	A	A	-1.9572
99	K	A	-2.5861
100	T	A	-1.5970
101	S	A	-1.4378
102	G	A	-1.4753
103	G	A	-1.4167
104	G	A	-1.2475
105	G	A	-1.0548
106	S	A	-1.1351
107	F	A	-0.9182
108	R	A	-1.3434
109	F	A	0.0000
110	P	A	0.0000
111	L	A	0.0000
112	I	A	-0.0123
113	C	A	0.0000
114	H	A	0.0000
115	L	A	0.0800
116	F	A	0.4260
117	G	A	0.0000
118	K	A	-1.8299
119	K	A	-2.2720
120	C	A	0.0000
121	V	A	0.0000
122	P	A	-1.0411
123	K	A	-1.4687
124	A	A	-0.8894
125	D	A	-1.5383
126	C	A	0.0000
127	P	A	-1.3788
128	T	A	-1.5927
129	E	A	-2.2077
130	N	A	-1.4593
131	V	A	0.0000
132	S	A	-0.7767
133	W	A	0.0000
134	I	A	0.0000
135	L	A	0.2326
136	G	A	0.0000
137	C	A	-0.8458
138	G	A	-1.6694
139	A	A	0.0000
140	K	A	-2.4043
141	S	A	0.0000
142	V	A	0.0000
143	C	A	0.0000
144	C	A	0.0000
145	N	A	0.0000
146	T	A	0.0000
147	A	A	0.0000
148	K	A	-0.7056
149	M	A	0.3483
150	P	A	0.8106
151	F	A	2.0116
152	C	A	0.0000
153	S	A	0.0000
154	T	A	0.8314
155	L	A	0.9256
156	G	A	0.0185
157	G	A	-0.1138
158	T	A	-0.6027
159	C	A	0.0000
160	Q	A	0.0000
161	A	A	0.0000
162	V	A	0.0000
163	C	A	-0.5672
164	G	A	-0.6859
165	G	A	-0.9262
166	N	A	-1.4136
167	I	A	-1.2755
168	Q	A	-1.9871
169	R	A	-2.8874
170	N	A	-2.2294
171	V	A	-1.2496
172	T	A	-0.4715
173	C	A	0.0262
174	S	A	-0.1640
175	G	A	-0.8841
176	I	A	0.0000
177	K	A	-0.7606
178	T	A	0.0000
179	C	A	0.0000
180	C	A	0.0000
181	I	A	0.0000
182	Y	A	-0.5209
183	T	A	-0.9821
184	S	A	-1.6186
185	K	A	-2.2766
186	S	A	-1.5055
187	N	A	-1.5944
188	Q	A	-1.7611
189	A	A	-0.9849
190	T	A	-0.9784
191	A	A	0.0000
192	S	A	-1.0742
193	N	A	-1.4894
194	H	A	-1.5037
195	V	A	0.0000
196	R	A	-2.0920
197	R	A	-2.8711
198	H	A	0.0000
199	S	A	0.0000
200	N	A	-2.4648
201	K	A	-3.1993
202	F	A	0.0000
203	I	A	-1.6292
204	R	A	-2.9019
205	N	A	-2.5726
206	G	A	-1.4442
207	F	A	-0.4223
208	E	A	-0.8188
209	G	A	-1.0312
210	G	A	0.0000
211	G	A	-0.7462
212	G	A	-1.2289
213	S	A	-0.8329
214	G	A	-0.4971
215	I	A	-0.4061
216	Q	A	0.0000
217	T	A	0.0000
218	E	A	-0.6520
219	A	A	-0.6990
220	L	A	0.0000
221	Y	A	0.9252
222	P	A	0.0301
223	G	A	-0.1303
224	L	A	0.5874
225	F	A	0.0000
226	Q	A	-0.5737
227	S	A	0.1096
228	C	A	0.0000
229	L	A	0.0000
230	Y	A	0.2329
231	G	A	0.0000
232	A	A	0.0000
233	G	A	0.0000
234	L	A	0.0000
235	G	A	-0.2640
236	G	A	-0.3042
237	A	A	0.0000
238	G	A	-0.1160
239	L	A	0.0000
240	Y	A	0.8031
241	G	A	0.0124
242	G	A	0.2842
243	S	A	0.5034
244	L	A	1.3923
245	S	A	0.0000
246	P	A	0.1668
247	L	A	0.2558
248	G	A	0.0000
249	S	A	0.4317
250	F	A	0.3816
251	S	A	-0.1325
252	S	A	0.0446
253	L	A	0.6100
254	G	A	-0.1345
255	G	A	-0.0483
256	I	A	0.0000
257	G	A	0.1299
258	Y	A	0.0580
259	L	A	0.0000
260	G	A	-0.6669
261	G	A	-0.9890
262	L	A	0.0000
263	S	A	0.0000
264	P	A	-0.1449
265	F	A	0.7698
266	G	A	0.0000
267	G	A	0.0000
268	L	A	0.8737
269	G	A	0.2896
270	N	A	0.0000
271	P	A	0.1270
272	L	A	0.0000
273	S	A	0.0000
274	S	A	0.0030
275	L	A	0.0000
276	G	A	-0.1792
277	Y	A	-0.0247
278	P	A	0.0000
279	G	A	-0.4074
280	L	A	0.0000
281	L	A	0.0000
282	G	A	0.0000
283	G	A	0.0000
284	Q	A	-1.2849
285	G	A	-1.2580
286	G	A	-1.4519
287	K	A	-2.1227
288	F	A	-1.5007
289	P	A	-1.2948
290	G	A	-1.7601
291	D	A	-1.5954
292	L	A	0.0000
293	R	A	0.0480
294	L	A	0.0000
295	I	A	0.3406
296	T	A	-0.9433
297	E	A	-1.8257
298	P	A	-0.9646
299	T	A	-0.2390
300	S	A	-0.4725
301	G	A	-0.7196
302	L	A	-0.2577
303	P	A	-0.9165
304	V	A	0.0000
305	S	A	0.0000
306	E	A	0.0585
307	A	A	0.0000
308	V	A	0.0000
309	Y	A	0.3796
310	V	A	-0.5562
311	G	A	0.0000
312	L	A	-0.8470
313	E	A	-2.5174
314	R	A	-3.0330
315	Q	A	-1.8862
316	R	A	0.0000
317	L	A	1.8432
318	V	A	1.5782
319	P	A	0.8931
320	A	A	0.4927
321	P	A	-0.0529
322	Y	A	-0.1425
323	R	A	-1.6160
324	V	A	-1.1018
325	P	A	-1.6686
326	R	A	-2.5742
327	P	A	-1.1595
328	A	A	-0.4170
329	P	A	0.3489
330	V	A	1.9178
331	P	A	1.2224
332	V	A	1.9030
333	P	A	0.8748
334	H	A	0.5516
335	V	A	2.1145
336	V	A	1.9226
337	P	A	0.4901
338	Q	A	-0.3426
339	P	A	0.2597
340	F	A	1.8810
341	T	A	1.4700
342	V	A	1.7596
343	D	A	0.1058
344	V	A	1.7293
345	P	A	1.1296
346	I	A	1.6614
347	P	A	0.4420
348	Q	A	-0.6635
349	P	A	-0.0691
350	F	A	0.6469
351	E	A	-0.7532
352	V	A	0.2501
353	P	A	0.3791
354	V	A	1.1085
355	P	A	0.1483
356	Q	A	-0.8223
357	P	A	-0.3281
358	V	A	-0.0893
359	P	A	-0.2655
360	I	A	-0.1092
361	H	A	-0.7944
362	T	A	-0.5168
363	L	A	-0.1906
364	T	A	-0.6842
365	E	A	-1.3858
366	V	A	-0.3946
367	T	A	-0.2206
368	D	A	-1.5037
369	T	A	-0.3406
370	A	A	0.3199
371	L	A	1.6101
372	I	A	1.3798
373	E	A	-0.6607
374	P	A	-0.6186
375	V	A	0.1206
376	T	A	-0.2365
377	T	A	0.0000
378	A	A	-0.0128
379	Y	A	0.0206
380	V	A	0.0000
381	T	A	-0.7182
382	E	A	-1.7036
383	H	A	-0.7965
384	G	A	-0.7189
385	P	A	-0.4667
386	M	A	-0.2173
387	I	A	0.0000
388	N	A	0.0000
389	Q	A	-0.2436
390	F	A	0.0000
391	Q	A	-0.3207
392	T	A	-0.7302
393	Q	A	-1.2657
394	V	A	-0.6509
395	P	A	-0.3959
396	F	A	0.0000
397	M	A	0.5965
398	V	A	0.4798
399	Y	A	0.5469
400	G	A	-0.3204
401	G	A	-0.8837
402	G	A	-0.6328
403	G	A	0.0000
404	S	A	-0.0552
405	S	A	0.0000
406	E	A	-0.4813
407	I	A	-0.0804
408	K	A	0.0000
409	Y	A	0.0000
410	H	A	-0.3752
411	N	A	0.0000
412	Y	A	-1.0757
413	N	A	-1.8323
414	S	A	-0.9988
415	N	A	0.0000
416	G	A	-1.0345
417	F	A	0.0000
418	N	A	-1.9310
419	P	A	-1.6935
420	K	A	-2.4001
421	G	A	-1.5870
422	P	A	-1.0319
423	G	A	-1.0398
424	P	A	-1.0426
425	G	A	0.0000
426	I	A	0.0000
427	L	A	0.0000
428	F	A	0.3322
429	G	A	0.0000
430	D	A	-1.0756
431	A	A	0.0000
432	F	A	0.0000
433	I	A	0.0664
434	P	A	-0.1845
435	A	A	0.0000
436	I	A	0.0000
437	V	A	0.1890
438	Q	A	-0.0982
439	P	A	0.0000
440	V	A	0.1783
441	S	A	0.0000
442	Q	A	-0.8374
443	I	A	0.3828
444	F	A	0.3273
445	P	A	-0.4526
446	G	A	-0.6100
447	P	A	-0.7123
448	G	A	-0.8944
449	P	A	-1.0470
450	G	A	0.0000
451	I	A	-0.0123
452	L	A	0.0000
453	F	A	0.0000
454	N	A	-1.7076
455	S	A	-0.7466
456	L	A	-0.0028
457	Q	A	-0.5442
458	Y	A	0.0000
459	T	A	0.0000
460	N	A	-1.0444
461	V	A	-0.5990
462	V	A	0.0000
463	K	A	-1.1648
464	D	A	-1.6218
465	Y	A	-1.2439
466	W	A	0.0000
467	G	A	-2.0042
468	N	A	-2.1895
469	D	A	-2.2516
470	L	A	-1.1485
471	G	A	0.0000
472	P	A	-1.8068
473	G	A	-1.2235
474	P	A	-1.2621
475	G	A	-1.8913
476	K	A	-2.6339
477	E	A	-2.6746
478	T	A	0.0000
479	V	A	-0.1844
480	L	A	0.0000
481	R	A	-1.0303
482	V	A	0.0000
483	A	A	0.0000
484	V	A	0.0000
485	T	A	-0.4414
486	A	A	0.0000
487	Q	A	-1.6769
488	H	A	-1.5955
489	P	A	-1.3120
490	K	A	-1.1382
491	P	A	0.0000
492	A	A	0.0000
493	S	A	-0.2009
494	L	A	0.1775
495	M	A	-0.2348
496	G	A	-0.5695
497	P	A	-0.7862
498	G	A	-0.6451
499	P	A	-0.7252
500	G	A	0.0000
501	Y	A	-0.8833
502	D	A	-1.9655
503	A	A	-1.3920
504	G	A	0.0000
505	I	A	-0.9075
506	E	A	-1.6914
507	L	A	0.0000
508	A	A	0.0000
509	H	A	0.0000
510	L	A	0.0000
511	L	A	0.0000
512	A	A	0.0000
513	F	A	0.0000
514	N	A	0.0000
515	K	A	0.0000
516	Y	A	-0.4617
517	G	A	0.0000
518	P	A	-1.8184
519	G	A	-1.0235
520	P	A	-0.9933
521	G	A	-1.2554
522	H	A	-2.1634
523	D	A	-2.8125
524	K	A	-2.2438
525	K	A	-2.5454
526	Q	A	-2.0085
527	F	A	0.0000
528	A	A	0.0000
529	A	A	-0.6168
530	L	A	0.0000
531	M	A	0.0000
532	L	A	0.0000
533	Y	A	-1.0075
534	E	A	0.0000
535	E	A	-3.0991
536	D	A	-3.1464
537	G	A	-1.8902
538	T	A	-1.6190
539	L	A	-0.9463
540	R	A	-1.3488
541	V	A	0.0000
542	E	A	0.0000
543	G	A	-0.7084
544	V	A	-1.1102
545	G	A	-1.1274
546	P	A	-1.0110
547	G	A	-1.3758
548	P	A	-1.6106
549	G	A	-1.7499
550	K	A	-2.5893
551	R	A	-3.1409
552	H	A	-2.6197
553	G	A	-1.5567
554	K	A	-1.6438
555	R	A	-1.9159
556	L	A	-0.7633
557	R	A	-1.4132
558	V	A	-0.7545
559	T	A	-1.2719
560	K	A	-1.8891
561	V	A	0.0220
562	I	A	-0.3792
563	P	A	-0.8157
564	H	A	-1.2322
565	A	A	0.0000
566	K	A	-2.2045
567	Y	A	-0.6596
568	N	A	-2.2724
569	E	A	-2.9722
570	K	A	-3.2833
571	S	A	-2.7277
572	E	A	-3.0449
573	A	A	-2.2088
574	A	A	0.0000
575	A	A	-1.9739
576	K	A	-2.1441
577	F	A	0.0000
578	Y	A	0.0000
579	P	A	-0.1886
580	S	A	-0.0242
581	Y	A	0.9816
582	H	A	0.0398
583	S	A	-0.1884
584	T	A	-0.5330
585	P	A	-1.3658
586	Q	A	-1.7315
587	R	A	-2.5435
588	P	A	-1.9399
589	G	A	-1.2106
590	T	A	-1.0839
591	P	A	-0.9741