Project name: TS10-7

Chain sequence(s)	H: QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYSVHWVRQAPGQGLEWMGVINTYGGNTDYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGYGSWLAYWGQGTTLTVSSDIQMTQSPSSLSASVGDRVTITCIVSSSISSSGLHWYQQKPEKAPKSLIFATSNLLSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHWSSYPLTFGAGTKLEIK
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.1752
• Maximal score value: 1.916
• Average score: -0.2223
• Total score value: -50.0103

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.1676
2	V	H	-0.3143
3	Q	H	-1.1674
4	L	H	0.0000
5	V	H	1.4544
6	Q	H	0.0000
7	S	H	-0.1480
8	G	H	-0.4672
9	A	H	-0.1290
10	E	H	-0.2082
11	V	H	1.5899
12	K	H	-0.4325
13	K	H	-1.8032
14	P	H	-0.5043
15	G	H	-0.4988
16	A	H	-0.0884
17	S	H	-0.0961
18	V	H	0.0000
19	K	H	-1.8409
20	V	H	0.0000
21	S	H	-0.0059
22	C	H	0.0000
23	K	H	-0.9003
24	A	H	0.0000
25	S	H	-0.2174
26	G	H	-0.3982
27	Y	H	0.2783
28	T	H	0.3433
29	F	H	1.9160
30	T	H	-0.0443
31	D	H	-1.8019
32	Y	H	0.0000
33	S	H	-0.0428
34	V	H	0.0000
35	H	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	-0.2087
39	Q	H	-0.1667
40	A	H	-0.0586
41	P	H	-0.3383
42	G	H	-0.7308
43	Q	H	-1.3129
44	G	H	-0.3819
45	L	H	0.0000
46	E	H	-0.4101
47	W	H	0.0000
48	M	H	0.0000
49	G	H	0.0000
50	V	H	0.0000
51	I	H	0.0000
52	N	H	-0.3086
53	T	H	0.0000
54	Y	H	1.2306
55	G	H	-0.2464
56	G	H	-0.4183
57	N	H	-1.2964
58	T	H	-0.4812
59	D	H	-1.1038
60	Y	H	0.1871
61	A	H	0.0000
62	Q	H	-1.2528
63	K	H	-1.8700
64	F	H	0.0000
65	Q	H	-1.2842
66	G	H	-0.7783
67	R	H	-0.5905
68	V	H	0.0000
69	T	H	-0.1331
70	M	H	0.0000
71	T	H	-0.1269
72	R	H	-0.6629
73	D	H	-0.9973
74	T	H	-0.2353
75	S	H	-0.2222
76	T	H	-0.0590
77	S	H	0.0000
78	T	H	0.0000
79	V	H	0.0000
80	Y	H	0.2801
81	M	H	0.0000
82	E	H	-1.1808
83	L	H	0.0000
84	S	H	-0.1192
85	S	H	-0.1767
86	L	H	0.0000
87	R	H	-1.5122
88	S	H	-0.7985
89	E	H	-1.8574
90	D	H	0.0000
91	T	H	-0.0166
92	A	H	0.0000
93	V	H	0.2797
94	Y	H	0.0000
95	Y	H	0.0000
96	C	H	0.0000
97	A	H	0.0000
98	R	H	0.0000
99	G	H	0.0000
100	Y	H	0.6074
101	G	H	0.0163
102	S	H	-0.0307
103	W	H	0.1073
104	L	H	0.0000
105	A	H	0.0963
106	Y	H	0.4937
107	W	H	0.2007
108	G	H	0.0000
109	Q	H	-1.2090
110	G	H	-0.2774
111	T	H	0.0000
112	T	H	-0.0019
113	L	H	0.0000
114	T	H	0.1679
115	V	H	0.0000
116	S	H	-0.1937
117	S	H	-0.2411
118	D	H	-1.7375
119	I	H	-0.2623
120	Q	H	-1.1486
121	M	H	0.0000
122	T	H	0.0090
123	Q	H	0.0000
124	S	H	-0.1425
125	P	H	-0.1575
126	S	H	-0.2665
127	S	H	-0.3828
128	L	H	0.2217
129	S	H	-0.3516
130	A	H	0.0000
131	S	H	0.1793
132	V	H	1.3186
133	G	H	-0.3778
134	D	H	-1.2106
135	R	H	-1.9992
136	V	H	0.0000
137	T	H	-0.0725
138	I	H	0.0000
139	T	H	-0.0229
140	C	H	0.0000
141	I	H	0.5745
142	V	H	0.0000
143	S	H	-0.2371
144	S	H	-0.2102
145	S	H	-0.2592
146	I	H	0.0000
147	S	H	-0.2568
148	S	H	-0.2591
149	S	H	-0.0787
150	G	H	0.0000
151	L	H	0.0000
152	H	H	0.0000
153	W	H	0.0000
154	Y	H	0.0000
155	Q	H	0.0000
156	Q	H	0.0000
157	K	H	-0.3157
158	P	H	-0.6374
159	E	H	-2.1752
160	K	H	-2.0278
161	A	H	-0.3020
162	P	H	0.0000
163	K	H	-1.1561
164	S	H	0.0000
165	L	H	0.0000
166	I	H	0.0000
167	F	H	0.3226
168	A	H	0.0730
169	T	H	0.0000
170	S	H	-0.3538
171	N	H	-0.6614
172	L	H	0.4970
173	L	H	0.3081
174	S	H	-0.2558
175	G	H	-0.4705
176	V	H	0.0912
177	P	H	-0.1208
178	S	H	-0.2964
179	R	H	-0.3915
180	F	H	0.0000
181	S	H	-0.1880
182	G	H	-0.1492
183	S	H	-0.2529
184	G	H	-0.2466
185	S	H	-0.2801
186	G	H	-0.2617
187	T	H	-0.3764
188	D	H	-1.7073
189	F	H	0.0000
190	T	H	-0.0228
191	L	H	0.0000
192	T	H	-0.0214
193	I	H	0.0000
194	S	H	-0.3878
195	S	H	-0.2305
196	L	H	0.0000
197	Q	H	-0.4273
198	P	H	-0.5908
199	E	H	-1.8544
200	D	H	0.0000
201	F	H	1.2596
202	A	H	0.0000
203	T	H	-0.2528
204	Y	H	0.0000
205	Y	H	0.0000
206	C	H	0.0000
207	Q	H	0.0000
208	H	H	0.0000
209	W	H	0.2232
210	S	H	-0.0472
211	S	H	0.0886
212	Y	H	1.1369
213	P	H	0.2997
214	L	H	0.0000
215	T	H	0.0251
216	F	H	0.1940
217	G	H	0.0000
218	A	H	0.0501
219	G	H	-0.0352
220	T	H	0.0000
221	K	H	-1.7245
222	L	H	0.0000
223	E	H	-1.6766
224	I	H	0.2978
225	K	H	-1.5309