Project name: Tau PHF

Status: done

submitted: 2019-02-23 17:10:45, status changed: 2019-02-23 17:32:18
Settings
Chain sequence(s) A: EQTVTEPVGSYARAERPQDFEGFVWRLDNDGKEALPRRNFRTSADALRAPEKKFHLDAAYVPSRREGMMDALHISGSSAFTPAQLKNVAAKLREKTAGPIYDVDLRQESHGYLDGIPVSWYGEERDWANLGKSQHEALADERRHHRLHAALHKTVYIAPLGKHKLPEGGEVRRVQKVQTEQEVAEAAGMRYFRIAATDHVWPTPENIDRFLAFYRRTLPQDAWLHFHSEAGVGRTTAFMVMTDMLKNPSVSLKDILYRQHEIGGFYYGEFPIKTKDKDSWKTKYYREKIVMIEQFYRRYVQENRADGYQTPWSVWLKSHPAKA
B: EQTVTEPVGSYARAERPQDFEGFVWRLDNDGKEALPRRNFRTSADALRAPEKKFHLDAAYVPSREGMMDALHISGSSAFTPAQLKNVAAKLREKTAGPIYDVDLRQESHGYLDGIPVSWYGERDWANLGKSQHEALADERHHRLHAALHKTVYIAPLGKHKLPEGGEVRRVQKVQTEQEVAEAAGMRYFRIAATDHVWPTPENIDRFLAFYRRTLPQDAWLHFHSEAGVGRTTAFMVMTDMLKNPSVSLKDILYRQHEIGGFYYGEFPIKTKDKDSWKTKYYREKIVMIEQFYRRYVQENRADGYQTPWSVWLKSHPAKA
Distance of aggregation 10 Å
Dynamic mode No
Show buried residues

Minimal score value
-3.8498
Maximal score value
1.7307
Average score
-0.9658
Total score value
-608.4616

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
32 E A -2.1390
33 Q A -1.6958
34 T A -0.3824
35 V A 0.9557
36 T A 0.1788
37 E A -0.4115
38 P A -0.5960
39 V A -0.1212
40 G A 0.0000
41 S A -0.6366
42 Y A -0.8341
43 A A -1.3539
44 R A -2.4903
45 A A -1.6453
46 E A -2.1815
47 R A -3.0314
48 P A -2.3327
49 Q A -2.5168
50 D A -2.3512
51 F A -2.0150
52 E A -2.1384
53 G A -0.8074
54 F A 0.0000
55 V A 0.0000
56 W A 0.0000
57 R A 0.0000
58 L A -0.3138
59 D A -0.5589
60 N A -1.8944
61 D A -2.7494
62 G A -2.4620
63 K A -3.2190
64 E A -3.1486
65 A A -1.6105
66 L A -1.3640
67 P A 0.0000
68 R A -2.0394
69 N A -0.9331
70 F A -0.3577
71 R A 0.0000
72 T A 0.0000
73 S A 0.0000
74 A A -0.8785
75 D A -0.7344
76 A A -0.5384
77 L A -0.5561
78 R A -1.9684
79 A A -1.5511
80 P A -2.2711
81 E A -3.3919
82 K A -3.7867
83 K A -3.4908
84 F A 0.0000
85 H A -2.8232
86 L A -2.0801
87 D A -1.6422
88 A A -1.0558
89 A A 0.2263
90 Y A 0.8436
91 V A 1.7011
92 P A 0.0000
93 S A -0.8046
94 R A -1.8264
95 E A -2.7051
96 G A -2.0277
97 M A 0.0000
98 D A -2.3442
99 A A -1.6332
100 L A 0.0000
101 H A -1.1198
102 I A 0.0000
103 S A 0.0000
104 G A 0.0000
105 S A 0.0000
106 S A 0.0000
107 A A 0.0000
108 F A 0.0000
109 T A -1.0819
110 P A -0.6986
111 A A -0.8993
112 Q A 0.0000
113 L A 0.0000
114 K A -2.2529
115 N A -1.5570
116 V A 0.0000
117 A A 0.0000
118 A A -2.0186
119 K A -2.4110
120 L A 0.0000
121 R A -2.5960
122 E A -3.0094
123 K A -2.2105
124 T A -1.7315
125 A A -1.0499
126 G A -1.2186
127 P A -1.1615
128 I A 0.0000
129 Y A 0.0000
130 D A 0.0000
131 V A 0.0000
132 D A 0.0000
133 L A 0.0000
134 R A 0.0000
135 Q A 0.0000
136 E A 0.0000
137 S A 0.0000
138 H A 0.0000
139 G A 0.0000
140 Y A 0.0000
141 L A 0.0000
142 D A -1.5155
143 G A -0.8360
144 I A -0.5054
145 P A 0.0000
146 V A 0.0000
147 S A 0.0000
148 W A -0.0436
149 Y A 0.0000
150 G A 0.0000
151 E A -2.0508
152 R A -1.6190
153 D A 0.0000
154 W A 0.0000
155 A A -0.9965
156 N A 0.0000
157 L A 0.0000
158 G A -1.9305
159 K A -1.6609
160 S A -1.8696
161 Q A -2.1288
162 H A -2.0701
163 E A -2.4768
164 A A 0.0000
165 L A -1.4465
166 A A -1.7838
167 D A -1.8173
168 E A 0.0000
169 R A -2.9554
170 H A -2.5616
171 R A -1.9784
172 L A 0.0000
173 H A -2.3909
174 A A -1.5400
175 A A 0.0000
176 L A -1.8337
177 H A -2.5796
178 K A -2.8338
179 T A -2.0520
180 V A 0.0000
181 Y A 0.0000
182 I A 0.0000
183 A A 0.0000
184 P A -0.8516
185 L A -1.0351
186 G A -1.5304
187 K A -1.9036
188 H A -2.4460
189 K A -2.7092
190 L A -1.7307
191 P A 0.0000
192 E A -1.6043
193 G A -1.4660
194 G A -0.8562
195 E A -1.0117
196 V A -0.9810
197 R A -1.8855
198 R A -2.6682
199 V A 0.0000
200 Q A -2.7761
201 K A -2.6682
202 V A -1.5298
203 Q A -1.6194
204 T A -1.3248
205 E A 0.0000
206 Q A -2.2050
207 E A -2.5248
208 V A 0.0000
209 A A 0.0000
210 E A -3.2168
211 A A -1.8946
212 A A -1.9714
213 G A -1.8793
214 M A 0.0000
215 R A -2.5587
216 Y A -1.4347
217 F A -0.1740
218 R A 0.0000
219 I A 0.0000
220 A A 0.0000
221 A A 0.0000
222 T A 0.0000
223 D A -0.4846
224 H A -0.4561
225 V A 0.0000
226 W A 0.0000
227 P A 0.0000
228 T A -1.0127
229 P A -1.2287
230 E A -2.3790
231 N A 0.0000
232 I A 0.0000
233 D A -1.3084
234 R A -1.5123
235 F A 0.0000
236 L A -0.8035
237 A A -0.7389
238 F A -0.4376
239 Y A -0.7112
240 R A -1.6114
241 T A -0.8937
242 L A -0.9064
243 P A -1.4258
244 Q A -2.1150
245 D A -2.4202
246 A A 0.0000
247 W A 0.0000
248 L A 0.0000
249 H A 0.0000
250 F A 0.0000
251 H A 0.0000
252 S A 0.0000
253 E A -0.5833
254 A A -0.4590
255 G A 0.0000
256 V A 0.2465
257 G A 0.1287
258 R A 0.0000
259 T A 0.0000
260 T A 0.0000
261 A A 0.0000
262 F A 0.0000
263 M A 0.0000
264 V A 0.0000
265 M A 0.0000
266 T A 0.0000
267 D A 0.0000
268 M A 0.0000
269 L A 0.0000
270 K A -0.7232
271 N A -0.9155
272 P A -0.7151
273 S A -0.7351
274 V A 0.0000
275 S A -0.6178
276 L A -1.1023
277 K A -1.5051
278 D A -0.9188
279 I A 0.0000
280 L A 0.0000
281 Y A 0.0000
282 R A 0.0000
283 Q A 0.0000
284 H A 0.0000
285 E A 0.0000
286 I A 0.0000
287 G A -0.7353
288 G A -0.1271
289 F A 0.0770
290 Y A 0.0000
291 Y A 0.0000
292 G A 0.0000
293 E A -1.9301
294 F A -1.4805
295 P A -1.2195
296 I A -1.5605
297 K A -2.4732
298 T A -2.5141
299 K A -3.6148
300 D A -3.7334
301 K A -3.3968
302 D A -2.5842
303 S A -2.3035
304 W A -1.2354
305 K A -1.6731
306 T A -1.7884
307 K A -2.1979
308 Y A 0.0000
309 Y A -1.2922
310 R A -2.3973
311 E A 0.0000
312 K A 0.0000
313 I A -1.1920
314 V A -1.1596
315 M A 0.0000
316 I A 0.0000
317 E A -2.1110
318 Q A -1.9449
319 F A 0.0000
320 Y A -1.7305
321 R A -2.8661
322 Y A 0.0000
323 V A 0.0000
324 Q A -2.2149
325 E A -2.4384
326 N A 0.0000
327 R A -2.3346
328 A A -1.8722
329 D A -2.6429
330 G A -2.0376
331 Y A -1.8198
332 Q A -1.8557
333 T A -0.6811
334 P A -0.3497
335 W A 0.0000
336 S A -0.4347
337 V A 0.5815
338 W A 0.0000
339 L A 0.0000
340 K A -1.5594
341 S A -0.9668
342 H A -1.3835
343 P A -1.3717
344 A A 0.0000
345 K A -1.6931
346 A A -1.1302
32 E B -2.1350
33 Q B -1.6922
34 T B -0.4282
35 V B 0.9011
36 T B 0.1457
37 E B -0.4935
38 P B -0.6263
39 V B -0.1476
40 G B 0.0000
41 S B -0.6615
42 Y B -0.8622
43 A B -1.3435
44 R B -2.4892
45 A B -1.6393
46 E B -2.3031
47 R B -3.3167
48 P B -2.6770
49 Q B -3.0507
50 D B -3.0574
51 F B 0.0000
52 E B -2.0970
53 G B -0.7629
54 F B 0.0000
55 V B 0.0000
56 W B 0.0000
57 R B 0.0000
58 L B -0.2591
59 D B -0.5579
60 N B -1.9043
61 D B -2.7493
62 G B -2.4577
63 K B -3.2272
64 E B -3.1665
65 A B -1.5704
66 L B -1.2057
67 P B 0.0000
68 R B -2.0494
69 N B -0.9128
70 F B -0.3279
71 R B 0.0000
72 T B 0.0000
73 S B 0.0000
74 A B -1.0120
75 D B -0.9663
76 A B -0.6083
77 L B -0.5273
78 R B -1.9900
79 A B -1.3651
80 P B 0.0000
81 E B -3.5458
82 K B -3.8498
83 K B -3.5816
84 F B 0.0000
85 H B -2.8897
86 L B -2.0763
87 D B -1.4936
88 A B -1.0117
89 A B 0.2518
90 Y B 0.8657
91 V B 1.7307
92 P B 0.0000
93 S B -0.7537
94 R B -1.7078
95 E B -2.6646
96 G B -2.0417
97 M B 0.0000
98 D B -2.3736
99 A B -1.6511
100 L B 0.0000
101 H B -1.1703
102 I B 0.0000
103 S B 0.0000
104 G B 0.0000
105 S B 0.0000
106 S B 0.0000
107 A B 0.0000
108 F B 0.0000
109 T B -1.0625
110 P B -0.6223
111 A B -0.8166
112 Q B 0.0000
113 L B 0.0000
114 K B -2.0256
115 N B -1.3718
116 V B 0.0000
117 A B 0.0000
118 A B -1.9258
119 K B -2.3529
120 L B 0.0000
121 R B -2.6155
122 E B -3.0772
123 K B -2.3818
124 T B -1.8317
125 A B -1.0742
126 G B 0.0000
127 P B -1.1620
128 I B 0.0000
129 Y B 0.0000
130 D B 0.0000
131 V B 0.0000
132 D B 0.0000
133 L B 0.0000
134 R B 0.0000
135 Q B 0.0000
136 E B 0.0000
137 S B 0.0000
138 H B 0.0000
139 G B 0.0000
140 Y B 0.0000
141 L B 0.0000
142 D B -1.6279
143 G B -0.8840
144 I B -0.5212
145 P B 0.0000
146 V B 0.0000
147 S B 0.0000
148 W B 0.0027
149 Y B 0.0000
150 G B 0.0000
151 E B -1.8956
152 R B -1.4513
153 D B 0.0000
154 W B 0.0000
155 A B -0.9989
156 N B 0.0000
157 L B 0.0000
158 G B -1.8986
159 K B -1.5934
160 S B -1.7537
161 Q B -1.8022
162 H B -2.0175
163 E B -2.4687
164 A B 0.0000
165 L B -1.3079
166 A B -1.5512
167 D B -1.5947
168 E B 0.0000
169 R B -2.0638
170 H B -2.1185
171 R B -1.6672
172 L B 0.0000
173 H B -2.0640
174 A B -1.3089
175 A B 0.0000
176 L B -1.7443
177 H B -2.6276
178 K B -2.8693
179 T B -2.1202
180 V B 0.0000
181 Y B 0.0000
182 I B 0.0000
183 A B 0.0000
184 P B -0.9063
185 L B -1.1992
186 G B -1.9711
187 K B -2.8992
188 H B -2.9375
189 K B -2.9520
190 L B -1.9636
191 P B 0.0000
192 E B -1.6269
193 G B -1.2472
194 G B -0.8045
195 E B -0.9612
196 V B -1.0362
197 R B -2.0530
198 R B -3.0147
199 V B 0.0000
200 Q B -2.8760
201 K B -2.7195
202 V B -1.5763
203 Q B -1.3846
204 T B -1.0005
205 E B 0.0000
206 Q B -1.8378
207 E B -2.2457
208 V B 0.0000
209 A B 0.0000
210 E B -3.0677
211 A B -1.7718
212 A B -1.8406
213 G B -1.9693
214 M B 0.0000
215 R B -2.4807
216 Y B -1.2863
217 F B -0.0619
218 R B 0.0000
219 I B 0.0000
220 A B 0.0000
221 A B 0.0000
222 T B 0.0000
223 D B -0.5320
224 H B -0.4099
225 V B 0.0000
226 W B 0.0000
227 P B 0.0000
228 T B -1.1082
229 P B -1.3308
230 E B -2.5594
231 N B 0.0000
232 I B 0.0000
233 D B -1.6809
234 R B -2.4047
235 F B 0.0000
236 L B -0.8334
237 A B -1.0387
238 F B -0.6822
239 Y B -0.8376
240 R B -1.6000
241 T B -0.8639
242 L B -0.9332
243 P B -1.4555
244 Q B -2.1220
245 D B -2.4143
246 A B 0.0000
247 W B 0.0000
248 L B 0.0000
249 H B 0.0000
250 F B 0.0000
251 H B 0.0000
252 S B 0.0000
253 E B -0.6885
254 A B -0.4941
255 G B 0.0000
256 V B 0.2906
257 G B 0.1400
258 R B 0.0000
259 T B 0.0000
260 T B 0.0000
261 A B 0.0000
262 F B 0.0000
263 M B 0.0000
264 V B 0.0000
265 M B 0.0000
266 T B 0.0000
267 D B 0.0000
268 M B 0.0000
269 L B -0.3906
270 K B -0.7350
271 N B -0.9029
272 P B -0.5945
273 S B -0.6734
274 V B 0.0000
275 S B -0.5597
276 L B -0.8247
277 K B -1.3393
278 D B -0.8052
279 I B 0.0000
280 L B 0.0000
281 Y B 0.0000
282 R B 0.0000
283 Q B 0.0000
284 H B 0.0000
285 E B 0.0000
286 I B 0.0000
287 G B -0.7765
288 G B -0.1242
289 F B 0.0784
290 Y B 0.0000
291 Y B 0.0000
292 G B 0.0000
293 E B -2.1394
294 F B 0.0000
295 P B -1.5876
296 I B -1.6993
297 K B -2.5649
298 T B -2.5645
299 K B -3.6320
300 D B -3.8088
301 K B -3.4251
302 D B -2.6143
303 S B -2.3569
304 W B -1.2105
305 K B -1.8293
306 T B -1.6563
307 K B -2.2507
308 Y B 0.0000
309 Y B -1.3796
310 R B -2.5427
311 E B 0.0000
312 K B 0.0000
313 I B 0.0000
314 V B -0.9168
315 M B 0.0000
316 I B 0.0000
317 E B -1.0593
318 Q B 0.0000
319 F B 0.0000
320 Y B -1.1836
321 R B -2.3402
322 Y B 0.0000
323 V B 0.0000
324 Q B -2.0765
325 E B -2.8674
326 N B 0.0000
327 R B -2.2018
328 A B -1.8164
329 D B -2.4980
330 G B -1.7521
331 Y B -1.6740
332 Q B -1.7256
333 T B -0.6026
334 P B -0.1950
335 W B 0.0000
336 S B -0.3679
337 V B 0.6463
338 W B 0.0000
339 L B -0.7176
340 K B -1.4975
341 S B -0.9466
342 H B -1.2948
343 P B -1.3231
344 A B 0.0000
345 K B -1.6715
346 A B -1.1750

 

Laboratory of Theory of Biopolymers 2015