Project name: WEI2-1

Chain sequence(s)	H: VQLQQSGPDLVKPGASVKMSCKASGYTFTSYVMHWVKQKPGQGLEWIGYINPYNDNTRYNEKFKGKATLTSDKSSSTAYMELSSLTSEDSAVYYCANYYGSNFAMDYWGQGTSVTVSS; L: DIQMTQTTSSLSASLGDRVTISCRASQDISNYLTWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSGSGTDYSLTINSLDQEDIATYFCQQGSTLPWTFGGGTKVEIK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.4576
• Maximal score value: 1.159
• Average score: -0.7
• Total score value: -157.5032

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	L	-1.8619
2	I	L	-1.5697
3	Q	L	-2.0464
4	M	L	-1.4780
5	T	L	-1.3063
6	Q	L	-0.9860
7	T	L	-0.6394
8	T	L	-0.4269
9	S	L	-0.7352
10	S	L	-0.7565
11	L	L	-0.4293
12	S	L	-0.5750
13	A	L	0.0000
14	S	L	-0.7367
15	L	L	-0.5938
16	G	L	-1.4112
17	D	L	-2.0438
18	R	L	-2.6698
19	V	L	0.0000
20	T	L	-0.7101
21	I	L	0.0000
22	S	L	-0.8771
23	C	L	0.0000
24	R	L	-2.9073
25	A	L	0.0000
26	S	L	-2.1692
27	Q	L	-2.9024
28	D	L	-2.8372
29	I	L	0.0000
30	S	L	-1.0080
31	N	L	-0.7741
32	Y	L	0.3334
33	L	L	0.0000
34	T	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	0.0000
38	Q	L	0.0000
39	K	L	-1.3577
40	P	L	-1.3057
41	D	L	-2.1522
42	G	L	-1.3028
43	T	L	-1.2121
44	V	L	0.0000
45	K	L	-0.7903
46	L	L	0.0000
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	0.1689
50	Y	L	0.4305
51	T	L	0.0000
52	S	L	0.0000
53	R	L	-1.7734
54	L	L	-0.6238
55	H	L	-0.8056
56	S	L	-0.5898
57	G	L	-0.5922
58	V	L	-0.3898
59	P	L	-0.4196
60	S	L	-0.6702
61	R	L	-1.2508
62	F	L	0.0000
63	S	L	-0.9391
64	G	L	-0.9359
65	S	L	-1.0434
66	G	L	-1.3545
67	S	L	-1.1028
68	G	L	-1.8472
69	T	L	-2.2701
70	D	L	-2.3642
71	Y	L	0.0000
72	S	L	-0.9858
73	L	L	0.0000
74	T	L	-0.8703
75	I	L	0.0000
76	N	L	-2.2525
77	S	L	-1.8667
78	L	L	0.0000
79	D	L	-2.4241
80	Q	L	-2.3641
81	E	L	-2.6524
82	D	L	0.0000
83	I	L	-1.0691
84	A	L	0.0000
85	T	L	-0.6001
86	Y	L	0.0000
87	F	L	0.0000
88	C	L	0.0000
89	Q	L	0.0000
90	Q	L	0.0000
91	G	L	0.6657
92	S	L	0.0608
93	T	L	0.1002
94	L	L	1.0101
95	P	L	-0.2087
96	W	L	0.0000
97	T	L	-0.5855
98	F	L	0.0000
99	G	L	0.0000
100	G	L	-1.0327
101	G	L	0.0000
102	T	L	0.0000
103	K	L	-1.1513
104	V	L	0.0000
105	E	L	-0.9768
106	I	L	0.3842
107	K	L	-1.0298
2	V	H	1.1590
3	Q	H	-0.8823
4	L	H	0.0000
5	Q	H	-2.1544
6	Q	H	0.0000
7	S	H	-1.1851
8	G	H	-1.0364
9	P	H	-0.4678
10	D	H	-0.1557
11	L	H	0.8897
12	V	H	-0.1514
13	K	H	-1.6070
14	P	H	-1.3307
15	G	H	-1.0427
16	A	H	-0.8032
17	S	H	-1.0088
18	V	H	-0.9653
19	K	H	-1.9717
20	M	H	0.0000
21	S	H	-0.9771
22	C	H	0.0000
23	K	H	-1.7557
24	A	H	0.0000
25	S	H	-0.5645
26	G	H	0.0014
27	Y	H	0.2626
28	T	H	0.1272
29	F	H	0.0000
30	T	H	-0.2237
31	S	H	0.3121
32	Y	H	0.6182
33	V	H	0.1973
34	M	H	0.0000
35	H	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	K	H	0.0000
39	Q	H	-1.4124
40	K	H	-2.2837
41	P	H	-1.4936
42	G	H	-1.6898
43	Q	H	-2.2181
44	G	H	-1.5971
45	L	H	0.0000
46	E	H	-1.8278
47	W	H	0.0000
48	I	H	0.0000
49	G	H	0.0000
50	Y	H	-0.4239
51	I	H	0.0000
52	N	H	-1.2582
52A	P	H	0.0000
53	Y	H	-0.3991
54	N	H	-2.0744
55	D	H	-2.9459
56	N	H	-2.7241
57	T	H	-1.9001
58	R	H	-1.8106
59	Y	H	-1.6763
60	N	H	-2.0478
61	E	H	-3.4576
62	K	H	-3.3250
63	F	H	0.0000
64	K	H	-3.3134
65	G	H	-2.0533
66	K	H	-1.6475
67	A	H	0.0000
68	T	H	-0.9830
69	L	H	0.0000
70	T	H	-1.0990
71	S	H	-1.0621
72	D	H	-1.5943
73	K	H	-1.4522
74	S	H	-1.0490
75	S	H	-1.0308
76	S	H	-1.0923
77	T	H	0.0000
78	A	H	0.0000
79	Y	H	-0.6470
80	M	H	0.0000
81	E	H	-1.4695
82	L	H	0.0000
82A	S	H	-0.9297
82B	S	H	-0.8379
82C	L	H	0.0000
83	T	H	-1.2625
84	S	H	-1.4441
85	E	H	-2.1152
86	D	H	0.0000
87	S	H	-0.7843
88	A	H	0.0000
89	V	H	-0.3841
90	Y	H	0.0000
91	Y	H	0.0000
92	C	H	0.0000
93	A	H	0.0000
94	N	H	0.0000
95	Y	H	0.0000
96	Y	H	0.6385
97	G	H	-0.0528
98	S	H	0.0535
99	N	H	0.5074
100	F	H	1.0572
100A	A	H	0.0000
100B	M	H	0.0000
101	D	H	0.1103
102	Y	H	0.5127
103	W	H	0.0000
104	G	H	0.0000
105	Q	H	-1.7028
106	G	H	-0.8434
107	T	H	0.0000
108	S	H	-0.4066
109	V	H	0.0000
110	T	H	-0.2002
111	V	H	0.0000
112	S	H	-0.5274
113	S	H	-0.6563