Project name: A1AT

Chain sequence(s)	A: FNKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAFTVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHLENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDEKGTEAAGAMFLEAIPMSIPPEVKFNKPFVFLMIEQNTKSPLFMGKVVNPTQK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.3764
• Maximal score value: 2.1885
• Average score: -1.0145
• Total score value: -377.3842

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
23	F	A	0.9611
24	N	A	-0.5438
25	K	A	-1.8852
26	I	A	0.0000
27	T	A	0.0000
28	P	A	-1.0987
29	N	A	-1.4639
30	L	A	0.0000
31	A	A	0.0000
32	E	A	-1.5323
33	F	A	0.0000
34	A	A	0.0000
35	F	A	0.0000
36	S	A	-0.7370
37	L	A	0.0000
38	Y	A	0.0000
39	R	A	-1.2082
40	Q	A	-1.2106
41	L	A	-1.0134
42	A	A	0.0000
43	H	A	-2.0176
44	Q	A	-2.0598
45	S	A	-1.6174
46	N	A	-1.7976
47	S	A	-0.8477
48	T	A	-0.8600
49	N	A	0.0000
50	I	A	0.0000
51	F	A	0.0000
52	F	A	0.0000
53	S	A	0.0000
54	P	A	0.0000
55	V	A	0.0000
56	S	A	0.0000
57	I	A	0.0000
58	A	A	0.0000
59	T	A	-0.0239
60	A	A	0.0000
61	F	A	0.0000
62	A	A	0.0000
63	M	A	0.0000
64	L	A	0.0000
65	S	A	0.0000
66	L	A	-0.0863
67	G	A	0.0000
68	T	A	0.0000
69	K	A	-2.2863
70	A	A	-2.0278
71	D	A	-2.9027
72	T	A	0.0000
73	H	A	-2.2741
74	D	A	-2.7931
75	E	A	-2.4907
76	I	A	0.0000
77	L	A	0.0000
78	E	A	-2.6535
79	G	A	0.0000
80	L	A	0.0000
81	N	A	-1.6702
82	F	A	0.0000
83	N	A	-2.4024
84	L	A	-1.7475
85	T	A	-1.3267
86	E	A	-2.2851
87	I	A	0.0000
88	P	A	-1.6014
89	E	A	-2.2272
90	A	A	-1.5456
91	Q	A	-2.1982
92	I	A	0.0000
93	H	A	-1.6633
94	E	A	-2.7845
95	G	A	0.0000
96	F	A	0.0000
97	Q	A	-1.9193
98	E	A	-2.3780
99	L	A	0.0000
100	L	A	-1.6904
101	R	A	-2.7141
102	T	A	-2.2001
103	L	A	-1.7727
104	N	A	-2.6856
105	Q	A	-2.8512
106	P	A	-2.2018
107	D	A	-2.6838
108	S	A	-2.3849
109	Q	A	-2.4730
110	L	A	-1.3509
111	Q	A	-1.2980
112	L	A	-0.6355
113	T	A	-0.4240
114	T	A	-0.2686
115	G	A	-0.5470
116	N	A	-0.7439
117	G	A	0.0000
118	L	A	0.0000
119	F	A	0.0000
120	L	A	0.0000
121	S	A	-1.2848
122	E	A	-2.4906
123	G	A	-1.8049
124	L	A	-1.7209
125	K	A	-2.6465
126	L	A	-1.7769
127	V	A	-1.9502
128	D	A	-3.0245
129	K	A	-3.1735
130	F	A	0.0000
131	L	A	-2.5096
132	E	A	-3.8792
133	D	A	0.0000
134	V	A	0.0000
135	K	A	-3.7702
136	K	A	-3.5236
137	L	A	-1.9007
138	Y	A	0.0000
139	H	A	-2.9586
140	S	A	-2.3894
141	E	A	-2.4061
142	A	A	-1.0999
143	F	A	-0.1364
144	T	A	-0.5872
145	V	A	0.0000
146	N	A	-2.9141
147	F	A	-2.7149
148	G	A	-2.6353
149	D	A	-3.2854
150	T	A	-3.8963
151	E	A	-4.3764
152	E	A	-4.3317
153	A	A	0.0000
154	K	A	-3.7927
155	K	A	-4.1708
156	Q	A	-3.0310
157	I	A	0.0000
158	N	A	0.0000
159	D	A	-2.7369
160	Y	A	-1.9133
161	V	A	0.0000
162	E	A	-2.7305
163	K	A	-2.9771
164	G	A	-2.0766
165	T	A	0.0000
166	Q	A	-2.5280
167	G	A	-2.3887
168	K	A	-2.0589
169	I	A	0.0000
170	V	A	-0.4382
171	D	A	-2.2052
172	L	A	0.0000
173	V	A	0.0000
174	K	A	-3.3839
175	E	A	-3.7128
176	L	A	-2.9836
177	D	A	-3.5480
178	R	A	-3.8947
179	D	A	-3.1593
180	T	A	0.0000
181	V	A	-1.0448
182	F	A	0.0000
183	A	A	0.0000
184	L	A	0.0000
185	V	A	0.0000
186	N	A	0.0000
187	Y	A	0.0000
188	I	A	0.0000
189	F	A	-0.2892
190	F	A	0.0000
191	K	A	-0.7487
192	G	A	-1.1299
193	K	A	-1.7457
194	W	A	0.0000
195	E	A	-2.4363
196	R	A	-1.6661
197	P	A	-1.6139
198	F	A	0.0000
199	E	A	-2.1607
200	V	A	-1.2498
201	K	A	-2.5200
202	D	A	-2.6750
203	T	A	-2.6351
204	E	A	-3.6033
205	E	A	-3.4751
206	E	A	-2.6144
207	D	A	-1.6795
208	F	A	0.0000
209	H	A	-1.1693
210	V	A	-0.6317
211	D	A	-1.6437
212	Q	A	-1.5721
213	V	A	0.5644
214	T	A	-0.1038
215	T	A	-0.6571
216	V	A	-0.9996
217	K	A	-2.6128
218	V	A	0.0000
219	P	A	-2.2286
220	M	A	0.0000
221	M	A	0.0000
222	K	A	-1.2320
223	R	A	-0.3337
224	L	A	0.8804
225	G	A	0.0000
226	M	A	-0.4917
227	F	A	0.0000
228	N	A	-1.9309
229	I	A	0.0000
230	Q	A	-1.2004
231	H	A	-1.1766
232	C	A	-1.4672
233	K	A	-2.4684
234	K	A	-2.3245
235	L	A	0.0000
236	S	A	0.0000
237	S	A	0.0000
238	W	A	-0.4500
239	V	A	0.0000
240	L	A	0.0000
241	L	A	0.0000
242	M	A	0.0000
243	K	A	-2.0642
244	Y	A	0.0000
245	L	A	-1.1089
246	G	A	-1.3458
247	N	A	-1.6378
248	A	A	0.0000
249	T	A	0.0000
250	A	A	0.0000
251	I	A	0.0000
252	F	A	0.0000
253	F	A	0.0000
254	L	A	0.0000
255	P	A	0.0000
256	D	A	-2.0243
257	E	A	-2.7162
258	G	A	-2.2155
259	K	A	-2.2198
260	L	A	-1.5912
261	Q	A	-2.1194
262	H	A	-2.0620
263	L	A	0.0000
264	E	A	0.0000
265	N	A	-2.1801
266	E	A	-1.8557
267	L	A	0.0000
268	T	A	-1.2591
269	H	A	-1.6193
270	D	A	-2.3535
271	I	A	0.0000
272	I	A	0.0000
273	T	A	-1.8098
274	K	A	-2.8453
275	F	A	0.0000
276	L	A	-1.7422
277	E	A	-3.1738
278	N	A	-3.2393
279	E	A	-3.5555
280	D	A	-3.7200
281	R	A	-2.7482
282	R	A	-1.8209
283	S	A	0.0000
284	A	A	0.0000
285	S	A	-0.2272
286	L	A	0.0000
287	H	A	-0.9140
288	L	A	0.0000
289	P	A	0.0000
290	K	A	-1.1383
291	L	A	0.0000
292	S	A	-0.6608
293	I	A	0.0000
294	T	A	-0.4991
295	G	A	0.0000
296	T	A	-0.3701
297	Y	A	-0.7600
298	D	A	-1.7958
299	L	A	0.0000
300	K	A	-2.0903
301	S	A	-1.5340
302	V	A	0.0000
303	L	A	0.0000
304	G	A	-1.4182
305	Q	A	-1.4916
306	L	A	-1.0466
307	G	A	-1.1022
308	I	A	0.0000
309	T	A	-1.0645
310	K	A	-1.7706
311	V	A	0.0000
312	F	A	0.0000
313	S	A	-1.4044
314	N	A	-1.8577
315	G	A	-1.6686
316	A	A	-1.7693
317	D	A	-2.0860
318	L	A	0.0000
319	S	A	-1.5240
320	G	A	-1.1905
321	V	A	0.0000
322	T	A	0.0000
323	E	A	-3.0290
324	E	A	-2.9877
325	A	A	-1.6547
326	P	A	-1.3003
327	L	A	0.0000
328	K	A	-0.9999
329	L	A	0.0000
330	S	A	-1.4225
331	K	A	-1.2893
332	A	A	0.0000
333	V	A	0.0000
334	H	A	0.0000
335	K	A	-0.4168
336	A	A	0.0000
337	V	A	0.0000
338	L	A	0.0000
339	T	A	-0.3454
340	I	A	0.0000
341	D	A	-0.9173
342	E	A	0.0000
343	K	A	-1.8566
344	G	A	-1.3865
345	T	A	-1.4166
346	E	A	-2.0635
347	A	A	-1.0895
348	A	A	-0.6000
349	G	A	-0.6934
350	A	A	0.3298
351	M	A	1.6986
352	F	A	2.0242
353	L	A	2.1885
354	E	A	1.0230
355	A	A	0.6844
356	I	A	1.2231
357	P	A	0.8539
358	M	A	1.5427
359	S	A	1.3294
360	I	A	1.8373
361	P	A	0.6371
362	P	A	-0.5912
363	E	A	-1.5694
364	V	A	0.0000
365	K	A	-0.8929
366	F	A	0.0000
367	N	A	-0.8057
368	K	A	-1.2929
369	P	A	-0.4006
370	F	A	0.0000
371	V	A	0.0000
372	F	A	0.0000
373	L	A	0.0000
374	M	A	0.0000
375	I	A	0.0000
376	E	A	0.0000
377	Q	A	-1.3295
378	N	A	-1.3122
379	T	A	0.0000
380	K	A	-0.5414
381	S	A	0.0000
382	P	A	0.0000
383	L	A	0.0000
384	F	A	0.0000
385	M	A	0.0000
386	G	A	0.0000
387	K	A	0.0000
388	V	A	0.0000
389	V	A	-0.4605
390	N	A	-0.6790
391	P	A	0.0000
392	T	A	-1.0470
393	Q	A	-1.3675
394	K	A	-1.9856