Project name: 812c257db6bfa7e

Chain sequence(s)	A: QVLTQTASSVSAAVGGTVTISCQSSQSVYNKNWLGWYQQKPGQPPRLLIYGASTLASGVPSRFSGSGSGTQFTLTISDVQCDDAATYYCAGGYSNNIVSFGGGTRVVVEGGGGSGGGGSGGGGSQSVEESGGRLVTPGTPLTLTCTVSGFSLSNYAMSWVRQAPGKGLEWIGIVSISAGTYYASWLRVTSPTTEDTATYFCATGGYTGNVWGPGTLVTVSSGYSSSAPSTCSKPTCPPPELLGGPSVFIFPPKPKDTLMISRTPEVTCVVVDVSQDDPEVQFTWYINNEQVRTARPPLREQQFNSTIRVVSTLPIAHQDWLRGKEFKCKVHNKALPAPIEKTISKARGQPLEPKVYTMGPPREELSSRSVSLACMINGFYPSDISVEWEKNGKAEDNYKTTPAVLDSDGSYFLYSKLSVPTSEWQRGDVFTCSVMHEALHNHYTQKSISRS
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.0713
• Maximal score value: 2.5423
• Average score: -0.5907
• Total score value: -266.3889

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	Q	A	-0.7006
3	V	A	0.7339
4	L	A	0.3752
5	T	A	-0.5739
6	Q	A	-1.1533
7	T	A	-0.7567
8	A	A	-0.4752
9	S	A	-0.3651
10	S	A	-0.2225
11	V	A	0.1322
12	S	A	-0.1336
13	A	A	-0.1693
14	A	A	-0.6367
15	V	A	-1.0940
16	G	A	-1.4300
17	G	A	-0.9798
18	T	A	-0.8604
19	V	A	0.0000
20	T	A	-0.1205
21	I	A	0.0000
22	S	A	-0.4466
23	C	A	0.0000
24	Q	A	-0.7221
25	S	A	-0.0374
26	S	A	-0.0072
27	Q	A	-0.4564
28	S	A	0.0248
29	V	A	0.8459
30	Y	A	0.0309
31	N	A	-1.4723
32	K	A	-1.7398
33	N	A	-1.1246
34	W	A	-0.1818
35	L	A	0.0000
36	G	A	0.0000
37	W	A	0.0000
38	Y	A	0.0796
39	Q	A	-0.8998
40	Q	A	-1.5365
41	K	A	-1.9505
42	P	A	-1.3363
43	G	A	-1.2702
44	Q	A	-1.8711
45	P	A	-1.4245
46	P	A	-1.4110
47	R	A	-1.6160
48	L	A	0.2360
49	L	A	0.0000
50	I	A	0.0000
51	Y	A	0.2647
52	G	A	-0.3781
53	A	A	-0.1375
54	S	A	-0.0895
55	T	A	0.2747
56	L	A	0.8511
57	A	A	0.2285
58	S	A	-0.2618
59	G	A	-0.6234
60	V	A	0.0000
61	P	A	-0.3119
62	S	A	-0.7666
63	R	A	-1.2336
64	F	A	0.0000
65	S	A	-0.5715
66	G	A	-0.6894
67	S	A	-0.8357
68	G	A	-0.9991
69	S	A	-0.7041
70	G	A	-0.6309
71	T	A	-0.2526
72	Q	A	-0.8467
73	F	A	-0.3647
74	T	A	-0.4655
75	L	A	0.0000
76	T	A	-0.4091
77	I	A	0.0000
78	S	A	-1.4270
79	D	A	-2.3568
80	V	A	0.0000
81	Q	A	-2.0675
82	C	A	-1.6248
83	D	A	-2.2989
84	D	A	-1.7182
85	A	A	-1.2507
86	A	A	0.0000
87	T	A	-0.4330
88	Y	A	0.0000
89	Y	A	-0.2260
90	C	A	0.0000
91	A	A	0.0000
92	G	A	0.7403
93	G	A	0.4787
94	Y	A	0.8216
95	S	A	-0.9757
96	N	A	-1.3428
97	N	A	-0.0741
98	I	A	2.2460
99	V	A	2.5423
100	S	A	1.4467
101	F	A	2.0225
102	G	A	0.2389
103	G	A	-0.2368
104	G	A	-0.0047
105	T	A	-0.0705
106	R	A	-0.5329
107	V	A	1.7470
108	V	A	1.9173
109	V	A	1.3932
110	E	A	0.3989
111	G	A	-0.4179
112	G	A	-0.8909
113	G	A	-0.8567
114	G	A	-0.6374
115	S	A	0.0000
116	G	A	-0.3608
117	G	A	0.0000
118	G	A	-0.5652
119	G	A	0.0000
120	S	A	0.0000
121	G	A	-1.5033
122	G	A	-1.1324
123	G	A	0.0000
124	G	A	-1.2560
125	S	A	-0.8435
126	Q	A	-1.0424
127	S	A	-0.5742
128	V	A	0.0527
129	E	A	-2.0338
130	E	A	-2.4417
131	S	A	-1.5404
132	G	A	0.0000
133	G	A	-0.4829
134	R	A	-0.4198
135	L	A	1.1318
136	V	A	1.0997
137	T	A	0.4956
138	P	A	0.3570
139	G	A	-0.1365
140	T	A	0.2136
141	P	A	0.5175
142	L	A	1.5165
143	T	A	1.0358
144	L	A	0.0000
145	T	A	0.0000
146	C	A	0.0000
147	T	A	0.3868
148	V	A	0.0000
149	S	A	0.3568
150	G	A	-0.1608
151	F	A	0.0000
152	S	A	0.0000
153	L	A	-0.4851
154	S	A	-0.5818
155	N	A	-0.9326
156	Y	A	0.0000
157	A	A	0.1107
158	M	A	0.0000
159	S	A	-0.6801
160	W	A	0.0000
161	V	A	-0.8291
162	R	A	-2.2276
163	Q	A	-2.0383
164	A	A	-1.2765
165	P	A	-1.0761
166	G	A	-1.6605
167	K	A	-1.8967
168	G	A	-0.9768
169	L	A	-0.4559
170	E	A	-1.0345
171	W	A	0.4652
172	I	A	1.4502
173	G	A	0.7390
174	I	A	1.6762
175	V	A	2.2111
176	S	A	1.2317
177	I	A	1.3764
178	S	A	0.3657
179	A	A	0.1399
180	G	A	-0.0612
181	T	A	0.3979
182	Y	A	0.9834
183	Y	A	1.4729
184	A	A	0.0000
185	S	A	0.7401
186	W	A	0.0000
202	L	A	0.4152
203	R	A	0.0607
204	V	A	1.0044
205	T	A	0.0000
206	S	A	0.1384
207	P	A	-0.1802
208	T	A	-0.3897
209	T	A	-0.9808
210	E	A	-1.1311
211	D	A	-1.8468
212	T	A	-1.1159
213	A	A	-0.5216
214	T	A	-0.0237
215	Y	A	0.3280
216	F	A	0.3958
217	C	A	0.0000
218	A	A	-0.4777
219	T	A	0.0000
220	G	A	0.0000
221	G	A	0.0000
222	Y	A	0.7495
223	T	A	-0.7285
224	G	A	-1.0910
225	N	A	-0.9479
226	V	A	0.0998
227	W	A	0.9575
228	G	A	0.0000
229	P	A	-0.2179
230	G	A	0.1911
231	T	A	0.5430
232	L	A	0.0000
233	V	A	0.7786
234	T	A	0.1308
235	V	A	-0.3511
236	S	A	-0.4846
237	S	A	-0.7297
238	G	A	-0.2795
239	Y	A	0.6269
240	S	A	0.1306
241	S	A	-0.1944
242	S	A	-0.2907
243	A	A	-0.3073
244	P	A	-0.3621
245	S	A	-0.5612
246	T	A	-0.4311
247	C	A	-0.0390
248	S	A	-0.7549
249	K	A	-1.5640
250	P	A	-0.7579
251	T	A	-0.5601
252	C	A	-0.0009
253	P	A	-0.3952
254	P	A	-0.6186
255	P	A	-1.0110
256	E	A	-1.7073
257	L	A	-0.6232
258	L	A	-0.4914
259	G	A	-1.1404
260	G	A	-0.9834
261	P	A	0.0000
262	S	A	0.1296
263	V	A	0.0000
264	F	A	1.3096
265	I	A	0.9410
266	F	A	1.1128
267	P	A	-0.2135
268	P	A	0.0000
269	K	A	-2.1282
270	P	A	-1.2788
271	K	A	-0.9350
272	D	A	0.0000
273	T	A	0.0000
274	L	A	-0.0697
275	M	A	0.7626
276	I	A	1.6094
277	S	A	0.2219
278	R	A	-1.1132
279	T	A	-0.8066
280	P	A	0.0000
281	E	A	-1.0543
282	V	A	0.0000
283	T	A	0.2673
284	C	A	0.0000
285	V	A	0.0000
286	V	A	0.0000
287	V	A	-0.1044
288	D	A	-0.7702
289	V	A	0.0000
290	S	A	-2.0678
291	Q	A	-2.6362
292	D	A	-2.9639
293	D	A	-2.4849
294	P	A	-2.4412
295	E	A	-2.8510
296	V	A	-1.6476
297	Q	A	-1.7618
298	F	A	-1.0416
299	T	A	-1.0677
300	W	A	0.0000
301	Y	A	-2.0206
302	I	A	-1.9149
303	N	A	-2.8685
304	N	A	-3.0555
305	E	A	-2.9979
306	Q	A	-2.4199
307	V	A	-1.4867
308	R	A	-2.1259
309	T	A	-1.4476
310	A	A	-1.5498
311	R	A	-2.0854
312	P	A	-0.9737
313	P	A	-0.4166
314	L	A	0.2505
315	R	A	-1.6025
316	E	A	-2.4670
317	Q	A	-2.3314
318	Q	A	-1.1188
319	F	A	0.6489
320	N	A	-0.6617
321	S	A	-0.8023
322	T	A	0.0000
323	I	A	0.0000
324	R	A	-1.7424
325	V	A	0.0000
326	V	A	-0.2191
327	S	A	0.0000
328	T	A	-0.6955
329	L	A	0.0000
330	P	A	-0.7162
331	I	A	0.0000
332	A	A	-0.9041
333	H	A	-0.9183
334	Q	A	-1.9566
335	D	A	-1.7949
336	W	A	0.0000
337	L	A	-1.5247
338	R	A	-2.8264
339	G	A	-2.3162
340	K	A	-2.3143
341	E	A	-2.2710
342	F	A	0.0000
343	K	A	-2.1468
344	C	A	0.0000
345	K	A	-1.6283
346	V	A	0.0000
347	H	A	-1.5914
348	N	A	0.0000
349	K	A	-2.4993
350	A	A	-1.5981
351	L	A	0.0000
352	P	A	-0.4992
353	A	A	-0.4683
354	P	A	-1.0103
355	I	A	-1.0500
356	E	A	-2.2157
357	K	A	-1.2917
358	T	A	-0.9375
359	I	A	-0.2323
360	S	A	-1.2087
361	K	A	-1.4612
362	A	A	-1.3141
363	R	A	-2.5867
364	G	A	-1.8914
365	Q	A	-1.8787
366	P	A	-1.3231
367	L	A	-1.0161
368	E	A	-2.4082
369	P	A	0.0000
370	K	A	-1.9698
371	V	A	0.0000
372	Y	A	0.3939
373	T	A	0.3080
374	M	A	0.2599
375	G	A	-0.6659
376	P	A	-1.0931
377	P	A	-1.6472
378	R	A	-2.8171
379	E	A	-2.8620
380	E	A	-2.0456
381	L	A	-1.6205
382	S	A	-1.4237
383	S	A	-1.4181
384	R	A	-2.0341
385	S	A	-1.1989
386	V	A	0.0000
387	S	A	-0.5347
388	L	A	0.0000
389	A	A	-0.1724
390	C	A	0.0000
391	M	A	0.4585
392	I	A	0.0000
393	N	A	-0.4238
394	G	A	-1.1465
395	F	A	0.0000
396	Y	A	-0.6526
397	P	A	0.0000
398	S	A	0.0500
399	D	A	-1.3077
400	I	A	-0.6329
401	S	A	0.0000
402	V	A	-0.2337
403	E	A	-1.1989
404	W	A	0.0000
405	E	A	-2.1342
406	K	A	-1.7856
407	N	A	-2.1567
408	G	A	-2.2321
409	K	A	-2.9160
410	A	A	-2.2239
411	E	A	-2.5109
412	D	A	-3.0713
413	N	A	-2.7789
414	Y	A	-2.4409
415	K	A	-2.5861
416	T	A	-1.1226
417	T	A	-0.4050
418	P	A	0.0551
419	A	A	0.6970
420	V	A	1.5604
421	L	A	1.2429
422	D	A	-0.6231
423	S	A	-1.1928
424	D	A	-2.0790
425	G	A	-0.9392
426	S	A	0.0000
427	Y	A	0.5373
428	F	A	0.6743
429	L	A	0.0000
430	Y	A	0.4936
431	S	A	0.0000
432	K	A	-2.1659
433	L	A	0.0000
434	S	A	-1.3983
435	V	A	0.0000
436	P	A	-1.0294
437	T	A	-1.5110
438	S	A	-1.7382
439	E	A	-1.6769
440	W	A	0.0000
441	Q	A	-2.8057
442	R	A	-2.9411
443	G	A	-2.0578
444	D	A	-1.1965
445	V	A	0.2054
446	F	A	0.0000
447	T	A	-1.0030
448	C	A	0.0000
449	S	A	0.0000
450	V	A	0.0000
451	M	A	-0.3363
452	H	A	0.0000
453	E	A	-1.1494
454	A	A	-1.3394
455	L	A	0.0000
456	H	A	-1.9157
457	N	A	-1.7540
458	H	A	-1.2307
459	Y	A	-0.3442
460	T	A	-1.0760
461	Q	A	-1.5315
462	K	A	-1.6136
463	S	A	-0.5918
464	I	A	0.0000
465	S	A	-1.0191
466	R	A	-2.3294
467	S	A	-1.2417