| Chain sequence(s) |
A: DREDLVYQAKLAEQAERYDEMVEESMKKVAGMDVELTVEERRNLLSVAYKKNVIGARRASWRRIISSSSIEQKKEENKGGEDKLKMIREEYRQMVETELKLICCDILDVLDKHLIPAANNTGESKVFYYKMKGDYHRYLAEFATGNNDRKEAAENSLVAYKAASDIAMTEELPPTHPIRLGLALNFSSVFYYEILNSSPDDRACRLAKAAFDDAIAELDTLSEESYKDSTLIIMMQLLRDNLTLWT P: RSFEPFG B: DREDLVYQAKLAEQAERYDEMVEESMKKVAGMDVELTVEERRNLLSVAYKKNVIGARRASWRRIISSSSIEQKKEENKGGEDKLKMIREEYRQMVETELKLICCDILDVLDKHLIPAANNTGESKVFYYKMKGDYHRYLAEFATGNNDRKEAAENSLVAYKAASDIAMTEELPPTHPIRLGLALNFSSVFYYEILNSSPDDRACRLAKAAFDDAIAELDTLSEESYKDSTLIIMMQLLRDNLTLWT |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 3 | D | A | -3.0286 | |
| 4 | R | A | -2.6262 | |
| 5 | E | A | -3.1042 | |
| 6 | D | A | -3.2945 | |
| 7 | L | A | -2.2711 | |
| 8 | V | A | -1.7534 | |
| 9 | Y | A | -1.4513 | |
| 10 | Q | A | -1.4471 | |
| 11 | A | A | 0.0000 | |
| 12 | K | A | -1.8529 | |
| 13 | L | A | 0.0000 | |
| 14 | A | A | 0.0000 | |
| 15 | E | A | -2.3264 | |
| 16 | Q | A | -2.0176 | |
| 17 | A | A | 0.0000 | |
| 18 | E | A | -2.7303 | |
| 19 | R | A | -1.9645 | |
| 20 | Y | A | -2.0359 | |
| 21 | D | A | -2.6502 | |
| 22 | E | A | -2.3375 | |
| 23 | M | A | 0.0000 | |
| 24 | V | A | -1.8998 | |
| 25 | E | A | -2.9367 | |
| 26 | S | A | 0.0000 | |
| 27 | M | A | 0.0000 | |
| 28 | K | A | -2.2005 | |
| 29 | K | A | -2.6648 | |
| 30 | V | A | 0.0000 | |
| 31 | A | A | 0.0000 | |
| 32 | G | A | -1.6695 | |
| 33 | M | A | -1.0389 | |
| 34 | D | A | -1.8608 | |
| 35 | V | A | -0.2629 | |
| 36 | E | A | -0.4245 | |
| 37 | L | A | 0.0000 | |
| 38 | T | A | -0.0429 | |
| 39 | V | A | 0.2341 | |
| 40 | E | A | -1.3684 | |
| 41 | E | A | 0.0000 | |
| 42 | R | A | 0.0000 | |
| 43 | N | A | -0.9441 | |
| 44 | L | A | 0.0000 | |
| 45 | L | A | 0.0000 | |
| 46 | S | A | -0.2751 | |
| 47 | V | A | 0.0840 | |
| 48 | A | A | 0.0000 | |
| 49 | Y | A | 0.0000 | |
| 50 | K | A | 0.0000 | |
| 51 | N | A | -0.6218 | |
| 52 | V | A | 0.0000 | |
| 53 | I | A | 0.0000 | |
| 54 | G | A | -0.2411 | |
| 55 | A | A | -0.5894 | |
| 56 | R | A | -1.0347 | |
| 57 | R | A | -1.0074 | |
| 58 | A | A | -0.8911 | |
| 59 | S | A | 0.0000 | |
| 60 | W | A | -0.9725 | |
| 61 | R | A | -1.5357 | |
| 62 | I | A | -0.9125 | |
| 63 | I | A | 0.0000 | |
| 64 | S | A | -1.1895 | |
| 65 | S | A | -1.4900 | |
| 66 | I | A | 0.0000 | |
| 67 | E | A | -2.7294 | |
| 68 | Q | A | -3.2778 | |
| 69 | K | A | -3.7964 | |
| 70 | E | A | 0.0000 | |
| 71 | E | A | -4.4412 | |
| 72 | N | A | -3.9255 | |
| 73 | K | A | -3.8358 | |
| 74 | G | A | -3.4229 | |
| 75 | G | A | -3.3347 | |
| 76 | E | A | -3.9657 | |
| 77 | D | A | -3.7434 | |
| 78 | K | A | -3.2078 | |
| 79 | L | A | 0.0000 | |
| 80 | K | A | -3.6442 | |
| 81 | M | A | -2.7519 | |
| 82 | I | A | 0.0000 | |
| 83 | R | A | -2.5672 | |
| 84 | E | A | -2.9948 | |
| 85 | Y | A | 0.0000 | |
| 86 | R | A | -1.9261 | |
| 87 | Q | A | -2.1145 | |
| 88 | M | A | -1.1200 | |
| 89 | V | A | 0.0000 | |
| 90 | E | A | -1.1255 | |
| 91 | T | A | -0.5924 | |
| 92 | E | A | -0.4393 | |
| 93 | L | A | 0.0000 | |
| 94 | K | A | -0.4599 | |
| 95 | L | A | 0.9047 | |
| 96 | I | A | 0.2786 | |
| 97 | C | A | 0.0000 | |
| 98 | C | A | 0.0643 | |
| 99 | D | A | -0.4280 | |
| 100 | I | A | 0.0000 | |
| 101 | L | A | 0.0000 | |
| 102 | D | A | -2.2871 | |
| 103 | V | A | 0.0000 | |
| 104 | L | A | 0.0000 | |
| 105 | D | A | -3.0499 | |
| 106 | K | A | -3.3091 | |
| 107 | H | A | -2.3530 | |
| 108 | L | A | 0.0000 | |
| 109 | I | A | -1.3684 | |
| 110 | P | A | -1.4701 | |
| 111 | A | A | -1.2350 | |
| 112 | A | A | 0.0000 | |
| 113 | N | A | -1.4386 | |
| 114 | T | A | -1.2123 | |
| 115 | G | A | -1.2240 | |
| 116 | E | A | -0.9679 | |
| 117 | S | A | 0.0000 | |
| 118 | K | A | -0.8670 | |
| 119 | V | A | 0.0000 | |
| 120 | F | A | 0.0000 | |
| 121 | Y | A | 0.0000 | |
| 122 | Y | A | -0.0059 | |
| 123 | K | A | 0.0000 | |
| 124 | M | A | 0.0000 | |
| 125 | K | A | -0.2663 | |
| 126 | G | A | 0.0000 | |
| 127 | D | A | 0.0000 | |
| 128 | Y | A | 0.0000 | |
| 129 | H | A | -0.6636 | |
| 130 | R | A | 0.0000 | |
| 131 | Y | A | 0.0000 | |
| 132 | L | A | -0.6025 | |
| 133 | A | A | 0.0000 | |
| 134 | E | A | -0.4692 | |
| 135 | F | A | -0.6863 | |
| 136 | A | A | -1.6402 | |
| 137 | T | A | -1.8044 | |
| 138 | G | A | -2.4931 | |
| 139 | N | A | -3.6974 | |
| 140 | D | A | -4.1285 | |
| 141 | R | A | -3.7170 | |
| 142 | K | A | -4.4999 | |
| 143 | E | A | -4.5588 | |
| 144 | A | A | 0.0000 | |
| 145 | A | A | -2.3423 | |
| 146 | E | A | -2.7957 | |
| 147 | N | A | -1.5875 | |
| 148 | S | A | 0.0000 | |
| 149 | L | A | -0.1549 | |
| 150 | V | A | 0.7718 | |
| 151 | A | A | 0.0000 | |
| 152 | Y | A | 0.0000 | |
| 153 | K | A | -1.1303 | |
| 154 | A | A | -0.6726 | |
| 155 | A | A | 0.0000 | |
| 156 | S | A | -1.0214 | |
| 157 | D | A | -1.9098 | |
| 158 | I | A | -1.0988 | |
| 159 | A | A | 0.0000 | |
| 160 | M | A | -0.0425 | |
| 161 | T | A | -0.7688 | |
| 162 | E | A | -1.9320 | |
| 163 | L | A | 0.0000 | |
| 164 | P | A | -0.8002 | |
| 165 | P | A | -0.6252 | |
| 166 | T | A | 0.0000 | |
| 167 | H | A | -0.5248 | |
| 168 | P | A | -0.6516 | |
| 169 | I | A | -0.3804 | |
| 170 | R | A | -0.3361 | |
| 171 | L | A | 0.0000 | |
| 172 | G | A | 0.0000 | |
| 173 | L | A | 0.0000 | |
| 174 | A | A | 0.0000 | |
| 175 | L | A | 0.0000 | |
| 176 | N | A | 0.0000 | |
| 177 | F | A | 0.0000 | |
| 178 | S | A | 0.0000 | |
| 179 | V | A | 0.0000 | |
| 180 | F | A | 0.0000 | |
| 181 | Y | A | -0.5579 | |
| 182 | Y | A | -0.7309 | |
| 183 | E | A | -0.8766 | |
| 184 | I | A | 0.0000 | |
| 185 | L | A | -0.7095 | |
| 186 | N | A | -1.5057 | |
| 187 | S | A | 0.0000 | |
| 188 | P | A | -1.8456 | |
| 189 | D | A | -3.0877 | |
| 190 | R | A | -3.1750 | |
| 191 | A | A | 0.0000 | |
| 192 | C | A | -2.4015 | |
| 193 | R | A | -3.2069 | |
| 194 | L | A | -1.6979 | |
| 195 | A | A | 0.0000 | |
| 196 | K | A | -3.1427 | |
| 197 | A | A | -1.9074 | |
| 198 | A | A | -1.4071 | |
| 199 | F | A | -1.8019 | |
| 200 | D | A | -2.3698 | |
| 201 | D | A | -2.1074 | |
| 202 | A | A | 0.0000 | |
| 203 | I | A | 0.2663 | |
| 204 | A | A | -0.7551 | |
| 205 | E | A | -1.4134 | |
| 206 | L | A | -0.0764 | |
| 207 | D | A | -1.4590 | |
| 208 | T | A | -0.7414 | |
| 209 | L | A | -0.7909 | |
| 210 | S | A | -1.7319 | |
| 211 | E | A | -2.6648 | |
| 212 | E | A | -2.9910 | |
| 213 | S | A | -2.1124 | |
| 214 | Y | A | -1.3264 | |
| 215 | K | A | -2.4789 | |
| 216 | D | A | -2.4349 | |
| 217 | S | A | 0.0000 | |
| 218 | T | A | -0.8197 | |
| 219 | L | A | -0.7119 | |
| 220 | I | A | 0.0000 | |
| 221 | M | A | 0.0000 | |
| 222 | Q | A | -1.6926 | |
| 223 | L | A | -0.6693 | |
| 224 | L | A | 0.0000 | |
| 225 | R | A | -2.4012 | |
| 226 | D | A | -1.1954 | |
| 227 | N | A | 0.0000 | |
| 228 | L | A | 0.0000 | |
| 229 | T | A | -0.4834 | |
| 230 | L | A | -0.1117 | |
| 231 | W | A | -0.2113 | |
| 232 | T | A | -0.1334 | |
| 35 | R | P | -1.5121 | |
| 36 | S | P | -0.1890 | |
| 37 | F | P | 0.8600 | |
| 39 | E | P | 0.1393 | |
| 40 | P | P | 0.3096 | |
| 41 | F | P | 0.7781 | |
| 42 | G | P | 0.0084 | |
| 3 | D | B | -3.0027 | |
| 4 | R | B | -2.6172 | |
| 5 | E | B | -3.0882 | |
| 6 | D | B | -3.2343 | |
| 7 | L | B | -2.2625 | |
| 8 | V | B | -1.7847 | |
| 9 | Y | B | -1.5327 | |
| 10 | Q | B | -1.5637 | |
| 11 | A | B | 0.0000 | |
| 12 | K | B | -2.0588 | |
| 13 | L | B | 0.0000 | |
| 14 | A | B | 0.0000 | |
| 15 | E | B | -2.7208 | |
| 16 | Q | B | -2.3966 | |
| 17 | A | B | 0.0000 | |
| 18 | E | B | -2.9644 | |
| 19 | R | B | -2.1405 | |
| 20 | Y | B | -2.2538 | |
| 21 | D | B | -2.7853 | |
| 22 | E | B | -2.4489 | |
| 23 | M | B | 0.0000 | |
| 24 | V | B | 0.0000 | |
| 25 | E | B | -2.9742 | |
| 26 | S | B | 0.0000 | |
| 27 | M | B | 0.0000 | |
| 28 | K | B | -2.1275 | |
| 29 | K | B | -2.6320 | |
| 30 | V | B | 0.0000 | |
| 31 | A | B | 0.0000 | |
| 32 | G | B | -1.6364 | |
| 33 | M | B | -1.0244 | |
| 34 | D | B | -1.8632 | |
| 35 | V | B | -0.2580 | |
| 36 | E | B | -0.3852 | |
| 37 | L | B | 0.0000 | |
| 38 | T | B | 0.1097 | |
| 39 | V | B | 0.5241 | |
| 40 | E | B | -1.2092 | |
| 41 | E | B | 0.0000 | |
| 42 | R | B | 0.0000 | |
| 43 | N | B | -0.7708 | |
| 44 | L | B | -0.6506 | |
| 45 | L | B | 0.0000 | |
| 46 | S | B | -0.3719 | |
| 47 | V | B | 0.0410 | |
| 48 | A | B | 0.0000 | |
| 49 | Y | B | 0.0000 | |
| 50 | K | B | -0.7608 | |
| 51 | N | B | -1.3460 | |
| 52 | V | B | 0.0000 | |
| 53 | I | B | 0.0000 | |
| 54 | G | B | -0.7209 | |
| 55 | A | B | -0.8024 | |
| 56 | R | B | -1.1080 | |
| 57 | R | B | -1.2291 | |
| 58 | A | B | -0.9571 | |
| 59 | S | B | 0.0000 | |
| 60 | W | B | -1.0352 | |
| 61 | R | B | -1.6443 | |
| 62 | I | B | -0.8102 | |
| 63 | I | B | 0.0000 | |
| 64 | S | B | -1.1233 | |
| 65 | S | B | -1.3101 | |
| 66 | I | B | -1.4115 | |
| 67 | E | B | 0.0000 | |
| 68 | Q | B | -3.0810 | |
| 69 | K | B | -3.6358 | |
| 70 | E | B | 0.0000 | |
| 71 | E | B | -4.3334 | |
| 72 | N | B | -3.9001 | |
| 73 | K | B | -3.7980 | |
| 74 | G | B | -3.3779 | |
| 75 | G | B | -3.2750 | |
| 76 | E | B | -3.9106 | |
| 77 | D | B | -3.7174 | |
| 78 | K | B | -3.1834 | |
| 79 | L | B | -3.6618 | |
| 80 | K | B | -3.6927 | |
| 81 | M | B | -2.8095 | |
| 82 | I | B | 0.0000 | |
| 83 | R | B | -2.8969 | |
| 84 | E | B | -3.1723 | |
| 85 | Y | B | 0.0000 | |
| 86 | R | B | -2.0511 | |
| 87 | Q | B | -2.2133 | |
| 88 | M | B | -1.1536 | |
| 89 | V | B | 0.0000 | |
| 90 | E | B | -1.1470 | |
| 91 | T | B | -0.5811 | |
| 92 | E | B | -0.4173 | |
| 93 | L | B | 0.0000 | |
| 94 | K | B | -0.5193 | |
| 95 | L | B | 0.8534 | |
| 96 | I | B | 0.1546 | |
| 97 | C | B | 0.0000 | |
| 98 | C | B | -0.2478 | |
| 99 | D | B | -0.7698 | |
| 100 | I | B | 0.0000 | |
| 101 | L | B | 0.0000 | |
| 102 | D | B | -3.0563 | |
| 103 | V | B | 0.0000 | |
| 104 | L | B | 0.0000 | |
| 105 | D | B | -3.3064 | |
| 106 | K | B | -3.5232 | |
| 107 | H | B | -2.4707 | |
| 108 | L | B | 0.0000 | |
| 109 | I | B | -1.3484 | |
| 110 | P | B | -1.4712 | |
| 111 | A | B | -1.2340 | |
| 112 | A | B | 0.0000 | |
| 113 | N | B | -1.4407 | |
| 114 | T | B | -1.2058 | |
| 115 | G | B | -1.2125 | |
| 116 | E | B | -0.9331 | |
| 117 | S | B | 0.0000 | |
| 118 | K | B | -0.8237 | |
| 119 | V | B | 0.0000 | |
| 120 | F | B | -0.1263 | |
| 121 | Y | B | 0.0000 | |
| 122 | Y | B | -0.0164 | |
| 123 | K | B | -0.2815 | |
| 124 | M | B | 0.0000 | |
| 125 | K | B | -0.4682 | |
| 126 | G | B | 0.0000 | |
| 127 | D | B | 0.0000 | |
| 128 | Y | B | 0.0000 | |
| 129 | H | B | -0.8104 | |
| 130 | R | B | 0.0000 | |
| 131 | Y | B | 0.0000 | |
| 132 | L | B | -0.7484 | |
| 133 | A | B | 0.0000 | |
| 134 | E | B | -0.9768 | |
| 135 | F | B | -0.8465 | |
| 136 | A | B | -1.7265 | |
| 137 | T | B | -1.8456 | |
| 138 | G | B | -2.4959 | |
| 139 | N | B | -3.7010 | |
| 140 | D | B | -4.1337 | |
| 141 | R | B | -3.8141 | |
| 142 | K | B | -4.5626 | |
| 143 | E | B | -4.6637 | |
| 144 | A | B | 0.0000 | |
| 145 | A | B | 0.0000 | |
| 146 | E | B | -2.9452 | |
| 147 | N | B | -1.9470 | |
| 148 | S | B | 0.0000 | |
| 149 | L | B | -0.1900 | |
| 150 | V | B | 0.7445 | |
| 151 | A | B | 0.0000 | |
| 152 | Y | B | 0.0000 | |
| 153 | K | B | -1.1344 | |
| 154 | A | B | -0.6623 | |
| 155 | A | B | 0.0000 | |
| 156 | S | B | -1.0255 | |
| 157 | D | B | -1.9054 | |
| 158 | I | B | -1.0813 | |
| 159 | A | B | 0.0000 | |
| 160 | M | B | -0.0410 | |
| 161 | T | B | -0.7669 | |
| 162 | E | B | -1.9395 | |
| 163 | L | B | 0.0000 | |
| 164 | P | B | -0.7770 | |
| 165 | P | B | -0.6311 | |
| 166 | T | B | 0.0000 | |
| 167 | H | B | -0.4932 | |
| 168 | P | B | -0.5087 | |
| 169 | I | B | -0.2513 | |
| 170 | R | B | -0.3065 | |
| 171 | L | B | 0.0000 | |
| 172 | G | B | -0.0886 | |
| 173 | L | B | 0.0000 | |
| 174 | A | B | 0.0000 | |
| 175 | L | B | 0.0000 | |
| 176 | N | B | -0.0579 | |
| 177 | F | B | 0.0000 | |
| 178 | S | B | 0.0000 | |
| 179 | V | B | -0.2572 | |
| 180 | F | B | 0.0000 | |
| 181 | Y | B | -0.8318 | |
| 182 | Y | B | -1.2718 | |
| 183 | E | B | -1.8975 | |
| 184 | I | B | 0.0000 | |
| 185 | L | B | -1.0222 | |
| 186 | N | B | -1.8876 | |
| 187 | S | B | -1.6933 | |
| 188 | P | B | -1.9928 | |
| 189 | D | B | -3.0611 | |
| 190 | R | B | -3.1234 | |
| 191 | A | B | 0.0000 | |
| 192 | C | B | -2.3974 | |
| 193 | R | B | -3.1998 | |
| 194 | L | B | -1.6631 | |
| 195 | A | B | 0.0000 | |
| 196 | K | B | -3.2144 | |
| 197 | A | B | -1.9458 | |
| 198 | A | B | -1.4507 | |
| 199 | F | B | -1.8146 | |
| 200 | D | B | -2.4521 | |
| 201 | D | B | -2.1427 | |
| 202 | A | B | 0.0000 | |
| 203 | I | B | 0.0420 | |
| 204 | A | B | -0.8386 | |
| 205 | E | B | -1.4274 | |
| 206 | L | B | -0.1137 | |
| 207 | D | B | -1.4649 | |
| 208 | T | B | -0.7380 | |
| 209 | L | B | -0.7769 | |
| 210 | S | B | -1.7118 | |
| 211 | E | B | -2.6537 | |
| 212 | E | B | -2.9833 | |
| 213 | S | B | -2.0771 | |
| 214 | Y | B | -1.2755 | |
| 215 | K | B | -2.3813 | |
| 216 | D | B | -2.2704 | |
| 217 | S | B | 0.0000 | |
| 218 | T | B | -0.5681 | |
| 219 | L | B | -0.1951 | |
| 220 | I | B | -0.4118 | |
| 221 | M | B | 0.0000 | |
| 222 | Q | B | -1.4143 | |
| 223 | L | B | -0.5596 | |
| 224 | L | B | 0.0000 | |
| 225 | R | B | -2.3179 | |
| 226 | D | B | -1.3564 | |
| 227 | N | B | -0.6047 | |
| 228 | L | B | 0.0000 | |
| 229 | T | B | -0.0268 | |
| 230 | L | B | 1.0485 | |
| 231 | W | B | 0.3073 | |
| 232 | T | B | 0.2114 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine