| Chain sequence(s) |
A: QVQLQESGPGLVKPSKTLSLTCTVSGGSISSGYWNWIRQPPGKGLEWIGTISYSGDTYYNPSLKSRVTISVVTSKNQFSLKLSSVTAADTAVYYCARYGSYVFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVES B: DIVMTQTPLSLSVTPGQPASISCRSSQSLLHSNGNTYLHWYLQKPGQSPQLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAVDVGVYYCSQSTHVPWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | Q | A | -1.6582 | |
| 2 | V | A | 0.0000 | |
| 3 | Q | A | -2.1256 | |
| 4 | L | A | 0.0000 | |
| 5 | Q | A | -1.8484 | |
| 6 | E | A | 0.0000 | |
| 7 | S | A | -0.6848 | |
| 8 | G | A | -0.4388 | |
| 9 | P | A | -0.5425 | |
| 10 | G | A | -0.4499 | |
| 11 | L | A | -0.5250 | |
| 12 | V | A | 0.0000 | |
| 13 | K | A | -2.4464 | |
| 14 | P | A | -1.7104 | |
| 15 | S | A | -1.6542 | |
| 16 | K | A | -2.4485 | |
| 17 | T | A | -1.7078 | |
| 18 | L | A | 0.0000 | |
| 19 | S | A | -1.0148 | |
| 20 | L | A | 0.0000 | |
| 21 | T | A | -0.5167 | |
| 22 | C | A | 0.0000 | |
| 23 | T | A | -0.9996 | |
| 24 | V | A | 0.0000 | |
| 25 | S | A | -1.2990 | |
| 26 | G | A | -1.3492 | |
| 27 | G | A | -1.1562 | |
| 28 | S | A | -0.8475 | |
| 29 | I | A | 0.0000 | |
| 30 | S | A | -0.0777 | |
| 31 | S | A | 0.0160 | |
| 32 | G | A | 0.1263 | |
| 33 | Y | A | 0.1774 | |
| 34 | W | A | 0.0000 | |
| 35 | N | A | 0.0000 | |
| 36 | W | A | 0.0000 | |
| 37 | I | A | 0.0000 | |
| 38 | R | A | 0.0000 | |
| 39 | Q | A | -0.8011 | |
| 40 | P | A | -0.9908 | |
| 41 | P | A | -1.1109 | |
| 42 | G | A | -1.4999 | |
| 43 | K | A | -2.3719 | |
| 44 | G | A | -1.5326 | |
| 45 | L | A | 0.0000 | |
| 46 | E | A | -0.6543 | |
| 47 | W | A | 0.0000 | |
| 48 | I | A | 0.0000 | |
| 49 | G | A | 0.0000 | |
| 50 | T | A | 0.0000 | |
| 51 | I | A | 0.0000 | |
| 52 | S | A | 0.0347 | |
| 53 | Y | A | 0.5889 | |
| 54 | S | A | -0.4325 | |
| 55 | G | A | -0.8264 | |
| 56 | D | A | -1.5387 | |
| 57 | T | A | -0.3314 | |
| 58 | Y | A | 0.8044 | |
| 59 | Y | A | 0.5227 | |
| 60 | N | A | 0.0000 | |
| 61 | P | A | -0.8656 | |
| 62 | S | A | -1.1267 | |
| 63 | L | A | 0.0000 | |
| 64 | K | A | -2.0160 | |
| 65 | S | A | -1.2777 | |
| 66 | R | A | -1.3882 | |
| 67 | V | A | 0.0000 | |
| 68 | T | A | -0.6024 | |
| 69 | I | A | 0.0000 | |
| 70 | S | A | -0.4160 | |
| 71 | V | A | 0.2181 | |
| 72 | V | A | -0.0104 | |
| 73 | T | A | -0.5642 | |
| 74 | S | A | -0.9603 | |
| 75 | K | A | -1.7532 | |
| 76 | N | A | -1.1048 | |
| 77 | Q | A | -0.8170 | |
| 78 | F | A | 0.0000 | |
| 79 | S | A | -0.3169 | |
| 80 | L | A | 0.0000 | |
| 81 | K | A | -1.6858 | |
| 82 | L | A | 0.0000 | |
| 83 | S | A | -1.2439 | |
| 84 | S | A | -1.1654 | |
| 85 | V | A | 0.0000 | |
| 86 | T | A | -0.6623 | |
| 87 | A | A | -0.1979 | |
| 88 | A | A | 0.0286 | |
| 89 | D | A | 0.0000 | |
| 90 | T | A | 0.0352 | |
| 91 | A | A | 0.0000 | |
| 92 | V | A | 0.1166 | |
| 93 | Y | A | 0.0000 | |
| 94 | Y | A | 0.0000 | |
| 95 | C | A | 0.0000 | |
| 96 | A | A | 0.0000 | |
| 97 | R | A | -0.6552 | |
| 98 | Y | A | -0.0486 | |
| 99 | G | A | -0.0607 | |
| 100 | S | A | -0.0409 | |
| 101 | Y | A | 0.3122 | |
| 102 | V | A | 0.0000 | |
| 103 | F | A | 0.0000 | |
| 104 | D | A | -0.4101 | |
| 105 | Y | A | -0.7801 | |
| 106 | W | A | 0.0000 | |
| 107 | G | A | 0.0000 | |
| 108 | Q | A | -1.8493 | |
| 109 | G | A | 0.0000 | |
| 110 | T | A | -0.4708 | |
| 111 | T | A | -0.1791 | |
| 112 | V | A | 0.0000 | |
| 113 | T | A | -0.2714 | |
| 114 | V | A | 0.0000 | |
| 115 | S | A | -0.9093 | |
| 116 | S | A | -0.8573 | |
| 117 | A | A | -0.5494 | |
| 118 | S | A | -0.6622 | |
| 119 | T | A | -0.7419 | |
| 120 | K | A | -1.1859 | |
| 121 | G | A | -1.3564 | |
| 122 | P | A | -0.6242 | |
| 123 | S | A | -0.3676 | |
| 124 | V | A | 0.0000 | |
| 125 | F | A | -0.6809 | |
| 126 | P | A | -1.1362 | |
| 127 | L | A | 0.0000 | |
| 128 | A | A | -0.8708 | |
| 129 | P | A | 0.0000 | |
| 130 | C | A | -0.4645 | |
| 131 | S | A | -0.5447 | |
| 132 | R | A | -0.8962 | |
| 133 | S | A | 0.0000 | |
| 134 | T | A | -0.8899 | |
| 135 | S | A | -1.3597 | |
| 136 | E | A | -2.0796 | |
| 137 | S | A | -1.3126 | |
| 138 | T | A | -0.9409 | |
| 139 | A | A | 0.0000 | |
| 140 | A | A | 0.0000 | |
| 141 | L | A | 0.0000 | |
| 142 | G | A | 0.0000 | |
| 143 | C | A | 0.0000 | |
| 144 | L | A | 0.0000 | |
| 145 | V | A | 0.0000 | |
| 146 | K | A | -0.2443 | |
| 147 | D | A | -0.3576 | |
| 148 | Y | A | 0.0000 | |
| 149 | F | A | 0.0000 | |
| 150 | P | A | 0.0000 | |
| 151 | E | A | -0.4917 | |
| 152 | P | A | -0.6842 | |
| 153 | V | A | -0.6918 | |
| 154 | T | A | -0.6533 | |
| 155 | V | A | -0.4325 | |
| 156 | S | A | -0.5365 | |
| 157 | W | A | 0.0000 | |
| 158 | N | A | -1.0336 | |
| 159 | S | A | -0.7891 | |
| 160 | G | A | -0.6066 | |
| 161 | A | A | -0.2832 | |
| 162 | L | A | -0.1365 | |
| 163 | T | A | -0.2463 | |
| 164 | S | A | -0.2711 | |
| 165 | G | A | -0.3738 | |
| 166 | V | A | 0.0708 | |
| 167 | H | A | -0.2308 | |
| 168 | T | A | -0.0035 | |
| 169 | F | A | 0.0000 | |
| 170 | P | A | -0.3192 | |
| 171 | A | A | 0.2927 | |
| 172 | V | A | 0.6450 | |
| 173 | L | A | 1.3265 | |
| 174 | Q | A | 0.3362 | |
| 175 | S | A | -0.0125 | |
| 176 | S | A | -0.1646 | |
| 177 | G | A | 0.1136 | |
| 178 | L | A | 0.2287 | |
| 179 | Y | A | 0.5239 | |
| 180 | S | A | 0.0000 | |
| 181 | L | A | 0.0000 | |
| 182 | S | A | 0.0000 | |
| 183 | S | A | 0.0000 | |
| 184 | V | A | 0.0000 | |
| 185 | V | A | 0.0000 | |
| 186 | T | A | -0.1851 | |
| 187 | V | A | 0.0000 | |
| 188 | P | A | -0.6410 | |
| 189 | S | A | -0.6914 | |
| 190 | S | A | -0.5505 | |
| 191 | S | A | -0.6634 | |
| 192 | L | A | -0.8236 | |
| 193 | G | A | -1.1735 | |
| 194 | T | A | -0.8999 | |
| 195 | K | A | -1.6325 | |
| 196 | T | A | -1.4970 | |
| 197 | Y | A | 0.0000 | |
| 198 | T | A | 0.0000 | |
| 199 | C | A | 0.0000 | |
| 200 | N | A | -1.8913 | |
| 201 | V | A | 0.0000 | |
| 202 | D | A | -2.1492 | |
| 203 | H | A | 0.0000 | |
| 204 | K | A | -2.7691 | |
| 205 | P | A | -1.6412 | |
| 206 | S | A | -1.8683 | |
| 207 | N | A | -2.5699 | |
| 208 | T | A | -2.1346 | |
| 209 | K | A | -2.7863 | |
| 210 | V | A | -2.0618 | |
| 211 | D | A | -2.9748 | |
| 212 | K | A | -2.6296 | |
| 213 | R | A | -3.0758 | |
| 214 | V | A | 0.0000 | |
| 215 | E | A | -2.6180 | |
| 216 | S | A | -1.1032 | |
| 217 | D | B | -1.2325 | |
| 218 | I | B | -0.2033 | |
| 219 | V | B | 0.7455 | |
| 220 | M | B | 0.0000 | |
| 221 | T | B | -0.4991 | |
| 222 | Q | B | 0.0000 | |
| 223 | T | B | -0.3825 | |
| 224 | P | B | -0.2757 | |
| 225 | L | B | 0.0100 | |
| 226 | S | B | -0.5934 | |
| 227 | L | B | 0.0000 | |
| 228 | S | B | -1.0736 | |
| 229 | V | B | 0.0000 | |
| 230 | T | B | -1.7172 | |
| 231 | P | B | -1.9419 | |
| 232 | G | B | -1.9800 | |
| 233 | Q | B | -2.3537 | |
| 234 | P | B | -2.1394 | |
| 235 | A | B | -1.2916 | |
| 236 | S | B | -0.7924 | |
| 237 | I | B | 0.0000 | |
| 238 | S | B | -0.8862 | |
| 239 | C | B | 0.0000 | |
| 240 | R | B | -2.1251 | |
| 241 | S | B | 0.0000 | |
| 242 | S | B | -0.8538 | |
| 243 | Q | B | -1.3803 | |
| 244 | S | B | -0.7239 | |
| 245 | L | B | 0.0000 | |
| 246 | L | B | 0.4295 | |
| 247 | H | B | -0.7168 | |
| 248 | S | B | -0.9992 | |
| 249 | N | B | -1.7387 | |
| 250 | G | B | -1.2883 | |
| 251 | N | B | -1.2399 | |
| 252 | T | B | -0.3807 | |
| 253 | Y | B | 0.0000 | |
| 254 | L | B | 0.0000 | |
| 255 | H | B | 0.0000 | |
| 256 | W | B | 0.0000 | |
| 257 | Y | B | 0.0000 | |
| 258 | L | B | 0.0000 | |
| 259 | Q | B | -1.1214 | |
| 260 | K | B | -1.4606 | |
| 261 | P | B | -1.4158 | |
| 262 | G | B | -1.6396 | |
| 263 | Q | B | -2.0260 | |
| 264 | S | B | -1.3918 | |
| 265 | P | B | 0.0000 | |
| 266 | Q | B | -1.2737 | |
| 267 | L | B | 0.0000 | |
| 268 | L | B | 0.0000 | |
| 269 | I | B | 0.0000 | |
| 270 | Y | B | -0.4483 | |
| 271 | K | B | -0.8331 | |
| 272 | V | B | 0.0000 | |
| 273 | S | B | -0.9274 | |
| 274 | N | B | -1.2587 | |
| 275 | R | B | -1.8098 | |
| 276 | F | B | -0.6942 | |
| 277 | S | B | -0.6009 | |
| 278 | G | B | -0.8275 | |
| 279 | V | B | -0.9326 | |
| 280 | P | B | -1.3220 | |
| 281 | D | B | -2.2722 | |
| 282 | R | B | -2.1206 | |
| 283 | F | B | 0.0000 | |
| 284 | S | B | -1.3430 | |
| 285 | G | B | 0.0000 | |
| 286 | S | B | -0.7590 | |
| 287 | G | B | -0.9631 | |
| 288 | S | B | -0.6407 | |
| 289 | G | B | -0.6138 | |
| 290 | T | B | -1.3580 | |
| 291 | D | B | -1.9742 | |
| 292 | F | B | 0.0000 | |
| 293 | T | B | -0.9866 | |
| 294 | L | B | 0.0000 | |
| 295 | K | B | -1.5706 | |
| 296 | I | B | 0.0000 | |
| 297 | S | B | -2.3193 | |
| 298 | R | B | -3.1185 | |
| 299 | V | B | 0.0000 | |
| 300 | E | B | -2.2474 | |
| 301 | A | B | -1.6817 | |
| 302 | V | B | -0.7404 | |
| 303 | D | B | 0.0000 | |
| 304 | V | B | 0.0000 | |
| 305 | G | B | 0.0000 | |
| 306 | V | B | -0.7538 | |
| 307 | Y | B | 0.0000 | |
| 308 | Y | B | 0.0000 | |
| 309 | C | B | 0.0000 | |
| 310 | S | B | 0.0000 | |
| 311 | Q | B | 0.0000 | |
| 312 | S | B | 0.0000 | |
| 313 | T | B | 0.0000 | |
| 314 | H | B | -0.0885 | |
| 315 | V | B | 0.8720 | |
| 316 | P | B | 0.3430 | |
| 317 | W | B | 0.0000 | |
| 318 | T | B | 0.1201 | |
| 319 | F | B | 0.1276 | |
| 320 | G | B | 0.0000 | |
| 321 | Q | B | -1.2647 | |
| 322 | G | B | 0.0000 | |
| 323 | T | B | 0.0000 | |
| 324 | K | B | -1.8229 | |
| 325 | V | B | 0.0000 | |
| 326 | E | B | -1.7213 | |
| 327 | I | B | 0.0000 | |
| 328 | K | B | -1.5107 | |
| 329 | R | B | -1.1427 | |
| 330 | T | B | -0.0480 | |
| 331 | V | B | 0.3171 | |
| 332 | A | B | -0.0727 | |
| 333 | A | B | -0.1503 | |
| 334 | P | B | 0.0000 | |
| 335 | S | B | -0.1131 | |
| 336 | V | B | -0.1519 | |
| 337 | F | B | 0.0000 | |
| 338 | I | B | 0.0000 | |
| 339 | F | B | 0.0000 | |
| 340 | P | B | -0.6873 | |
| 341 | P | B | 0.0000 | |
| 342 | S | B | -1.2790 | |
| 343 | D | B | -2.6922 | |
| 344 | E | B | -2.2487 | |
| 345 | Q | B | 0.0000 | |
| 346 | L | B | -1.9527 | |
| 347 | K | B | -2.5380 | |
| 348 | S | B | -1.6171 | |
| 349 | G | B | -1.0503 | |
| 350 | T | B | -1.0155 | |
| 351 | A | B | 0.0000 | |
| 352 | S | B | 0.0000 | |
| 353 | V | B | 0.0000 | |
| 354 | V | B | 0.0000 | |
| 355 | C | B | 0.0000 | |
| 356 | L | B | 0.0000 | |
| 357 | L | B | 0.0000 | |
| 358 | N | B | 0.0000 | |
| 359 | N | B | -1.1183 | |
| 360 | F | B | 0.0000 | |
| 361 | Y | B | 0.0000 | |
| 362 | P | B | -1.7849 | |
| 363 | R | B | -3.1733 | |
| 364 | E | B | -3.3041 | |
| 365 | A | B | -2.4314 | |
| 366 | K | B | -2.6533 | |
| 367 | V | B | -1.3752 | |
| 368 | Q | B | -1.2449 | |
| 369 | W | B | 0.0000 | |
| 370 | K | B | -0.9066 | |
| 371 | V | B | 0.0000 | |
| 372 | D | B | -2.1549 | |
| 373 | N | B | -1.6642 | |
| 374 | A | B | -0.3846 | |
| 375 | L | B | 0.5773 | |
| 376 | Q | B | -0.3344 | |
| 377 | S | B | -0.5689 | |
| 378 | G | B | -0.8998 | |
| 379 | N | B | -0.7986 | |
| 380 | S | B | -1.1237 | |
| 381 | Q | B | -1.2487 | |
| 382 | E | B | -1.4401 | |
| 383 | S | B | -0.6424 | |
| 384 | V | B | -0.7168 | |
| 385 | T | B | -1.2636 | |
| 386 | E | B | -2.3472 | |
| 387 | Q | B | 0.0000 | |
| 388 | D | B | -2.2140 | |
| 389 | S | B | -1.9540 | |
| 390 | K | B | -2.6410 | |
| 391 | D | B | -2.5520 | |
| 392 | S | B | 0.0000 | |
| 393 | T | B | 0.0000 | |
| 394 | Y | B | 0.0000 | |
| 395 | S | B | 0.0000 | |
| 396 | L | B | 0.0000 | |
| 397 | S | B | 0.0000 | |
| 398 | S | B | 0.0000 | |
| 399 | T | B | -0.5441 | |
| 400 | L | B | 0.0000 | |
| 401 | T | B | -0.4515 | |
| 402 | L | B | -0.7893 | |
| 403 | S | B | -1.3698 | |
| 404 | K | B | -2.1344 | |
| 405 | A | B | -2.1326 | |
| 406 | D | B | -2.9970 | |
| 407 | Y | B | 0.0000 | |
| 408 | E | B | -3.7204 | |
| 409 | K | B | -3.8287 | |
| 410 | H | B | -3.3045 | |
| 411 | K | B | -3.4098 | |
| 412 | V | B | -2.1386 | |
| 413 | Y | B | 0.0000 | |
| 414 | A | B | -0.9471 | |
| 415 | C | B | 0.0000 | |
| 416 | E | B | -1.0882 | |
| 417 | V | B | 0.0000 | |
| 418 | T | B | -1.3467 | |
| 419 | H | B | -1.6203 | |
| 420 | Q | B | -1.8232 | |
| 421 | G | B | -0.5197 | |
| 422 | L | B | -0.3092 | |
| 423 | S | B | -0.4517 | |
| 424 | S | B | -0.4402 | |
| 425 | P | B | -0.5657 | |
| 426 | V | B | 0.1082 | |
| 427 | T | B | -0.4808 | |
| 428 | K | B | -0.7460 | |
| 429 | S | B | -0.9951 | |
| 430 | F | B | 0.0000 | |
| 431 | N | B | -2.5092 | |
| 432 | R | B | -2.8778 | |
| 433 | G | B | -2.2710 | |
| 434 | E | B | -2.2230 | |
| 435 | C | B | -0.7103 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine