Project name: mAb4

Chain sequence(s)	H: QVQLQQSGPGLVKPSQTLSLTCAISGDSVSSNSAAWNWIRQSPSRGLEWLGRTYYRSKWYNDYAVSVKSRITINPDTSKNQFSLQLHSVTPEDTAVYYCARDVSSWYGWFDPWGQGTLVTVSS; L: QSALTQPRSVSGSPGQSVTISCTGTSSDVGGYNYVSWFQQHPGKAPQLMIYDVSNRPSGVPDRFSGSKSGNTASLTISGLQAEDEADYYCCSYAGSYTLVFGGGTKLTVLGQP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -2.5341
• Maximal score value: 1.7386
• Average score: -0.5885
• Total score value: -138.8869

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
2	Q	L	-0.2115
3	S	L	-0.2781
4	A	L	-0.3463
5	L	L	0.0000
6	T	L	-0.5627
7	Q	L	-0.8306
8	P	L	-1.4144
9	R	L	-2.5126
10	S	L	-1.7422
11	V	L	-0.6743
12	S	L	-0.2678
13	G	L	-0.2595
14	S	L	-0.6750
15	P	L	-1.4053
16	G	L	-1.5006
17	Q	L	-1.7885
18	S	L	-1.1041
19	V	L	-0.1718
20	T	L	-0.0462
21	I	L	0.0000
22	S	L	-0.2571
23	C	L	0.0000
24	T	L	-0.5114
25	G	L	-0.5863
26	T	L	-0.6491
27	S	L	-0.6654
28	S	L	-0.5078
29	D	L	0.0000
30	V	L	0.0000
30A	G	L	-1.0666
30B	G	L	-0.6911
30C	Y	L	-0.3652
31	N	L	-1.0786
32	Y	L	-0.0840
33	V	L	0.0000
34	S	L	0.0000
35	W	L	0.0000
36	F	L	0.0000
37	Q	L	0.0000
38	Q	L	-1.4551
39	H	L	-1.8783
40	P	L	-1.4198
41	G	L	-1.5775
42	K	L	-2.4635
43	A	L	-1.5340
44	P	L	0.0000
45	Q	L	-1.2251
46	L	L	0.0000
47	M	L	0.0000
48	I	L	0.0000
49	Y	L	-0.5078
50	D	L	-0.6894
51	V	L	-0.7718
52	S	L	-1.0273
53	N	L	-1.2998
54	R	L	-1.7510
55	P	L	-0.8394
56	S	L	-0.9416
57	G	L	-0.9008
58	V	L	-1.0009
59	P	L	-1.3819
60	D	L	-2.2969
61	R	L	-1.4422
62	F	L	0.0000
63	S	L	-1.0124
64	G	L	0.0000
65	S	L	-0.8023
66	K	L	-1.0845
67	S	L	-0.8963
68	G	L	-1.1058
69	N	L	-1.1358
70	T	L	-0.7848
71	A	L	0.0000
72	S	L	-0.3406
73	L	L	0.0000
74	T	L	-0.2626
75	I	L	0.0000
76	S	L	-1.2591
77	G	L	-1.4197
78	L	L	0.0000
79	Q	L	-1.9828
80	A	L	-1.6197
81	E	L	-2.4014
82	D	L	0.0000
83	E	L	-1.8814
84	A	L	0.0000
85	D	L	-1.5103
86	Y	L	0.0000
87	Y	L	0.0000
88	C	L	0.0000
89	C	L	0.0000
90	S	L	0.0000
91	Y	L	0.1714
92	A	L	0.0000
93	G	L	-0.2123
94	S	L	0.1156
95	Y	L	0.4990
95A	T	L	0.0000
96	L	L	0.0000
97	V	L	0.0000
98	F	L	0.0000
99	G	L	0.0000
100	G	L	-1.3006
101	G	L	-1.4875
102	T	L	0.0000
103	K	L	-2.5064
104	L	L	0.0000
105	T	L	-0.8332
106	V	L	0.0000
107	L	L	0.4302
108	G	L	-0.4869
109	Q	L	-0.9549
110	P	L	-0.6803
1	Q	H	-1.5526
2	V	H	-1.1888
3	Q	H	-2.0376
4	L	H	0.0000
5	Q	H	-1.9059
6	Q	H	-1.3384
7	S	H	-0.8424
8	G	H	-0.3154
9	P	H	0.1267
10	G	H	0.7046
11	L	H	1.1097
12	V	H	0.0000
13	K	H	-1.5435
14	P	H	-1.4199
15	S	H	-1.2993
16	Q	H	-1.6780
17	T	H	-1.2204
18	L	H	0.0000
19	S	H	-0.6323
20	L	H	0.0000
21	T	H	-0.7766
22	C	H	0.0000
23	A	H	-1.3223
24	I	H	0.0000
25	S	H	-1.5165
26	G	H	-1.2945
27	D	H	-1.1128
28	S	H	-0.7435
29	V	H	0.0000
30	S	H	-0.7403
31	S	H	-0.7863
31A	N	H	-1.2575
31B	S	H	-0.5282
32	A	H	0.0000
33	A	H	0.0000
34	W	H	0.0000
35	N	H	0.0000
36	W	H	0.0000
37	I	H	0.0000
38	R	H	-0.3611
39	Q	H	-0.6538
40	S	H	-1.0197
41	P	H	-0.9633
42	S	H	-1.3678
43	R	H	-2.5341
44	G	H	-1.4888
45	L	H	0.0000
46	E	H	-0.9146
47	W	H	0.0000
48	L	H	0.0000
49	G	H	0.0000
50	R	H	0.0000
51	T	H	0.0000
52	Y	H	0.0000
52A	Y	H	-0.2817
52B	R	H	-0.7427
53	S	H	-1.0732
54	K	H	-1.4566
55	W	H	-0.4201
56	Y	H	0.1727
57	N	H	-0.0232
58	D	H	0.0000
59	Y	H	0.0798
60	A	H	0.0000
61	V	H	1.0168
62	S	H	0.0438
63	V	H	0.0000
64	K	H	-1.2806
65	S	H	-1.0269
66	R	H	-1.4013
67	I	H	0.0000
68	T	H	-1.0052
69	I	H	0.0000
70	N	H	-1.5521
71	P	H	-1.2577
72	D	H	-1.6343
73	T	H	-1.3200
74	S	H	-1.3643
75	K	H	-2.2441
76	N	H	-1.6664
77	Q	H	-1.5920
78	F	H	0.0000
79	S	H	-0.8209
80	L	H	0.0000
81	Q	H	-0.8842
82	L	H	0.0000
82A	H	H	-1.2995
82B	S	H	-1.2345
82C	V	H	0.0000
83	T	H	-1.3861
84	P	H	-1.4555
85	E	H	-2.2150
86	D	H	0.0000
87	T	H	-0.2254
88	A	H	0.0000
89	V	H	0.7470
90	Y	H	0.0000
91	Y	H	0.0000
92	C	H	0.0000
93	A	H	0.0000
94	R	H	-0.4558
95	D	H	0.0000
96	V	H	0.2750
97	S	H	0.3034
98	S	H	0.1696
99	W	H	1.0462
100	Y	H	1.0093
100A	G	H	0.0000
100B	W	H	0.0000
100C	F	H	0.0000
101	D	H	-0.3879
102	P	H	-0.7013
103	W	H	-0.7471
104	G	H	0.0000
105	Q	H	-1.8096
106	G	H	0.0000
107	T	H	0.2331
108	L	H	1.7386
109	V	H	0.0000
110	T	H	0.3410
111	V	H	0.0000
112	S	H	-0.6405
113	S	H	-0.6387