Project name: 8458c227a085cfa

Chain sequence(s)	A: QSVEESGGRLVTPGTPLTLTCTVSGFSLSNYAMSWVRQAPGKGLEWIGIVSISAGTYYASWAKGRFTISKTSTTVVLRVTSPTTEDTATYFCATGGYTGNVWGPGTLVTVSSGQPKAPSVFPLAPCCGDTPSSTVTLGCLVKGYLPEPVTVTWNSGTLTNGVRTFPSVRQSSGLYSLSSVVSVTSSSQPVTCNVAHPATNTKVDKTVGAAPSTCSKPTCPPPELLGGPSVFIFPPKPKDTLMISRTPEVTCVVVDVSQDDPEVQFTWYINNEQVRTARPPLREQQFNSTIRVVSTLPIAHQDWLRGKEFKCKVHNKALPAPIEKTISKARGQPLEPKVYTMGPPREELSSRSVSLACMINGFYPSDISVEWEKNGKAEDNYKTTPAVLDSDGSYFLYSKLSVPTSEWQRGDVFTCSVMHEALHNHYTQKSISRSPGKGDYKDDDDKGDYKDDDDKGDYKDDDDKAEAAAKAAEAAAKADYKDDDDKGDYKDDDDKGDYKDDDDK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -5.1567
• Maximal score value: 2.7596
• Average score: -0.9348
• Total score value: -471.1226

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	A	-1.6932
2	S	A	-1.5329
3	V	A	0.0000
4	E	A	-2.4739
5	E	A	-1.6145
6	S	A	-1.1963
7	G	A	-1.1675
8	G	A	-0.8084
9	R	A	0.0392
10	L	A	1.8752
11	V	A	1.1235
12	T	A	0.5236
13	P	A	-0.5859
14	G	A	-0.7386
15	T	A	-0.2936
16	P	A	-0.5539
17	L	A	-0.3059
18	T	A	-0.8385
19	L	A	0.0000
20	T	A	-0.4906
21	C	A	0.0000
22	T	A	-0.7910
23	V	A	0.0000
24	S	A	-1.0567
25	G	A	-1.0058
26	F	A	-0.5800
27	S	A	-0.8573
28	L	A	0.0000
29	S	A	-1.1775
30	N	A	-1.1164
31	Y	A	-0.0653
32	A	A	0.3265
33	M	A	0.0000
34	S	A	0.0000
35	W	A	0.0000
36	V	A	0.0000
37	R	A	0.0000
38	Q	A	-0.8598
39	A	A	0.0000
40	P	A	-1.2468
41	G	A	-1.3507
42	K	A	-1.9450
43	G	A	-1.0328
44	L	A	0.0385
45	E	A	-0.2522
46	W	A	0.6937
47	I	A	0.0000
48	G	A	0.0000
49	I	A	1.4150
50	V	A	0.0000
51	S	A	0.2669
52	I	A	0.0000
53	S	A	-0.8615
54	A	A	-0.1945
55	G	A	-0.2065
56	T	A	0.7417
57	Y	A	1.6899
58	Y	A	2.0589
59	A	A	0.8709
60	S	A	0.3459
61	W	A	-0.0683
62	A	A	-0.6730
63	K	A	-1.1915
64	G	A	0.0000
65	R	A	-2.0569
66	F	A	0.0000
67	T	A	-0.4894
68	I	A	-0.4228
69	S	A	-0.8943
70	K	A	-1.8757
71	T	A	-0.9831
72	S	A	-0.7083
73	T	A	-0.7386
74	T	A	-0.6456
75	V	A	0.0000
76	V	A	-0.3190
77	L	A	0.0000
78	R	A	-1.7952
79	V	A	0.0000
80	T	A	-0.9461
81	S	A	-0.6295
82	P	A	0.0000
83	T	A	-0.9513
84	T	A	-1.0759
85	E	A	-1.9292
86	D	A	0.0000
87	T	A	-0.5126
88	A	A	0.0000
89	T	A	-0.4343
90	Y	A	0.0000
91	F	A	-0.2373
92	C	A	0.0000
93	A	A	0.0000
94	T	A	0.0000
95	G	A	0.8141
96	G	A	1.0833
97	Y	A	1.3920
98	T	A	0.7165
99	G	A	0.3632
100	N	A	-0.2084
101	V	A	1.5732
102	W	A	1.5204
103	G	A	0.3351
104	P	A	0.0064
105	G	A	0.0892
106	T	A	0.7624
107	L	A	1.2828
108	V	A	1.7170
109	T	A	0.9978
110	V	A	1.0235
111	S	A	0.5279
112	S	A	-0.3909
113	G	A	-0.7250
114	Q	A	0.0000
115	P	A	-1.1685
116	K	A	-1.4283
117	A	A	0.0000
118	P	A	-0.5971
119	S	A	0.4151
120	V	A	1.5548
121	F	A	2.6664
122	P	A	1.8952
123	L	A	1.7681
124	A	A	0.3670
125	P	A	0.0000
126	C	A	0.3080
127	C	A	-0.6151
128	G	A	-0.7068
129	D	A	-1.0448
130	T	A	-0.3768
131	P	A	-0.2760
132	S	A	0.0000
133	S	A	0.2354
134	T	A	0.8545
135	V	A	1.9996
136	T	A	1.2882
137	L	A	0.4943
138	G	A	0.0000
139	C	A	0.0000
140	L	A	-0.0700
141	V	A	0.0000
142	K	A	-0.7370
143	G	A	-0.5376
144	Y	A	0.0000
145	L	A	0.7086
146	P	A	0.0000
147	E	A	-0.7493
148	P	A	-0.7123
149	V	A	-0.4706
150	T	A	-0.4581
151	V	A	0.0000
152	T	A	-0.7593
153	W	A	0.0000
154	N	A	-0.7713
155	S	A	-0.8141
156	G	A	-0.6593
157	T	A	-0.4725
158	L	A	-0.2741
159	T	A	-0.9610
160	N	A	-1.4674
161	G	A	-0.8647
162	V	A	-0.8811
163	R	A	-1.6102
164	T	A	-0.2923
165	F	A	0.7451
166	P	A	0.1808
167	S	A	-0.0185
168	V	A	0.1835
169	R	A	-1.8911
170	Q	A	-1.7772
171	S	A	-1.2022
172	S	A	-1.1165
173	G	A	-0.3795
174	L	A	0.0000
175	Y	A	0.2979
176	S	A	0.0000
177	L	A	0.0053
178	S	A	0.0000
179	S	A	0.4940
180	V	A	1.8550
181	V	A	2.7596
182	S	A	1.9740
183	V	A	1.9069
184	T	A	0.9537
185	S	A	0.5925
186	S	A	-0.4059
187	S	A	-0.4583
188	Q	A	-0.8599
189	P	A	-0.8350
190	V	A	0.0000
191	T	A	-1.1889
192	C	A	0.0000
193	N	A	-1.6079
194	V	A	0.0000
195	A	A	-1.2261
196	H	A	0.0000
197	P	A	-1.1864
198	A	A	-0.1114
199	T	A	-0.5497
200	N	A	-1.5479
201	T	A	-1.0821
202	K	A	-2.2706
203	V	A	-1.4862
204	D	A	-2.6311
205	K	A	-2.0779
206	T	A	-1.3153
207	V	A	0.0000
208	G	A	-0.8677
209	A	A	-0.2163
210	A	A	-0.2386
211	P	A	-0.3571
212	S	A	-0.2331
213	T	A	0.0166
214	C	A	0.0599
215	S	A	-0.6346
216	K	A	-1.5263
217	P	A	-0.8956
218	T	A	-0.4228
219	C	A	0.1918
220	P	A	-0.5684
221	P	A	-0.7858
222	P	A	-0.7522
223	E	A	-0.9617
224	L	A	1.1433
225	L	A	1.5237
226	G	A	0.3150
227	G	A	-0.1426
228	P	A	0.0000
229	S	A	-0.2393
230	V	A	0.0000
231	F	A	0.9844
232	I	A	0.0000
233	F	A	1.0616
234	P	A	-0.0665
235	P	A	0.0000
236	K	A	-2.1286
237	P	A	-1.3683
238	K	A	-0.9768
239	D	A	-1.1189
240	T	A	0.0000
241	L	A	-0.2099
242	M	A	0.8260
243	I	A	1.7232
244	S	A	0.5268
245	R	A	-0.4498
246	T	A	-0.5551
247	P	A	0.0000
248	E	A	-1.2412
249	V	A	0.0000
250	T	A	0.3037
251	C	A	0.0000
252	V	A	0.0000
253	V	A	0.0000
254	V	A	-0.9825
255	D	A	-2.4293
256	V	A	0.0000
257	S	A	-2.3726
258	Q	A	-2.8604
259	D	A	-2.9944
260	D	A	-2.5564
261	P	A	-2.7673
262	E	A	-2.9908
263	V	A	-1.8060
264	Q	A	-1.7850
265	F	A	-0.9854
266	T	A	-0.9470
267	W	A	0.0000
268	Y	A	-1.9544
269	I	A	-1.9438
270	N	A	-2.9565
271	N	A	-3.0402
272	E	A	-2.9543
273	Q	A	-2.2459
274	V	A	-1.4624
275	R	A	-2.1213
276	T	A	-1.4254
277	A	A	-1.5579
278	R	A	-2.0687
279	P	A	-1.0536
280	P	A	-0.5163
281	L	A	0.0397
282	R	A	-2.1105
283	E	A	-2.7014
284	Q	A	-2.7942
285	Q	A	-1.8697
286	F	A	0.3907
287	N	A	-1.0690
288	S	A	-1.2145
289	T	A	-2.2913
290	I	A	0.0000
291	R	A	-2.3277
292	V	A	0.0000
293	V	A	-0.3865
294	S	A	0.0000
295	T	A	-0.7698
296	L	A	0.0000
297	P	A	-0.7915
298	I	A	0.0000
299	A	A	-0.9772
300	H	A	-1.0222
301	Q	A	-2.0159
302	D	A	-2.0227
303	W	A	0.0000
304	L	A	-1.5176
305	R	A	-2.8395
306	G	A	-2.2977
307	K	A	-2.2521
308	E	A	-2.1570
309	F	A	0.0000
310	K	A	-1.9758
311	C	A	0.0000
312	K	A	-1.3414
313	V	A	0.0000
314	H	A	-1.4974
315	N	A	0.0000
316	K	A	-2.5469
317	A	A	-1.2764
318	L	A	0.0000
319	P	A	-0.3806
320	A	A	-0.5287
321	P	A	-0.8166
322	I	A	-0.6284
323	E	A	-1.8695
324	K	A	-1.2025
325	T	A	-0.8680
326	I	A	0.0383
327	S	A	-0.9422
328	K	A	-1.3199
329	A	A	-1.2286
330	R	A	-2.5070
331	G	A	-1.7038
332	Q	A	-1.8080
333	P	A	-1.2483
334	L	A	-1.0139
335	E	A	-2.4105
336	P	A	0.0000
337	K	A	-1.9841
338	V	A	0.0000
339	Y	A	0.0054
340	T	A	-0.0282
341	M	A	0.1561
342	G	A	-0.7205
343	P	A	0.0000
344	P	A	-1.7619
345	R	A	-2.8913
346	E	A	-2.9381
347	E	A	-2.2279
348	L	A	-1.7487
349	S	A	-1.5423
350	S	A	-1.5460
351	R	A	-2.1363
352	S	A	-1.4183
353	V	A	0.0000
354	S	A	-0.4081
355	L	A	0.0000
356	A	A	0.0224
357	C	A	0.0000
358	M	A	0.2291
359	I	A	0.0000
360	N	A	-0.5842
361	G	A	-1.1064
362	F	A	0.0000
363	Y	A	-0.5698
364	P	A	0.0000
365	S	A	0.1736
366	D	A	-0.9727
367	I	A	-0.4640
368	S	A	-0.5439
369	V	A	0.0000
370	E	A	-1.4017
371	W	A	0.0000
372	E	A	-2.1365
373	K	A	-1.9608
374	N	A	-2.8620
375	G	A	-2.2209
376	K	A	-2.8727
377	A	A	-2.2164
378	E	A	-2.4408
379	D	A	-3.0230
380	N	A	-2.5525
381	Y	A	-2.0183
382	K	A	-2.3284
383	T	A	-1.0299
384	T	A	-0.3528
385	P	A	0.1110
386	A	A	0.7178
387	V	A	1.5398
388	L	A	1.3342
389	D	A	-0.3954
390	S	A	-1.0425
391	D	A	-1.9793
392	G	A	-0.8389
393	S	A	0.0000
394	Y	A	0.6363
395	F	A	0.6252
396	L	A	0.0000
397	Y	A	0.2457
398	S	A	0.0000
399	K	A	-1.3063
400	L	A	0.0000
401	S	A	-1.1794
402	V	A	0.0000
403	P	A	-1.4013
404	T	A	-1.5790
405	S	A	-1.6785
406	E	A	-1.7839
407	W	A	0.0000
408	Q	A	-2.6150
409	R	A	-3.0253
410	G	A	-2.3687
411	D	A	-2.1492
412	V	A	-1.4059
413	F	A	0.0000
414	T	A	-1.0486
415	C	A	0.0000
416	S	A	0.0000
417	V	A	0.0000
418	M	A	0.0000
419	H	A	0.0000
420	E	A	-1.0732
421	A	A	-1.3464
422	L	A	0.0000
423	H	A	-1.9543
424	N	A	-1.7885
425	H	A	-1.3338
426	Y	A	-0.4605
427	T	A	-0.9450
428	Q	A	-1.1211
429	K	A	-1.1005
430	S	A	-0.7659
431	I	A	0.0000
432	S	A	-1.6416
433	R	A	-2.6555
434	S	A	-1.6326
435	P	A	-1.2773
436	G	A	-1.7519
437	K	A	-2.6108
438	G	A	-2.2086
439	D	A	-2.1804
440	Y	A	-0.8245
441	K	A	-2.6701
442	D	A	-3.5778
443	D	A	-4.2713
444	D	A	-4.3169
445	D	A	-4.1731
446	K	A	-3.4426
447	G	A	-2.4672
448	D	A	-2.2964
449	Y	A	-1.0576
450	K	A	-2.7067
451	D	A	-3.5956
452	D	A	-4.2951
453	D	A	-4.2583
454	D	A	-3.9748
455	K	A	-3.5413
456	G	A	-2.2630
457	D	A	-2.0960
458	Y	A	-1.1070
459	K	A	-3.0622
460	D	A	-4.3333
461	D	A	-4.5346
462	D	A	-5.1567
463	D	A	-4.6972
464	K	A	-4.1627
465	A	A	-2.7753
466	E	A	-3.3199
467	A	A	-2.3517
468	A	A	-1.8832
469	A	A	-2.0905
470	K	A	-2.6506
471	A	A	-1.5045
472	A	A	-1.7169
473	E	A	-2.7011
474	A	A	-1.7032
475	A	A	-1.4201
476	A	A	-1.6561
477	K	A	-2.3771
478	A	A	-1.5161
479	D	A	-2.2570
480	Y	A	-1.3429
481	K	A	-3.2170
482	D	A	-4.0907
483	D	A	-4.3302
484	D	A	-4.7254
485	D	A	-4.2132
486	K	A	-3.5263
487	G	A	-2.4413
488	D	A	-2.3995
489	Y	A	-1.3648
490	K	A	-3.0817
491	D	A	-4.0756
492	D	A	-4.5037
493	D	A	-4.7537
494	D	A	-4.2804
495	K	A	-3.9145
496	G	A	-2.6371
497	D	A	-2.3768
498	Y	A	-1.1100
499	K	A	-3.1097
500	D	A	-4.0877
501	D	A	-4.5434
502	D	A	-4.6616
503	D	A	-4.2142
504	K	A	-3.2461