| Chain sequence(s) |
A: EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQAIYKQFDVDRSGTIGSSELPGAFEAAGFHLNEHLYSMIIRRYSDEGGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS C: DAIDALSSDFT B: EEVRQFRRLFAQLAGDDMEVSATELMNILNKVVTRHPDLKTDGFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKKWQAIYKQFDVDRSGTIGSSELPGAFEAAGFHLNEHLYSMIIRRYSDEGGNMDFDNFISCLVRLDAMFRAFKSLDKDGTGQIQVNIQEWLQLTMYS |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 94 | E | A | -3.5401 | |
| 95 | E | A | -3.8030 | |
| 96 | V | A | -3.0762 | |
| 97 | R | A | -4.1563 | |
| 98 | Q | A | -3.8798 | |
| 99 | F | A | -2.8989 | |
| 100 | R | A | -3.6855 | |
| 101 | R | A | -3.5040 | |
| 102 | L | A | 0.0000 | |
| 103 | F | A | 0.0000 | |
| 104 | A | A | -1.6839 | |
| 105 | Q | A | -1.8072 | |
| 106 | L | A | -1.3019 | |
| 107 | A | A | -1.2181 | |
| 108 | G | A | -1.8503 | |
| 109 | D | A | -2.6094 | |
| 110 | D | A | -2.6590 | |
| 111 | M | A | -1.3683 | |
| 112 | E | A | -1.5854 | |
| 113 | V | A | 0.0000 | |
| 114 | S | A | -0.9211 | |
| 115 | A | A | -0.4827 | |
| 116 | T | A | -0.4667 | |
| 117 | E | A | -0.9213 | |
| 118 | L | A | 0.0000 | |
| 119 | M | A | -0.5287 | |
| 120 | N | A | -1.2352 | |
| 121 | I | A | 0.0000 | |
| 122 | L | A | 0.0000 | |
| 123 | N | A | -1.5255 | |
| 124 | K | A | -1.8435 | |
| 125 | V | A | 0.0000 | |
| 126 | V | A | 0.0000 | |
| 127 | T | A | -1.7868 | |
| 128 | R | A | -2.5115 | |
| 129 | H | A | -2.0478 | |
| 130 | P | A | -2.0708 | |
| 131 | D | A | -3.0284 | |
| 132 | L | A | 0.0000 | |
| 133 | K | A | -2.8211 | |
| 134 | T | A | -2.2444 | |
| 135 | D | A | -2.3687 | |
| 136 | G | A | -1.5363 | |
| 137 | F | A | 0.0000 | |
| 138 | G | A | -0.2738 | |
| 139 | I | A | 0.4475 | |
| 140 | D | A | -0.0104 | |
| 141 | T | A | 0.0000 | |
| 142 | C | A | 0.0000 | |
| 143 | R | A | -0.4456 | |
| 144 | S | A | -0.0724 | |
| 145 | M | A | 0.0000 | |
| 146 | V | A | 0.0000 | |
| 147 | A | A | 0.0000 | |
| 148 | V | A | 0.2022 | |
| 149 | M | A | -0.1059 | |
| 150 | D | A | 0.0000 | |
| 151 | S | A | -1.1387 | |
| 152 | D | A | -2.0270 | |
| 153 | T | A | -1.2257 | |
| 154 | T | A | -1.0987 | |
| 155 | G | A | -1.2185 | |
| 156 | K | A | -1.5814 | |
| 157 | L | A | 0.0000 | |
| 158 | G | A | -1.2812 | |
| 159 | F | A | 0.0000 | |
| 160 | E | A | -1.7866 | |
| 161 | E | A | -1.1733 | |
| 162 | F | A | 0.0000 | |
| 163 | K | A | -0.6801 | |
| 164 | Y | A | 0.2487 | |
| 165 | L | A | 0.0000 | |
| 166 | W | A | 0.0000 | |
| 167 | N | A | -1.2644 | |
| 168 | N | A | -1.1296 | |
| 169 | I | A | 0.0000 | |
| 170 | K | A | -1.7969 | |
| 171 | K | A | -1.8959 | |
| 172 | W | A | 0.0000 | |
| 173 | Q | A | 0.0000 | |
| 174 | A | A | -0.9100 | |
| 175 | I | A | -0.7923 | |
| 176 | Y | A | 0.0000 | |
| 177 | K | A | -1.0862 | |
| 178 | Q | A | -0.9367 | |
| 179 | F | A | -0.3517 | |
| 180 | D | A | 0.0000 | |
| 181 | V | A | 0.0033 | |
| 182 | D | A | -1.8426 | |
| 183 | R | A | -2.6828 | |
| 184 | S | A | -1.9177 | |
| 185 | G | A | 0.0000 | |
| 186 | T | A | -1.5795 | |
| 187 | I | A | 0.0000 | |
| 188 | G | A | -0.9283 | |
| 189 | S | A | -0.8125 | |
| 190 | S | A | -0.6012 | |
| 191 | E | A | -0.4592 | |
| 192 | L | A | 0.0000 | |
| 193 | P | A | -1.0323 | |
| 194 | G | A | -1.1479 | |
| 195 | A | A | 0.0000 | |
| 196 | F | A | 0.0000 | |
| 197 | E | A | -2.2513 | |
| 198 | A | A | -1.2120 | |
| 199 | A | A | 0.0000 | |
| 200 | G | A | -1.4184 | |
| 201 | F | A | 0.0000 | |
| 202 | H | A | -1.8732 | |
| 203 | L | A | -1.5614 | |
| 204 | N | A | -1.9541 | |
| 205 | E | A | -2.5902 | |
| 206 | H | A | -2.1072 | |
| 207 | L | A | 0.0000 | |
| 208 | Y | A | -1.2801 | |
| 209 | S | A | -1.2958 | |
| 210 | M | A | -1.0423 | |
| 211 | I | A | 0.0000 | |
| 212 | I | A | -0.9274 | |
| 213 | R | A | -2.1914 | |
| 214 | R | A | 0.0000 | |
| 215 | Y | A | 0.0000 | |
| 216 | S | A | 0.0000 | |
| 217 | D | A | -2.5535 | |
| 218 | E | A | -2.8668 | |
| 219 | G | A | -1.8556 | |
| 220 | G | A | -1.8109 | |
| 221 | N | A | -1.4491 | |
| 222 | M | A | 0.0000 | |
| 223 | D | A | -1.5843 | |
| 224 | F | A | 0.0000 | |
| 225 | D | A | -1.0408 | |
| 226 | N | A | -0.7504 | |
| 227 | F | A | 0.0000 | |
| 228 | I | A | 0.0000 | |
| 229 | S | A | 0.0000 | |
| 230 | C | A | 0.0000 | |
| 231 | L | A | 0.0000 | |
| 232 | V | A | 0.0000 | |
| 233 | R | A | 0.0000 | |
| 234 | L | A | 0.0000 | |
| 235 | D | A | -1.1660 | |
| 236 | A | A | -0.9639 | |
| 237 | M | A | 0.0000 | |
| 238 | F | A | -1.2517 | |
| 239 | R | A | -2.4396 | |
| 240 | A | A | -1.2614 | |
| 241 | F | A | 0.0000 | |
| 242 | K | A | -2.9230 | |
| 243 | S | A | -1.9377 | |
| 244 | L | A | -1.6926 | |
| 245 | D | A | -2.8036 | |
| 246 | K | A | -3.1582 | |
| 247 | D | A | -3.1975 | |
| 248 | G | A | -2.3184 | |
| 249 | T | A | -1.7993 | |
| 250 | G | A | -1.5710 | |
| 251 | Q | A | -2.2688 | |
| 252 | I | A | 0.0000 | |
| 253 | Q | A | -2.2737 | |
| 254 | V | A | 0.0000 | |
| 255 | N | A | -1.8669 | |
| 256 | I | A | -1.2149 | |
| 257 | Q | A | -1.6886 | |
| 258 | E | A | -1.6763 | |
| 259 | W | A | 0.0000 | |
| 260 | L | A | 0.0000 | |
| 261 | Q | A | -0.8151 | |
| 262 | L | A | -0.1959 | |
| 263 | T | A | 0.0000 | |
| 264 | M | A | 0.0000 | |
| 265 | Y | A | 0.0000 | |
| 266 | S | A | 0.0000 | |
| 394 | E | B | -3.3142 | |
| 395 | E | B | -3.7289 | |
| 396 | V | B | -2.8579 | |
| 397 | R | B | -4.1402 | |
| 398 | Q | B | -3.7827 | |
| 399 | F | B | -2.6769 | |
| 400 | R | B | -3.8724 | |
| 401 | R | B | -3.4043 | |
| 402 | L | B | -1.3298 | |
| 403 | F | B | 0.0000 | |
| 404 | A | B | -1.4565 | |
| 405 | Q | B | -1.3912 | |
| 406 | L | B | -0.5293 | |
| 407 | A | B | -0.7456 | |
| 408 | G | B | -1.5905 | |
| 409 | D | B | -2.5901 | |
| 410 | D | B | -2.4942 | |
| 411 | M | B | -1.0563 | |
| 412 | E | B | -1.2414 | |
| 413 | V | B | 0.0000 | |
| 414 | S | B | -0.7343 | |
| 415 | A | B | -0.4018 | |
| 416 | T | B | -0.4324 | |
| 417 | E | B | -0.7522 | |
| 418 | L | B | 0.0000 | |
| 419 | M | B | -0.6303 | |
| 420 | N | B | -1.3066 | |
| 421 | I | B | 0.0000 | |
| 422 | L | B | 0.0000 | |
| 423 | N | B | -1.7973 | |
| 424 | K | B | -2.2392 | |
| 425 | V | B | -1.3134 | |
| 426 | V | B | -1.6591 | |
| 427 | T | B | -2.0637 | |
| 428 | R | B | -2.6752 | |
| 429 | H | B | -2.4842 | |
| 430 | P | B | -2.2323 | |
| 431 | D | B | -3.2356 | |
| 432 | L | B | 0.0000 | |
| 433 | K | B | -2.8791 | |
| 434 | T | B | -2.2033 | |
| 435 | D | B | -2.3664 | |
| 436 | G | B | -1.5985 | |
| 437 | F | B | 0.0000 | |
| 438 | G | B | -0.3146 | |
| 439 | I | B | 0.2194 | |
| 440 | D | B | -0.0794 | |
| 441 | T | B | -0.0606 | |
| 442 | C | B | 0.0000 | |
| 443 | R | B | -0.4302 | |
| 444 | S | B | -0.0677 | |
| 445 | M | B | 0.0000 | |
| 446 | V | B | 0.0000 | |
| 447 | A | B | 0.0000 | |
| 448 | V | B | 0.2186 | |
| 449 | M | B | -0.2340 | |
| 450 | D | B | 0.0000 | |
| 451 | S | B | -1.0912 | |
| 452 | D | B | -1.9914 | |
| 453 | T | B | -1.2383 | |
| 454 | T | B | -1.0526 | |
| 455 | G | B | -1.1332 | |
| 456 | K | B | -1.2982 | |
| 457 | L | B | 0.0000 | |
| 458 | G | B | -1.2763 | |
| 459 | F | B | 0.0000 | |
| 460 | E | B | -1.8919 | |
| 461 | E | B | -1.0919 | |
| 462 | F | B | 0.0000 | |
| 463 | K | B | -0.7487 | |
| 464 | Y | B | 0.2834 | |
| 465 | L | B | 0.0000 | |
| 466 | W | B | -0.8164 | |
| 467 | N | B | -1.3073 | |
| 468 | N | B | -1.4341 | |
| 469 | I | B | 0.0000 | |
| 470 | K | B | -2.7042 | |
| 471 | K | B | -2.5721 | |
| 472 | W | B | 0.0000 | |
| 473 | Q | B | -1.7442 | |
| 474 | A | B | -1.5454 | |
| 475 | I | B | 0.0000 | |
| 476 | Y | B | 0.0000 | |
| 477 | K | B | -1.6355 | |
| 478 | Q | B | -1.3126 | |
| 479 | F | B | -0.5876 | |
| 480 | D | B | 0.0000 | |
| 481 | V | B | -0.1119 | |
| 482 | D | B | -1.8405 | |
| 483 | R | B | -2.6960 | |
| 484 | S | B | -2.0265 | |
| 485 | G | B | 0.0000 | |
| 486 | T | B | -1.5924 | |
| 487 | I | B | 0.0000 | |
| 488 | G | B | -0.9519 | |
| 489 | S | B | -0.7393 | |
| 490 | S | B | -0.2836 | |
| 491 | E | B | -0.6195 | |
| 492 | L | B | 0.0000 | |
| 493 | P | B | -0.9475 | |
| 494 | G | B | -1.0584 | |
| 495 | A | B | 0.0000 | |
| 496 | F | B | 0.0000 | |
| 497 | E | B | -2.2977 | |
| 498 | A | B | -1.2730 | |
| 499 | A | B | -1.2754 | |
| 500 | G | B | -1.3538 | |
| 501 | F | B | 0.0000 | |
| 502 | H | B | -1.7471 | |
| 503 | L | B | -1.3623 | |
| 504 | N | B | -1.8308 | |
| 505 | E | B | -2.4756 | |
| 506 | H | B | -2.0053 | |
| 507 | L | B | 0.0000 | |
| 508 | Y | B | -1.0978 | |
| 509 | S | B | -1.0809 | |
| 510 | M | B | -0.8888 | |
| 511 | I | B | 0.0000 | |
| 512 | I | B | -1.0822 | |
| 513 | R | B | -2.0920 | |
| 514 | R | B | -1.1713 | |
| 515 | Y | B | 0.0000 | |
| 516 | S | B | 0.0000 | |
| 517 | D | B | -3.0526 | |
| 518 | E | B | -3.0540 | |
| 519 | G | B | -2.0487 | |
| 520 | G | B | -1.8797 | |
| 521 | N | B | -1.5601 | |
| 522 | M | B | 0.0000 | |
| 523 | D | B | -1.6714 | |
| 524 | F | B | 0.0000 | |
| 525 | D | B | 0.0000 | |
| 526 | N | B | -1.0294 | |
| 527 | F | B | 0.0000 | |
| 528 | I | B | 0.0000 | |
| 529 | S | B | -0.1840 | |
| 530 | C | B | 0.0000 | |
| 531 | L | B | 0.0000 | |
| 532 | V | B | 0.0000 | |
| 533 | R | B | -0.3333 | |
| 534 | L | B | 0.0000 | |
| 535 | D | B | -0.6988 | |
| 536 | A | B | -0.7710 | |
| 537 | M | B | 0.0000 | |
| 538 | F | B | -1.0882 | |
| 539 | R | B | -2.3133 | |
| 540 | A | B | -1.2295 | |
| 541 | F | B | 0.0000 | |
| 542 | K | B | -2.9348 | |
| 543 | S | B | -1.8531 | |
| 544 | L | B | -1.4414 | |
| 545 | D | B | -2.8057 | |
| 546 | K | B | -3.1732 | |
| 547 | D | B | -3.2262 | |
| 548 | G | B | -2.5267 | |
| 549 | T | B | -1.9249 | |
| 550 | G | B | -1.8787 | |
| 551 | Q | B | -2.8504 | |
| 552 | I | B | 0.0000 | |
| 553 | Q | B | -2.2019 | |
| 554 | V | B | 0.0000 | |
| 555 | N | B | -1.6648 | |
| 556 | I | B | -1.1356 | |
| 557 | Q | B | -1.8758 | |
| 558 | E | B | -2.0089 | |
| 559 | W | B | 0.0000 | |
| 560 | L | B | 0.0000 | |
| 561 | Q | B | -1.0059 | |
| 562 | L | B | -0.3232 | |
| 563 | T | B | 0.0000 | |
| 564 | M | B | 0.0000 | |
| 565 | Y | B | 0.0000 | |
| 566 | S | B | 0.0000 | |
| 601 | D | C | -2.5679 | |
| 602 | A | C | 0.0000 | |
| 603 | I | C | -1.8092 | |
| 604 | D | C | -2.8605 | |
| 605 | A | C | -1.4878 | |
| 606 | L | C | 0.0000 | |
| 607 | S | C | -1.7613 | |
| 608 | S | C | -1.3243 | |
| 609 | D | C | -1.6539 | |
| 610 | F | C | 0.0000 | |
| 611 | T | C | -0.7620 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine