Project name: 881a1be2deb194

Chain sequence(s)	A: GLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKF
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.9403
• Maximal score value: 3.2976
• Average score: -1.1455
• Total score value: -400.9229

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
39	G	A	0.7555
40	L	A	2.6578
41	I	A	3.2976
42	Y	A	2.7874
43	G	A	1.0495
44	N	A	0.3688
45	Y	A	2.1244
46	L	A	0.8548
47	H	A	-0.7674
48	L	A	-0.6429
49	E	A	-2.0550
50	K	A	-2.3594
51	V	A	-0.4552
52	L	A	0.2300
53	N	A	-1.6237
54	A	A	-1.1187
55	Q	A	-1.4090
56	E	A	-2.7298
57	L	A	0.0000
58	Q	A	-2.7344
59	S	A	0.0000
60	E	A	-4.1751
61	T	A	-2.9095
62	K	A	-3.1906
63	G	A	-2.9259
64	N	A	-3.5086
65	K	A	-3.7637
66	I	A	-2.6019
67	H	A	-2.1620
68	D	A	-1.3347
69	E	A	0.0000
70	H	A	-0.9937
71	L	A	0.2809
72	F	A	0.4503
73	I	A	0.0540
74	I	A	0.8506
75	T	A	0.0000
76	H	A	-0.1837
77	Q	A	0.0390
78	A	A	0.2391
79	Y	A	0.0000
80	E	A	-0.1398
81	L	A	0.7235
82	W	A	0.6594
83	F	A	0.0000
84	K	A	-0.3373
85	Q	A	-0.1010
86	I	A	0.0000
87	L	A	0.0000
88	W	A	0.6025
89	E	A	0.0000
90	L	A	0.0000
91	D	A	-0.8802
92	S	A	-0.9480
93	V	A	0.0000
94	R	A	-2.1184
95	E	A	-2.8946
96	I	A	-2.1806
97	F	A	0.0000
98	Q	A	-2.5580
99	N	A	-2.4804
100	G	A	-2.2068
101	H	A	-3.0369
102	V	A	0.0000
103	R	A	-3.5433
104	D	A	-3.3202
105	E	A	-3.7338
106	R	A	-3.1479
107	N	A	-2.0897
108	M	A	0.0000
109	L	A	0.3326
110	K	A	-0.8062
111	V	A	0.0000
112	V	A	-0.3510
113	S	A	-0.9500
114	R	A	-1.2001
115	M	A	0.0000
116	H	A	-1.7711
117	R	A	-1.9133
118	V	A	0.0000
119	S	A	0.0000
120	V	A	-0.0618
121	I	A	0.0000
122	L	A	0.0000
123	K	A	-1.2438
124	L	A	0.2366
125	L	A	0.0000
126	V	A	0.0000
127	Q	A	-1.1464
128	Q	A	-0.4922
129	F	A	0.0000
130	S	A	-0.4767
131	I	A	0.6448
132	L	A	0.0000
133	E	A	-1.0854
134	T	A	-0.3333
135	M	A	0.0000
136	T	A	-0.4412
137	A	A	-0.5919
138	L	A	0.2937
139	D	A	-1.2925
140	F	A	0.0000
141	N	A	-1.8013
142	D	A	-2.9241
143	F	A	0.0000
144	R	A	-2.0810
145	E	A	-2.4647
146	Y	A	-1.7320
147	L	A	-0.6743
148	S	A	-0.9052
149	P	A	-0.8274
150	A	A	-0.5169
151	S	A	-0.7139
152	G	A	-0.8044
153	F	A	-0.8035
154	Q	A	-1.8500
155	S	A	-0.8098
156	L	A	-0.6771
157	Q	A	-0.3600
158	F	A	0.0000
159	R	A	0.0000
160	L	A	0.0000
161	L	A	0.0000
162	E	A	0.0000
163	N	A	0.0000
164	K	A	-1.2611
165	I	A	0.0000
166	G	A	0.0000
167	V	A	0.0000
168	L	A	-0.3823
169	Q	A	-1.7812
170	N	A	-1.9794
171	M	A	0.0000
172	R	A	0.0000
173	V	A	0.0000
174	P	A	-1.0264
175	Y	A	-0.6257
176	N	A	0.0000
177	R	A	-2.6601
178	R	A	-3.1620
179	H	A	-2.8710
180	Y	A	0.0000
181	R	A	-3.1864
182	D	A	-3.8762
183	N	A	-3.1177
184	F	A	0.0000
185	K	A	-3.7440
186	G	A	-3.0127
187	E	A	-3.5541
188	E	A	-3.5659
189	N	A	-3.4802
190	E	A	-3.2024
191	L	A	-2.0436
192	L	A	0.0000
193	L	A	-1.8799
194	K	A	-3.0706
195	S	A	0.0000
196	E	A	-2.1250
197	Q	A	-2.9308
198	E	A	-3.4620
199	K	A	-3.0454
200	T	A	0.0000
201	L	A	0.0000
202	L	A	0.0000
203	E	A	-1.8058
204	L	A	0.0000
205	V	A	0.0000
206	E	A	-1.2734
207	A	A	-1.2049
208	W	A	-1.2257
209	L	A	0.0000
210	E	A	-1.8627
211	R	A	-2.5683
212	T	A	0.0000
213	P	A	-0.6656
214	G	A	0.0000
215	L	A	0.0000
216	E	A	-1.6754
217	P	A	-1.5070
218	H	A	-1.6721
219	G	A	-1.3450
220	F	A	0.0000
221	N	A	-1.4025
222	F	A	0.0000
223	W	A	-1.0945
224	G	A	-1.3803
225	K	A	-1.8371
226	L	A	0.0000
227	E	A	-2.0388
228	K	A	-2.4646
229	N	A	-2.3489
230	I	A	0.0000
231	T	A	-2.5152
232	R	A	-3.5344
233	G	A	0.0000
234	L	A	0.0000
235	E	A	-3.3810
236	E	A	-3.4345
237	E	A	-2.5909
238	F	A	-1.4524
239	I	A	-1.1505
240	R	A	-2.6783
241	I	A	0.0000
242	Q	A	-2.7577
243	A	A	-2.3096
244	K	A	-4.1929
245	E	A	-4.2020
246	E	A	-4.4121
247	S	A	-4.0335
248	E	A	-4.4093
249	E	A	-4.7912
250	K	A	-4.9403
251	E	A	-4.8321
252	E	A	-4.4916
253	Q	A	-3.8525
254	V	A	-2.8569
255	A	A	-2.8646
256	E	A	-4.0557
257	F	A	0.0000
258	Q	A	-3.3875
259	K	A	-3.9022
260	Q	A	-2.8250
261	K	A	-3.0392
262	E	A	-3.1564
263	V	A	-1.4242
264	L	A	0.0000
265	L	A	-0.7607
266	S	A	-1.3269
267	L	A	0.0000
268	F	A	-1.1405
269	D	A	-2.8202
270	E	A	-3.6629
271	K	A	-4.1771
272	R	A	-4.0025
273	H	A	0.0000
274	E	A	-3.9388
275	H	A	-3.6307
276	L	A	-2.9190
277	L	A	-2.3268
278	S	A	-2.2643
279	K	A	-2.9820
280	G	A	-2.5088
281	E	A	-2.9647
282	R	A	-2.0375
283	R	A	-1.1419
284	L	A	0.0000
285	S	A	-1.1459
286	Y	A	-1.5754
287	R	A	-2.0495
288	A	A	0.0000
289	L	A	0.0000
290	Q	A	-0.8528
291	G	A	0.0000
292	A	A	0.0000
293	L	A	0.0000
294	M	A	0.0000
295	I	A	0.0000
296	Y	A	-0.3554
297	F	A	0.0000
298	Y	A	0.0000
299	R	A	-2.2466
300	E	A	-2.7934
301	E	A	-2.1693
302	P	A	-1.8907
303	R	A	-2.0228
304	F	A	0.0000
305	Q	A	-2.0323
306	V	A	-0.7224
307	P	A	0.0000
308	F	A	-0.7456
309	Q	A	-0.5797
310	L	A	0.0000
311	L	A	0.0000
312	T	A	-0.3571
313	S	A	0.0000
314	L	A	0.0000
315	M	A	-0.3557
316	D	A	-1.1276
317	I	A	0.0000
318	D	A	0.0000
319	S	A	-0.9080
320	L	A	0.0000
321	M	A	0.0000
322	T	A	-0.7532
323	K	A	-1.0848
324	W	A	-0.6554
325	R	A	0.0000
326	Y	A	-0.0140
327	N	A	-0.5275
328	H	A	-0.2992
329	V	A	0.0000
330	C	A	-0.2828
331	M	A	0.0000
332	V	A	-0.9553
333	H	A	-1.5099
334	R	A	-1.4825
335	M	A	0.0000
336	L	A	0.0000
337	G	A	-1.3728
338	S	A	-1.4747
339	K	A	-1.9457
340	A	A	-1.1655
341	G	A	-0.8402
342	T	A	-0.9619
343	G	A	-0.7814
344	G	A	-0.6624
345	S	A	0.0000
346	S	A	-0.8790
347	G	A	0.0000
348	Y	A	-1.2145
349	H	A	-1.5702
350	Y	A	0.0000
351	L	A	0.0000
352	R	A	-0.9823
353	S	A	-0.8200
354	T	A	0.0000
355	V	A	-0.5148
356	S	A	-1.1511
357	D	A	-2.4984
358	R	A	-2.1773
359	Y	A	0.0000
360	K	A	-1.1577
361	V	A	0.0000
362	F	A	0.0000
363	V	A	0.0000
364	D	A	0.0000
365	L	A	0.0000
366	F	A	-0.2404
367	N	A	-0.9758
368	L	A	0.0000
369	S	A	-0.0288
370	T	A	-0.0131
371	Y	A	0.5665
372	L	A	1.0455
373	I	A	0.0000
374	P	A	-0.9620
375	R	A	-2.2860
376	H	A	-2.1046
377	W	A	-1.7999
378	I	A	-1.1878
379	P	A	0.0000
380	K	A	-2.2280
381	M	A	-1.2696
382	N	A	-1.7167
383	P	A	-1.0296
384	T	A	-0.6148
385	I	A	-0.2119
386	H	A	-1.2075
387	K	A	-1.2551
388	F	A	0.6906