| Chain sequence(s) |
A: DQSFLWNVFQRVDKDRSGVISDTELQQALSNGTWTPFNPVTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQNVFRTYDRDNSGMIDKNELKQALSGFGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIVLQRLTDIFRRYDTDQDGWIQVSYEQYLSMVFSIV C: GPPYPTYPGYPGYSQ B: QSFLWNVFQRVDKDRSGVISDTELQQALSNGTWTPFNPVTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQNVFRTYDRDNSGMIDKNELKQALSGFGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIVLQRLTDIFRRYDTDQDGWIQVSYEQYLSMVFSIV D: QGPPYPTYPGYP |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 24 | D | A | -1.9198 | |
| 25 | Q | A | -1.6635 | |
| 26 | S | A | -0.7399 | |
| 27 | F | A | 0.2324 | |
| 28 | L | A | 0.0000 | |
| 29 | W | A | -0.5386 | |
| 30 | N | A | -1.4273 | |
| 31 | V | A | -0.8799 | |
| 32 | F | A | 0.0000 | |
| 33 | Q | A | -3.2053 | |
| 34 | R | A | -3.5002 | |
| 35 | V | A | 0.0000 | |
| 36 | D | A | 0.0000 | |
| 37 | K | A | -4.1299 | |
| 38 | D | A | -3.9595 | |
| 39 | R | A | -3.8981 | |
| 40 | S | A | -2.1731 | |
| 41 | G | A | -1.4588 | |
| 42 | V | A | -0.9338 | |
| 43 | I | A | 0.0000 | |
| 44 | S | A | -1.3376 | |
| 45 | D | A | -1.6371 | |
| 46 | T | A | -1.4868 | |
| 47 | E | A | -1.8190 | |
| 48 | L | A | 0.0000 | |
| 49 | Q | A | -1.4474 | |
| 50 | Q | A | -1.6928 | |
| 51 | A | A | -0.8646 | |
| 52 | L | A | -0.4237 | |
| 53 | S | A | -0.3796 | |
| 54 | N | A | 0.0000 | |
| 55 | G | A | -0.3424 | |
| 56 | T | A | 0.1644 | |
| 57 | W | A | 0.9744 | |
| 58 | T | A | 0.2459 | |
| 59 | P | A | -0.4050 | |
| 60 | F | A | 0.0000 | |
| 61 | N | A | -0.3129 | |
| 62 | P | A | -0.1999 | |
| 63 | V | A | 0.8892 | |
| 64 | T | A | 0.0000 | |
| 65 | V | A | 0.0000 | |
| 66 | R | A | -1.4552 | |
| 67 | S | A | -0.4425 | |
| 68 | I | A | 0.0000 | |
| 69 | I | A | 0.0000 | |
| 70 | S | A | -1.3145 | |
| 71 | M | A | -0.6941 | |
| 72 | F | A | -0.9891 | |
| 73 | D | A | 0.0000 | |
| 74 | R | A | -3.1924 | |
| 75 | E | A | -3.5206 | |
| 76 | N | A | -2.9216 | |
| 77 | K | A | -1.9527 | |
| 78 | A | A | -1.4678 | |
| 79 | G | A | 0.0000 | |
| 80 | V | A | 0.0000 | |
| 81 | N | A | -0.5749 | |
| 82 | F | A | 0.0150 | |
| 83 | S | A | -0.2424 | |
| 84 | E | A | -0.6084 | |
| 85 | F | A | 0.0000 | |
| 86 | T | A | -0.7037 | |
| 87 | G | A | -0.6844 | |
| 88 | V | A | 0.0000 | |
| 89 | W | A | -0.6535 | |
| 90 | K | A | -2.0864 | |
| 91 | Y | A | 0.0000 | |
| 92 | I | A | -1.0935 | |
| 93 | T | A | -1.8158 | |
| 94 | D | A | -2.7331 | |
| 95 | W | A | 0.0000 | |
| 96 | Q | A | -2.3558 | |
| 97 | N | A | -2.6643 | |
| 98 | V | A | -1.5620 | |
| 99 | F | A | 0.0000 | |
| 100 | R | A | -3.2305 | |
| 101 | T | A | -2.0135 | |
| 102 | Y | A | -2.2318 | |
| 103 | D | A | 0.0000 | |
| 104 | R | A | -3.6155 | |
| 105 | D | A | -3.6851 | |
| 106 | N | A | -3.1939 | |
| 107 | S | A | -2.0237 | |
| 108 | G | A | -1.6767 | |
| 109 | M | A | 0.0000 | |
| 110 | I | A | 0.0000 | |
| 111 | D | A | -2.1508 | |
| 112 | K | A | -2.2594 | |
| 113 | N | A | -2.3708 | |
| 114 | E | A | -2.3457 | |
| 115 | L | A | 0.0000 | |
| 116 | K | A | -2.4974 | |
| 117 | Q | A | -2.0679 | |
| 118 | A | A | 0.0000 | |
| 119 | L | A | 0.0000 | |
| 120 | S | A | -1.5701 | |
| 121 | G | A | -1.2631 | |
| 122 | F | A | 0.0000 | |
| 123 | G | A | -0.9072 | |
| 124 | Y | A | 0.0000 | |
| 125 | R | A | -2.1949 | |
| 126 | L | A | -1.4391 | |
| 127 | S | A | -1.6447 | |
| 128 | D | A | -2.5097 | |
| 129 | Q | A | -2.2089 | |
| 130 | F | A | 0.0000 | |
| 131 | H | A | 0.0000 | |
| 132 | D | A | -2.8385 | |
| 133 | I | A | -1.3226 | |
| 134 | L | A | 0.0000 | |
| 135 | I | A | 0.0000 | |
| 136 | R | A | -2.8633 | |
| 137 | K | A | -1.4278 | |
| 138 | F | A | -1.1540 | |
| 139 | D | A | 0.0000 | |
| 140 | R | A | -2.8136 | |
| 141 | Q | A | -2.1025 | |
| 142 | G | A | -2.4962 | |
| 143 | R | A | -2.8830 | |
| 144 | G | A | -2.4664 | |
| 145 | Q | A | -2.0403 | |
| 146 | I | A | 0.0000 | |
| 147 | A | A | 0.0000 | |
| 148 | F | A | 0.0000 | |
| 149 | D | A | 0.0000 | |
| 150 | D | A | 0.0000 | |
| 151 | F | A | 0.0000 | |
| 152 | I | A | 0.0000 | |
| 153 | Q | A | 0.3279 | |
| 154 | G | A | 0.0000 | |
| 155 | C | A | 0.0000 | |
| 156 | I | A | -0.0449 | |
| 157 | V | A | -0.0542 | |
| 158 | L | A | 0.0000 | |
| 159 | Q | A | -0.6275 | |
| 160 | R | A | -1.1506 | |
| 161 | L | A | 0.0000 | |
| 162 | T | A | 0.0000 | |
| 163 | D | A | -1.3635 | |
| 164 | I | A | -1.0249 | |
| 165 | F | A | 0.0000 | |
| 166 | R | A | -2.1569 | |
| 167 | R | A | -2.2209 | |
| 168 | Y | A | -1.3751 | |
| 169 | D | A | 0.0000 | |
| 170 | T | A | -1.8630 | |
| 171 | D | A | -2.5440 | |
| 172 | Q | A | -2.4812 | |
| 173 | D | A | -2.4965 | |
| 174 | G | A | 0.0000 | |
| 175 | W | A | -0.5932 | |
| 176 | I | A | 0.0000 | |
| 177 | Q | A | -1.2826 | |
| 178 | V | A | 0.0000 | |
| 179 | S | A | -0.6361 | |
| 180 | Y | A | -0.7691 | |
| 181 | E | A | -0.8329 | |
| 182 | Q | A | -0.8229 | |
| 183 | Y | A | 0.0000 | |
| 184 | L | A | 0.0000 | |
| 185 | S | A | -0.0782 | |
| 186 | M | A | 0.0000 | |
| 187 | V | A | 0.0000 | |
| 188 | F | A | 0.0000 | |
| 189 | S | A | 0.1263 | |
| 190 | I | A | 0.9459 | |
| 191 | V | A | 1.6416 | |
| 25 | Q | B | -0.6813 | |
| 26 | S | B | 0.1052 | |
| 27 | F | B | 1.2305 | |
| 28 | L | B | 0.0000 | |
| 29 | W | B | 0.0441 | |
| 30 | N | B | -1.0524 | |
| 31 | V | B | 0.0000 | |
| 32 | F | B | 0.0000 | |
| 33 | Q | B | -3.0069 | |
| 34 | R | B | -3.3993 | |
| 35 | V | B | 0.0000 | |
| 36 | D | B | 0.0000 | |
| 37 | K | B | -3.9074 | |
| 38 | D | B | -3.8476 | |
| 39 | R | B | -3.7335 | |
| 40 | S | B | -2.0228 | |
| 41 | G | B | -1.3572 | |
| 42 | V | B | -0.8521 | |
| 43 | I | B | 0.0000 | |
| 44 | S | B | -1.1440 | |
| 45 | D | B | -1.0539 | |
| 46 | T | B | -1.0160 | |
| 47 | E | B | -1.5957 | |
| 48 | L | B | 0.0000 | |
| 49 | Q | B | -1.0505 | |
| 50 | Q | B | -1.6461 | |
| 51 | A | B | -1.1121 | |
| 52 | L | B | -0.4872 | |
| 53 | S | B | -0.3546 | |
| 54 | N | B | 0.0000 | |
| 55 | G | B | -0.3337 | |
| 56 | T | B | 0.0640 | |
| 57 | W | B | 0.9324 | |
| 58 | T | B | 0.1798 | |
| 59 | P | B | -0.3545 | |
| 60 | F | B | 0.0000 | |
| 61 | N | B | 0.0000 | |
| 62 | P | B | 0.0261 | |
| 63 | V | B | 1.0790 | |
| 64 | T | B | 0.0000 | |
| 65 | V | B | 0.0000 | |
| 66 | R | B | -1.2201 | |
| 67 | S | B | -0.4253 | |
| 68 | I | B | 0.0000 | |
| 69 | I | B | 0.0000 | |
| 70 | S | B | -1.4738 | |
| 71 | M | B | -0.5020 | |
| 72 | F | B | -0.9759 | |
| 73 | D | B | -2.0951 | |
| 74 | R | B | -3.2458 | |
| 75 | E | B | -3.5511 | |
| 76 | N | B | -2.8887 | |
| 77 | K | B | -1.9013 | |
| 78 | A | B | -1.4374 | |
| 79 | G | B | 0.0000 | |
| 80 | V | B | 0.0000 | |
| 81 | N | B | -0.6203 | |
| 82 | F | B | 0.2100 | |
| 83 | S | B | -0.0949 | |
| 84 | E | B | -0.5347 | |
| 85 | F | B | 0.0000 | |
| 86 | T | B | -0.5270 | |
| 87 | G | B | -0.6730 | |
| 88 | V | B | 0.0000 | |
| 89 | W | B | -0.9948 | |
| 90 | K | B | -2.2051 | |
| 91 | Y | B | 0.0000 | |
| 92 | I | B | 0.0000 | |
| 93 | T | B | -1.9102 | |
| 94 | D | B | -2.6779 | |
| 95 | W | B | 0.0000 | |
| 96 | Q | B | -2.1873 | |
| 97 | N | B | -2.6046 | |
| 98 | V | B | 0.0000 | |
| 99 | F | B | 0.0000 | |
| 100 | R | B | -3.0117 | |
| 101 | T | B | -2.1695 | |
| 102 | Y | B | 0.0000 | |
| 103 | D | B | 0.0000 | |
| 104 | R | B | -3.8656 | |
| 105 | D | B | -3.6205 | |
| 106 | N | B | -3.1883 | |
| 107 | S | B | -2.1004 | |
| 108 | G | B | -1.7550 | |
| 109 | M | B | 0.0000 | |
| 110 | I | B | 0.0000 | |
| 111 | D | B | -1.9727 | |
| 112 | K | B | -1.7260 | |
| 113 | N | B | -2.2066 | |
| 114 | E | B | 0.0000 | |
| 115 | L | B | 0.0000 | |
| 116 | K | B | -1.7751 | |
| 117 | Q | B | -1.6535 | |
| 118 | A | B | 0.0000 | |
| 119 | L | B | 0.0000 | |
| 120 | S | B | -1.1595 | |
| 121 | G | B | -0.8017 | |
| 122 | F | B | -0.3088 | |
| 123 | G | B | -0.8269 | |
| 124 | Y | B | -1.0937 | |
| 125 | R | B | -2.0674 | |
| 126 | L | B | -1.3481 | |
| 127 | S | B | -1.3760 | |
| 128 | D | B | -1.8977 | |
| 129 | Q | B | -1.5576 | |
| 130 | F | B | 0.0000 | |
| 131 | H | B | 0.0000 | |
| 132 | D | B | -1.4280 | |
| 133 | I | B | -0.6055 | |
| 134 | L | B | 0.0000 | |
| 135 | I | B | 0.0000 | |
| 136 | R | B | -2.7735 | |
| 137 | K | B | -1.6531 | |
| 138 | F | B | -1.2990 | |
| 139 | D | B | -2.4397 | |
| 140 | R | B | -2.7497 | |
| 141 | Q | B | -2.6413 | |
| 142 | G | B | -2.7805 | |
| 143 | R | B | -3.0212 | |
| 144 | G | B | -2.4190 | |
| 145 | Q | B | -2.0840 | |
| 146 | I | B | 0.0000 | |
| 147 | A | B | 0.0000 | |
| 148 | F | B | 0.0000 | |
| 149 | D | B | 0.0000 | |
| 150 | D | B | 0.0000 | |
| 151 | F | B | 0.0000 | |
| 152 | I | B | 0.0000 | |
| 153 | Q | B | 0.0000 | |
| 154 | G | B | 0.0000 | |
| 155 | C | B | 0.0000 | |
| 156 | I | B | 0.0000 | |
| 157 | V | B | -0.4615 | |
| 158 | L | B | 0.0000 | |
| 159 | Q | B | -1.1040 | |
| 160 | R | B | -1.9475 | |
| 161 | L | B | 0.0000 | |
| 162 | T | B | -1.5599 | |
| 163 | D | B | -2.2360 | |
| 164 | I | B | -1.5478 | |
| 165 | F | B | 0.0000 | |
| 166 | R | B | -2.9464 | |
| 167 | R | B | -2.6223 | |
| 168 | Y | B | -1.6581 | |
| 169 | D | B | 0.0000 | |
| 170 | T | B | -2.1002 | |
| 171 | D | B | -2.9234 | |
| 172 | Q | B | -3.2634 | |
| 173 | D | B | -2.8324 | |
| 174 | G | B | -1.6529 | |
| 175 | W | B | -0.9742 | |
| 176 | I | B | 0.0000 | |
| 177 | Q | B | -1.3083 | |
| 178 | V | B | 0.0000 | |
| 179 | S | B | -0.5460 | |
| 180 | Y | B | 0.0000 | |
| 181 | E | B | -0.7735 | |
| 182 | Q | B | -0.6852 | |
| 183 | Y | B | 0.0000 | |
| 184 | L | B | 0.0000 | |
| 185 | S | B | -0.0371 | |
| 186 | M | B | 0.0000 | |
| 187 | V | B | 0.0000 | |
| 188 | F | B | 0.0000 | |
| 189 | S | B | 0.6334 | |
| 190 | I | B | 1.2193 | |
| 191 | V | B | 2.1372 | |
| 2 | G | C | -1.2988 | |
| 3 | P | C | -1.6212 | |
| 4 | P | C | -1.2715 | |
| 5 | Y | C | 0.0000 | |
| 6 | P | C | 0.0000 | |
| 7 | T | C | 0.2711 | |
| 8 | Y | C | 1.1125 | |
| 9 | P | C | 0.2898 | |
| 10 | G | C | -0.0735 | |
| 11 | Y | C | -0.2263 | |
| 12 | P | C | -0.8898 | |
| 13 | G | C | -1.0284 | |
| 14 | Y | C | -0.1815 | |
| 15 | S | C | -0.6132 | |
| 16 | Q | C | -1.2442 | |
| 1 | Q | D | -1.7313 | |
| 2 | G | D | -1.1892 | |
| 3 | P | D | -0.2753 | |
| 4 | P | D | 0.0067 | |
| 5 | Y | D | 1.0369 | |
| 6 | P | D | 0.2996 | |
| 7 | T | D | -0.1917 | |
| 8 | Y | D | 0.1175 | |
| 9 | P | D | -0.6349 | |
| 10 | G | D | -0.0343 | |
| 11 | Y | D | 0.0597 | |
| 12 | P | D | -0.0216 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine