Project name: TS10-8

Chain sequence(s)	H: QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYSVHWVRQAPGQGLEWMGVINTYSGNTDYAQKFQGRVTMTRDTSTSTVYMELSSLRSEDTAVYYCARGYGSWFAYWGQGTTLTVSSDIQMTQSPSSLSASVGDRVTITCSVQSSISSSGLHWYQQKPEKAPKSLIFGTSNRASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQHWSSYPLTFGAGTKLEIK
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.1752
• Maximal score value: 1.9159
• Average score: -0.2419
• Total score value: -54.4282

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	Q	H	-1.1681
2	V	H	-0.3170
3	Q	H	-1.1679
4	L	H	0.0000
5	V	H	1.4544
6	Q	H	0.0000
7	S	H	-0.1480
8	G	H	-0.4672
9	A	H	-0.1290
10	E	H	-0.2082
11	V	H	1.5899
12	K	H	-0.4325
13	K	H	-1.7954
14	P	H	-0.4610
15	G	H	-0.5097
16	A	H	-0.0884
17	S	H	-0.0932
18	V	H	0.0000
19	K	H	-1.8303
20	V	H	0.0000
21	S	H	-0.0059
22	C	H	0.0000
23	K	H	-0.9003
24	A	H	0.0000
25	S	H	-0.2174
26	G	H	-0.3982
27	Y	H	0.2802
28	T	H	0.3437
29	F	H	1.9159
30	T	H	-0.0451
31	D	H	-1.8021
32	Y	H	0.0000
33	S	H	-0.0426
34	V	H	0.0000
35	H	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	R	H	-0.2095
39	Q	H	-0.1662
40	A	H	-0.0584
41	P	H	-0.3383
42	G	H	-0.7308
43	Q	H	-1.3132
44	G	H	-0.3836
45	L	H	0.0000
46	E	H	-0.4144
47	W	H	0.0000
48	M	H	0.0000
49	G	H	0.0000
50	V	H	0.0000
51	I	H	0.0000
52	N	H	-0.3184
53	T	H	0.0000
54	Y	H	1.2766
55	S	H	0.0029
56	G	H	-0.3952
57	N	H	-1.2998
58	T	H	-0.4853
59	D	H	-1.1482
60	Y	H	0.1707
61	A	H	0.0000
62	Q	H	-1.2479
63	K	H	-1.8691
64	F	H	0.0000
65	Q	H	-1.2842
66	G	H	-0.7807
67	R	H	-0.6039
68	V	H	0.0000
69	T	H	-0.1263
70	M	H	0.0000
71	T	H	-0.1219
72	R	H	-0.6108
73	D	H	-0.9962
74	T	H	-0.2362
75	S	H	-0.2221
76	T	H	-0.0590
77	S	H	0.0000
78	T	H	0.0000
79	V	H	0.0000
80	Y	H	0.2801
81	M	H	0.0000
82	E	H	-1.1120
83	L	H	0.0000
84	S	H	-0.1211
85	S	H	-0.2960
86	L	H	0.0000
87	R	H	-1.4668
88	S	H	-0.7499
89	E	H	-1.8501
90	D	H	0.0000
91	T	H	-0.0169
92	A	H	0.0000
93	V	H	0.2738
94	Y	H	0.0000
95	Y	H	0.0000
96	C	H	0.0000
97	A	H	0.0000
98	R	H	0.0000
99	G	H	0.0000
100	Y	H	0.6611
101	G	H	0.0221
102	S	H	-0.0329
103	W	H	0.1210
104	F	H	0.0000
105	A	H	0.0977
106	Y	H	0.4709
107	W	H	0.1963
108	G	H	0.0000
109	Q	H	-1.2090
110	G	H	-0.2777
111	T	H	0.0000
112	T	H	-0.0028
113	L	H	0.0000
114	T	H	0.1680
115	V	H	0.0000
116	S	H	-0.2081
117	S	H	-0.2437
118	D	H	-1.7512
119	I	H	-0.3367
120	Q	H	-1.1617
121	M	H	0.0000
122	T	H	-0.0729
123	Q	H	0.0000
124	S	H	-0.1617
125	P	H	-0.1499
126	S	H	-0.2639
127	S	H	-0.3634
128	L	H	0.2893
129	S	H	-0.3394
130	A	H	0.0000
131	S	H	0.1752
132	V	H	1.2966
133	G	H	-0.3810
134	D	H	-1.2065
135	R	H	-1.9985
136	V	H	0.0000
137	T	H	-0.0725
138	I	H	0.0000
139	T	H	-0.0294
140	C	H	0.0000
141	S	H	-0.2760
142	V	H	0.0000
143	Q	H	-1.2284
144	S	H	-0.4229
145	S	H	-0.2649
146	I	H	0.0000
147	S	H	-0.2565
148	S	H	-0.2589
149	S	H	-0.0775
150	G	H	0.0000
151	L	H	0.0000
152	H	H	0.0000
153	W	H	0.0000
154	Y	H	0.0000
155	Q	H	0.0000
156	Q	H	0.0000
157	K	H	-0.3630
158	P	H	-0.6458
159	E	H	-2.1752
160	K	H	-2.0281
161	A	H	-0.3081
162	P	H	-0.2453
163	K	H	-1.2037
164	S	H	0.0000
165	L	H	0.0000
166	I	H	0.0000
167	F	H	0.3451
168	G	H	-0.0506
169	T	H	0.0000
170	S	H	-0.3665
171	N	H	-1.0145
172	R	H	-0.9481
173	A	H	-0.1816
174	S	H	-0.2965
175	G	H	-0.4694
176	V	H	0.0943
177	P	H	-0.1202
178	S	H	-0.2929
179	R	H	-0.3723
180	F	H	0.0000
181	S	H	-0.1071
182	G	H	-0.1315
183	S	H	-0.2513
184	G	H	-0.2389
185	S	H	-0.2787
186	G	H	-0.2626
187	T	H	-0.3809
188	D	H	-1.8023
189	F	H	0.0000
190	T	H	-0.0237
191	L	H	0.0000
192	T	H	-0.0214
193	I	H	0.0000
194	S	H	-0.3858
195	S	H	-0.2305
196	L	H	0.0000
197	Q	H	-0.4380
198	P	H	-0.6056
199	E	H	-1.8568
200	D	H	0.0000
201	F	H	1.3620
202	A	H	0.0000
203	T	H	-0.2441
204	Y	H	0.0000
205	Y	H	0.0000
206	C	H	0.0000
207	Q	H	0.0000
208	H	H	0.0000
209	W	H	0.2321
210	S	H	-0.0465
211	S	H	0.0525
212	Y	H	1.0291
213	P	H	0.2699
214	L	H	0.0000
215	T	H	0.0233
216	F	H	0.1841
217	G	H	0.0000
218	A	H	0.0502
219	G	H	-0.0347
220	T	H	0.0000
221	K	H	-1.6637
222	L	H	0.0000
223	E	H	-1.6574
224	I	H	0.4054
225	K	H	-1.5114