Project name: 8b517a5b6efb97c

Chain sequence(s)	A: DHHEGQPRSVCALEENAKRALISCVQTHLTADTTQKLSAVKDQLHCDDVYCVFVRICDRNNGTLEHPSNEFFSNAEKTDIRSAVVTCRENLQRQAEAAKTSGGGGSAGLGGAGLYGGSLSPLGSFSSLGGIGYLGGLSPFGGLGNPLSSLGYPGLLGGQGGKFPGDLRLITEPTSGLPVSEAVYVGLERQRLVPAPYRVPRPAPVPVPHVVPQPFTVDVPIPQPFEVPVGGGGSFRFPLICHLFGKKCVPKADCPTENVSWILGCGAKSVCCNTAKMPFCSTLGGTCQAVCGGNIQRNVTCSGIKTCCIYTSKSNQATASNHVRRHSNKFIRNGFEGGGGSSEIKYHNYNSNGFNPKGPGPGILFGDAFIPAIVQPVSQIFPGPGPGILFNSLQYTNVVKDYWGNDLGPGPGKETVLRVAVTAQHPKPASLMGPGPGYDAGIELAHLLAFNKYGPGPGHDKKQFAALMLYEEDGTLRVEGVGPGPGKRHGKRLRVTKVIPHAKYNEKSEAAAKFYPSYHSTPQRPGTP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.9473
• Maximal score value: 2.3321
• Average score: -0.8336
• Total score value: -440.153

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	A	-2.6179
2	H	A	-2.9829
3	H	A	-3.3151
4	E	A	-3.4954
5	G	A	-2.5638
6	Q	A	-2.9835
7	P	A	-2.1488
8	R	A	-2.4930
9	S	A	-0.7777
10	V	A	0.3406
11	C	A	-0.2445
12	A	A	-1.1262
13	L	A	-0.8289
14	E	A	-1.6095
15	E	A	-2.7193
16	N	A	-2.6399
17	A	A	-1.5846
18	K	A	-2.3828
19	R	A	-2.4735
20	A	A	-1.1871
21	L	A	-0.4315
22	I	A	-0.3466
23	S	A	-0.4639
24	C	A	0.0835
25	V	A	0.0000
26	Q	A	-0.7849
27	T	A	-0.5196
28	H	A	-0.6330
29	L	A	0.0474
30	T	A	-0.7796
31	A	A	-1.0892
32	D	A	-2.4333
33	T	A	-1.7822
34	T	A	-1.5906
35	Q	A	-2.5053
36	K	A	-2.8187
37	L	A	-1.6242
38	S	A	-1.8100
39	A	A	-1.7445
40	V	A	-1.4189
41	K	A	-2.5552
42	D	A	-3.0433
43	Q	A	-2.4988
44	L	A	-2.2108
45	H	A	-2.1352
46	C	A	-1.5539
47	D	A	-1.5218
48	D	A	-1.0145
49	V	A	0.0000
50	Y	A	0.6575
51	C	A	0.0000
52	V	A	0.6451
53	F	A	0.4547
54	V	A	-0.0187
55	R	A	-0.8053
56	I	A	0.0000
57	C	A	-1.9031
58	D	A	-3.0108
59	R	A	-3.3794
60	N	A	-2.6940
61	N	A	-2.6983
62	G	A	-2.0241
63	T	A	-1.8629
64	L	A	-1.5994
65	E	A	-2.2813
66	H	A	-2.2053
67	P	A	-2.1658
68	S	A	-2.1100
69	N	A	-2.6388
70	E	A	-2.3453
71	F	A	-1.2177
72	F	A	0.0000
73	S	A	-2.0453
74	N	A	-2.4311
75	A	A	-1.9160
76	E	A	-2.9091
77	K	A	-3.1493
78	T	A	-2.7161
79	D	A	-3.0485
80	I	A	-1.9355
81	R	A	-2.3322
82	S	A	-1.5319
83	A	A	-1.0374
84	V	A	-0.5414
85	V	A	-0.3741
86	T	A	-1.1328
87	C	A	0.0000
88	R	A	-2.7457
89	E	A	-3.2833
90	N	A	-3.0229
91	L	A	-2.4137
92	Q	A	-3.4659
93	R	A	-3.9473
94	Q	A	-2.7635
95	A	A	0.0000
96	E	A	-2.8254
97	A	A	-1.8780
98	A	A	0.0000
99	K	A	-1.4375
100	T	A	-0.9695
101	S	A	-0.9798
102	G	A	-0.9498
103	G	A	-0.8829
104	G	A	0.0000
105	G	A	-0.6465
106	S	A	-0.8337
107	A	A	0.0000
108	G	A	-0.1028
109	L	A	0.0000
110	G	A	0.0000
111	G	A	-0.2480
112	A	A	-0.2175
113	G	A	-0.2688
114	L	A	0.5063
115	Y	A	1.2170
116	G	A	0.0000
117	G	A	0.0000
118	S	A	0.0000
119	L	A	0.0000
120	S	A	0.0000
121	P	A	0.2853
122	L	A	1.1420
123	G	A	0.2593
124	S	A	0.3276
125	F	A	0.5161
126	S	A	0.0000
127	S	A	0.0000
128	L	A	0.0000
129	G	A	0.0000
130	G	A	0.0000
131	I	A	0.0000
132	G	A	0.0000
133	Y	A	-0.0051
134	L	A	0.0000
135	G	A	-0.6722
136	G	A	-0.3385
137	L	A	0.0192
138	S	A	0.0451
139	P	A	0.4121
140	F	A	0.2378
141	G	A	0.0000
142	G	A	0.0000
143	L	A	-0.1444
144	G	A	-0.2081
145	N	A	0.0000
146	P	A	-0.1403
147	L	A	0.0000
148	S	A	0.0000
149	S	A	0.3164
150	L	A	1.1914
151	G	A	-0.0857
152	Y	A	0.0000
153	P	A	0.0000
154	G	A	0.0000
155	L	A	0.0000
156	L	A	-0.6016
157	G	A	-1.0011
158	G	A	-1.7176
159	Q	A	-1.6189
160	G	A	-1.6311
161	G	A	-1.7545
162	K	A	-2.1026
163	F	A	0.0000
164	P	A	-1.2485
165	G	A	-1.6794
166	D	A	-2.3288
167	L	A	-2.0687
168	R	A	-2.1583
169	L	A	0.0983
170	I	A	0.9167
171	T	A	0.5019
172	E	A	-0.4019
173	P	A	-0.3055
174	T	A	-0.0032
175	S	A	-0.2345
176	G	A	0.0663
177	L	A	0.9264
178	P	A	0.5030
179	V	A	0.6150
180	S	A	-0.1338
181	E	A	-0.9810
182	A	A	-0.1583
183	V	A	0.5796
184	Y	A	1.0517
185	V	A	2.3321
186	G	A	1.1633
187	L	A	0.7987
188	E	A	-1.7742
189	R	A	-3.3195
190	Q	A	-2.9826
191	R	A	-1.9240
192	L	A	1.1299
193	V	A	1.7966
194	P	A	0.9278
195	A	A	0.5000
196	P	A	0.2618
197	Y	A	0.5728
198	R	A	-0.9206
199	V	A	0.0834
200	P	A	-0.9267
201	R	A	-2.0176
202	P	A	-0.9857
203	A	A	-0.2548
204	P	A	0.4838
205	V	A	1.9121
206	P	A	1.2243
207	V	A	1.8504
208	P	A	0.7131
209	H	A	0.3047
210	V	A	1.5556
211	V	A	0.9726
212	P	A	-0.1119
213	Q	A	-1.1063
214	P	A	-0.7648
215	F	A	-0.4340
216	T	A	-0.4687
217	V	A	-0.4182
218	D	A	-0.9890
219	V	A	0.8323
220	P	A	0.4715
221	I	A	0.8291
222	P	A	0.0447
223	Q	A	-0.9091
224	P	A	-0.2359
225	F	A	0.5268
226	E	A	-0.5731
227	V	A	0.6481
228	P	A	0.7899
229	V	A	1.3742
230	G	A	-0.0603
231	G	A	-0.3833
232	G	A	-0.5917
233	G	A	-0.3540
234	S	A	0.0589
235	F	A	0.7068
236	R	A	-0.8539
237	F	A	-0.4852
238	P	A	-0.4090
239	L	A	0.0000
240	I	A	-0.0968
241	C	A	-0.4848
242	H	A	0.0000
243	L	A	0.0000
244	F	A	0.0358
245	G	A	-0.6258
246	K	A	-2.3317
247	K	A	-2.5920
248	C	A	-1.5301
249	V	A	-0.9782
250	P	A	-1.2707
251	K	A	-2.4949
252	A	A	-1.6650
253	D	A	-2.2750
254	C	A	0.0000
255	P	A	0.0000
256	T	A	-1.8539
257	E	A	-2.4058
258	N	A	-1.8593
259	V	A	-1.0368
260	S	A	0.0000
261	W	A	-0.5118
262	I	A	-0.7554
263	L	A	0.0000
264	G	A	0.0000
265	C	A	0.0000
266	G	A	-1.4977
267	A	A	-1.4645
268	K	A	-2.2396
269	S	A	0.0000
270	V	A	-0.9816
271	C	A	0.0000
272	C	A	0.0000
273	N	A	0.0000
274	T	A	-1.1371
275	A	A	-0.7660
276	K	A	-1.0687
277	M	A	0.1637
278	P	A	0.1372
279	F	A	1.0550
280	C	A	0.0000
281	S	A	0.2745
282	T	A	0.5621
283	L	A	0.9555
284	G	A	-0.0897
285	G	A	-0.6581
286	T	A	-0.6040
287	C	A	-0.3676
288	Q	A	0.0000
289	A	A	0.0000
290	V	A	-0.7485
291	C	A	-0.5573
292	G	A	-1.1572
293	G	A	-1.0950
294	N	A	-1.5666
295	I	A	0.0000
296	Q	A	-2.4960
297	R	A	-3.0324
298	N	A	-2.4737
299	V	A	-1.1664
300	T	A	-0.3224
301	C	A	0.0000
302	S	A	-0.1381
303	G	A	-0.4177
304	I	A	0.0000
305	K	A	-1.1892
306	T	A	0.0000
307	C	A	0.0000
308	C	A	0.0000
309	I	A	0.0000
310	Y	A	0.3620
311	T	A	-1.1183
312	S	A	-1.9005
313	K	A	-2.2144
314	S	A	-1.6521
315	N	A	-1.6903
316	Q	A	-1.5752
317	A	A	-0.9187
318	T	A	-0.7820
319	A	A	0.0000
320	S	A	-1.1108
321	N	A	-1.5832
322	H	A	-1.3619
323	V	A	0.0000
324	R	A	-2.7719
325	R	A	-2.6999
326	H	A	0.0000
327	S	A	0.0000
328	N	A	-2.9240
329	K	A	-3.3393
330	F	A	0.0000
331	I	A	0.0000
332	R	A	-3.4518
333	N	A	-2.5407
334	G	A	-1.3817
335	F	A	0.0000
336	E	A	0.0000
337	G	A	-1.4136
338	G	A	-1.7930
339	G	A	-1.9338
340	G	A	-1.1881
341	S	A	-1.0535
342	S	A	-1.6824
343	E	A	-1.3955
344	I	A	0.0000
345	K	A	0.0000
346	Y	A	-0.2138
347	H	A	-0.4859
348	N	A	0.0000
349	Y	A	-0.4390
350	N	A	-1.6367
351	S	A	-0.8798
352	N	A	0.0000
353	G	A	-1.0502
354	F	A	0.0000
355	N	A	-1.9823
356	P	A	0.0000
357	K	A	-2.7208
358	G	A	-1.9774
359	P	A	-1.1909
360	G	A	-1.0679
361	P	A	-0.7057
362	G	A	0.0000
363	I	A	0.0000
364	L	A	0.0000
365	F	A	0.0000
366	G	A	-0.2677
367	D	A	-0.0398
368	A	A	0.1502
369	F	A	1.1001
370	I	A	1.0715
371	P	A	0.0000
372	A	A	0.2162
373	I	A	0.5730
374	V	A	0.1992
375	Q	A	0.0000
376	P	A	0.0000
377	V	A	0.0000
378	S	A	0.0000
379	Q	A	-1.6199
380	I	A	-0.3758
381	F	A	-0.1741
382	P	A	-0.8471
383	G	A	-1.1651
384	P	A	-1.2998
385	G	A	-0.9886
386	P	A	-0.8710
387	G	A	-0.5957
388	I	A	0.0000
389	L	A	0.0000
390	F	A	0.0000
391	N	A	-0.5506
392	S	A	-0.4145
393	L	A	0.0000
394	Q	A	-0.1750
395	Y	A	0.0000
396	T	A	-0.8715
397	N	A	-1.2076
398	V	A	-0.1208
399	V	A	-0.0615
400	K	A	-1.3724
401	D	A	-1.5613
402	Y	A	0.0000
403	W	A	0.0000
404	G	A	0.0000
405	N	A	-0.9430
406	D	A	-1.5153
407	L	A	0.3273
408	G	A	-0.3594
409	P	A	-0.9668
410	G	A	-0.8855
411	P	A	-1.0258
412	G	A	-1.2311
413	K	A	-1.9859
414	E	A	-1.3917
415	T	A	0.0000
416	V	A	0.0000
417	L	A	0.0000
418	R	A	0.0000
419	V	A	0.0000
420	A	A	0.0000
421	V	A	0.0000
422	T	A	-0.1584
423	A	A	-0.8465
424	Q	A	-1.3470
425	H	A	-1.5737
426	P	A	-1.3665
427	K	A	-2.1753
428	P	A	-1.1936
429	A	A	0.0000
430	S	A	-0.6501
431	L	A	0.0000
432	M	A	0.0000
433	G	A	0.0000
434	P	A	-0.2262
435	G	A	-0.6176
436	P	A	-0.5152
437	G	A	-0.1773
438	Y	A	0.1241
439	D	A	-1.1466
440	A	A	0.0000
441	G	A	0.0000
442	I	A	1.1959
443	E	A	0.0367
444	L	A	0.0000
445	A	A	-0.3292
446	H	A	-0.5687
447	L	A	0.0000
448	L	A	0.0000
449	A	A	-1.3101
450	F	A	-0.4754
451	N	A	0.0000
452	K	A	-1.8501
453	Y	A	0.3584
454	G	A	-0.2992
455	P	A	-0.8773
456	G	A	-0.5298
457	P	A	-0.6567
458	G	A	-0.8821
459	H	A	-1.1133
460	D	A	-1.6270
461	K	A	-1.7429
462	K	A	-2.4144
463	Q	A	-1.7406
464	F	A	0.0000
465	A	A	0.0000
466	A	A	0.0000
467	L	A	0.0000
468	M	A	0.0000
469	L	A	-0.6002
470	Y	A	0.0000
471	E	A	-1.8726
472	E	A	-3.1045
473	D	A	-2.9053
474	G	A	-2.0117
475	T	A	-2.0443
476	L	A	-1.9144
477	R	A	-2.1116
478	V	A	0.0000
479	E	A	-2.0814
480	G	A	-1.1775
481	V	A	-0.7272
482	G	A	0.0000
483	P	A	-2.0409
484	G	A	-2.3961
485	P	A	-1.6119
486	G	A	-1.8392
487	K	A	-2.9851
488	R	A	-2.4217
489	H	A	-2.4962
490	G	A	-2.8290
491	K	A	-3.7599
492	R	A	-3.1474
493	L	A	-2.0233
494	R	A	-2.3093
495	V	A	-0.6748
496	T	A	-0.9952
497	K	A	-1.4189
498	V	A	0.0000
499	I	A	0.0000
500	P	A	0.0000
501	H	A	-0.6641
502	A	A	-0.9367
503	K	A	-2.2370
504	Y	A	-1.8231
505	N	A	-2.7367
506	E	A	-2.7739
507	K	A	-3.1066
508	S	A	-2.5054
509	E	A	-2.8921
510	A	A	-1.8507
511	A	A	0.0000
512	A	A	-2.1275
513	K	A	-2.5425
514	F	A	-1.2536
515	Y	A	0.0000
516	P	A	-0.5511
517	S	A	-1.1043
518	Y	A	-1.0191
519	H	A	-1.1956
520	S	A	-0.9256
521	T	A	-1.0510
522	P	A	-1.4976
523	Q	A	-2.5041
524	R	A	-2.7579
525	P	A	-1.7368
526	G	A	-1.5229
527	T	A	-1.5464
528	P	A	-0.9879