| Chain sequence(s) |
A: KVRWPDFNQEAYVGGTMVRSGQDPYARNKFNQVESDKLRMDRAIPDTRHDQCQRKQWRVDLPATSVVITFHNEARSALLRTVVSVLKKSPPHLIKEIILVDDYSNDPEDGALLGKIEKVRVLRNDRREGLMRSRVRGADAAQAKVLTFLDSHCECNEHWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGGFDWNLVFKWDYMTPEQRRSRQGNPVAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDVWGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGTVFARNTRRAAEVWMDEYKNFYYAAVPSARNVPYGNIQSRLELRKKLSCKPFKWYLENVYPELRVPDHQDIAFGALQQGTNCLDTLGHFADGVVGVYECHNAGGNQEWALTKEKSVKHMDLCLTVVDRAPGSLIKLQGCRENDSRQKWEQIEGNSKLRHVGSNLCLDSRTAKSGGLSVEVCGPALSQQWKFTLN P: STTPAPTTK |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 75 | K | A | -2.7556 | |
| 76 | V | A | -2.6980 | |
| 77 | R | A | -3.0476 | |
| 78 | W | A | -2.3362 | |
| 79 | P | A | -1.9532 | |
| 80 | D | A | -2.7187 | |
| 81 | F | A | 0.0000 | |
| 82 | N | A | -2.3872 | |
| 83 | Q | A | -2.2639 | |
| 84 | E | A | -2.6815 | |
| 85 | A | A | -1.4979 | |
| 86 | Y | A | 0.0000 | |
| 87 | V | A | 0.0000 | |
| 88 | G | A | -1.0743 | |
| 89 | G | A | -0.6787 | |
| 90 | T | A | -0.2231 | |
| 91 | M | A | 0.0147 | |
| 92 | V | A | -1.0299 | |
| 93 | R | A | -2.2020 | |
| 94 | S | A | -1.7210 | |
| 95 | G | A | -1.8349 | |
| 96 | Q | A | -2.4745 | |
| 97 | D | A | -2.6504 | |
| 98 | P | A | -1.4852 | |
| 99 | Y | A | -0.9566 | |
| 100 | A | A | -1.3125 | |
| 101 | R | A | -1.7675 | |
| 102 | N | A | 0.0000 | |
| 103 | K | A | -1.6456 | |
| 104 | F | A | 0.0000 | |
| 105 | N | A | -1.0497 | |
| 106 | Q | A | 0.0000 | |
| 107 | V | A | -0.3289 | |
| 108 | E | A | -1.3083 | |
| 109 | S | A | 0.0000 | |
| 110 | D | A | -1.1822 | |
| 111 | K | A | -2.0276 | |
| 112 | L | A | -1.5379 | |
| 113 | R | A | -2.4821 | |
| 114 | M | A | -1.3513 | |
| 115 | D | A | -1.0574 | |
| 116 | R | A | -0.7967 | |
| 117 | A | A | -0.4333 | |
| 118 | I | A | -0.5763 | |
| 119 | P | A | -1.1713 | |
| 120 | D | A | -2.5071 | |
| 121 | T | A | -1.7093 | |
| 122 | R | A | -2.1698 | |
| 123 | H | A | -2.2843 | |
| 124 | D | A | -3.4364 | |
| 125 | Q | A | -3.1204 | |
| 126 | C | A | 0.0000 | |
| 127 | Q | A | -3.5691 | |
| 128 | R | A | -3.6293 | |
| 129 | K | A | -2.8507 | |
| 130 | Q | A | -1.9938 | |
| 131 | W | A | -0.6532 | |
| 132 | R | A | -0.7749 | |
| 133 | V | A | 0.4465 | |
| 134 | D | A | -1.1353 | |
| 135 | L | A | 0.0000 | |
| 136 | P | A | -0.8940 | |
| 137 | A | A | -1.2783 | |
| 138 | T | A | 0.0000 | |
| 139 | S | A | 0.0000 | |
| 140 | V | A | 0.0000 | |
| 141 | V | A | 0.0000 | |
| 142 | I | A | 0.0000 | |
| 143 | T | A | -0.2385 | |
| 144 | F | A | 0.0000 | |
| 145 | H | A | -0.4540 | |
| 146 | N | A | -1.0097 | |
| 147 | E | A | 0.0000 | |
| 148 | A | A | 0.0000 | |
| 149 | R | A | 0.0000 | |
| 150 | S | A | 0.0000 | |
| 151 | A | A | 0.0000 | |
| 152 | L | A | 0.0000 | |
| 153 | L | A | 0.0000 | |
| 154 | R | A | 0.0000 | |
| 155 | T | A | 0.0000 | |
| 156 | V | A | 0.0000 | |
| 157 | V | A | 0.0000 | |
| 158 | S | A | 0.0000 | |
| 159 | V | A | 0.0000 | |
| 160 | L | A | -0.9360 | |
| 161 | K | A | -1.5659 | |
| 162 | K | A | -1.4396 | |
| 163 | S | A | 0.0000 | |
| 164 | P | A | -0.7927 | |
| 165 | P | A | -1.2484 | |
| 166 | H | A | -1.4171 | |
| 167 | L | A | 0.0000 | |
| 168 | I | A | 0.0000 | |
| 169 | K | A | -2.0870 | |
| 170 | E | A | 0.0000 | |
| 171 | I | A | 0.0000 | |
| 172 | I | A | 0.0000 | |
| 173 | L | A | 0.0000 | |
| 174 | V | A | 0.0000 | |
| 175 | D | A | 0.0000 | |
| 176 | D | A | 0.0000 | |
| 177 | Y | A | -0.9733 | |
| 178 | S | A | 0.0000 | |
| 179 | N | A | -1.8014 | |
| 180 | D | A | -1.9311 | |
| 181 | P | A | -1.4684 | |
| 182 | E | A | -1.7635 | |
| 183 | D | A | 0.0000 | |
| 184 | G | A | 0.0000 | |
| 185 | A | A | -0.7263 | |
| 186 | L | A | -0.3482 | |
| 187 | L | A | 0.0000 | |
| 188 | G | A | -1.2479 | |
| 189 | K | A | -2.5169 | |
| 190 | I | A | 0.0000 | |
| 191 | E | A | -2.0488 | |
| 192 | K | A | -1.8638 | |
| 193 | V | A | 0.0000 | |
| 194 | R | A | -0.7802 | |
| 195 | V | A | -0.0834 | |
| 196 | L | A | -0.2297 | |
| 197 | R | A | -0.9981 | |
| 198 | N | A | 0.0000 | |
| 199 | D | A | -2.7028 | |
| 200 | R | A | -2.7540 | |
| 201 | R | A | -1.5683 | |
| 202 | E | A | -1.3389 | |
| 203 | G | A | 0.0000 | |
| 204 | L | A | -0.1936 | |
| 205 | M | A | 0.0000 | |
| 206 | R | A | -0.5250 | |
| 207 | S | A | 0.0000 | |
| 208 | R | A | 0.0000 | |
| 209 | V | A | -1.0254 | |
| 210 | R | A | -1.5166 | |
| 211 | G | A | 0.0000 | |
| 212 | A | A | 0.0000 | |
| 213 | D | A | -2.4152 | |
| 214 | A | A | -1.3292 | |
| 215 | A | A | 0.0000 | |
| 216 | Q | A | -2.0045 | |
| 217 | A | A | 0.0000 | |
| 218 | K | A | -1.2968 | |
| 219 | V | A | 0.0000 | |
| 220 | L | A | 0.0000 | |
| 221 | T | A | 0.0000 | |
| 222 | F | A | 0.0000 | |
| 223 | L | A | 0.0000 | |
| 224 | D | A | -0.5149 | |
| 225 | S | A | 0.0000 | |
| 226 | H | A | 0.0000 | |
| 227 | C | A | 0.0000 | |
| 228 | E | A | 0.0000 | |
| 229 | C | A | 0.0000 | |
| 230 | N | A | 0.0000 | |
| 231 | E | A | -2.4954 | |
| 232 | H | A | -1.6408 | |
| 233 | W | A | 0.0000 | |
| 234 | L | A | 0.0000 | |
| 235 | E | A | 0.0000 | |
| 236 | P | A | -0.5660 | |
| 237 | L | A | 0.0000 | |
| 238 | L | A | 0.0000 | |
| 239 | E | A | -1.1607 | |
| 240 | R | A | -1.4460 | |
| 241 | V | A | 0.0000 | |
| 242 | A | A | -2.0157 | |
| 243 | E | A | -2.7763 | |
| 244 | D | A | -2.4797 | |
| 245 | R | A | -2.4279 | |
| 246 | T | A | -1.3479 | |
| 247 | R | A | -1.4805 | |
| 248 | V | A | 0.0000 | |
| 249 | V | A | 0.0000 | |
| 250 | S | A | 0.0000 | |
| 251 | P | A | 0.0000 | |
| 252 | I | A | 0.0000 | |
| 253 | I | A | 0.0000 | |
| 254 | D | A | 0.0000 | |
| 255 | V | A | -0.0104 | |
| 256 | I | A | 0.0000 | |
| 257 | N | A | -1.6351 | |
| 258 | M | A | -1.5929 | |
| 259 | D | A | -2.0142 | |
| 260 | N | A | -2.4533 | |
| 261 | F | A | 0.0000 | |
| 262 | Q | A | -1.7705 | |
| 263 | Y | A | 0.0000 | |
| 264 | V | A | -0.3241 | |
| 265 | G | A | 0.0000 | |
| 266 | A | A | 0.0000 | |
| 267 | S | A | -0.7722 | |
| 268 | A | A | -0.6864 | |
| 269 | D | A | -0.7532 | |
| 270 | L | A | 0.0000 | |
| 271 | K | A | -0.5345 | |
| 272 | G | A | 0.0000 | |
| 273 | G | A | 0.0000 | |
| 274 | F | A | 0.0000 | |
| 275 | D | A | -1.4153 | |
| 276 | W | A | 0.0000 | |
| 277 | N | A | -0.4951 | |
| 278 | L | A | 0.0000 | |
| 279 | V | A | -0.0848 | |
| 280 | F | A | 0.0000 | |
| 281 | K | A | -1.0260 | |
| 282 | W | A | -0.4159 | |
| 283 | D | A | -0.3693 | |
| 284 | Y | A | 0.6230 | |
| 285 | M | A | 0.0000 | |
| 286 | T | A | -1.2340 | |
| 287 | P | A | -1.8143 | |
| 288 | E | A | -3.0573 | |
| 289 | Q | A | -2.3394 | |
| 290 | R | A | -2.7613 | |
| 291 | R | A | -3.6176 | |
| 292 | S | A | -2.6127 | |
| 293 | R | A | -2.4682 | |
| 294 | Q | A | -2.5496 | |
| 295 | G | A | -1.7167 | |
| 296 | N | A | -1.4198 | |
| 297 | P | A | -1.7335 | |
| 298 | V | A | 0.0000 | |
| 299 | A | A | -0.6707 | |
| 300 | P | A | -0.5194 | |
| 301 | I | A | 0.0000 | |
| 302 | K | A | -1.3246 | |
| 303 | T | A | 0.0000 | |
| 304 | P | A | 0.0000 | |
| 305 | M | A | 0.0000 | |
| 306 | I | A | 0.0000 | |
| 307 | A | A | 0.0000 | |
| 308 | G | A | 0.0000 | |
| 309 | G | A | -0.2390 | |
| 310 | L | A | 0.0000 | |
| 311 | F | A | 0.0000 | |
| 312 | V | A | 0.0000 | |
| 313 | M | A | 0.0000 | |
| 314 | D | A | 0.0000 | |
| 315 | K | A | -0.8141 | |
| 316 | F | A | 0.4364 | |
| 317 | Y | A | 0.0000 | |
| 318 | F | A | 0.0000 | |
| 319 | E | A | -1.4685 | |
| 320 | E | A | -1.7767 | |
| 321 | L | A | 0.0000 | |
| 322 | G | A | -0.9080 | |
| 323 | K | A | -1.1605 | |
| 324 | Y | A | 0.0000 | |
| 325 | D | A | 0.0000 | |
| 326 | M | A | 0.4864 | |
| 327 | M | A | 0.5833 | |
| 328 | M | A | 0.0000 | |
| 329 | D | A | -0.2199 | |
| 330 | V | A | 0.0000 | |
| 331 | W | A | 0.1871 | |
| 332 | G | A | 0.0000 | |
| 333 | G | A | 0.0000 | |
| 334 | E | A | 0.0000 | |
| 335 | N | A | -0.0751 | |
| 336 | L | A | 0.0000 | |
| 337 | E | A | 0.0000 | |
| 338 | I | A | 0.0000 | |
| 339 | S | A | 0.0000 | |
| 340 | F | A | 0.0000 | |
| 341 | R | A | 0.0000 | |
| 342 | V | A | 0.0000 | |
| 343 | W | A | 0.0000 | |
| 344 | Q | A | 0.0000 | |
| 345 | C | A | -0.7507 | |
| 346 | G | A | -0.5922 | |
| 347 | G | A | 0.0000 | |
| 348 | S | A | -0.6855 | |
| 349 | L | A | 0.0000 | |
| 350 | E | A | 0.0000 | |
| 351 | I | A | 0.0000 | |
| 352 | I | A | 0.0000 | |
| 353 | P | A | 0.0000 | |
| 354 | C | A | 0.0000 | |
| 355 | S | A | 0.0000 | |
| 356 | R | A | 0.0000 | |
| 357 | V | A | 0.0000 | |
| 358 | G | A | 0.0000 | |
| 359 | H | A | 0.0000 | |
| 360 | V | A | 0.0000 | |
| 361 | F | A | 0.0000 | |
| 362 | R | A | -1.7336 | |
| 363 | K | A | -2.4710 | |
| 364 | Q | A | -2.1267 | |
| 365 | H | A | -1.2555 | |
| 366 | P | A | -1.0169 | |
| 367 | Y | A | -0.3617 | |
| 368 | T | A | -0.1070 | |
| 369 | F | A | -0.2312 | |
| 370 | P | A | -0.5382 | |
| 371 | G | A | -0.7565 | |
| 372 | G | A | -0.6241 | |
| 373 | S | A | -0.5099 | |
| 374 | G | A | -0.7037 | |
| 375 | T | A | -0.7800 | |
| 376 | V | A | 0.0000 | |
| 377 | F | A | -0.1228 | |
| 378 | A | A | 0.0000 | |
| 379 | R | A | -1.1311 | |
| 380 | N | A | 0.0000 | |
| 381 | T | A | 0.0000 | |
| 382 | R | A | -0.7850 | |
| 383 | R | A | 0.0000 | |
| 384 | A | A | 0.0000 | |
| 385 | A | A | 0.0000 | |
| 386 | E | A | -0.7902 | |
| 387 | V | A | 0.0000 | |
| 388 | W | A | 0.0000 | |
| 389 | M | A | 0.0000 | |
| 390 | D | A | -1.8932 | |
| 391 | E | A | -2.5672 | |
| 392 | Y | A | -1.3929 | |
| 393 | K | A | -1.4492 | |
| 394 | N | A | -1.7665 | |
| 395 | F | A | -0.9770 | |
| 396 | Y | A | 0.0000 | |
| 397 | Y | A | -0.7895 | |
| 398 | A | A | -0.6730 | |
| 399 | A | A | -0.1800 | |
| 400 | V | A | -0.1540 | |
| 401 | P | A | -0.6997 | |
| 402 | S | A | -1.0140 | |
| 403 | A | A | 0.0000 | |
| 404 | R | A | -2.3244 | |
| 405 | N | A | -2.1679 | |
| 406 | V | A | 0.0000 | |
| 407 | P | A | -1.1481 | |
| 408 | Y | A | -0.9249 | |
| 409 | G | A | -1.1770 | |
| 410 | N | A | -1.6867 | |
| 411 | I | A | 0.0000 | |
| 412 | Q | A | -2.0654 | |
| 413 | S | A | -1.6544 | |
| 414 | R | A | 0.0000 | |
| 415 | L | A | -1.7599 | |
| 416 | E | A | -3.0439 | |
| 417 | L | A | -2.2165 | |
| 418 | R | A | -2.1877 | |
| 419 | K | A | -3.2263 | |
| 420 | K | A | -2.9049 | |
| 421 | L | A | -1.9165 | |
| 422 | S | A | -1.7276 | |
| 423 | C | A | -1.2194 | |
| 424 | K | A | -1.4957 | |
| 425 | P | A | -1.3575 | |
| 426 | F | A | 0.0000 | |
| 427 | K | A | -2.6992 | |
| 428 | W | A | -1.8209 | |
| 429 | Y | A | 0.0000 | |
| 430 | L | A | 0.0000 | |
| 431 | E | A | -3.0016 | |
| 432 | N | A | -2.4452 | |
| 433 | V | A | -1.4954 | |
| 434 | Y | A | 0.0000 | |
| 435 | P | A | -2.1912 | |
| 436 | E | A | -2.1631 | |
| 437 | L | A | -1.6871 | |
| 438 | R | A | -2.1469 | |
| 439 | V | A | -0.8306 | |
| 440 | P | A | -1.3836 | |
| 441 | D | A | -2.8462 | |
| 442 | H | A | -2.6836 | |
| 443 | Q | A | -2.7849 | |
| 444 | D | A | -2.3354 | |
| 445 | I | A | -0.3815 | |
| 446 | A | A | 0.4070 | |
| 447 | F | A | 0.7395 | |
| 448 | G | A | 0.0000 | |
| 449 | A | A | -0.5907 | |
| 450 | L | A | 0.0000 | |
| 451 | Q | A | -0.9536 | |
| 452 | Q | A | 0.0000 | |
| 453 | G | A | -0.9668 | |
| 454 | T | A | -0.8792 | |
| 455 | N | A | -0.9363 | |
| 456 | C | A | 0.0000 | |
| 457 | L | A | 0.0000 | |
| 458 | D | A | 0.0000 | |
| 459 | T | A | 0.0000 | |
| 460 | L | A | 0.7642 | |
| 461 | G | A | -0.1019 | |
| 462 | H | A | 0.1489 | |
| 463 | F | A | 1.0287 | |
| 464 | A | A | -0.2772 | |
| 465 | D | A | -1.3981 | |
| 466 | G | A | -0.3819 | |
| 467 | V | A | 0.0173 | |
| 468 | V | A | 0.0000 | |
| 469 | G | A | 0.0000 | |
| 470 | V | A | 0.4558 | |
| 471 | Y | A | 0.4361 | |
| 472 | E | A | -1.5990 | |
| 473 | C | A | -1.3370 | |
| 474 | H | A | -1.6239 | |
| 475 | N | A | -2.1575 | |
| 476 | A | A | -1.2972 | |
| 477 | G | A | -1.3443 | |
| 478 | G | A | -1.2160 | |
| 479 | N | A | -0.8597 | |
| 480 | Q | A | 0.0000 | |
| 481 | E | A | -0.8905 | |
| 482 | W | A | 0.0000 | |
| 483 | A | A | 0.0000 | |
| 484 | L | A | -0.5014 | |
| 485 | T | A | -1.4237 | |
| 486 | K | A | -2.6555 | |
| 487 | E | A | -3.7285 | |
| 488 | K | A | -2.6262 | |
| 489 | S | A | -1.8710 | |
| 490 | V | A | 0.0000 | |
| 491 | K | A | -0.4909 | |
| 492 | H | A | 0.0000 | |
| 493 | M | A | -0.1015 | |
| 494 | D | A | -1.2521 | |
| 495 | L | A | 0.0000 | |
| 496 | C | A | 0.0000 | |
| 497 | L | A | 0.0000 | |
| 498 | T | A | 0.0000 | |
| 499 | V | A | 0.0000 | |
| 500 | V | A | -0.6666 | |
| 501 | D | A | -1.8866 | |
| 502 | R | A | -2.2867 | |
| 503 | A | A | -1.1090 | |
| 504 | P | A | -0.8309 | |
| 505 | G | A | -0.6885 | |
| 506 | S | A | -0.7268 | |
| 507 | L | A | -0.1257 | |
| 508 | I | A | 0.0000 | |
| 509 | K | A | -0.5298 | |
| 510 | L | A | 0.0000 | |
| 511 | Q | A | -0.6964 | |
| 512 | G | A | -0.9057 | |
| 513 | C | A | -1.4146 | |
| 514 | R | A | -2.7773 | |
| 515 | E | A | -3.4815 | |
| 516 | N | A | -2.8516 | |
| 517 | D | A | 0.0000 | |
| 518 | S | A | -1.4249 | |
| 519 | R | A | -1.3163 | |
| 520 | Q | A | 0.0000 | |
| 521 | K | A | -1.4946 | |
| 522 | W | A | 0.0000 | |
| 523 | E | A | -1.0417 | |
| 524 | Q | A | -1.9264 | |
| 525 | I | A | -1.9124 | |
| 526 | E | A | -2.6819 | |
| 527 | G | A | -2.2140 | |
| 528 | N | A | -2.6638 | |
| 529 | S | A | -2.1476 | |
| 530 | K | A | -1.7006 | |
| 531 | L | A | 0.0000 | |
| 532 | R | A | -1.0954 | |
| 533 | H | A | 0.0000 | |
| 534 | V | A | -0.5555 | |
| 535 | G | A | -0.7405 | |
| 536 | S | A | -0.9063 | |
| 537 | N | A | -1.2887 | |
| 538 | L | A | 0.0000 | |
| 539 | C | A | 0.0000 | |
| 540 | L | A | 0.0000 | |
| 541 | D | A | 0.0000 | |
| 542 | S | A | -0.7937 | |
| 543 | R | A | -1.6120 | |
| 544 | T | A | -1.3638 | |
| 545 | A | A | -1.0911 | |
| 546 | K | A | -2.1020 | |
| 547 | S | A | -1.3506 | |
| 548 | G | A | -0.8885 | |
| 549 | G | A | 0.0000 | |
| 550 | L | A | 0.0000 | |
| 551 | S | A | 0.0000 | |
| 552 | V | A | 0.0000 | |
| 553 | E | A | -0.4190 | |
| 554 | V | A | 0.3707 | |
| 555 | C | A | 0.0459 | |
| 556 | G | A | 0.0655 | |
| 557 | P | A | 0.1086 | |
| 558 | A | A | 0.2978 | |
| 559 | L | A | 0.9574 | |
| 560 | S | A | -0.0797 | |
| 561 | Q | A | 0.0000 | |
| 562 | Q | A | -1.0802 | |
| 563 | W | A | 0.0000 | |
| 564 | K | A | -1.6167 | |
| 565 | F | A | -0.2336 | |
| 566 | T | A | 0.2937 | |
| 567 | L | A | 1.0330 | |
| 568 | N | A | -0.6073 | |
| 5 | S | P | -0.8702 | |
| 6 | T | P | -0.9647 | |
| 7 | T | P | -0.6484 | |
| 8 | P | P | -0.6325 | |
| 9 | A | P | -0.4310 | |
| 10 | P | P | 0.0000 | |
| 11 | T | P | -0.3548 | |
| 12 | T | P | -0.7853 | |
| 13 | K | P | -1.7184 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine