Project name: 8d490b7d1e89461

Chain sequence(s)	A: TLPSSSSLRAHGLQINGPECGITTHEMIVNGSYAKPGQFPWMVFLVVHNRKGQSFQCGGTILTQRHILTAAHCIYPNGLVAVGAEAYYGNIHKRHGKRLRVTKVIPHAKYNEKSFSHDIAVFVVEKPFQFGTNARPICIPTALVNIAGTDNIVAGWGFIREGGPDTNYLKYTTVTAQPNHICSANYLAFDSRVMYCAYLTATDSCQGDSGGPAMYRVSGGRRYVQVGIVSFGRGCARENVPGVYTRVDVFAPWLKQVVASYDRAYTTQCPCRWDCPPCHNHPSPSNFCEKLRFFLRTQPGGGGSKELEFKNGKCIFNGMNMAKTTVQYTDPTRCTAYFCEPGKHEMIIKGCPPPDDYDYEAYYDPTRWPDCCEAYKGGGGSVQSHPRCRVPPQIEHCNNLVLQWSFIRRDGRCEQSLVCHQSPNSFQTRAECEALCPPVPKRGPPARTVKCSYWLLHMDRCSANWEASRRDIFGRNHDYMVFTGCGYQKRVVYIYSLRTKSCRVKPWWWKLPRPKKILFGDAFIPAIVQPVSQIFPAFPVVNAPLQIPHGGGGSSEIKYHNYNSNGFNPKGPGPGILFGDAFIPAIVQPVSQIFPGPGPGILFNSLQYTNVVKDYWGNDLGPGPGKETVLRVAVTAQHPKPASLMGPGPGYDAGIELAHLLAFNKYGPGPGHDKKQFAALMLYEEDGTLRVEGVGPGPGKRHGKRLRVTKVIPHAKYNEKSEAAAKFYPSYHSTPQRPGTP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.7886
• Maximal score value: 1.4639
• Average score: -0.7229
• Total score value: -535.6488

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	T	A	-1.1646
2	L	A	0.0000
3	P	A	-1.2835
4	S	A	-1.1212
5	S	A	-1.6073
6	S	A	-1.2132
7	S	A	-1.2875
8	L	A	0.0000
9	R	A	-2.9152
10	A	A	-1.6565
11	H	A	-1.8688
12	G	A	-1.4278
13	L	A	0.0000
14	Q	A	-2.3310
15	I	A	0.0000
16	N	A	-2.3669
17	G	A	-1.6604
18	P	A	-1.4332
19	E	A	-1.8953
20	C	A	0.0000
21	G	A	0.0000
22	I	A	-0.2636
23	T	A	-0.5351
24	T	A	0.0000
25	H	A	-0.6076
26	E	A	-0.7222
27	M	A	0.0000
28	I	A	0.0000
29	V	A	0.0000
30	N	A	-1.6680
31	G	A	-1.0669
32	S	A	-0.3438
33	Y	A	0.0503
34	A	A	0.0000
35	K	A	-1.2243
36	P	A	-0.9686
37	G	A	-0.8902
38	Q	A	-0.8441
39	F	A	0.0000
40	P	A	0.0000
41	W	A	0.0000
42	M	A	0.0000
43	V	A	0.0000
44	F	A	0.0000
45	L	A	0.0000
46	V	A	0.0000
47	V	A	-0.6310
48	H	A	-2.1224
49	N	A	-3.1994
50	R	A	-3.5582
51	K	A	-3.3840
52	G	A	-2.6477
53	Q	A	-2.2257
54	S	A	-0.9851
55	F	A	-0.0108
56	Q	A	-0.5579
57	C	A	0.0000
58	G	A	0.0000
59	G	A	0.0000
60	T	A	0.0000
61	I	A	0.0000
62	L	A	-0.0035
63	T	A	-0.5970
64	Q	A	-1.3650
65	R	A	0.0000
66	H	A	0.0000
67	I	A	0.0000
68	L	A	0.0000
69	T	A	0.0000
70	A	A	0.0000
71	A	A	0.0000
72	H	A	-0.4221
73	C	A	0.0000
74	I	A	0.5606
75	Y	A	0.6824
76	P	A	-0.2143
77	N	A	-0.8442
78	G	A	0.0573
79	L	A	0.3371
80	V	A	0.0000
81	A	A	-0.7330
82	V	A	0.0000
83	G	A	0.0000
84	A	A	0.0000
85	E	A	-1.4640
86	A	A	0.0000
87	Y	A	0.0000
88	Y	A	0.0000
89	G	A	-1.0171
90	N	A	-2.1065
91	I	A	-2.1693
92	H	A	-2.4297
93	K	A	-3.1736
94	R	A	-3.4552
95	H	A	-2.8739
96	G	A	-2.4634
97	K	A	-2.5985
98	R	A	-2.4030
99	L	A	0.0000
100	R	A	-2.5700
101	V	A	-1.3505
102	T	A	-1.2118
103	K	A	-1.0286
104	V	A	0.0471
105	I	A	0.1638
106	P	A	-0.1633
107	H	A	-0.6302
108	A	A	-0.8904
109	K	A	-1.8499
110	Y	A	-1.7728
111	N	A	-2.7482
112	E	A	-3.0740
113	K	A	-2.8250
114	S	A	-1.7217
115	F	A	-1.2571
116	S	A	-1.3400
117	H	A	-0.9655
118	D	A	0.0000
119	I	A	0.0000
120	A	A	0.0000
121	V	A	0.0000
122	F	A	0.0000
123	V	A	0.0000
124	V	A	0.0000
125	E	A	-2.6341
126	K	A	-2.7566
127	P	A	-1.7101
128	F	A	0.0000
129	Q	A	-1.6090
130	F	A	-0.7790
131	G	A	-0.6423
132	T	A	-0.5435
133	N	A	-0.9252
134	A	A	0.0000
135	R	A	-0.9123
136	P	A	0.0000
137	I	A	0.0000
138	C	A	0.0000
139	I	A	-0.0568
140	P	A	0.0000
141	T	A	-0.3296
142	A	A	0.8191
143	L	A	1.4639
144	V	A	0.4105
145	N	A	-0.7851
146	I	A	0.0000
147	A	A	-0.9049
148	G	A	-1.1101
149	T	A	-1.3241
150	D	A	-1.9736
151	N	A	0.0000
152	I	A	0.0000
153	V	A	0.0000
154	A	A	0.0000
155	G	A	0.0000
156	W	A	0.0000
157	G	A	-1.4377
158	F	A	-1.9908
159	I	A	-2.0759
160	R	A	-3.5098
161	E	A	-3.5558
162	G	A	-2.2329
163	G	A	-1.8528
164	P	A	-1.7927
165	D	A	-2.2596
166	T	A	0.0000
167	N	A	-1.3704
168	Y	A	-0.2222
169	L	A	0.0000
170	K	A	-0.3547
171	Y	A	-0.3081
172	T	A	-0.4760
173	T	A	-0.5926
174	V	A	0.0000
175	T	A	-0.7806
176	A	A	0.0000
177	Q	A	-0.3302
178	P	A	-0.4978
179	N	A	-0.8487
180	H	A	-0.7648
181	I	A	0.3570
182	C	A	0.0000
183	S	A	0.1448
184	A	A	0.1588
185	N	A	-0.4216
186	Y	A	0.0000
187	L	A	1.3955
188	A	A	0.4908
189	F	A	0.0000
190	D	A	-1.2225
191	S	A	-1.5940
192	R	A	-2.0153
193	V	A	-0.8455
194	M	A	0.0000
195	Y	A	0.0000
196	C	A	0.0000
197	A	A	0.0000
198	Y	A	-0.0713
199	L	A	-0.6123
200	T	A	-1.0916
201	A	A	-1.4259
202	T	A	-0.8146
203	D	A	0.0000
204	S	A	-0.6114
205	C	A	0.0000
206	Q	A	-2.0535
207	G	A	-0.7933
208	D	A	0.0000
209	S	A	-0.5147
210	G	A	0.0000
211	G	A	0.0000
212	P	A	0.0000
213	A	A	0.0000
214	M	A	0.0000
215	Y	A	0.0000
216	R	A	-1.2081
217	V	A	-0.4808
218	S	A	-0.6893
219	G	A	-1.1094
220	G	A	-1.4909
221	R	A	-2.2465
222	R	A	-1.7193
223	Y	A	0.0000
224	V	A	0.0000
225	Q	A	0.0000
226	V	A	0.0000
227	G	A	0.0000
228	I	A	0.0000
229	V	A	0.0000
230	S	A	0.0000
231	F	A	-0.4206
232	G	A	-1.5576
233	R	A	-2.5569
234	G	A	-2.8608
235	C	A	-2.6397
236	A	A	-2.5654
237	R	A	-3.7886
238	E	A	-3.2343
239	N	A	-2.5327
240	V	A	-2.0176
241	P	A	0.0000
242	G	A	-0.6185
243	V	A	0.0000
244	Y	A	0.0000
245	T	A	0.0000
246	R	A	-0.1988
247	V	A	0.0000
248	D	A	0.5644
249	V	A	0.6904
250	F	A	0.0000
251	A	A	-0.2765
252	P	A	-0.9312
253	W	A	-0.8191
254	L	A	0.0000
255	K	A	-2.2426
256	Q	A	-2.0593
257	V	A	0.0000
258	V	A	-1.0994
259	A	A	-1.4260
260	S	A	-1.3314
261	Y	A	-0.7843
262	D	A	-1.3763
263	R	A	-1.9980
264	A	A	-0.7444
265	Y	A	-0.4239
266	T	A	0.0000
267	T	A	-1.2729
268	Q	A	-1.3685
269	C	A	-0.2818
270	P	A	-0.4997
271	C	A	-0.9878
272	R	A	-1.9110
273	W	A	-1.5398
274	D	A	-2.1907
275	C	A	0.0000
276	P	A	-0.8228
277	P	A	-0.7965
278	C	A	-0.8404
279	H	A	-1.5115
280	N	A	-1.7468
281	H	A	-1.4450
282	P	A	0.0000
283	S	A	-0.3799
284	P	A	-0.2931
285	S	A	-0.2122
286	N	A	0.0000
287	F	A	-0.1282
288	C	A	0.0000
289	E	A	0.0000
290	K	A	0.0000
291	L	A	0.0000
292	R	A	0.0000
293	F	A	-0.9603
294	F	A	-1.1014
295	L	A	0.0000
296	R	A	-1.3821
297	T	A	-1.8492
298	Q	A	-1.4925
299	P	A	-0.9967
300	G	A	-1.1493
301	G	A	-1.6392
302	G	A	-1.2304
303	G	A	-1.3376
304	S	A	0.0000
305	K	A	-2.4350
306	E	A	-2.8213
307	L	A	-1.6391
308	E	A	-2.2925
309	F	A	-1.6853
310	K	A	-1.7712
311	N	A	-2.0700
312	G	A	-1.7246
313	K	A	-1.5832
314	C	A	0.0000
315	I	A	0.0000
316	F	A	0.0000
317	N	A	-1.1163
318	G	A	-1.2370
319	M	A	-0.8750
320	N	A	-1.1748
321	M	A	0.0000
322	A	A	-2.2566
323	K	A	-2.7057
324	T	A	-1.5631
325	T	A	-0.6962
326	V	A	0.0000
327	Q	A	-0.6255
328	Y	A	-0.9080
329	T	A	-1.3956
330	D	A	-1.6947
331	P	A	-1.2103
332	T	A	-1.0079
333	R	A	-1.1293
334	C	A	0.0000
335	T	A	0.0000
336	A	A	0.0000
337	Y	A	-0.1241
338	F	A	0.0000
339	C	A	0.0000
340	E	A	-2.8105
341	P	A	-2.1158
342	G	A	-1.5670
343	K	A	-2.2068
344	H	A	-1.8998
345	E	A	-1.9367
346	M	A	0.0000
347	I	A	0.0000
348	I	A	0.0000
349	K	A	-1.5060
350	G	A	-1.4037
351	C	A	0.0000
352	P	A	0.0000
353	P	A	-1.4390
354	P	A	-1.4692
355	D	A	-2.9219
356	D	A	-1.9607
357	Y	A	0.0000
358	D	A	0.0000
359	Y	A	-0.3704
360	E	A	0.0000
361	A	A	0.0000
362	Y	A	0.1650
363	Y	A	0.0000
364	D	A	-1.2234
365	P	A	-1.5064
366	T	A	-1.4714
367	R	A	-2.2453
368	W	A	0.0000
369	P	A	-1.3014
370	D	A	-1.1602
371	C	A	0.0000
372	C	A	0.0000
373	E	A	-1.3220
374	A	A	0.0000
375	Y	A	0.0000
376	K	A	-1.4860
377	G	A	-1.1660
378	G	A	-1.3416
379	G	A	-1.3058
380	G	A	0.0000
381	S	A	0.0000
382	V	A	0.0000
383	Q	A	-1.9561
384	S	A	-1.0750
385	H	A	-1.3216
386	P	A	-1.3036
387	R	A	-1.6393
388	C	A	0.0000
389	R	A	0.0000
390	V	A	0.0000
391	P	A	0.0000
392	P	A	0.0000
393	Q	A	0.0000
394	I	A	0.0000
395	E	A	-1.2524
396	H	A	-1.7250
397	C	A	0.0000
398	N	A	-2.0613
399	N	A	-1.6321
400	L	A	-0.6981
401	V	A	0.0000
402	L	A	0.0000
403	Q	A	0.0000
404	W	A	0.0000
405	S	A	0.0000
406	F	A	0.0000
407	I	A	0.0000
408	R	A	-2.0003
409	R	A	-2.7901
410	D	A	-1.8268
411	G	A	-1.8513
412	R	A	-2.4694
413	C	A	-1.2869
414	E	A	-0.8248
415	Q	A	-1.2049
416	S	A	0.0000
417	L	A	0.0000
418	V	A	0.0000
419	C	A	0.0000
420	H	A	0.0000
421	Q	A	0.0000
422	S	A	-1.1280
423	P	A	-0.9414
424	N	A	-1.1040
425	S	A	-0.0470
426	F	A	1.2685
427	Q	A	0.1803
428	T	A	-0.1579
429	R	A	0.0000
430	A	A	0.0000
431	E	A	-1.1222
432	C	A	0.0000
433	E	A	0.0000
434	A	A	-0.4823
435	L	A	-0.4511
436	C	A	-0.1783
437	P	A	-0.1432
438	P	A	0.0000
439	V	A	0.5775
440	P	A	-0.9530
441	K	A	-2.0574
442	R	A	-2.5076
443	G	A	-1.9096
444	P	A	-1.5794
445	P	A	-1.3125
446	A	A	-1.6267
447	R	A	-2.3591
448	T	A	-1.2844
449	V	A	0.0000
450	K	A	-0.9779
451	C	A	0.0000
452	S	A	0.0000
453	Y	A	0.0000
454	W	A	0.0000
455	L	A	0.0000
456	L	A	0.0000
457	H	A	0.0000
458	M	A	-0.6606
459	D	A	-1.4146
460	R	A	0.0000
461	C	A	0.0000
462	S	A	-1.0878
463	A	A	-1.2500
464	N	A	-1.4699
465	W	A	-0.7540
466	E	A	0.0000
467	A	A	-1.0499
468	S	A	-0.9557
469	R	A	0.0000
470	R	A	-1.4368
471	D	A	-2.1529
472	I	A	-1.0914
473	F	A	0.0000
474	G	A	-1.3996
475	R	A	-1.4683
476	N	A	-1.1785
477	H	A	0.0000
478	D	A	0.0000
479	Y	A	0.0000
480	M	A	0.0000
481	V	A	0.0000
482	F	A	0.0000
483	T	A	0.0000
484	G	A	0.0000
485	C	A	0.0000
486	G	A	-0.7454
487	Y	A	0.0000
488	Q	A	-2.0091
489	K	A	-2.2782
490	R	A	-1.4421
491	V	A	0.0000
492	V	A	0.0000
493	Y	A	0.0000
494	I	A	0.0000
495	Y	A	0.0000
496	S	A	0.0000
497	L	A	0.0000
498	R	A	0.0000
499	T	A	0.0000
500	K	A	-0.5565
501	S	A	0.0000
502	C	A	0.0000
503	R	A	0.0000
504	V	A	0.0000
505	K	A	0.0000
506	P	A	0.0000
507	W	A	0.8489
508	W	A	0.8708
509	W	A	-0.0065
510	K	A	-1.6835
511	L	A	-1.5192
512	P	A	-2.0560
513	R	A	-3.0203
514	P	A	0.0000
515	K	A	-3.1608
516	K	A	-2.9251
517	I	A	0.0000
518	L	A	-0.9515
519	F	A	0.0000
520	G	A	0.0000
521	D	A	0.0000
522	A	A	0.0787
523	F	A	0.0000
524	I	A	0.0000
525	P	A	0.0000
526	A	A	0.7569
527	I	A	0.8817
528	V	A	0.5847
529	Q	A	-0.2575
530	P	A	-0.7888
531	V	A	0.0000
532	S	A	-0.6646
533	Q	A	-0.4832
534	I	A	0.0000
535	F	A	0.2538
536	P	A	0.4087
537	A	A	0.2217
538	F	A	0.3270
539	P	A	0.2080
540	V	A	0.1088
541	V	A	-0.4694
542	N	A	-1.2135
543	A	A	-0.7546
544	P	A	-0.0667
545	L	A	1.0585
546	Q	A	0.0000
547	I	A	0.9715
548	P	A	0.0000
549	H	A	-1.0350
550	G	A	-1.2686
551	G	A	-0.8501
552	G	A	-1.1067
553	G	A	-1.1505
554	S	A	-1.0907
555	S	A	0.0000
556	E	A	-1.9788
557	I	A	0.0000
558	K	A	-0.8075
559	Y	A	0.0000
560	H	A	-1.5349
561	N	A	-1.5971
562	Y	A	-0.9247
563	N	A	-1.4967
564	S	A	-0.9382
565	N	A	0.0000
566	G	A	-0.8628
567	F	A	0.0000
568	N	A	-1.3244
569	P	A	-1.7955
570	K	A	-2.2027
571	G	A	-1.6463
572	P	A	-1.3507
573	G	A	-1.3356
574	P	A	-1.2706
575	G	A	0.0000
576	I	A	0.0000
577	L	A	0.0000
578	F	A	0.0000
579	G	A	0.0000
580	D	A	-1.1408
581	A	A	0.0000
582	F	A	0.6013
583	I	A	0.0000
584	P	A	0.0000
585	A	A	0.0000
586	I	A	0.0000
587	V	A	0.0000
588	Q	A	0.0000
589	P	A	0.0000
590	V	A	0.0000
591	S	A	-0.2587
592	Q	A	0.0000
593	I	A	0.0000
594	F	A	0.0000
595	P	A	-0.2315
596	G	A	-0.6028
597	P	A	-0.9472
598	G	A	-0.9908
599	P	A	-0.8108
600	G	A	0.0000
601	I	A	0.0000
602	L	A	0.0000
603	F	A	0.0000
604	N	A	0.0000
605	S	A	0.0000
606	L	A	0.0000
607	Q	A	0.0000
608	Y	A	0.0000
609	T	A	0.0000
610	N	A	0.0000
611	V	A	0.0000
612	V	A	0.0000
613	K	A	-0.9735
614	D	A	0.0000
615	Y	A	0.0000
616	W	A	0.0000
617	G	A	0.0000
618	N	A	-1.7430
619	D	A	-1.5826
620	L	A	0.0000
621	G	A	0.0000
622	P	A	-1.5214
623	G	A	-1.5963
624	P	A	-1.7990
625	G	A	-1.9586
626	K	A	-2.9974
627	E	A	-2.7098
628	T	A	-1.6278
629	V	A	-0.4986
630	L	A	0.0000
631	R	A	0.0000
632	V	A	0.0000
633	A	A	0.0000
634	V	A	0.0000
635	T	A	0.0000
636	A	A	0.0000
637	Q	A	-0.9387
638	H	A	-0.7913
639	P	A	-0.4343
640	K	A	0.0000
641	P	A	-0.1704
642	A	A	-0.2630
643	S	A	-0.5420
644	L	A	0.0000
645	M	A	0.0169
646	G	A	-0.1164
647	P	A	-0.4335
648	G	A	-0.5510
649	P	A	-0.8877
650	G	A	-1.0168
651	Y	A	-1.0314
652	D	A	-2.2012
653	A	A	-1.3917
654	G	A	0.0000
655	I	A	-1.0754
656	E	A	-1.8998
657	L	A	0.0000
658	A	A	0.0000
659	H	A	-0.1454
660	L	A	0.1918
661	L	A	0.0000
662	A	A	0.0000
663	F	A	1.0456
664	N	A	-0.1309
665	K	A	-0.1635
666	Y	A	0.9785
667	G	A	0.0533
668	P	A	-0.5420
669	G	A	-0.8259
670	P	A	-1.1574
671	G	A	-1.2897
672	H	A	-1.4147
673	D	A	-1.9492
674	K	A	-2.8552
675	K	A	-2.7964
676	Q	A	-1.7777
677	F	A	0.0000
678	A	A	-1.3180
679	A	A	0.0000
680	L	A	0.0000
681	M	A	0.0000
682	L	A	0.0000
683	Y	A	0.0000
684	E	A	0.0000
685	E	A	0.0000
686	D	A	0.0799
687	G	A	0.0000
688	T	A	0.0000
689	L	A	0.0000
690	R	A	0.0000
691	V	A	0.0000
692	E	A	-1.4211
693	G	A	0.0000
694	V	A	0.0000
695	G	A	-1.4683
696	P	A	-1.5775
697	G	A	-1.2137
698	P	A	-1.0246
699	G	A	-1.2475
700	K	A	-2.0120
701	R	A	-3.1454
702	H	A	-2.6629
703	G	A	-2.6400
704	K	A	-3.1600
705	R	A	-2.8448
706	L	A	0.0000
707	R	A	-1.2031
708	V	A	0.0000
709	T	A	0.0000
710	K	A	-0.7555
711	V	A	0.0000
712	I	A	0.0000
713	P	A	0.0000
714	H	A	-0.4167
715	A	A	-0.3279
716	K	A	-0.5865
717	Y	A	-0.3125
718	N	A	0.0000
719	E	A	-2.2423
720	K	A	-1.4738
721	S	A	0.0000
722	E	A	-1.8742
723	A	A	-1.2198
724	A	A	0.0000
725	A	A	0.0000
726	K	A	-1.3966
727	F	A	-0.7162
728	Y	A	0.0000
729	P	A	-0.7035
730	S	A	-0.6730
731	Y	A	-0.5312
732	H	A	-1.2096
733	S	A	-1.0937
734	T	A	-1.1135
735	P	A	-1.5260
736	Q	A	-2.3878
737	R	A	-2.5605
738	P	A	-1.7735
739	G	A	-1.1048
740	T	A	0.0000
741	P	A	-0.3731