Project name: 8d7a39af3f9f76d

Chain sequence(s)	A: DHHEGQPRSVCALEENAKRALISCVQTHLTADTTQKLSAVKDQLHCDDVYCVFVRICDRNNGTLEHPSNEFFSNAEKTDIRSAVVTCRENLQRQAEAAKTSGGGGSNSEEDMMETTTEFEYEAGACPFQVLKISNNKSLIINCTNECGYGLSDGEPCVNATNPPLNFTVRGDYNCTVGSCRNGTCPSNGTVEFCWANKTNSEKRPSARSYSVQLYGGGGSLDLHTLIQNPSLSLYQDPSRFVTNKSDIYLLRASIPADTARLLPPKTPCVRSRYWTNDTEKVERSLDVYNKINHSGSESYNITLTIQKDDWTTILYINPKGKNITILNVSDVYIGISSRAGGGGSSEIKYHNYNSNGFNPKGPGPGILFGDAFIPAIVQPVSQIFPGPGPGILFNSLQYTNVVKDYWGNDLGPGPGKETVLRVAVTAQHPKPASLMGPGPGYDAGIELAHLLAFNKYGPGPGHDKKQFAALMLYEEDGTLRVEGVGPGPGKRHGKRLRVTKVIPHAKYNEKSEAAAKFYPSYHSTPQRPGTP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.8
• Maximal score value: 1.9026
• Average score: -0.674
• Total score value: -358.5618

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	A	-2.4207
2	H	A	-1.8666
3	H	A	-1.1622
4	E	A	0.0000
5	G	A	0.0000
6	Q	A	-0.3932
7	P	A	-0.9492
8	R	A	-1.6114
9	S	A	-0.5311
10	V	A	0.0639
11	C	A	-0.0877
12	A	A	-0.7706
13	L	A	0.0000
14	E	A	-3.5449
15	E	A	-3.8000
16	N	A	-3.2030
17	A	A	0.0000
18	K	A	-2.5898
19	R	A	-2.9705
20	A	A	-1.5035
21	L	A	0.0000
22	I	A	-0.7018
23	S	A	-0.9204
24	C	A	-0.7474
25	V	A	0.0000
26	Q	A	-1.4666
27	T	A	-0.9215
28	H	A	-1.3175
29	L	A	0.0000
30	T	A	-1.2391
31	A	A	-1.3192
32	D	A	-2.2913
33	T	A	0.0000
34	T	A	-1.5975
35	Q	A	-2.1074
36	K	A	-1.0675
37	L	A	0.0000
38	S	A	-1.4226
39	A	A	-1.4369
40	V	A	0.0000
41	K	A	-1.8702
42	D	A	-2.6793
43	Q	A	-2.5840
44	L	A	-2.3017
45	H	A	-2.1583
46	C	A	0.0000
47	D	A	-1.7407
48	D	A	0.0000
49	V	A	0.0000
50	Y	A	0.0000
51	C	A	0.0000
52	V	A	0.0000
53	F	A	0.0000
54	V	A	0.0000
55	R	A	-0.8080
56	I	A	0.0000
57	C	A	0.0000
58	D	A	-1.2680
59	R	A	-2.0416
60	N	A	-1.8518
61	N	A	-2.5752
62	G	A	-1.3745
63	T	A	-0.7699
64	L	A	-0.0107
65	E	A	-1.4850
66	H	A	-1.6737
67	P	A	-1.1694
68	S	A	0.0000
69	N	A	-1.5142
70	E	A	-1.8546
71	F	A	0.0802
72	F	A	0.0000
73	S	A	-0.8429
74	N	A	-1.8992
75	A	A	-0.9358
76	E	A	-1.0459
77	K	A	0.0000
78	T	A	-1.4272
79	D	A	-1.6561
80	I	A	0.0000
81	R	A	0.0000
82	S	A	-0.7425
83	A	A	0.0000
84	V	A	0.0000
85	V	A	0.0000
86	T	A	-0.1763
87	C	A	0.0000
88	R	A	0.0000
89	E	A	0.0000
90	N	A	-1.0121
91	L	A	0.0000
92	Q	A	0.0000
93	R	A	-1.8134
94	Q	A	-1.8535
95	A	A	-1.3566
96	E	A	-1.6891
97	A	A	-1.1317
98	A	A	-1.1228
99	K	A	0.0000
100	T	A	-0.7053
101	S	A	-0.9332
102	G	A	-0.9083
103	G	A	-1.1554
104	G	A	-1.1809
105	G	A	-1.1999
106	S	A	-1.3558
107	N	A	-1.9971
108	S	A	-1.8398
109	E	A	-2.2243
110	E	A	-1.5495
111	D	A	-1.2296
112	M	A	-1.1034
113	M	A	-0.8629
114	E	A	0.0000
115	T	A	0.0000
116	T	A	-0.5990
117	T	A	-0.3884
118	E	A	-0.9033
119	F	A	-0.8811
120	E	A	-0.9302
121	Y	A	0.5540
122	E	A	-0.2953
123	A	A	-0.2792
124	G	A	-0.9402
125	A	A	-0.3528
126	C	A	0.0000
127	P	A	-0.4019
128	F	A	0.0000
129	Q	A	0.0000
130	V	A	0.0000
131	L	A	0.0000
132	K	A	-0.7248
133	I	A	0.7703
134	S	A	-0.5874
135	N	A	-1.8432
136	N	A	-1.8950
137	K	A	-1.5131
138	S	A	-0.3256
139	L	A	1.4487
140	I	A	1.5632
141	I	A	1.9026
142	N	A	-0.0525
143	C	A	0.0000
144	T	A	-0.6878
145	N	A	-1.6531
146	E	A	-2.2310
147	C	A	0.0000
148	G	A	-0.6183
149	Y	A	0.3629
150	G	A	-0.9744
151	L	A	-1.6057
152	S	A	-2.0421
153	D	A	-2.6080
154	G	A	-1.9348
155	E	A	-2.2716
156	P	A	-1.1574
157	C	A	-0.0466
158	V	A	0.0000
159	N	A	0.9580
160	A	A	0.0000
161	T	A	0.0000
162	N	A	-0.4045
163	P	A	-0.4723
164	P	A	-0.1798
165	L	A	-0.3974
166	N	A	-0.8434
167	F	A	0.0744
168	T	A	-0.0487
169	V	A	-0.0467
170	R	A	-1.4203
171	G	A	-0.6287
172	D	A	0.0000
173	Y	A	0.0000
174	N	A	0.0000
175	C	A	0.0000
176	T	A	0.0000
177	V	A	-0.3963
178	G	A	-0.6686
179	S	A	-0.8631
180	C	A	0.0000
181	R	A	0.0000
182	N	A	-1.8264
183	G	A	-1.4527
184	T	A	-0.7901
185	C	A	0.0000
186	P	A	-0.6002
187	S	A	-0.7693
188	N	A	-1.0731
189	G	A	-0.7767
190	T	A	-0.5648
191	V	A	0.0000
192	E	A	-0.5342
193	F	A	0.0000
194	C	A	0.0000
195	W	A	0.0000
196	A	A	0.0000
197	N	A	0.0000
198	K	A	0.0000
199	T	A	-2.0507
200	N	A	-2.2887
201	S	A	-2.1442
202	E	A	-2.8324
203	K	A	-3.3509
204	R	A	-2.8297
205	P	A	-1.3607
206	S	A	-1.0249
207	A	A	0.0000
208	R	A	-0.3069
209	S	A	0.0000
210	Y	A	0.0000
211	S	A	0.0000
212	V	A	0.0000
213	Q	A	0.0000
214	L	A	0.0000
215	Y	A	0.9918
216	G	A	-0.0946
217	G	A	-0.7969
218	G	A	-0.7167
219	G	A	-0.5402
220	S	A	0.0000
221	L	A	0.0000
222	D	A	0.0000
223	L	A	0.0000
224	H	A	-0.5813
225	T	A	-0.8111
226	L	A	0.0000
227	I	A	0.0000
228	Q	A	-1.5533
229	N	A	-1.0165
230	P	A	-0.3876
231	S	A	-0.0449
232	L	A	0.0000
233	S	A	0.1549
234	L	A	1.5320
235	Y	A	1.1165
236	Q	A	0.0355
237	D	A	-0.5902
238	P	A	0.0000
239	S	A	0.0000
240	R	A	-1.5573
241	F	A	-0.6486
242	V	A	0.0000
243	T	A	0.0000
244	N	A	0.0000
245	K	A	-2.0235
246	S	A	-1.8338
247	D	A	-2.1627
248	I	A	0.0000
249	Y	A	0.6516
250	L	A	0.5472
251	L	A	0.0000
252	R	A	-0.5473
253	A	A	-0.7274
254	S	A	-0.5552
255	I	A	-0.7251
256	P	A	-1.3151
257	A	A	-1.7367
258	D	A	-2.0538
259	T	A	-1.0752
260	A	A	0.0000
261	R	A	-1.8312
262	L	A	0.3301
263	L	A	0.1689
264	P	A	-0.6612
265	P	A	-0.7324
266	K	A	-1.7767
267	T	A	-1.0589
268	P	A	-1.0566
269	C	A	-0.6180
270	V	A	0.0000
271	R	A	-2.2823
272	S	A	-1.8059
273	R	A	-2.2584
274	Y	A	-0.8188
275	W	A	-0.2050
276	T	A	-1.1240
277	N	A	-2.5150
278	D	A	-3.1710
279	T	A	-2.3603
280	E	A	-3.1676
281	K	A	-2.6796
282	V	A	0.0000
283	E	A	-1.1490
284	R	A	0.0000
285	S	A	-1.2543
286	L	A	0.0000
287	D	A	-1.6316
288	V	A	0.0000
289	Y	A	-1.0121
290	N	A	-1.3861
291	K	A	-1.6926
292	I	A	-0.8519
293	N	A	-1.4900
294	H	A	-1.4457
295	S	A	-1.2444
296	G	A	-1.3070
297	S	A	-1.5787
298	E	A	-2.2875
299	S	A	-1.2090
300	Y	A	-1.4729
301	N	A	-1.6240
302	I	A	-1.1773
303	T	A	-0.6395
304	L	A	0.0000
305	T	A	-0.8453
306	I	A	0.0000
307	Q	A	-2.3676
308	K	A	0.0000
309	D	A	-1.9268
310	D	A	0.0000
311	W	A	-0.5566
312	T	A	0.0000
313	T	A	-0.1475
314	I	A	0.0000
315	L	A	0.0000
316	Y	A	-0.0611
317	I	A	0.0000
318	N	A	-1.1815
319	P	A	-1.6810
320	K	A	-2.5331
321	G	A	-2.0361
322	K	A	-2.3982
323	N	A	-1.5517
324	I	A	0.0000
325	T	A	0.0000
326	I	A	0.0000
327	L	A	0.0000
328	N	A	0.0000
329	V	A	0.0000
330	S	A	0.0000
331	D	A	-1.1954
332	V	A	0.1204
333	Y	A	0.7454
334	I	A	0.6241
335	G	A	0.8005
336	I	A	0.6078
337	S	A	0.1043
338	S	A	0.0000
339	R	A	-0.5927
340	A	A	0.0000
341	G	A	0.0000
342	G	A	-0.5329
343	G	A	-0.6837
344	G	A	-0.8397
345	S	A	0.0000
346	S	A	0.0000
347	E	A	0.0000
348	I	A	0.0000
349	K	A	0.1054
350	Y	A	0.7483
351	H	A	-0.0434
352	N	A	-1.0371
353	Y	A	-0.5155
354	N	A	0.0000
355	S	A	-1.1427
356	N	A	-1.4173
357	G	A	-0.7808
358	F	A	0.1312
359	N	A	0.0000
360	P	A	0.0000
361	K	A	0.0000
362	G	A	0.0000
363	P	A	0.0000
364	G	A	0.0000
365	P	A	0.1779
366	G	A	-0.2080
367	I	A	0.0000
368	L	A	0.0487
369	F	A	0.0000
370	G	A	-0.3814
371	D	A	-0.8477
372	A	A	0.0000
373	F	A	0.0000
374	I	A	0.0000
375	P	A	0.0000
376	A	A	0.0000
377	I	A	0.4138
378	V	A	0.0000
379	Q	A	-1.0514
380	P	A	-0.2763
381	V	A	0.0000
382	S	A	0.2369
383	Q	A	0.6294
384	I	A	1.7197
385	F	A	0.9159
386	P	A	0.1392
387	G	A	-0.5934
388	P	A	-0.8745
389	G	A	-0.5660
390	P	A	0.0000
391	G	A	-0.2552
392	I	A	0.2095
393	L	A	0.0000
394	F	A	0.0950
395	N	A	0.0000
396	S	A	-0.2812
397	L	A	0.0000
398	Q	A	0.0000
399	Y	A	0.2960
400	T	A	-0.0228
401	N	A	-0.0350
402	V	A	0.0724
403	V	A	0.0000
404	K	A	-0.9765
405	D	A	-0.8159
406	Y	A	-0.2695
407	W	A	0.8263
408	G	A	-0.0435
409	N	A	0.0000
410	D	A	-1.1490
411	L	A	0.5820
412	G	A	-0.3239
413	P	A	-1.1289
414	G	A	-0.7455
415	P	A	-0.8096
416	G	A	-1.5136
417	K	A	-2.0752
418	E	A	-2.4127
419	T	A	-1.2690
420	V	A	-0.3662
421	L	A	-0.0168
422	R	A	-0.0519
423	V	A	0.3869
424	A	A	0.0000
425	V	A	0.4599
426	T	A	0.0781
427	A	A	-0.1598
428	Q	A	-0.6279
429	H	A	0.0000
430	P	A	0.0000
431	K	A	-0.3909
432	P	A	-0.4015
433	A	A	-0.1241
434	S	A	0.1775
435	L	A	0.0000
436	M	A	0.7829
437	G	A	0.0000
438	P	A	-0.4258
439	G	A	-0.5262
440	P	A	-1.1230
441	G	A	-1.2343
442	Y	A	-1.5204
443	D	A	-2.8856
444	A	A	-1.6217
445	G	A	-1.4384
446	I	A	0.0000
447	E	A	0.0000
448	L	A	-0.5394
449	A	A	-0.4835
450	H	A	-0.3490
451	L	A	0.6267
452	L	A	1.5410
453	A	A	0.0000
454	F	A	0.7449
455	N	A	0.0000
456	K	A	0.0000
457	Y	A	0.0000
458	G	A	0.0000
459	P	A	-0.5833
460	G	A	-0.5607
461	P	A	0.0000
462	G	A	0.0000
463	H	A	-0.9295
464	D	A	-1.8177
465	K	A	-3.0856
466	K	A	-3.0633
467	Q	A	-1.9017
468	F	A	0.0000
469	A	A	-0.7556
470	A	A	0.0000
471	L	A	0.3263
472	M	A	0.0000
473	L	A	0.3579
474	Y	A	0.0000
475	E	A	-0.9047
476	E	A	-1.9219
477	D	A	-2.3606
478	G	A	-1.5195
479	T	A	-1.2143
480	L	A	-0.3845
481	R	A	0.0000
482	V	A	0.0000
483	E	A	0.0000
484	G	A	0.0000
485	V	A	0.0000
486	G	A	0.0000
487	P	A	-1.2596
488	G	A	-1.8194
489	P	A	-1.4610
490	G	A	-1.4298
491	K	A	-1.5677
492	R	A	-2.1876
493	H	A	0.0000
494	G	A	-1.8828
495	K	A	-3.0213
496	R	A	-2.7678
497	L	A	-1.1932
498	R	A	-1.6849
499	V	A	-0.5481
500	T	A	-0.8463
501	K	A	-1.3610
502	V	A	-0.3501
503	I	A	0.0000
504	P	A	0.0000
505	H	A	-0.5503
506	A	A	0.0000
507	K	A	-1.8999
508	Y	A	0.0000
509	N	A	-2.1726
510	E	A	-2.3774
511	K	A	-3.0149
512	S	A	-2.0327
513	E	A	-2.3285
514	A	A	-1.1307
515	A	A	0.0000
516	A	A	-1.1183
517	K	A	-1.1106
518	F	A	1.2641
519	Y	A	0.7968
520	P	A	0.1808
521	S	A	0.3979
522	Y	A	0.6265
523	H	A	-0.4184
524	S	A	-0.4936
525	T	A	-0.8219
526	P	A	-1.3692
527	Q	A	-2.1953
528	R	A	-2.8047
529	P	A	-1.7448
530	G	A	-1.3413
531	T	A	-1.0150
532	P	A	-0.3593