Project name: 3J9T chain D

Chain sequence(s)	Q: MEGVYFNIDNGFIEGVVRGYRNGLLSNNQYINLTQCDTLEDLKLQLSSTDYGNFLSSVSSESLTTSLIQEYASSKLYHEFNYIRDQSSGSTRKFMDYITYGYMIDNVALMITGTIHDRDKGEILQRCHPLGWFDTLPTLSVATDLESLYETVLVDTPLAPYFKNCFDTAEELDDMNIEIIRNKLYKAYLEDFYNFVTEEIPEPAKECMQTLLGFEADRRSINIALNSLQSSDIDPDLKSDLLPNIGKLYPLATFHLAQAQDFEGVRAALANVYEYRGFLETGNLEDHFYQLEMELCRDAFTQQFAISTVWAWMKSKEQEVRNITWIAECIAQNQRERINNYISVY
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.4701
• Maximal score value: 2.3194
• Average score: -0.5229
• Total score value: -180.3897

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	Q	0.4677
2	E	Q	-0.4251
3	G	Q	0.1407
4	V	Q	1.3254
5	Y	Q	1.3631
6	F	Q	2.3194
7	N	Q	1.6653
8	I	Q	2.0725
9	D	Q	0.3602
10	N	Q	0.0000
11	G	Q	0.7635
12	F	Q	0.3018
13	I	Q	0.0000
14	E	Q	0.0000
15	G	Q	-0.8306
16	V	Q	-0.6403
17	V	Q	0.0000
18	R	Q	-2.5182
19	G	Q	-1.7833
20	Y	Q	-1.5958
21	R	Q	-2.1975
22	N	Q	-2.2924
23	G	Q	-1.4105
24	L	Q	-1.1481
25	L	Q	0.0000
26	S	Q	-1.1445
27	N	Q	-1.0876
28	N	Q	-1.4831
29	Q	Q	-1.1099
30	Y	Q	0.0000
31	I	Q	-0.5802
32	N	Q	-1.5562
33	L	Q	0.0000
34	T	Q	0.0000
35	Q	Q	-1.7816
36	C	Q	-1.7999
37	D	Q	-2.1964
38	T	Q	-1.7162
39	L	Q	-1.8384
40	E	Q	-2.4196
41	D	Q	-1.6093
42	L	Q	0.0000
43	K	Q	-0.9599
44	L	Q	0.2641
45	Q	Q	-0.2114
46	L	Q	0.0000
47	S	Q	-0.3412
48	S	Q	-0.4159
49	T	Q	-0.8014
50	D	Q	-1.2562
51	Y	Q	0.0000
52	G	Q	0.0000
53	N	Q	-1.3432
54	F	Q	-0.6557
55	L	Q	0.0000
56	S	Q	-0.2566
57	S	Q	0.0621
58	V	Q	0.8016
59	S	Q	-0.1510
60	S	Q	-0.9986
61	E	Q	-2.2472
62	S	Q	-1.7786
63	L	Q	0.0000
64	T	Q	-0.7797
65	T	Q	-0.7029
66	S	Q	-0.7833
67	L	Q	-0.4694
68	I	Q	0.0000
69	Q	Q	-1.1733
70	E	Q	-1.8723
71	Y	Q	0.0000
72	A	Q	0.0000
73	S	Q	-0.7357
74	S	Q	-0.7111
75	K	Q	0.0000
76	L	Q	0.0000
77	Y	Q	0.2420
78	H	Q	-0.5731
79	E	Q	0.0000
80	F	Q	0.0000
81	N	Q	-0.1770
82	Y	Q	-0.2398
83	I	Q	0.0000
84	R	Q	-1.5896
85	D	Q	-2.3975
86	Q	Q	-2.0144
87	S	Q	0.0000
88	S	Q	-1.2425
89	G	Q	-0.8770
90	S	Q	-1.0894
91	T	Q	0.0000
92	R	Q	-1.8886
93	K	Q	-1.4178
94	F	Q	0.0000
95	M	Q	0.0000
96	D	Q	0.0000
97	Y	Q	0.0513
98	I	Q	0.0000
99	T	Q	0.0000
100	Y	Q	0.0000
101	G	Q	-0.0048
102	Y	Q	-0.1551
103	M	Q	0.0000
104	I	Q	0.0000
105	D	Q	-0.3641
106	N	Q	-0.0137
107	V	Q	0.0000
108	A	Q	0.0000
109	L	Q	0.4209
110	M	Q	0.0000
111	I	Q	0.0000
112	T	Q	0.0000
113	G	Q	0.0000
114	T	Q	-0.4826
115	I	Q	0.7033
116	H	Q	-1.2291
117	D	Q	-2.7720
118	R	Q	-3.2465
119	D	Q	-3.4701
120	K	Q	-2.7932
121	G	Q	-1.6877
122	E	Q	-1.7533
123	I	Q	-0.6169
124	L	Q	0.5353
125	Q	Q	0.0000
126	R	Q	-0.9846
127	C	Q	0.0000
128	H	Q	0.0000
129	P	Q	0.0000
130	L	Q	0.4394
131	G	Q	0.0497
132	W	Q	0.0000
133	F	Q	0.7891
134	D	Q	-0.7452
135	T	Q	0.0000
136	L	Q	0.0000
137	P	Q	-0.0213
138	T	Q	0.3005
139	L	Q	0.0000
140	S	Q	0.0000
141	V	Q	1.4666
142	A	Q	-0.1690
143	T	Q	-0.2737
144	D	Q	-1.9510
145	L	Q	-1.2628
146	E	Q	-2.3380
147	S	Q	-1.7597
148	L	Q	0.0000
149	Y	Q	-0.6566
150	E	Q	-1.1620
151	T	Q	0.0849
152	V	Q	0.0000
153	L	Q	1.9854
154	V	Q	2.0865
155	D	Q	1.0281
156	T	Q	0.8256
157	P	Q	0.5804
158	L	Q	1.5307
159	A	Q	0.0000
160	P	Q	-0.2984
161	Y	Q	0.0000
162	F	Q	0.1126
163	K	Q	-1.0527
164	N	Q	-0.2216
165	C	Q	0.0000
166	F	Q	0.5242
167	D	Q	-0.5887
168	T	Q	-0.8804
169	A	Q	-1.0661
170	E	Q	-2.1800
171	E	Q	-2.2924
172	L	Q	-0.2249
173	D	Q	0.0000
174	D	Q	-2.0981
175	M	Q	-0.9232
176	N	Q	-1.5435
177	I	Q	-0.9126
178	E	Q	-2.1120
179	I	Q	0.0000
180	I	Q	-0.9700
181	R	Q	-1.4516
182	N	Q	-0.9721
183	K	Q	-0.7202
184	L	Q	0.0000
185	Y	Q	-0.6259
186	K	Q	-0.8285
187	A	Q	-1.0048
188	Y	Q	-0.5424
189	L	Q	0.0000
190	E	Q	-1.5619
191	D	Q	-1.3356
192	F	Q	0.0000
193	Y	Q	-1.0694
194	N	Q	-1.5070
195	F	Q	-0.9369
196	V	Q	0.0000
197	T	Q	-0.9811
198	E	Q	-1.9110
199	E	Q	-1.2873
200	I	Q	-0.6291
201	P	Q	-0.8605
202	E	Q	-1.0058
203	P	Q	0.0000
204	A	Q	-0.5392
205	K	Q	0.0000
206	E	Q	-1.8071
207	C	Q	-1.5656
208	M	Q	0.0000
209	Q	Q	-1.1960
210	T	Q	-0.6681
211	L	Q	0.0000
212	L	Q	0.0000
213	G	Q	0.0000
214	F	Q	-0.3302
215	E	Q	0.0000
216	A	Q	0.0000
217	D	Q	0.0000
218	R	Q	0.0000
219	R	Q	-0.5269
220	S	Q	0.0000
221	I	Q	0.0000
222	N	Q	-0.7962
223	I	Q	0.0000
224	A	Q	0.0000
225	L	Q	-0.9275
226	N	Q	-1.7012
227	S	Q	0.0000
228	L	Q	-1.5890
229	Q	Q	-1.9967
230	S	Q	-1.1489
231	S	Q	-0.8941
232	D	Q	-0.7905
233	I	Q	-0.0339
234	D	Q	-1.4553
235	P	Q	-0.8900
236	D	Q	-0.5428
237	L	Q	0.1981
238	K	Q	-0.7833
239	S	Q	0.0000
240	D	Q	0.0000
241	L	Q	0.6726
242	L	Q	0.0127
243	P	Q	0.0445
244	N	Q	0.4226
245	I	Q	1.4686
246	G	Q	0.3189
247	K	Q	-0.4931
248	L	Q	0.0000
249	Y	Q	1.6826
250	P	Q	1.2587
251	L	Q	1.9795
252	A	Q	1.2919
253	T	Q	0.0000
254	F	Q	0.8250
255	H	Q	-0.2967
256	L	Q	0.0000
257	A	Q	0.0000
258	Q	Q	-1.3210
259	A	Q	-1.5582
260	Q	Q	-2.1421
261	D	Q	-2.2840
262	F	Q	-0.9620
263	E	Q	-1.6211
264	G	Q	-1.1133
265	V	Q	-0.5933
266	R	Q	0.0000
267	A	Q	-1.1383
268	A	Q	-0.5649
269	L	Q	-0.1905
270	A	Q	-0.5835
271	N	Q	-0.7061
272	V	Q	0.8238
273	Y	Q	0.0000
274	E	Q	-0.8467
275	Y	Q	0.0000
276	R	Q	-2.0074
277	G	Q	-1.0540
278	F	Q	-0.1084
279	L	Q	0.6472
280	E	Q	-1.1317
281	T	Q	-0.7542
282	G	Q	-1.0400
283	N	Q	-0.7308
284	L	Q	0.0000
285	E	Q	-1.1270
286	D	Q	0.0000
287	H	Q	0.0000
288	F	Q	0.0000
289	Y	Q	-0.1678
290	Q	Q	0.0000
291	L	Q	0.0000
292	E	Q	-0.7159
293	M	Q	-0.7992
294	E	Q	-2.0241
295	L	Q	-1.7889
296	C	Q	0.0000
297	R	Q	-2.9968
298	D	Q	-2.8460
299	A	Q	0.0000
300	F	Q	-1.4994
301	T	Q	-1.1562
302	Q	Q	-1.3354
303	Q	Q	-1.4465
304	F	Q	-0.3006
305	A	Q	0.0000
306	I	Q	0.0000
307	S	Q	0.0000
308	T	Q	0.0000
309	V	Q	0.0000
310	W	Q	0.0000
311	A	Q	0.0000
312	W	Q	0.0000
313	M	Q	0.0000
314	K	Q	-0.4995
315	S	Q	0.0000
316	K	Q	0.0000
317	E	Q	-1.4551
318	Q	Q	-0.9517
319	E	Q	0.0000
320	V	Q	0.0000
321	R	Q	-1.2365
322	N	Q	0.0000
323	I	Q	0.0000
324	T	Q	0.0000
325	W	Q	-0.6098
326	I	Q	0.0000
327	A	Q	0.0000
328	E	Q	-1.7868
329	C	Q	-2.3087
330	I	Q	0.0000
331	A	Q	0.0000
332	Q	Q	-2.6145
333	N	Q	-3.0139
334	Q	Q	-3.3113
335	R	Q	-3.1892
336	E	Q	0.0000
337	R	Q	-1.9980
338	I	Q	-0.6561
339	N	Q	0.0000
340	N	Q	-0.8150
341	Y	Q	0.5993
342	I	Q	0.0000
343	S	Q	0.6523
344	V	Q	1.0603
345	Y	Q	-0.1138