Project name: WEI2-2

Chain sequence(s)	H: VQLQQSGPDLVKPGASVKMSCKASGYTFTSYVMHWVKQKPGQGLEWIGYINPYNDNTRYNEKFKGKATLTSDKSSSTAYMELSSLTSEDSAVYYCANYYGSNFAMDYWGQGTSVTVSS; L: DIQMTQTTSSLSASLGDRVTISCRASQDISNYLTWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSGSGTDYSLTINSLDQEDIATYFCQQGSTLPWTFGGGTKVEIK
Distance of aggregation	5 Å
Dynamic mode	No

• Minimal score value: -2.258
• Maximal score value: 1.5263
• Average score: -0.2804
• Total score value: -63.0982

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	L	-1.7513
2	I	L	-0.3287
3	Q	L	-1.1408
4	M	L	-0.1255
5	T	L	-0.2587
6	Q	L	-0.1381
7	T	L	-0.0988
8	T	L	-0.0909
9	S	L	-0.2598
10	S	L	-0.2879
11	L	L	0.1904
12	S	L	-0.1917
13	A	L	0.0000
14	S	L	0.0907
15	L	L	0.8816
16	G	L	-0.4478
17	D	L	-1.2193
18	R	L	-2.1085
19	V	L	0.0000
20	T	L	-0.0463
21	I	L	0.0000
22	S	L	-0.1880
23	C	L	0.0000
24	R	L	-1.9558
25	A	L	0.0000
26	S	L	-0.3005
27	Q	L	-1.5308
28	D	L	-2.0144
29	I	L	0.0000
30	S	L	-0.2653
31	N	L	-0.2400
32	Y	L	0.4763
33	L	L	0.0000
34	T	L	0.0000
35	W	L	0.0000
36	Y	L	0.0000
37	Q	L	0.0000
38	Q	L	0.0000
39	K	L	-0.2367
40	P	L	-0.6158
41	D	L	-1.8545
42	G	L	-0.4343
43	T	L	-0.0440
44	V	L	0.0000
45	K	L	-0.8726
46	L	L	0.0000
47	L	L	0.0000
48	I	L	0.0000
49	Y	L	0.3424
50	Y	L	0.6599
51	T	L	0.0000
52	S	L	0.0000
53	R	L	-1.7812
54	L	L	-0.0074
55	H	L	-0.4352
56	S	L	-0.3799
57	G	L	-0.4490
58	V	L	0.1912
59	P	L	-0.0979
60	S	L	-0.3098
61	R	L	-0.4646
62	F	L	0.0000
63	S	L	-0.1114
64	G	L	-0.3394
65	S	L	-0.2743
66	G	L	-0.3271
67	S	L	-0.2767
68	G	L	-0.3746
69	T	L	-0.2282
70	D	L	-1.1908
71	Y	L	0.0000
72	S	L	-0.0626
73	L	L	0.0000
74	T	L	-0.0140
75	I	L	0.0000
76	N	L	-1.0573
77	S	L	-0.3606
78	L	L	0.0000
79	D	L	-1.4592
80	Q	L	-1.7646
81	E	L	-2.0412
82	D	L	0.0000
83	I	L	0.2087
84	A	L	0.0000
85	T	L	-0.1183
86	Y	L	0.0000
87	F	L	0.0000
88	C	L	0.0000
89	Q	L	0.0000
90	Q	L	0.0000
91	G	L	-0.0661
92	S	L	-0.1073
93	T	L	0.2212
94	L	L	1.5263
95	P	L	0.4212
96	W	L	0.0000
97	T	L	-0.0119
98	F	L	0.0000
99	G	L	0.0000
100	G	L	-0.4755
101	G	L	0.0000
102	T	L	0.0000
103	K	L	-0.7485
104	V	L	0.0000
105	E	L	-0.8326
106	I	L	1.2164
107	K	L	-1.3782
2	V	H	1.4970
3	Q	H	-0.8725
4	L	H	0.0000
5	Q	H	-1.1983
6	Q	H	0.0000
7	S	H	-0.1410
8	G	H	-0.5222
9	P	H	-0.4591
10	D	H	-0.3251
11	L	H	1.4866
12	V	H	0.2142
13	K	H	-1.6719
14	P	H	-0.4815
15	G	H	-0.5121
16	A	H	-0.0913
17	S	H	-0.1003
18	V	H	-0.1480
19	K	H	-1.7740
20	M	H	0.0000
21	S	H	-0.0321
22	C	H	0.0000
23	K	H	-0.9940
24	A	H	0.0000
25	S	H	-0.1707
26	G	H	-0.2236
27	Y	H	0.1631
28	T	H	-0.0245
29	F	H	0.0000
30	T	H	0.0916
31	S	H	-0.1216
32	Y	H	0.3709
33	V	H	0.2541
34	M	H	0.0000
35	H	H	0.0000
36	W	H	0.0000
37	V	H	0.0000
38	K	H	0.0000
39	Q	H	-0.3569
40	K	H	-1.2886
41	P	H	-0.5625
42	G	H	-0.7336
43	Q	H	-1.2990
44	G	H	-0.3563
45	L	H	0.0000
46	E	H	-1.2770
47	W	H	0.0000
48	I	H	0.0000
49	G	H	0.0000
50	Y	H	0.2214
51	I	H	0.0000
52	N	H	-0.3541
52A	P	H	0.0000
53	Y	H	1.0815
54	N	H	-1.3637
55	D	H	-2.2580
56	N	H	-1.6044
57	T	H	-0.4989
58	R	H	-1.3131
59	Y	H	-0.0672
60	N	H	-0.4327
61	E	H	-2.1539
62	K	H	-2.0308
63	F	H	0.0000
64	K	H	-1.7868
65	G	H	-0.8689
66	K	H	-0.5618
67	A	H	0.0000
68	T	H	-0.0421
69	L	H	0.0000
70	T	H	-0.0386
71	S	H	-0.1979
72	D	H	-1.0233
73	K	H	-1.0729
74	S	H	-0.4102
75	S	H	-0.2599
76	S	H	-0.1893
77	T	H	0.0000
78	A	H	0.0000
79	Y	H	0.2477
80	M	H	0.0000
81	E	H	-0.9385
82	L	H	0.0000
82A	S	H	-0.1715
82B	S	H	-0.2974
82C	L	H	0.0000
83	T	H	-0.0716
84	S	H	-0.5517
85	E	H	-1.8590
86	D	H	0.0000
87	S	H	-0.0451
88	A	H	0.0000
89	V	H	0.2765
90	Y	H	0.0000
91	Y	H	0.0000
92	C	H	0.0000
93	A	H	0.0000
94	N	H	0.0000
95	Y	H	0.0000
96	Y	H	0.4775
97	G	H	-0.3995
98	S	H	-0.3383
99	N	H	-0.0501
100	F	H	1.0051
100A	A	H	0.0000
100B	M	H	0.0000
101	D	H	-0.0634
102	Y	H	0.5991
103	W	H	0.0000
104	G	H	0.0000
105	Q	H	-1.0026
106	G	H	-0.2353
107	T	H	0.0000
108	S	H	-0.1033
109	V	H	0.0000
110	T	H	-0.0392
111	V	H	0.0000
112	S	H	-0.2368
113	S	H	-0.2491