Project name: 9115c3cb06dde50

Chain sequence(s)	A: PVDRSLLKLKMVQVVFRHGARSPLKPLPLEEQVEWNPQLLEVPPQTQFDYTVTNLAGGPKPYSPYDSQYHETTLKGGMFAGQLTKVGMQQMFALGERLRKNYVEDIPFLSPTFNPQEVFIRSTNIFRNLESTRCLLAGLFQCQKEGPIIIHTDEADSEVLYPNYQSCWSLRQRTRGRRQTASLQPGISEDLKKVKDRMGIDSSDKVDFFILLDNVAAEQAHNLPSCPMLKRFARMIEQRAVDTSLYILPKEDRESLQMAVGPFLHILESNLLKAMDSATAPDKIRKLYLYAAHDVTFIPLLMTLGIFDHKWPPFAVDLTMELYQHLESKEWFVQLYYHGKEQVPRGCPDGLCPLDMFLNAMSVYTLSPEKYHALCSQT
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.0589
• Maximal score value: 1.2127
• Average score: -0.8677
• Total score value: -327.9954

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
42	P	A	-0.3503
43	V	A	-0.3582
44	D	A	-2.1113
45	R	A	-2.4216
46	S	A	-1.4449
47	L	A	-1.3768
48	L	A	0.0000
49	K	A	-1.9950
50	L	A	-1.0653
51	K	A	-1.4296
52	M	A	0.0000
53	V	A	0.0000
54	Q	A	0.0000
55	V	A	0.0000
56	V	A	0.0000
57	F	A	0.0000
58	R	A	0.0000
59	H	A	0.0000
60	G	A	0.0000
61	A	A	0.0000
62	R	A	0.0000
63	S	A	0.0000
64	P	A	0.0000
65	L	A	-0.0952
66	K	A	-0.7083
67	P	A	-0.7148
68	L	A	0.0000
69	P	A	-1.6262
70	L	A	-1.8980
71	E	A	-2.7882
72	E	A	-3.1461
73	Q	A	-2.4204
74	V	A	-1.6590
75	E	A	-2.3729
76	W	A	0.0000
77	N	A	-1.5676
78	P	A	-1.2028
79	Q	A	-1.6939
80	L	A	-0.8013
81	L	A	-0.5062
82	E	A	-1.3938
83	V	A	-0.1601
84	P	A	-0.5697
85	P	A	-0.8046
86	Q	A	-1.0046
87	T	A	0.0000
88	Q	A	-1.6062
89	F	A	0.0000
90	D	A	-1.9748
91	Y	A	-0.6444
92	T	A	-0.3397
93	V	A	-0.2761
94	T	A	-0.8587
95	N	A	-1.0573
96	L	A	-0.2948
97	A	A	-0.3006
98	G	A	-0.6818
99	G	A	-0.9291
100	P	A	-1.1131
101	K	A	-1.9142
102	P	A	-0.9439
103	Y	A	0.3927
104	S	A	-0.0421
105	P	A	-0.2981
106	Y	A	-0.0993
107	D	A	-0.5652
108	S	A	-1.1851
109	Q	A	-1.8864
110	Y	A	0.0000
111	H	A	-1.6722
112	E	A	-2.3943
113	T	A	-1.4604
114	T	A	-0.9699
115	L	A	0.0000
116	K	A	-2.6347
117	G	A	-2.1232
118	G	A	-1.4795
119	M	A	0.0000
120	F	A	-0.2653
121	A	A	0.0000
122	G	A	0.0000
123	Q	A	0.2868
124	L	A	0.0000
125	T	A	0.0000
126	K	A	-0.9637
127	V	A	-0.2333
128	G	A	0.0000
129	M	A	0.0000
130	Q	A	-0.7925
131	Q	A	-0.6905
132	M	A	0.0000
133	F	A	-0.5551
134	A	A	-0.6472
135	L	A	0.0000
136	G	A	0.0000
137	E	A	-1.7248
138	R	A	-1.8783
139	L	A	0.0000
140	R	A	-2.3457
141	K	A	-3.2767
142	N	A	-2.4511
143	Y	A	0.0000
144	V	A	-1.9170
145	E	A	-3.2134
146	D	A	-2.8785
147	I	A	-1.1643
148	P	A	-0.9069
149	F	A	0.0000
150	L	A	0.0000
151	S	A	-0.7941
152	P	A	-1.0834
153	T	A	-1.2519
154	F	A	0.0000
155	N	A	-1.7612
156	P	A	-1.3017
157	Q	A	-2.2678
158	E	A	-1.5953
159	V	A	0.0000
160	F	A	-0.2668
161	I	A	0.0000
162	R	A	0.0000
163	S	A	0.0000
164	T	A	0.0000
165	N	A	0.0000
166	I	A	0.0000
167	F	A	1.1454
168	R	A	0.0000
169	N	A	0.0000
170	L	A	0.0000
171	E	A	0.1617
172	S	A	0.0000
173	T	A	0.0000
174	R	A	0.0000
175	C	A	0.0000
176	L	A	0.0000
177	L	A	0.0000
178	A	A	0.0000
179	G	A	0.0000
180	L	A	0.0000
181	F	A	0.0000
182	Q	A	-1.1833
183	C	A	-1.1454
184	Q	A	-1.5202
185	K	A	-2.4113
186	E	A	-2.7032
187	G	A	-1.6066
188	P	A	-0.9819
189	I	A	0.0000
190	I	A	0.3865
191	I	A	0.0000
192	H	A	-0.2196
193	T	A	0.0000
194	D	A	-1.5374
195	E	A	-2.5120
196	A	A	-1.7728
197	D	A	-2.7000
198	S	A	-1.8776
199	E	A	0.0000
200	V	A	-0.1584
201	L	A	0.0000
202	Y	A	0.5383
203	P	A	0.0000
204	N	A	0.0000
205	Y	A	-1.0423
206	Q	A	-1.5423
207	S	A	-1.1713
208	C	A	0.0000
209	W	A	-0.7017
210	S	A	0.0000
211	L	A	0.0000
212	R	A	-2.3936
213	Q	A	-2.6529
214	R	A	-2.6358
215	T	A	0.0000
216	R	A	-3.8533
217	G	A	-2.8935
218	R	A	-2.1509
219	R	A	-3.0327
220	Q	A	-2.4857
221	T	A	-1.0470
222	A	A	0.0000
223	S	A	-0.2277
224	L	A	0.7670
225	Q	A	0.1422
226	P	A	-0.3594
227	G	A	-0.7863
228	I	A	0.0000
229	S	A	-1.0269
230	E	A	-2.1187
231	D	A	-1.9546
232	L	A	-1.8118
233	K	A	-3.5292
234	K	A	-3.3492
235	V	A	0.0000
236	K	A	-3.2724
237	D	A	-4.0589
238	R	A	-3.3685
239	M	A	0.0000
240	G	A	-2.4537
241	I	A	0.0000
242	D	A	-2.9085
243	S	A	-2.3979
244	S	A	-1.7490
245	D	A	-2.4987
246	K	A	-2.5267
247	V	A	0.0000
248	D	A	-0.8915
249	F	A	0.0000
250	F	A	0.5760
251	I	A	0.1975
252	L	A	0.0000
253	L	A	0.0000
254	D	A	-0.0148
255	N	A	0.0000
256	V	A	0.0000
257	A	A	-0.5822
258	A	A	0.0000
259	E	A	0.0000
260	Q	A	-1.2933
261	A	A	-0.5513
262	H	A	-0.8261
263	N	A	-1.4751
264	L	A	-0.8199
265	P	A	-0.8943
266	S	A	-0.9676
267	C	A	-0.9076
268	P	A	-1.3211
269	M	A	-1.7288
270	L	A	0.0000
271	K	A	-2.7727
272	R	A	-2.7628
273	F	A	-2.0976
274	A	A	-2.0862
275	R	A	-2.7308
276	M	A	-1.5256
277	I	A	0.0000
278	E	A	-1.5835
279	Q	A	-1.8163
280	R	A	-1.1545
281	A	A	0.0000
282	V	A	0.0000
283	D	A	-0.6633
284	T	A	0.0000
285	S	A	0.1552
286	L	A	-0.3010
287	Y	A	-0.1178
288	I	A	-1.0228
289	L	A	0.0000
290	P	A	-1.4695
291	K	A	-2.8615
292	E	A	-3.2700
293	D	A	-2.7353
294	R	A	-2.9148
295	E	A	-2.4848
296	S	A	0.0000
297	L	A	0.0000
298	Q	A	-1.0238
299	M	A	0.0000
300	A	A	0.0000
301	V	A	0.0000
302	G	A	0.0000
303	P	A	0.0000
304	F	A	0.0000
305	L	A	0.0000
306	H	A	-0.2745
307	I	A	0.1809
308	L	A	0.0000
309	E	A	-0.2517
310	S	A	-0.1169
311	N	A	0.0000
312	L	A	0.0000
313	L	A	0.0769
314	K	A	-1.0127
315	A	A	-0.5565
316	M	A	-0.3527
317	D	A	-1.7281
318	S	A	-1.0292
319	A	A	-0.8231
320	T	A	-1.1900
321	A	A	-1.6430
322	P	A	-1.9272
323	D	A	-2.8834
324	K	A	-2.7640
325	I	A	-1.6670
326	R	A	-1.7760
327	K	A	-1.2163
328	L	A	0.0000
329	Y	A	0.0000
330	L	A	0.0000
331	Y	A	0.0000
332	A	A	0.0000
333	A	A	0.0000
334	H	A	0.0000
335	D	A	0.4625
336	V	A	1.2127
337	T	A	0.0000
338	F	A	0.0000
339	I	A	0.0000
340	P	A	0.0000
341	L	A	0.0000
342	L	A	0.0000
343	M	A	0.0000
344	T	A	0.0000
345	L	A	0.0000
346	G	A	-0.7111
347	I	A	0.0000
348	F	A	-0.5635
349	D	A	-1.3333
350	H	A	-1.5214
351	K	A	-2.1439
352	W	A	-0.7944
353	P	A	0.0000
354	P	A	-0.2909
355	F	A	0.1091
356	A	A	-0.1840
357	V	A	0.0000
358	D	A	0.0000
359	L	A	0.0000
360	T	A	0.0000
361	M	A	0.0000
362	E	A	0.0000
363	L	A	0.0000
364	Y	A	0.0000
365	Q	A	-1.9154
366	H	A	-2.3054
367	L	A	-1.6292
368	E	A	-2.3018
369	S	A	-2.2281
370	K	A	-3.1478
371	E	A	-3.0784
372	W	A	-1.6918
373	F	A	0.0000
374	V	A	0.0000
375	Q	A	-0.3436
376	L	A	0.0000
377	Y	A	-1.3159
378	Y	A	0.0000
379	H	A	-1.7777
380	G	A	-2.1010
381	K	A	-2.8481
382	E	A	-2.5053
383	Q	A	-1.0773
384	V	A	0.3232
385	P	A	0.0000
386	R	A	-0.9359
387	G	A	-0.9803
388	C	A	-0.8823
389	P	A	-0.9356
390	D	A	-1.5642
391	G	A	-0.6765
392	L	A	-0.5093
393	C	A	0.0000
394	P	A	-1.0011
395	L	A	0.0000
396	D	A	-1.9962
397	M	A	-1.0105
398	F	A	0.0000
399	L	A	-0.8464
400	N	A	-1.4697
401	A	A	-0.9205
402	M	A	0.0000
403	S	A	-0.3493
404	V	A	-0.1824
405	Y	A	0.0000
406	T	A	-0.2021
407	L	A	0.0000
408	S	A	-1.4137
409	P	A	-1.8469
410	E	A	-2.9772
411	K	A	-2.7475
412	Y	A	0.0000
413	H	A	-2.0478
414	A	A	-1.3645
415	L	A	-0.6068
416	C	A	-0.5846
417	S	A	-0.6037
418	Q	A	-1.1964
419	T	A	-0.5797