| Chain sequence(s) |
A: YCPKTYTFDDGKVIIKAGARVEEEKVKRLYWASKEVNSQFFRVYGIDKPLEEGNPDDILTMVIYNSPEEYKLNSVLYGYDTNNGGMYIEPEGTFFTYEREAQESTYTLEELFRHEYTHYLQGRYAVPGQWGRTKLYDNDRLTWYEEGGAELFAGSTRTSGILPRKSIVSNIHNTTRNNRYKLSDTVHSKYGASFEFYNYACMFMDYMYNKDMGILNKLNDLAKNNDVDGYDNYIRDLSSNHALNDKYQDHMQERIDNYENLTVPFVADDYLVRHAYKNPNEIYSEISEVAKLKDAKSEVKKSQYFSTFTLRGSYTGGVSKGKLEDQKAMNKFIDDSLKKLDTYSWSGYKTLTAYFTNYKVDSSNKVTYDVVFHGYLPNEG B: GPA |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 342 | Y | A | 1.1090 | |
| 343 | C | A | -0.1556 | |
| 344 | P | A | -0.5265 | |
| 345 | K | A | -1.1630 | |
| 346 | T | A | -0.6750 | |
| 347 | Y | A | 0.0000 | |
| 348 | T | A | -0.9738 | |
| 349 | F | A | 0.0000 | |
| 350 | D | A | -1.9012 | |
| 351 | D | A | -2.8596 | |
| 352 | G | A | -1.8275 | |
| 353 | K | A | -1.3486 | |
| 354 | V | A | -0.4309 | |
| 355 | I | A | -0.1251 | |
| 356 | I | A | 0.0000 | |
| 357 | K | A | -0.7670 | |
| 358 | A | A | 0.0000 | |
| 359 | G | A | 0.0000 | |
| 360 | A | A | -1.3924 | |
| 361 | R | A | -2.6470 | |
| 362 | V | A | 0.0000 | |
| 363 | E | A | -3.4444 | |
| 364 | E | A | -2.9155 | |
| 365 | E | A | -2.7399 | |
| 366 | K | A | -2.2575 | |
| 367 | V | A | 0.0000 | |
| 368 | K | A | -1.3794 | |
| 369 | R | A | -1.2749 | |
| 370 | L | A | 0.0000 | |
| 371 | Y | A | 0.0000 | |
| 372 | W | A | 0.0000 | |
| 373 | A | A | 0.0000 | |
| 374 | S | A | 0.0000 | |
| 375 | K | A | 0.0000 | |
| 376 | E | A | 0.0000 | |
| 377 | V | A | 0.0000 | |
| 378 | N | A | -0.2406 | |
| 379 | S | A | 0.0000 | |
| 380 | Q | A | 0.0000 | |
| 381 | F | A | 0.0000 | |
| 382 | F | A | 0.0000 | |
| 383 | R | A | 0.0000 | |
| 384 | V | A | 0.0000 | |
| 385 | Y | A | 0.0000 | |
| 386 | G | A | -0.6174 | |
| 387 | I | A | -0.6211 | |
| 388 | D | A | -1.1226 | |
| 389 | K | A | -2.0064 | |
| 390 | P | A | -1.5833 | |
| 391 | L | A | -0.9521 | |
| 392 | E | A | -1.8746 | |
| 393 | E | A | -2.7663 | |
| 394 | G | A | -1.8210 | |
| 395 | N | A | -1.7785 | |
| 396 | P | A | -1.3468 | |
| 397 | D | A | 0.0000 | |
| 398 | D | A | -1.5267 | |
| 399 | I | A | -0.2347 | |
| 400 | L | A | 0.0000 | |
| 401 | T | A | -0.2586 | |
| 402 | M | A | 0.0000 | |
| 403 | V | A | 0.0000 | |
| 404 | I | A | 0.0000 | |
| 405 | Y | A | 0.0000 | |
| 406 | N | A | -1.2398 | |
| 407 | S | A | -1.8819 | |
| 408 | P | A | -1.9271 | |
| 409 | E | A | -2.3310 | |
| 410 | E | A | -1.2281 | |
| 411 | Y | A | 0.0000 | |
| 412 | K | A | -2.1277 | |
| 413 | L | A | 0.1975 | |
| 414 | N | A | 0.0291 | |
| 415 | S | A | 0.0000 | |
| 416 | V | A | 1.2288 | |
| 417 | L | A | 1.4065 | |
| 418 | Y | A | 1.8231 | |
| 419 | G | A | 0.4947 | |
| 420 | Y | A | 0.6232 | |
| 421 | D | A | -1.2576 | |
| 422 | T | A | -1.1256 | |
| 423 | N | A | -1.8876 | |
| 424 | N | A | 0.0000 | |
| 425 | G | A | 0.0000 | |
| 426 | G | A | 0.0000 | |
| 427 | M | A | 0.0000 | |
| 428 | Y | A | 0.1663 | |
| 429 | I | A | -0.0434 | |
| 430 | E | A | 0.0000 | |
| 431 | P | A | -1.1103 | |
| 432 | E | A | -1.8262 | |
| 433 | G | A | 0.0000 | |
| 434 | T | A | 0.0000 | |
| 435 | F | A | 0.0000 | |
| 436 | F | A | 0.0000 | |
| 437 | T | A | 0.0000 | |
| 438 | Y | A | 0.0000 | |
| 439 | E | A | -1.4431 | |
| 440 | R | A | 0.0000 | |
| 441 | E | A | -2.6122 | |
| 442 | A | A | -1.8219 | |
| 443 | Q | A | -2.3181 | |
| 444 | E | A | -2.3539 | |
| 445 | S | A | -1.3210 | |
| 446 | T | A | -0.6288 | |
| 447 | Y | A | 0.0000 | |
| 448 | T | A | -0.3949 | |
| 449 | L | A | 0.0000 | |
| 450 | E | A | 0.0000 | |
| 451 | E | A | 0.0000 | |
| 452 | L | A | 0.0000 | |
| 453 | F | A | 0.0000 | |
| 454 | R | A | 0.0000 | |
| 455 | H | A | 0.0000 | |
| 456 | E | A | 0.0000 | |
| 457 | Y | A | 0.0000 | |
| 458 | T | A | 0.0000 | |
| 459 | H | A | -0.0080 | |
| 460 | Y | A | 0.0000 | |
| 461 | L | A | 0.0000 | |
| 462 | Q | A | 0.0000 | |
| 463 | G | A | -0.2171 | |
| 464 | R | A | -1.0734 | |
| 465 | Y | A | 0.0000 | |
| 466 | A | A | 0.0000 | |
| 467 | V | A | 0.0000 | |
| 468 | P | A | -0.9727 | |
| 469 | G | A | -1.3051 | |
| 470 | Q | A | -1.3773 | |
| 471 | W | A | -0.6625 | |
| 472 | G | A | -2.1281 | |
| 473 | R | A | -2.8206 | |
| 474 | T | A | -2.4058 | |
| 475 | K | A | -3.3132 | |
| 476 | L | A | 0.0000 | |
| 477 | Y | A | -2.4407 | |
| 478 | D | A | -3.5151 | |
| 479 | N | A | -3.0684 | |
| 480 | D | A | -2.2901 | |
| 481 | R | A | -2.1591 | |
| 482 | L | A | 0.0000 | |
| 483 | T | A | 0.0000 | |
| 484 | W | A | 0.0000 | |
| 485 | Y | A | 0.0000 | |
| 486 | E | A | 0.0000 | |
| 487 | E | A | 0.0000 | |
| 488 | G | A | 0.0000 | |
| 489 | G | A | 0.0000 | |
| 490 | A | A | 0.0000 | |
| 491 | E | A | 0.0000 | |
| 492 | L | A | 0.0000 | |
| 493 | F | A | 0.0000 | |
| 494 | A | A | 0.0000 | |
| 495 | G | A | 0.0000 | |
| 496 | S | A | 0.0000 | |
| 497 | T | A | 0.2596 | |
| 498 | R | A | -0.3386 | |
| 499 | T | A | -1.2486 | |
| 500 | S | A | -0.8659 | |
| 501 | G | A | 0.0000 | |
| 502 | I | A | 0.0000 | |
| 503 | L | A | 0.2426 | |
| 504 | P | A | 0.0231 | |
| 505 | R | A | 0.0000 | |
| 506 | K | A | -1.3463 | |
| 507 | S | A | 0.0000 | |
| 508 | I | A | 0.0000 | |
| 509 | V | A | 0.0000 | |
| 510 | S | A | -1.1566 | |
| 511 | N | A | -1.4943 | |
| 512 | I | A | 0.0000 | |
| 513 | H | A | -2.0633 | |
| 514 | N | A | -1.9286 | |
| 515 | T | A | -1.8941 | |
| 516 | T | A | -2.1812 | |
| 517 | R | A | -3.4806 | |
| 518 | N | A | -2.9854 | |
| 519 | N | A | -2.7558 | |
| 520 | R | A | 0.0000 | |
| 521 | Y | A | -1.9605 | |
| 522 | K | A | -2.9416 | |
| 523 | L | A | 0.0000 | |
| 524 | S | A | -2.3085 | |
| 525 | D | A | -2.5439 | |
| 526 | T | A | 0.0000 | |
| 527 | V | A | 0.0000 | |
| 528 | H | A | -2.3988 | |
| 529 | S | A | 0.0000 | |
| 530 | K | A | -2.2137 | |
| 531 | Y | A | -0.5469 | |
| 532 | G | A | -0.7042 | |
| 533 | A | A | -0.5733 | |
| 534 | S | A | -0.6884 | |
| 535 | F | A | -0.6306 | |
| 536 | E | A | -1.6102 | |
| 537 | F | A | 0.0000 | |
| 538 | Y | A | 0.0000 | |
| 539 | N | A | 0.0000 | |
| 540 | Y | A | 0.0000 | |
| 541 | A | A | 0.0000 | |
| 542 | C | A | 0.0000 | |
| 543 | M | A | 0.0000 | |
| 544 | F | A | 0.0000 | |
| 545 | M | A | 0.0000 | |
| 546 | D | A | 0.0000 | |
| 547 | Y | A | 0.0000 | |
| 548 | M | A | 0.0000 | |
| 549 | Y | A | -0.5662 | |
| 550 | N | A | -1.3258 | |
| 551 | K | A | -2.1473 | |
| 552 | D | A | -1.3642 | |
| 553 | M | A | -1.1232 | |
| 554 | G | A | -0.7968 | |
| 555 | I | A | -0.7768 | |
| 556 | L | A | 0.0000 | |
| 557 | N | A | -1.2369 | |
| 558 | K | A | -1.8985 | |
| 559 | L | A | 0.0000 | |
| 560 | N | A | 0.0000 | |
| 561 | D | A | -2.9558 | |
| 562 | L | A | 0.0000 | |
| 563 | A | A | 0.0000 | |
| 564 | K | A | -2.0822 | |
| 565 | N | A | -2.5430 | |
| 566 | N | A | -2.6445 | |
| 567 | D | A | -2.7751 | |
| 568 | V | A | -2.3867 | |
| 569 | D | A | -2.7116 | |
| 570 | G | A | -2.3887 | |
| 571 | Y | A | 0.0000 | |
| 572 | D | A | -2.6140 | |
| 573 | N | A | -2.7857 | |
| 574 | Y | A | -2.0981 | |
| 575 | I | A | 0.0000 | |
| 576 | R | A | -3.4283 | |
| 577 | D | A | -3.3334 | |
| 578 | L | A | 0.0000 | |
| 579 | S | A | -2.3855 | |
| 580 | S | A | -1.9748 | |
| 581 | N | A | -2.4144 | |
| 582 | H | A | -2.4916 | |
| 583 | A | A | -1.7444 | |
| 584 | L | A | 0.0000 | |
| 585 | N | A | -2.6957 | |
| 586 | D | A | -3.6571 | |
| 587 | K | A | -3.4662 | |
| 588 | Y | A | 0.0000 | |
| 589 | Q | A | -3.2087 | |
| 590 | D | A | -3.7127 | |
| 591 | H | A | 0.0000 | |
| 592 | M | A | 0.0000 | |
| 593 | Q | A | -3.0286 | |
| 594 | E | A | -3.3304 | |
| 595 | R | A | -2.7091 | |
| 596 | I | A | 0.0000 | |
| 597 | D | A | -3.3720 | |
| 598 | N | A | -3.1325 | |
| 599 | Y | A | -2.6110 | |
| 600 | E | A | -3.0257 | |
| 601 | N | A | -2.6293 | |
| 602 | L | A | -1.3520 | |
| 603 | T | A | -0.3004 | |
| 604 | V | A | 0.6801 | |
| 605 | P | A | 0.0000 | |
| 606 | F | A | 1.7581 | |
| 607 | V | A | 0.0000 | |
| 608 | A | A | -0.5810 | |
| 609 | D | A | -1.6895 | |
| 610 | D | A | -1.5592 | |
| 611 | Y | A | 0.0000 | |
| 612 | L | A | -0.8898 | |
| 613 | V | A | -0.3537 | |
| 614 | R | A | -1.1910 | |
| 615 | H | A | -0.4457 | |
| 616 | A | A | 0.2726 | |
| 617 | Y | A | 0.3089 | |
| 618 | K | A | -0.6578 | |
| 619 | N | A | -1.8146 | |
| 620 | P | A | -1.6110 | |
| 621 | N | A | -2.3176 | |
| 622 | E | A | -2.4685 | |
| 623 | I | A | 0.0000 | |
| 624 | Y | A | -1.6489 | |
| 625 | S | A | -1.7006 | |
| 626 | E | A | -1.8568 | |
| 627 | I | A | 0.0000 | |
| 628 | S | A | -2.5608 | |
| 629 | E | A | -2.7995 | |
| 630 | V | A | 0.0000 | |
| 631 | A | A | 0.0000 | |
| 632 | K | A | -2.7086 | |
| 633 | L | A | 0.0000 | |
| 634 | K | A | -3.5520 | |
| 635 | D | A | -3.1210 | |
| 636 | A | A | -2.6568 | |
| 637 | K | A | -2.8462 | |
| 638 | S | A | -1.4544 | |
| 639 | E | A | -1.1488 | |
| 640 | V | A | 0.2087 | |
| 641 | K | A | -1.3876 | |
| 642 | K | A | -2.4762 | |
| 643 | S | A | 0.0000 | |
| 644 | Q | A | -1.3031 | |
| 645 | Y | A | -0.2285 | |
| 646 | F | A | -0.7765 | |
| 647 | S | A | 0.0000 | |
| 648 | T | A | 0.0000 | |
| 649 | F | A | 0.0000 | |
| 650 | T | A | 0.0000 | |
| 651 | L | A | 0.0000 | |
| 652 | R | A | -1.9216 | |
| 653 | G | A | 0.0000 | |
| 654 | S | A | -1.9537 | |
| 655 | Y | A | -1.2668 | |
| 656 | T | A | -0.9491 | |
| 657 | G | A | -0.4376 | |
| 658 | G | A | -0.3285 | |
| 659 | V | A | 0.3547 | |
| 660 | S | A | -1.4052 | |
| 661 | K | A | -2.3393 | |
| 662 | G | A | -1.7111 | |
| 663 | K | A | -2.1341 | |
| 664 | L | A | -1.6067 | |
| 665 | E | A | -2.8833 | |
| 666 | D | A | 0.0000 | |
| 667 | Q | A | -1.7938 | |
| 668 | K | A | -2.2868 | |
| 669 | A | A | -1.8411 | |
| 670 | M | A | 0.0000 | |
| 671 | N | A | -1.9391 | |
| 672 | K | A | -2.5160 | |
| 673 | F | A | -1.4650 | |
| 674 | I | A | 0.0000 | |
| 675 | D | A | -2.3227 | |
| 676 | D | A | -3.2720 | |
| 677 | S | A | 0.0000 | |
| 678 | L | A | 0.0000 | |
| 679 | K | A | -3.0789 | |
| 680 | K | A | -2.7363 | |
| 681 | L | A | 0.0000 | |
| 682 | D | A | -1.6326 | |
| 683 | T | A | -0.9810 | |
| 684 | Y | A | -0.5116 | |
| 685 | S | A | -0.1571 | |
| 686 | W | A | 0.0000 | |
| 687 | S | A | -0.3789 | |
| 688 | G | A | 0.0000 | |
| 689 | Y | A | 0.0000 | |
| 690 | K | A | -1.0472 | |
| 691 | T | A | 0.0000 | |
| 692 | L | A | 0.0000 | |
| 693 | T | A | 0.0000 | |
| 694 | A | A | 0.0000 | |
| 695 | Y | A | 0.0000 | |
| 696 | F | A | 0.0000 | |
| 697 | T | A | 0.0000 | |
| 698 | N | A | -1.7696 | |
| 699 | Y | A | -1.3699 | |
| 700 | K | A | -2.2151 | |
| 701 | V | A | -1.2208 | |
| 702 | D | A | -1.2118 | |
| 703 | S | A | -1.1492 | |
| 704 | S | A | -0.9444 | |
| 705 | N | A | -1.6970 | |
| 706 | K | A | -1.3744 | |
| 707 | V | A | 0.0000 | |
| 708 | T | A | -1.0456 | |
| 709 | Y | A | 0.0000 | |
| 710 | D | A | -1.5779 | |
| 711 | V | A | 0.0000 | |
| 712 | V | A | 0.0000 | |
| 713 | F | A | 0.0000 | |
| 714 | H | A | 0.0000 | |
| 715 | G | A | 0.0000 | |
| 716 | Y | A | 0.1437 | |
| 717 | L | A | 0.0000 | |
| 718 | P | A | 0.0000 | |
| 719 | N | A | -2.3066 | |
| 720 | E | A | -2.5973 | |
| 721 | G | A | -1.6830 | |
| 2 | G | B | -0.1001 | |
| 3 | P | B | 0.0000 | |
| 4 | A | B | -0.3499 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine