Project name: Full TAU and FKBP12

Status: done

submitted: 2019-02-20 00:09:56, status changed: 2019-02-20 00:26:10
Settings
Chain sequence(s) A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
B: GVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
Distance of aggregation 10 Å
Dynamic mode No
Show buried residues

Minimal score value
-4.1738
Maximal score value
1.8664
Average score
-1.147
Total score value
-628.5725

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index residue name chain Aggrescan3D score mutation
residue index residue name chain Aggrescan3D score
mutation
1 M A -0.0443
2 A A -1.2962
3 E A -2.3676
4 P A -2.2536
5 R A -2.9969
6 Q A -2.4246
7 E A -1.5906
8 F A 0.0000
9 E A -1.9528
10 V A 0.0000
11 M A -1.4700
12 E A -2.5702
13 D A -2.7509
14 H A 0.0000
15 A A -1.8574
16 G A -1.8023
17 T A -1.5137
18 Y A 0.0000
19 G A 0.0000
20 L A -1.3562
21 G A -2.0094
22 D A -3.1248
23 R A -3.0610
24 K A -2.7808
25 D A -2.1834
26 Q A 0.0000
27 G A 0.0000
28 G A -0.0772
29 Y A 0.8363
30 T A 0.7307
31 M A 0.5672
32 H A -0.9776
33 Q A -2.5056
34 D A -3.6323
35 Q A 0.0000
36 E A -2.8303
37 G A -2.9988
38 D A -3.2951
39 T A -2.4556
40 D A -2.6178
41 A A -1.8967
42 G A -1.2363
43 L A -0.3890
44 K A -2.3866
45 E A -2.8700
46 S A -1.3623
47 P A -0.1665
48 L A 0.5662
49 Q A -0.2711
50 T A 0.0000
51 P A 0.0000
52 T A -2.9880
53 E A -3.5608
54 D A -2.3475
55 G A -1.8504
56 S A -1.5739
57 E A -2.7383
58 E A -2.3589
59 P A -1.6971
60 G A -1.4863
61 S A -1.8958
62 E A -2.4136
63 T A -2.1647
64 S A -1.8751
65 D A -2.1501
66 A A -1.5044
67 K A -2.2974
68 S A -1.1420
69 T A -0.9789
70 P A -1.3123
71 T A 0.0000
72 A A 0.0000
73 E A -1.9673
74 D A -1.3199
75 V A -0.0841
76 T A -0.2866
77 A A 0.4786
78 P A 0.7038
79 L A 1.4027
80 V A 0.5015
81 D A -1.8132
82 E A -2.3962
83 G A -1.8417
84 A A -1.4605
85 P A -1.4287
86 G A -1.8105
87 K A -2.7855
88 Q A -2.1562
89 A A -1.4644
90 A A -1.3330
91 A A -1.2794
92 Q A -1.6294
93 P A -1.8215
94 H A -2.2530
95 T A -2.0682
96 E A -2.7941
97 I A -1.4693
98 P A -1.9741
99 E A -2.7363
100 G A -2.0934
101 T A -1.8811
102 T A -1.7148
103 A A -2.2093
104 E A -2.9009
105 E A -2.6319
106 A A -2.0957
107 G A -1.9289
108 I A -0.9268
109 G A -1.9575
110 D A -2.5735
111 T A -1.8290
112 P A -1.2974
113 S A -1.3528
114 L A -1.6349
115 E A -2.8414
116 D A -2.8417
117 E A -1.9946
118 A A 0.0000
119 A A -0.6233
120 G A -1.1364
121 H A -1.0982
122 V A 0.8320
123 T A -0.5038
124 Q A -0.7669
125 A A -0.9646
126 R A 0.0000
127 M A -0.2887
128 V A -0.3563
129 S A -1.2790
130 K A -2.2126
131 S A -2.0885
132 K A -2.7285
133 D A -3.5549
134 G A -2.0342
135 T A -1.4849
136 G A -1.7744
137 S A -2.6681
138 D A -3.2816
139 D A -3.8000
140 K A -3.2908
141 K A -2.2297
142 A A 0.0000
143 K A -1.4614
144 G A -1.6979
145 A A -1.9274
146 D A -3.1145
147 G A -2.6325
148 K A -2.6391
149 T A -2.0319
150 K A -1.5893
151 I A 0.5872
152 A A 0.0551
153 T A -0.3216
154 P A -1.2759
155 R A -2.5654
156 G A -1.8988
157 A A -1.1245
158 A A -1.0620
159 P A -1.0298
160 P A -1.4575
161 G A -2.1654
162 Q A -2.9853
163 K A -2.9820
164 G A -2.5557
165 Q A -2.7615
166 A A -2.2901
167 N A -2.5580
168 A A -1.2709
169 T A -1.1063
170 R A -1.4546
171 I A 0.3843
172 P A -0.0973
173 A A -0.9187
174 K A -1.9609
175 T A -1.0451
176 P A -1.0832
177 P A -0.9158
178 A A -0.7390
179 P A -1.4664
180 K A -1.9662
181 T A -1.1574
182 P A -1.2205
183 P A -1.4435
184 S A -1.0136
185 S A -0.6171
186 G A -1.2109
187 E A -1.8927
188 P A -2.1257
189 P A -1.9131
190 K A -2.8413
191 S A -2.3062
192 G A -2.0821
193 D A -3.3792
194 R A -3.4563
195 S A 0.0000
196 G A -1.3107
197 Y A 0.0000
198 S A -0.6374
199 S A 0.0000
200 P A -0.7303
201 G A -0.9401
202 S A -0.4815
203 P A -0.5255
204 G A -1.1616
205 T A -0.9188
206 P A -0.9700
207 G A -0.5663
208 S A 0.0000
209 R A -1.0361
210 S A -1.0967
211 R A -2.0342
212 T A -1.2476
213 P A -1.2128
214 S A -1.1385
215 L A -1.2828
216 P A 0.0000
217 T A -2.1393
218 P A -2.1018
219 P A -1.1597
220 T A -1.3805
221 R A -3.0605
222 E A -3.1306
223 P A 0.0000
224 K A -3.2314
225 K A -2.3537
226 V A -0.6289
227 A A 0.3584
228 V A 1.8664
229 V A 1.7565
230 R A -0.9406
231 T A -1.2560
232 P A -1.2393
233 P A -1.5496
234 K A -2.0907
235 S A 0.0000
236 P A 0.0000
237 S A -0.7171
238 S A 0.0000
239 A A -0.9645
240 K A -1.2631
241 S A -1.8493
242 R A -2.3562
243 L A -0.8440
244 Q A -1.1943
245 T A -0.5569
246 A A -0.1404
247 P A -0.2586
248 V A -0.0557
249 P A 0.0000
250 M A -0.7452
251 P A -1.0731
252 D A -1.6569
253 L A -0.1329
254 K A -1.2205
255 N A -1.3783
256 V A -0.4467
257 K A -1.0408
258 S A -1.1600
259 K A -1.0627
260 I A 0.5799
261 G A 0.0000
262 S A -0.6877
263 T A -0.4755
264 E A -1.1354
265 N A -1.9692
266 L A -1.2246
267 K A -1.7906
268 H A -2.1241
269 Q A -2.1781
270 P A -1.8737
271 G A -1.7452
272 G A -1.2762
273 G A -0.6706
274 K A 0.0000
275 V A -0.1328
276 Q A -1.6982
277 I A -1.2617
278 I A 0.0000
279 N A -2.7560
280 K A -3.1271
281 K A -2.6222
282 L A -1.3193
283 D A 0.0000
284 L A 0.0000
285 S A -1.5505
286 N A -2.0124
287 V A -1.1799
288 Q A -1.8747
289 S A -1.7498
290 K A -1.9739
291 C A -1.8683
292 G A 0.0000
293 S A -1.9232
294 K A -2.8008
295 D A -2.7766
296 N A -1.8930
297 I A -1.3184
298 K A -2.0269
299 H A 0.0000
300 V A 0.0000
301 P A 0.0589
302 G A -0.8286
303 G A -0.8899
304 G A -0.3416
305 S A 0.1065
306 V A 1.4163
307 Q A 0.2969
308 I A 0.0000
309 V A 0.7957
310 Y A 0.6833
311 K A -1.0670
312 P A 0.0484
313 V A 1.1743
314 D A -0.5793
315 L A 0.4338
316 S A -0.5151
317 K A -1.6567
318 V A -0.3115
319 T A -0.2738
320 S A -0.8622
321 K A -1.6153
322 C A -0.8524
323 G A -0.3419
324 S A 0.0000
325 L A -0.1648
326 G A -0.7031
327 N A -0.9094
328 I A 0.5842
329 H A -0.8673
330 H A -1.3005
331 K A -0.9738
332 P A -1.0949
333 G A -1.5236
334 G A -1.4611
335 G A -1.9092
336 Q A -2.8521
337 V A -2.0183
338 E A -1.4492
339 V A -1.2416
340 K A -2.3907
341 S A -2.0016
342 E A -2.6070
343 K A -1.2904
344 L A 0.0190
345 D A -0.6509
346 F A -0.6290
347 K A 0.0000
348 D A -1.9139
349 R A -2.1841
350 V A -1.0650
351 Q A -1.8721
352 S A -1.2823
353 K A -1.1496
354 I A 0.6434
355 G A -0.1054
356 S A 0.0082
357 L A 0.1481
358 D A -1.3481
359 N A -0.7108
360 I A 1.0350
361 T A 0.2356
362 H A 0.1428
363 V A 1.4174
364 P A 0.2063
365 G A -0.8499
366 G A -1.4692
367 G A -1.7619
368 N A -2.2445
369 K A -2.2702
370 K A -2.0019
371 I A -0.4144
372 E A -1.9752
373 T A -1.5483
374 H A -1.7389
375 K A -1.4267
376 L A 0.7267
377 T A 0.5434
378 F A 0.5763
379 R A -1.8940
380 E A -3.0240
381 N A -2.6791
382 A A -2.1303
383 K A -2.8072
384 A A -1.8073
385 K A -2.7161
386 T A -1.9267
387 D A -2.1438
388 H A -2.1478
389 G A -1.0451
390 A A -0.5077
391 E A -0.8841
392 I A 0.0945
393 V A 0.1563
394 Y A -0.8256
395 K A -1.6300
396 S A -0.1774
397 P A 0.5096
398 V A 1.2805
399 V A 1.5938
400 S A -0.0049
401 G A -0.4124
402 D A -1.1706
403 T A -0.9932
404 S A -0.8721
405 P A -1.1775
406 R A -2.3771
407 H A -1.4011
408 L A 0.0350
409 S A -0.6185
410 N A -1.3854
411 V A -0.9371
412 S A -0.9314
413 S A -0.6563
414 T A 0.0210
415 G A 0.0000
416 S A 0.5654
417 I A 1.5864
418 D A -0.2940
419 M A 0.7397
420 V A 0.1479
421 D A -1.1278
422 S A -0.7048
423 P A -0.3288
424 Q A -0.8813
425 L A 0.0000
426 A A 0.5628
427 T A 0.2154
428 L A 0.6295
429 A A -0.3895
430 D A -1.9048
431 E A -1.7374
432 V A 0.2594
433 S A -0.3666
434 A A -0.1483
435 S A -0.2163
436 L A -0.4957
437 A A -0.8010
438 K A -1.8933
439 Q A -1.0528
440 G A -0.6052
441 L A 0.9443
1 G B -1.1123
2 V B -1.0456
3 Q B -1.6921
4 V B -1.5411
5 E B -2.1154
6 T B -1.0642
7 I B -0.0057
8 S B -0.6886
9 P B -0.7070
10 G B 0.0000
11 D B -1.0632
12 G B 0.0000
13 R B -2.4061
14 T B -1.2778
15 F B -1.2813
16 P B 0.0000
17 K B -2.0155
18 R B -1.8607
19 G B -1.6720
20 Q B -1.7307
21 T B -1.6904
22 C B 0.0000
23 V B 0.0000
24 V B 0.0000
25 H B -1.4718
26 Y B 0.0000
27 T B 0.0000
28 G B 0.0000
29 M B -2.0472
30 L B -2.0403
31 E B -3.1355
32 D B -3.4888
33 G B -2.9304
34 K B -3.5236
35 K B -3.1137
36 F B -1.0219
37 D B -2.0521
38 S B -2.3902
39 S B 0.0000
40 R B -3.0503
41 D B -3.8713
42 R B -4.1738
43 N B -3.7740
44 K B -3.4551
45 P B -1.7640
46 F B -1.1382
47 K B -1.7687
48 F B 0.0000
49 M B -1.2343
50 L B 0.0000
51 G B 0.0000
52 K B -1.8005
53 Q B -1.3734
54 E B -1.5507
55 V B -0.6879
56 I B -0.0589
57 R B 0.0000
58 G B 0.0000
59 W B 0.0000
60 E B 0.0000
61 E B -0.5343
62 G B 0.0000
63 V B 0.0000
64 A B -0.8788
65 Q B -1.1582
66 M B 0.0000
67 S B 0.0000
68 V B -0.7739
69 G B -0.7927
70 Q B 0.0000
71 R B -1.0771
72 A B 0.0000
73 K B -1.3820
74 L B 0.0000
75 T B -0.9182
76 I B 0.0000
77 S B -0.9579
78 P B 0.0000
79 D B -1.8272
80 Y B -0.6274
81 A B -0.2655
82 Y B -0.2043
83 G B -0.9247
84 A B -0.7756
85 T B -0.5428
86 G B -0.4748
87 H B -0.5131
88 P B -0.4302
89 G B 0.0525
90 I B 1.1993
91 I B 0.0000
92 P B -0.3586
93 P B -0.7509
94 H B -1.3890
95 A B 0.0000
96 T B -1.1087
97 L B 0.0000
98 V B -0.9692
99 F B 0.0000
100 D B 0.0000
101 V B 0.0000
102 E B -0.9608
103 L B 0.0000
104 L B -0.5841
105 K B -1.6498
106 L B -1.6241
107 E B -2.3414

 

Laboratory of Theory of Biopolymers 2015