| Chain sequence(s) |
A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL B: VSEIRHTADRWRVSLDVNHFAPDELTVKTKDGVVEITGKHEERQDEHGYISRCFTRKYTLPPGVDPTQVSSSLSPEGTLTVEAPMP |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | M | A | -0.0443 | |
| 2 | A | A | -1.2962 | |
| 3 | E | A | -2.3676 | |
| 4 | P | A | -2.2536 | |
| 5 | R | A | -2.9969 | |
| 6 | Q | A | -2.4246 | |
| 7 | E | A | -1.5906 | |
| 8 | F | A | 0.0000 | |
| 9 | E | A | -1.9528 | |
| 10 | V | A | 0.0000 | |
| 11 | M | A | -1.4700 | |
| 12 | E | A | -2.5702 | |
| 13 | D | A | -2.7509 | |
| 14 | H | A | 0.0000 | |
| 15 | A | A | -1.8574 | |
| 16 | G | A | -1.8023 | |
| 17 | T | A | -1.5137 | |
| 18 | Y | A | 0.0000 | |
| 19 | G | A | 0.0000 | |
| 20 | L | A | -1.3562 | |
| 21 | G | A | -2.0094 | |
| 22 | D | A | -3.1248 | |
| 23 | R | A | -3.0610 | |
| 24 | K | A | -2.7808 | |
| 25 | D | A | -2.1834 | |
| 26 | Q | A | 0.0000 | |
| 27 | G | A | 0.0000 | |
| 28 | G | A | -0.0772 | |
| 29 | Y | A | 0.8363 | |
| 30 | T | A | 0.7307 | |
| 31 | M | A | 0.5672 | |
| 32 | H | A | -0.9776 | |
| 33 | Q | A | -2.5056 | |
| 34 | D | A | -3.6323 | |
| 35 | Q | A | 0.0000 | |
| 36 | E | A | -2.8303 | |
| 37 | G | A | -2.9988 | |
| 38 | D | A | -3.2951 | |
| 39 | T | A | -2.4556 | |
| 40 | D | A | -2.6178 | |
| 41 | A | A | -1.8967 | |
| 42 | G | A | -1.2363 | |
| 43 | L | A | -0.3890 | |
| 44 | K | A | -2.3866 | |
| 45 | E | A | -2.8700 | |
| 46 | S | A | -1.3623 | |
| 47 | P | A | -0.1665 | |
| 48 | L | A | 0.5662 | |
| 49 | Q | A | -0.2711 | |
| 50 | T | A | 0.0000 | |
| 51 | P | A | 0.0000 | |
| 52 | T | A | -2.9880 | |
| 53 | E | A | -3.5608 | |
| 54 | D | A | -2.3475 | |
| 55 | G | A | -1.8504 | |
| 56 | S | A | -1.5739 | |
| 57 | E | A | -2.7383 | |
| 58 | E | A | -2.3589 | |
| 59 | P | A | -1.6971 | |
| 60 | G | A | -1.4863 | |
| 61 | S | A | -1.8958 | |
| 62 | E | A | -2.4136 | |
| 63 | T | A | -2.1647 | |
| 64 | S | A | -1.8751 | |
| 65 | D | A | -2.1501 | |
| 66 | A | A | -1.5044 | |
| 67 | K | A | -2.2974 | |
| 68 | S | A | -1.1420 | |
| 69 | T | A | -0.9789 | |
| 70 | P | A | -1.3123 | |
| 71 | T | A | 0.0000 | |
| 72 | A | A | 0.0000 | |
| 73 | E | A | -1.9673 | |
| 74 | D | A | -1.3199 | |
| 75 | V | A | -0.0841 | |
| 76 | T | A | -0.2866 | |
| 77 | A | A | 0.4786 | |
| 78 | P | A | 0.7038 | |
| 79 | L | A | 1.4027 | |
| 80 | V | A | 0.5015 | |
| 81 | D | A | -1.8132 | |
| 82 | E | A | -2.3962 | |
| 83 | G | A | -1.8417 | |
| 84 | A | A | -1.4605 | |
| 85 | P | A | -1.4287 | |
| 86 | G | A | -1.8105 | |
| 87 | K | A | -2.7855 | |
| 88 | Q | A | -2.1562 | |
| 89 | A | A | -1.4649 | |
| 90 | A | A | -1.3335 | |
| 91 | A | A | -1.2785 | |
| 92 | Q | A | -1.6284 | |
| 93 | P | A | -1.7971 | |
| 94 | H | A | -2.2197 | |
| 95 | T | A | -2.0477 | |
| 96 | E | A | -2.7955 | |
| 97 | I | A | -1.4737 | |
| 98 | P | A | -1.9776 | |
| 99 | E | A | -2.7443 | |
| 100 | G | A | -2.1061 | |
| 101 | T | A | -1.8906 | |
| 102 | T | A | -1.6991 | |
| 103 | A | A | -2.2166 | |
| 104 | E | A | -2.9129 | |
| 105 | E | A | -2.6175 | |
| 106 | A | A | -2.0271 | |
| 107 | G | A | -1.8741 | |
| 108 | I | A | -0.9348 | |
| 109 | G | A | -1.9802 | |
| 110 | D | A | -2.5909 | |
| 111 | T | A | -1.8601 | |
| 112 | P | A | -1.3253 | |
| 113 | S | A | -1.3550 | |
| 114 | L | A | -1.6337 | |
| 115 | E | A | -2.7228 | |
| 116 | D | A | -2.5700 | |
| 117 | E | A | -1.7577 | |
| 118 | A | A | 0.0000 | |
| 119 | A | A | -0.5356 | |
| 120 | G | A | -1.0212 | |
| 121 | H | A | -1.0340 | |
| 122 | V | A | 0.8362 | |
| 123 | T | A | -0.4742 | |
| 124 | Q | A | -0.7522 | |
| 125 | A | A | -1.0005 | |
| 126 | R | A | 0.0000 | |
| 127 | M | A | -0.2436 | |
| 128 | V | A | -0.3180 | |
| 129 | S | A | -1.2489 | |
| 130 | K | A | -2.2401 | |
| 131 | S | A | -2.1387 | |
| 132 | K | A | -2.9177 | |
| 133 | D | A | -3.6537 | |
| 134 | G | A | -2.0892 | |
| 135 | T | A | -1.5279 | |
| 136 | G | A | -1.8054 | |
| 137 | S | A | -2.6648 | |
| 138 | D | A | -3.2491 | |
| 139 | D | A | -3.7054 | |
| 140 | K | A | -3.0934 | |
| 141 | K | A | -1.9719 | |
| 142 | A | A | -1.4856 | |
| 143 | K | A | -1.3515 | |
| 144 | G | A | -1.6482 | |
| 145 | A | A | -1.9061 | |
| 146 | D | A | -3.1077 | |
| 147 | G | A | -2.6278 | |
| 148 | K | A | -2.6121 | |
| 149 | T | A | -1.9784 | |
| 150 | K | A | -1.5074 | |
| 151 | I | A | 0.7352 | |
| 152 | A | A | 0.1528 | |
| 153 | T | A | -0.2934 | |
| 154 | P | A | -1.2724 | |
| 155 | R | A | -2.5773 | |
| 156 | G | A | -1.9020 | |
| 157 | A | A | -1.1276 | |
| 158 | A | A | -1.0648 | |
| 159 | P | A | -1.0342 | |
| 160 | P | A | -1.4501 | |
| 161 | G | A | -2.1536 | |
| 162 | Q | A | -2.9382 | |
| 163 | K | A | -2.8746 | |
| 164 | G | A | -2.5041 | |
| 165 | Q | A | -2.7287 | |
| 166 | A | A | -2.2682 | |
| 167 | N | A | -2.5358 | |
| 168 | A | A | -1.3068 | |
| 169 | T | A | -1.1713 | |
| 170 | R | A | -1.6041 | |
| 171 | I | A | 0.0828 | |
| 172 | P | A | -0.2163 | |
| 173 | A | A | -0.8526 | |
| 174 | K | A | -1.7840 | |
| 175 | T | A | -1.0734 | |
| 176 | P | A | -1.1537 | |
| 177 | P | A | -0.9669 | |
| 178 | A | A | -0.7557 | |
| 179 | P | A | -1.4437 | |
| 180 | K | A | -1.9598 | |
| 181 | T | A | -1.1263 | |
| 182 | P | A | -1.1229 | |
| 183 | P | A | -1.3100 | |
| 184 | S | A | 0.0000 | |
| 185 | S | A | -0.5955 | |
| 186 | G | A | -1.2098 | |
| 187 | E | A | -2.0497 | |
| 188 | P | A | -2.1997 | |
| 189 | P | A | -1.9530 | |
| 190 | K | A | -2.8688 | |
| 191 | S | A | -2.5041 | |
| 192 | G | A | -2.1294 | |
| 193 | D | A | -3.4089 | |
| 194 | R | A | -3.5045 | |
| 195 | S | A | 0.0000 | |
| 196 | G | A | -1.3919 | |
| 197 | Y | A | 0.0000 | |
| 198 | S | A | -0.6474 | |
| 199 | S | A | 0.0000 | |
| 200 | P | A | -0.3007 | |
| 201 | G | A | -0.2622 | |
| 202 | S | A | -0.1265 | |
| 203 | P | A | -0.4240 | |
| 204 | G | A | -1.0214 | |
| 205 | T | A | -0.4756 | |
| 206 | P | A | -0.3148 | |
| 207 | G | A | -0.5244 | |
| 208 | S | A | 0.0000 | |
| 209 | R | A | -1.2624 | |
| 210 | S | A | -1.0862 | |
| 211 | R | A | -1.7833 | |
| 212 | T | A | -1.1094 | |
| 213 | P | A | -1.1505 | |
| 214 | S | A | -1.1410 | |
| 215 | L | A | -1.3377 | |
| 216 | P | A | 0.0000 | |
| 217 | T | A | -2.2356 | |
| 218 | P | A | -2.1960 | |
| 219 | P | A | -1.1990 | |
| 220 | T | A | -1.4320 | |
| 221 | R | A | -3.1685 | |
| 222 | E | A | -3.2034 | |
| 223 | P | A | 0.0000 | |
| 224 | K | A | -3.3953 | |
| 225 | K | A | -2.4268 | |
| 226 | V | A | -0.6613 | |
| 227 | A | A | 0.3389 | |
| 228 | V | A | 1.8639 | |
| 229 | V | A | 1.7540 | |
| 230 | R | A | -0.9557 | |
| 231 | T | A | -1.2654 | |
| 232 | P | A | -1.2295 | |
| 233 | P | A | -1.4565 | |
| 234 | K | A | -2.0567 | |
| 235 | S | A | 0.0000 | |
| 236 | P | A | 0.0000 | |
| 237 | S | A | -0.7485 | |
| 238 | S | A | 0.0000 | |
| 239 | A | A | -0.9609 | |
| 240 | K | A | -1.2559 | |
| 241 | S | A | -1.8461 | |
| 242 | R | A | -2.3546 | |
| 243 | L | A | -0.8441 | |
| 244 | Q | A | -1.1922 | |
| 245 | T | A | -0.5560 | |
| 246 | A | A | -0.1529 | |
| 247 | P | A | -0.2888 | |
| 248 | V | A | -0.6765 | |
| 249 | P | A | 0.0000 | |
| 250 | M | A | -1.0757 | |
| 251 | P | A | -0.9205 | |
| 252 | D | A | -2.0408 | |
| 253 | L | A | -1.2714 | |
| 254 | K | A | -1.7530 | |
| 255 | N | A | -1.9734 | |
| 256 | V | A | -1.5224 | |
| 257 | K | A | -2.3997 | |
| 258 | S | A | -2.0525 | |
| 259 | K | A | -1.9633 | |
| 260 | I | A | -1.0576 | |
| 261 | G | A | -1.3653 | |
| 262 | S | A | -1.2006 | |
| 263 | T | A | -0.8973 | |
| 264 | E | A | -1.4555 | |
| 265 | N | A | -2.0102 | |
| 266 | L | A | -1.4847 | |
| 267 | K | A | -2.3604 | |
| 268 | H | A | -2.0724 | |
| 269 | Q | A | -1.6337 | |
| 270 | P | A | -1.5025 | |
| 271 | G | A | -1.7390 | |
| 272 | G | A | -1.1556 | |
| 273 | G | A | -0.5285 | |
| 274 | K | A | -0.6567 | |
| 275 | V | A | -0.3392 | |
| 276 | Q | A | -1.8063 | |
| 277 | I | A | -1.1985 | |
| 278 | I | A | 0.0000 | |
| 279 | N | A | -2.6940 | |
| 280 | K | A | -2.9326 | |
| 281 | K | A | -2.2057 | |
| 282 | L | A | -1.0840 | |
| 283 | D | A | 0.0000 | |
| 284 | L | A | -1.5323 | |
| 285 | S | A | -1.4842 | |
| 286 | N | A | -1.9085 | |
| 287 | V | A | -1.0938 | |
| 288 | Q | A | -1.8522 | |
| 289 | S | A | -1.7748 | |
| 290 | K | A | -2.2466 | |
| 291 | C | A | -2.0654 | |
| 292 | G | A | -2.1985 | |
| 293 | S | A | -2.2022 | |
| 294 | K | A | -3.0351 | |
| 295 | D | A | -2.7648 | |
| 296 | N | A | -1.8864 | |
| 297 | I | A | -1.3114 | |
| 298 | K | A | -2.0076 | |
| 299 | H | A | 0.0000 | |
| 300 | V | A | 0.0000 | |
| 301 | P | A | 0.0808 | |
| 302 | G | A | -0.8091 | |
| 303 | G | A | -0.8753 | |
| 304 | G | A | -0.3269 | |
| 305 | S | A | 0.1243 | |
| 306 | V | A | 1.4663 | |
| 307 | Q | A | 0.3531 | |
| 308 | I | A | 0.0000 | |
| 309 | V | A | 0.8604 | |
| 310 | Y | A | 0.7652 | |
| 311 | K | A | -1.0059 | |
| 312 | P | A | 0.1647 | |
| 313 | V | A | 1.3735 | |
| 314 | D | A | -0.1577 | |
| 315 | L | A | 0.6309 | |
| 316 | S | A | -0.3920 | |
| 317 | K | A | -1.5712 | |
| 318 | V | A | -0.2376 | |
| 319 | T | A | -0.1961 | |
| 320 | S | A | -0.8630 | |
| 321 | K | A | -1.6162 | |
| 322 | C | A | -0.8550 | |
| 323 | G | A | -0.3421 | |
| 324 | S | A | 0.0000 | |
| 325 | L | A | -0.1479 | |
| 326 | G | A | -0.6895 | |
| 327 | N | A | -0.8314 | |
| 328 | I | A | 0.5983 | |
| 329 | H | A | -0.8587 | |
| 330 | H | A | -1.2881 | |
| 331 | K | A | -0.9482 | |
| 332 | P | A | -1.0762 | |
| 333 | G | A | -1.5077 | |
| 334 | G | A | -1.4543 | |
| 335 | G | A | -2.0039 | |
| 336 | Q | A | -2.9634 | |
| 337 | V | A | -2.1095 | |
| 338 | E | A | -2.2755 | |
| 339 | V | A | -0.5677 | |
| 340 | K | A | -2.1204 | |
| 341 | S | A | -2.0355 | |
| 342 | E | A | -2.7571 | |
| 343 | K | A | -1.6485 | |
| 344 | L | A | -0.3665 | |
| 345 | D | A | -1.2421 | |
| 346 | F | A | 0.0857 | |
| 347 | K | A | -1.0100 | |
| 348 | D | A | -1.6295 | |
| 349 | R | A | -1.7125 | |
| 350 | V | A | -0.0352 | |
| 351 | Q | A | -1.4656 | |
| 352 | S | A | -0.9121 | |
| 353 | K | A | -0.9058 | |
| 354 | I | A | 0.7123 | |
| 355 | G | A | -0.0853 | |
| 356 | S | A | 0.0052 | |
| 357 | L | A | 0.0715 | |
| 358 | D | A | -1.4643 | |
| 359 | N | A | -0.7569 | |
| 360 | I | A | 1.0095 | |
| 361 | T | A | 0.2246 | |
| 362 | H | A | 0.1428 | |
| 363 | V | A | 1.4174 | |
| 364 | P | A | 0.1938 | |
| 365 | G | A | -0.8656 | |
| 366 | G | A | -1.4885 | |
| 367 | G | A | -1.8190 | |
| 368 | N | A | -2.3330 | |
| 369 | K | A | -2.4439 | |
| 370 | K | A | -2.0794 | |
| 371 | I | A | -0.4631 | |
| 372 | E | A | -1.9972 | |
| 373 | T | A | -1.5483 | |
| 374 | H | A | -1.7389 | |
| 375 | K | A | -1.4267 | |
| 376 | L | A | 0.7267 | |
| 377 | T | A | 0.5434 | |
| 378 | F | A | 0.5763 | |
| 379 | R | A | -1.8940 | |
| 380 | E | A | -3.0240 | |
| 381 | N | A | -2.6791 | |
| 382 | A | A | -2.1303 | |
| 383 | K | A | -2.7899 | |
| 384 | A | A | -1.7934 | |
| 385 | K | A | -2.6889 | |
| 386 | T | A | -1.8825 | |
| 387 | D | A | -2.1126 | |
| 388 | H | A | -2.1073 | |
| 389 | G | A | -0.9992 | |
| 390 | A | A | -0.4881 | |
| 391 | E | A | -0.8706 | |
| 392 | I | A | 0.1116 | |
| 393 | V | A | 0.1840 | |
| 394 | Y | A | -0.7062 | |
| 395 | K | A | -1.5811 | |
| 396 | S | A | -0.1526 | |
| 397 | P | A | 0.5811 | |
| 398 | V | A | 1.3740 | |
| 399 | V | A | 1.7156 | |
| 400 | S | A | 0.2375 | |
| 401 | G | A | -0.0688 | |
| 402 | D | A | -0.4692 | |
| 403 | T | A | -0.6288 | |
| 404 | S | A | -0.6308 | |
| 405 | P | A | -0.9714 | |
| 406 | R | A | -2.2350 | |
| 407 | H | A | -1.3964 | |
| 408 | L | A | 0.0116 | |
| 409 | S | A | -0.6251 | |
| 410 | N | A | -1.3661 | |
| 411 | V | A | -0.7531 | |
| 412 | S | A | -0.7451 | |
| 413 | S | A | -0.6469 | |
| 414 | T | A | 0.0115 | |
| 415 | G | A | 0.0000 | |
| 416 | S | A | 0.4372 | |
| 417 | I | A | 1.5161 | |
| 418 | D | A | -0.3674 | |
| 419 | M | A | 0.5924 | |
| 420 | V | A | -0.1209 | |
| 421 | D | A | -1.7481 | |
| 422 | S | A | -1.0124 | |
| 423 | P | A | -0.4751 | |
| 424 | Q | A | -0.9610 | |
| 425 | L | A | 0.0000 | |
| 426 | A | A | 0.5696 | |
| 427 | T | A | 0.2596 | |
| 428 | L | A | 0.7266 | |
| 429 | A | A | -0.3437 | |
| 430 | D | A | -1.8759 | |
| 431 | E | A | -1.7247 | |
| 432 | V | A | 0.2722 | |
| 433 | S | A | -0.3688 | |
| 434 | A | A | -0.1455 | |
| 435 | S | A | -0.2217 | |
| 436 | L | A | -0.6048 | |
| 437 | A | A | -0.8862 | |
| 438 | K | A | -2.0042 | |
| 439 | Q | A | -1.0600 | |
| 440 | G | A | -0.5144 | |
| 441 | L | A | 0.9972 | |
| 85 | V | B | 0.3841 | |
| 86 | S | B | -0.8100 | |
| 87 | E | B | -2.1193 | |
| 88 | I | B | -1.3493 | |
| 89 | R | B | -2.1430 | |
| 90 | H | B | -1.6825 | |
| 91 | T | B | -1.2202 | |
| 92 | A | B | -1.2215 | |
| 93 | D | B | -1.7952 | |
| 94 | R | B | -1.8910 | |
| 95 | W | B | 0.0000 | |
| 96 | R | B | -1.7555 | |
| 97 | V | B | 0.0000 | |
| 98 | S | B | 0.0000 | |
| 99 | L | B | 0.0000 | |
| 100 | D | B | -1.6410 | |
| 101 | V | B | -1.1295 | |
| 102 | N | B | -2.3120 | |
| 103 | H | B | -2.0952 | |
| 104 | F | B | -1.4126 | |
| 105 | A | B | -1.1684 | |
| 106 | P | B | -1.1399 | |
| 107 | D | B | -2.1197 | |
| 108 | E | B | -1.8016 | |
| 109 | L | B | -0.5694 | |
| 110 | T | B | -0.7394 | |
| 111 | V | B | -0.5161 | |
| 112 | K | B | -1.9478 | |
| 113 | T | B | -2.2340 | |
| 114 | K | B | -3.0423 | |
| 115 | D | B | -2.7591 | |
| 116 | G | B | -1.6052 | |
| 117 | V | B | -1.5003 | |
| 118 | V | B | 0.0000 | |
| 119 | E | B | -1.6562 | |
| 120 | I | B | 0.0000 | |
| 121 | T | B | -0.1579 | |
| 122 | G | B | 0.0000 | |
| 123 | K | B | -1.7534 | |
| 124 | H | B | 0.0000 | |
| 125 | E | B | -3.1691 | |
| 126 | E | B | -3.2415 | |
| 127 | R | B | -2.5389 | |
| 128 | Q | B | -2.8926 | |
| 129 | D | B | -3.3695 | |
| 130 | E | B | -3.1642 | |
| 131 | H | B | -2.3273 | |
| 132 | G | B | -1.6809 | |
| 133 | Y | B | -0.9276 | |
| 134 | I | B | -1.1262 | |
| 135 | S | B | -1.8443 | |
| 136 | R | B | -0.9845 | |
| 137 | C | B | 0.5631 | |
| 138 | F | B | 1.7531 | |
| 139 | T | B | 0.2569 | |
| 140 | R | B | -0.9720 | |
| 141 | K | B | -2.1193 | |
| 142 | Y | B | -1.0069 | |
| 143 | T | B | -0.8713 | |
| 144 | L | B | 0.0000 | |
| 145 | P | B | -0.5384 | |
| 146 | P | B | -0.9813 | |
| 147 | G | B | -1.0364 | |
| 148 | V | B | 0.0000 | |
| 149 | D | B | -1.9249 | |
| 150 | P | B | -1.7714 | |
| 151 | T | B | -0.9222 | |
| 152 | Q | B | -0.9825 | |
| 153 | V | B | -0.7131 | |
| 154 | S | B | -0.5380 | |
| 155 | S | B | -0.1466 | |
| 156 | S | B | -0.1636 | |
| 157 | L | B | -0.3184 | |
| 158 | S | B | -0.9127 | |
| 159 | P | B | -1.2635 | |
| 160 | E | B | -2.5086 | |
| 161 | G | B | -2.0630 | |
| 162 | T | B | -1.3735 | |
| 163 | L | B | 0.0000 | |
| 164 | T | B | -0.7442 | |
| 165 | V | B | 0.0000 | |
| 166 | E | B | -1.0600 | |
| 167 | A | B | 0.0000 | |
| 168 | P | B | -1.2050 | |
| 169 | M | B | -1.1024 | |
| 170 | P | B | -1.0311 |