Project name: 92567096b4b52a0

Chain sequence(s)	A: TIDIKSFLKPGEKTYTQRCRLFVGNLPTDITEEDFKRLFERYGEPSEVFINRDRGFGFIRLESRTLAEIAKAELDGTILKSRPLRIRFATHGAALTVKNLSPVVSNELLEQAFSQFGPVEKAVVVVDDRGRATGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPVIVEPMEQFDDEDGLPEKLMQKTQQYHKEREQPPRFAQPGTFEFEYASRWKALDEMEKQQREQVDRNIREAKEKLEAEMEAARHEHQLMLM
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -5.2743
• Maximal score value: 2.3092
• Average score: -1.5381
• Total score value: -395.2922

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
64	T	A	0.5367
65	I	A	1.3779
66	D	A	-0.6120
67	I	A	-0.0317
68	K	A	-1.3968
69	S	A	-0.7421
70	F	A	-0.3180
71	L	A	-1.0079
72	K	A	-1.8607
73	P	A	-1.2956
74	G	A	-1.3425
75	E	A	-1.5981
76	K	A	-1.6258
77	T	A	-1.0238
78	Y	A	-0.9317
79	T	A	0.0000
80	Q	A	0.0000
81	R	A	-1.3151
82	C	A	0.0000
83	R	A	-0.8939
84	L	A	0.0000
85	F	A	0.2048
86	V	A	0.0000
87	G	A	0.0000
88	N	A	-1.3235
89	L	A	0.0000
90	P	A	-2.1237
91	T	A	-2.4554
92	D	A	-2.7019
93	I	A	0.0000
94	T	A	-2.9315
95	E	A	-3.3994
96	E	A	-3.9965
97	D	A	-4.0512
98	F	A	0.0000
99	K	A	-3.9720
100	R	A	-4.4066
101	L	A	0.0000
102	F	A	0.0000
103	E	A	-4.1943
104	R	A	-3.4061
105	Y	A	0.0000
106	G	A	-2.4099
107	E	A	-2.9656
108	P	A	-1.7601
109	S	A	-0.9193
110	E	A	-0.5168
111	V	A	-0.0148
112	F	A	0.6712
113	I	A	-0.5899
114	N	A	-2.0102
115	R	A	-3.4269
116	D	A	-3.6687
117	R	A	-3.2224
118	G	A	0.0000
119	F	A	-0.7775
120	G	A	0.0000
121	F	A	0.7413
122	I	A	0.0000
123	R	A	-0.6865
124	L	A	0.0000
125	E	A	-1.2969
126	S	A	0.0000
127	R	A	-1.5536
128	T	A	-1.0316
129	L	A	-0.9655
130	A	A	0.0000
131	E	A	-2.2861
132	I	A	-1.0825
133	A	A	0.0000
134	K	A	-1.9410
135	A	A	-1.5823
136	E	A	-1.9616
137	L	A	-1.2046
138	D	A	-1.6913
139	G	A	-0.9807
140	T	A	-0.2433
141	I	A	0.6980
142	L	A	-0.3700
143	K	A	-2.0227
144	S	A	-1.2529
145	R	A	-2.0169
146	P	A	-0.9768
147	L	A	0.0000
148	R	A	-1.9172
149	I	A	0.0000
150	R	A	-1.7424
151	F	A	-0.7421
152	A	A	-0.2272
153	T	A	-0.2745
154	H	A	-0.6473
155	G	A	-0.7624
156	A	A	0.0000
157	A	A	0.0000
158	L	A	0.0000
159	T	A	0.0000
160	V	A	0.0000
161	K	A	-1.1748
162	N	A	-1.2001
163	L	A	0.0000
164	S	A	-0.1741
165	P	A	0.2619
166	V	A	1.5889
167	V	A	0.0000
168	S	A	-0.6132
169	N	A	-1.4916
170	E	A	-2.5614
171	L	A	-1.1213
172	L	A	0.0000
173	E	A	-2.0682
174	Q	A	-2.2503
175	A	A	0.0000
176	F	A	0.0000
177	S	A	-1.3257
178	Q	A	-1.7332
179	F	A	0.0000
180	G	A	-0.9152
181	P	A	-0.5688
182	V	A	-0.6671
183	E	A	0.0000
184	K	A	-0.8339
185	A	A	-0.4884
186	V	A	0.3994
187	V	A	0.0000
188	V	A	0.7505
189	V	A	0.1034
190	D	A	-1.8580
191	D	A	-3.0850
192	R	A	-3.3761
193	G	A	-2.3614
194	R	A	-2.5327
195	A	A	-0.7344
196	T	A	-0.5475
197	G	A	-0.6493
198	K	A	-0.7387
199	G	A	0.0000
200	F	A	0.1517
201	V	A	0.0000
202	E	A	0.0000
203	F	A	0.0000
204	A	A	-0.3813
205	A	A	-1.0544
206	K	A	-2.2493
207	P	A	-1.8100
208	P	A	-1.8373
209	A	A	0.0000
210	R	A	-3.5228
211	K	A	-3.2291
212	A	A	0.0000
213	L	A	-2.5216
214	E	A	-4.1161
215	R	A	-3.9274
216	C	A	0.0000
217	G	A	-2.5717
218	D	A	-3.2064
219	G	A	-2.1606
220	A	A	-0.8600
221	F	A	-0.2725
222	L	A	0.2924
223	L	A	0.2858
224	T	A	0.1465
225	T	A	-0.2772
226	T	A	-0.6151
227	P	A	-0.8833
228	R	A	-1.5974
229	P	A	-0.7050
230	V	A	0.0000
231	I	A	0.0636
232	V	A	-0.5274
233	E	A	-1.4236
234	P	A	-1.2093
235	M	A	-0.7411
236	E	A	-1.3525
237	Q	A	-1.1788
238	F	A	-0.4249
239	D	A	-2.8593
240	D	A	-3.5416
241	E	A	-3.8094
242	D	A	-3.4152
243	G	A	-1.8824
244	L	A	-0.0443
245	P	A	-0.6710
246	E	A	-2.1346
247	K	A	-1.9024
248	L	A	0.1026
249	M	A	-0.7540
250	Q	A	-2.3293
251	K	A	-2.9055
252	T	A	-2.6281
253	Q	A	-3.4399
254	Q	A	-3.9217
255	Y	A	-3.7044
256	H	A	-4.8057
257	K	A	-5.1312
258	E	A	-5.1517
259	R	A	-5.1768
260	E	A	-4.8543
261	Q	A	-3.8908
262	P	A	-2.3860
263	P	A	-1.6094
264	R	A	-1.4327
265	F	A	0.5316
266	A	A	-0.3193
267	Q	A	-1.2173
268	P	A	-0.9200
269	G	A	-0.9443
270	T	A	-0.3047
271	F	A	0.7973
272	E	A	-0.6099
273	F	A	-0.5445
274	E	A	-1.6939
275	Y	A	-0.3522
276	A	A	-0.5354
277	S	A	-1.5022
278	R	A	-2.3047
279	W	A	-0.8789
280	K	A	-2.7293
281	A	A	-2.0632
282	L	A	-1.6875
283	D	A	-3.8853
284	E	A	-4.3115
285	M	A	-2.9085
286	E	A	-4.9821
287	K	A	-5.2743
288	Q	A	-4.7968
289	Q	A	-4.9517
290	R	A	-5.2420
291	E	A	-4.7378
292	Q	A	-4.4274
293	V	A	-2.9241
294	D	A	-3.5102
295	R	A	-4.4636
296	N	A	-3.4605
297	I	A	-2.4883
298	R	A	-4.4853
299	E	A	-4.8299
300	A	A	-3.6436
301	K	A	-4.6999
302	E	A	-4.9580
303	K	A	-4.3402
304	L	A	-3.3863
305	E	A	-4.1919
306	A	A	-3.4164
307	E	A	-3.6564
308	M	A	-3.2807
309	E	A	-3.7764
310	A	A	-2.9344
311	A	A	-3.1004
312	R	A	-4.0361
313	H	A	-3.1264
314	E	A	-2.6388
315	H	A	-2.2550
316	Q	A	-1.3100
317	L	A	0.7933
318	M	A	1.5812
319	L	A	2.3092
320	M	A	2.1641