| Chain sequence(s) |
A: DSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVNTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRRVEPYGENFNKALVQQMEQLRQKLGPH B: AKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRRTQVNTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPH |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 94 | D | A | -2.7503 | |
| 95 | S | A | -2.5369 | |
| 96 | E | A | -3.8943 | |
| 97 | K | A | -3.6363 | |
| 98 | L | A | -1.7261 | |
| 99 | K | A | -3.3044 | |
| 100 | E | A | -3.8449 | |
| 101 | E | A | -3.0442 | |
| 102 | I | A | -0.9891 | |
| 103 | G | A | -2.2502 | |
| 104 | K | A | -3.6169 | |
| 105 | E | A | -2.5748 | |
| 106 | L | A | -2.3388 | |
| 107 | E | A | -3.2740 | |
| 108 | E | A | -2.8837 | |
| 109 | L | A | 0.0000 | |
| 110 | R | A | -1.8204 | |
| 111 | A | A | -1.2241 | |
| 112 | R | A | -1.6432 | |
| 113 | L | A | 0.0000 | |
| 114 | L | A | -0.1717 | |
| 115 | P | A | -0.3974 | |
| 116 | H | A | -1.0050 | |
| 117 | A | A | -1.2637 | |
| 118 | N | A | -2.0124 | |
| 119 | E | A | -1.8539 | |
| 120 | V | A | 0.0000 | |
| 121 | S | A | -2.2698 | |
| 122 | Q | A | -2.4949 | |
| 123 | K | A | -2.0612 | |
| 124 | I | A | 0.0000 | |
| 125 | G | A | 0.0000 | |
| 126 | D | A | -2.8778 | |
| 127 | N | A | 0.0000 | |
| 128 | L | A | 0.0000 | |
| 129 | R | A | -3.3822 | |
| 130 | E | A | -3.3142 | |
| 131 | L | A | 0.0000 | |
| 132 | Q | A | -2.5709 | |
| 133 | Q | A | -2.7419 | |
| 134 | R | A | -1.8346 | |
| 135 | L | A | 0.0000 | |
| 136 | E | A | -2.5207 | |
| 137 | P | A | -1.7593 | |
| 138 | Y | A | -1.6209 | |
| 139 | A | A | 0.0000 | |
| 140 | D | A | -2.9925 | |
| 141 | Q | A | -2.0951 | |
| 142 | L | A | 0.0000 | |
| 143 | R | A | -1.8960 | |
| 144 | T | A | -1.3038 | |
| 145 | Q | A | -1.4623 | |
| 146 | V | A | 0.0000 | |
| 147 | N | A | -1.3786 | |
| 148 | T | A | -0.9900 | |
| 149 | Q | A | -1.5265 | |
| 150 | A | A | 0.0000 | |
| 151 | E | A | -2.1579 | |
| 152 | Q | A | -2.1806 | |
| 153 | L | A | 0.0000 | |
| 154 | R | A | -2.1747 | |
| 155 | R | A | -2.8235 | |
| 156 | Q | A | -1.9458 | |
| 157 | L | A | 0.0000 | |
| 158 | T | A | -1.3871 | |
| 159 | P | A | -1.3188 | |
| 160 | Y | A | 0.0000 | |
| 161 | A | A | 0.0000 | |
| 162 | Q | A | -1.7590 | |
| 163 | R | A | -2.3553 | |
| 164 | M | A | 0.0000 | |
| 165 | E | A | -2.5975 | |
| 166 | R | A | -3.3301 | |
| 167 | V | A | -2.2059 | |
| 168 | L | A | 0.0000 | |
| 169 | R | A | -3.7560 | |
| 170 | E | A | -3.7185 | |
| 171 | N | A | -2.4860 | |
| 172 | A | A | -2.7256 | |
| 173 | D | A | -3.2720 | |
| 174 | S | A | -1.8945 | |
| 175 | L | A | -1.6610 | |
| 176 | Q | A | -2.1379 | |
| 177 | A | A | -1.3238 | |
| 178 | S | A | -1.0342 | |
| 179 | L | A | 0.0000 | |
| 180 | R | A | -2.7064 | |
| 181 | P | A | -1.6389 | |
| 182 | H | A | -1.4798 | |
| 183 | A | A | 0.0000 | |
| 184 | D | A | -1.9987 | |
| 185 | E | A | -1.6290 | |
| 186 | L | A | 0.0000 | |
| 187 | K | A | -1.7351 | |
| 188 | A | A | -1.3030 | |
| 189 | K | A | -1.8071 | |
| 190 | I | A | 0.0000 | |
| 191 | D | A | -2.2654 | |
| 192 | Q | A | -2.7857 | |
| 193 | N | A | 0.0000 | |
| 194 | V | A | 0.0000 | |
| 195 | E | A | -3.8984 | |
| 196 | E | A | -3.7979 | |
| 197 | L | A | 0.0000 | |
| 198 | K | A | -2.7662 | |
| 199 | G | A | -2.3642 | |
| 200 | R | A | -2.6550 | |
| 201 | L | A | 0.0000 | |
| 202 | T | A | -1.3845 | |
| 203 | P | A | -1.0534 | |
| 204 | Y | A | -0.7469 | |
| 205 | A | A | 0.0000 | |
| 206 | D | A | -1.1428 | |
| 207 | E | A | -0.5890 | |
| 208 | F | A | 0.0000 | |
| 209 | K | A | -1.0050 | |
| 210 | V | A | 0.2155 | |
| 211 | K | A | -1.0440 | |
| 212 | I | A | 0.0000 | |
| 213 | D | A | -2.1281 | |
| 214 | Q | A | -1.8221 | |
| 215 | T | A | 0.0000 | |
| 216 | V | A | 0.0000 | |
| 217 | E | A | -2.5605 | |
| 218 | E | A | -2.4570 | |
| 219 | L | A | 0.0000 | |
| 220 | R | A | -2.3204 | |
| 221 | R | A | -2.5624 | |
| 222 | S | A | -1.6736 | |
| 223 | L | A | 0.0000 | |
| 224 | A | A | -1.6990 | |
| 225 | P | A | -1.1315 | |
| 226 | Y | A | -0.8681 | |
| 227 | A | A | 0.0000 | |
| 228 | Q | A | -2.7780 | |
| 229 | D | A | -3.2830 | |
| 230 | T | A | -3.0630 | |
| 231 | Q | A | -3.6658 | |
| 232 | E | A | -3.5800 | |
| 233 | K | A | -3.6384 | |
| 234 | L | A | 0.0000 | |
| 235 | N | A | -2.8312 | |
| 236 | H | A | -3.1093 | |
| 237 | Q | A | -2.1838 | |
| 238 | L | A | 0.0000 | |
| 239 | E | A | -2.5014 | |
| 240 | G | A | -1.2019 | |
| 241 | L | A | 0.0000 | |
| 242 | T | A | -1.2315 | |
| 243 | F | A | -0.1279 | |
| 244 | Q | A | -1.5267 | |
| 245 | M | A | 0.0000 | |
| 246 | K | A | -1.9677 | |
| 247 | K | A | -2.9695 | |
| 248 | N | A | -2.3346 | |
| 249 | A | A | 0.0000 | |
| 250 | E | A | -3.6667 | |
| 251 | E | A | -3.3923 | |
| 252 | L | A | 0.0000 | |
| 253 | K | A | -2.3886 | |
| 254 | A | A | -1.8661 | |
| 255 | R | A | -2.4515 | |
| 256 | I | A | 0.0000 | |
| 257 | S | A | -1.6577 | |
| 258 | A | A | -1.4037 | |
| 259 | S | A | -2.0697 | |
| 260 | A | A | 0.0000 | |
| 261 | E | A | -2.9160 | |
| 262 | E | A | -3.0675 | |
| 263 | L | A | 0.0000 | |
| 264 | R | A | -2.5591 | |
| 265 | Q | A | -2.7258 | |
| 266 | R | A | -2.5861 | |
| 267 | L | A | 0.0000 | |
| 268 | A | A | -1.6631 | |
| 269 | P | A | -1.8773 | |
| 270 | L | A | -1.8317 | |
| 271 | A | A | 0.0000 | |
| 272 | E | A | -3.2291 | |
| 273 | D | A | -3.1054 | |
| 274 | V | A | 0.0000 | |
| 275 | R | A | -3.1203 | |
| 276 | G | A | -2.8649 | |
| 277 | N | A | -3.1399 | |
| 278 | L | A | 0.0000 | |
| 279 | R | A | -3.2148 | |
| 280 | G | A | -2.4951 | |
| 281 | N | A | -2.8076 | |
| 282 | T | A | -2.5217 | |
| 283 | E | A | -3.1025 | |
| 284 | G | A | -2.5573 | |
| 285 | L | A | 0.0000 | |
| 286 | Q | A | -2.1117 | |
| 287 | K | A | -2.6235 | |
| 288 | S | A | -2.2373 | |
| 289 | L | A | 0.0000 | |
| 290 | A | A | -1.6806 | |
| 291 | E | A | -2.3131 | |
| 292 | L | A | 0.0000 | |
| 293 | G | A | -1.6786 | |
| 294 | G | A | -1.7564 | |
| 295 | H | A | -1.8050 | |
| 296 | L | A | 0.0000 | |
| 297 | D | A | -2.2915 | |
| 298 | Q | A | -2.5664 | |
| 299 | Q | A | -2.6158 | |
| 300 | V | A | 0.0000 | |
| 301 | E | A | -3.0070 | |
| 302 | E | A | -3.6025 | |
| 303 | F | A | 0.0000 | |
| 304 | R | A | -2.9123 | |
| 305 | R | A | -3.6676 | |
| 306 | R | A | -3.5412 | |
| 307 | V | A | 0.0000 | |
| 308 | E | A | -2.2840 | |
| 309 | P | A | -1.8651 | |
| 310 | Y | A | 0.0000 | |
| 311 | G | A | 0.0000 | |
| 312 | E | A | -2.8739 | |
| 313 | N | A | -2.3622 | |
| 314 | F | A | -1.6977 | |
| 315 | N | A | 0.0000 | |
| 316 | K | A | -2.6456 | |
| 317 | A | A | -1.6602 | |
| 318 | L | A | 0.0000 | |
| 319 | V | A | -1.5091 | |
| 320 | Q | A | -2.0259 | |
| 321 | Q | A | -1.5800 | |
| 322 | M | A | 0.0000 | |
| 323 | E | A | -1.8771 | |
| 324 | Q | A | -2.4214 | |
| 325 | L | A | 0.0000 | |
| 326 | R | A | -2.2478 | |
| 327 | Q | A | -2.6654 | |
| 328 | K | A | -2.8098 | |
| 329 | L | A | 0.0000 | |
| 330 | G | A | 0.0000 | |
| 331 | P | A | -1.4589 | |
| 332 | H | A | -1.4730 | |
| 92 | A | B | -1.4581 | |
| 93 | K | B | -3.0419 | |
| 94 | D | B | -3.5254 | |
| 95 | S | B | -3.0665 | |
| 96 | E | B | -4.4588 | |
| 97 | K | B | -4.0459 | |
| 98 | L | B | -2.0464 | |
| 99 | K | B | -3.4392 | |
| 100 | E | B | -4.2851 | |
| 101 | E | B | -3.3377 | |
| 102 | I | B | -0.7746 | |
| 103 | G | B | -2.5278 | |
| 104 | K | B | -4.0352 | |
| 105 | E | B | -3.9282 | |
| 106 | L | B | -3.2779 | |
| 107 | E | B | -4.2374 | |
| 108 | E | B | -3.6981 | |
| 109 | L | B | 0.0000 | |
| 110 | R | B | -2.3342 | |
| 111 | A | B | -1.6987 | |
| 112 | R | B | -2.4737 | |
| 113 | L | B | 0.0000 | |
| 114 | L | B | -0.1111 | |
| 115 | P | B | -0.4958 | |
| 116 | H | B | -1.1115 | |
| 117 | A | B | 0.0000 | |
| 118 | N | B | -2.0641 | |
| 119 | E | B | -1.9593 | |
| 120 | V | B | 0.0000 | |
| 121 | S | B | -2.2512 | |
| 122 | Q | B | -2.5116 | |
| 123 | K | B | -2.2426 | |
| 124 | I | B | 0.0000 | |
| 125 | G | B | -2.3012 | |
| 126 | D | B | -2.8907 | |
| 127 | N | B | 0.0000 | |
| 128 | L | B | 0.0000 | |
| 129 | R | B | -3.4103 | |
| 130 | E | B | -3.4908 | |
| 131 | L | B | 0.0000 | |
| 132 | Q | B | -2.7727 | |
| 133 | Q | B | -2.9792 | |
| 134 | R | B | -1.9699 | |
| 135 | L | B | 0.0000 | |
| 136 | E | B | -3.0618 | |
| 137 | P | B | -1.9895 | |
| 138 | Y | B | -1.7097 | |
| 139 | A | B | 0.0000 | |
| 140 | D | B | -3.0829 | |
| 141 | Q | B | -2.2099 | |
| 142 | L | B | 0.0000 | |
| 143 | R | B | -2.0448 | |
| 144 | T | B | -1.4455 | |
| 145 | Q | B | -1.7009 | |
| 146 | V | B | 0.0000 | |
| 147 | N | B | -1.5045 | |
| 148 | T | B | -1.1536 | |
| 149 | Q | B | -1.8673 | |
| 150 | A | B | 0.0000 | |
| 151 | E | B | -2.4095 | |
| 152 | Q | B | -2.5078 | |
| 153 | L | B | 0.0000 | |
| 154 | R | B | -2.3636 | |
| 155 | R | B | -2.9644 | |
| 156 | Q | B | -2.2489 | |
| 157 | L | B | 0.0000 | |
| 158 | T | B | -1.5285 | |
| 159 | P | B | -1.3838 | |
| 160 | Y | B | 0.0000 | |
| 161 | A | B | 0.0000 | |
| 162 | Q | B | -2.0884 | |
| 163 | R | B | -2.0256 | |
| 164 | M | B | 0.0000 | |
| 165 | E | B | -2.4322 | |
| 166 | R | B | -3.3745 | |
| 167 | V | B | -2.2888 | |
| 168 | L | B | 0.0000 | |
| 169 | R | B | -3.4976 | |
| 170 | E | B | -3.6323 | |
| 171 | N | B | -2.4030 | |
| 172 | A | B | -2.6847 | |
| 173 | D | B | -3.1436 | |
| 174 | S | B | -1.8766 | |
| 175 | L | B | 0.0000 | |
| 176 | Q | B | -2.3020 | |
| 177 | A | B | -1.4705 | |
| 178 | S | B | -1.0662 | |
| 179 | L | B | 0.0000 | |
| 180 | R | B | -2.6721 | |
| 181 | P | B | -1.8730 | |
| 182 | H | B | -2.0791 | |
| 183 | A | B | 0.0000 | |
| 184 | D | B | -2.5531 | |
| 185 | E | B | -2.5303 | |
| 186 | L | B | 0.0000 | |
| 187 | K | B | -2.3854 | |
| 188 | A | B | -1.7845 | |
| 189 | K | B | -2.1263 | |
| 190 | I | B | 0.0000 | |
| 191 | D | B | -2.6301 | |
| 192 | Q | B | -2.6891 | |
| 193 | N | B | 0.0000 | |
| 194 | V | B | 0.0000 | |
| 195 | E | B | -3.6352 | |
| 196 | E | B | -2.9153 | |
| 197 | L | B | 0.0000 | |
| 198 | K | B | -2.3603 | |
| 199 | G | B | -2.1332 | |
| 200 | R | B | -2.2026 | |
| 201 | L | B | 0.0000 | |
| 202 | T | B | 0.0000 | |
| 203 | P | B | -1.0619 | |
| 204 | Y | B | 0.0000 | |
| 205 | A | B | 0.0000 | |
| 206 | D | B | -1.3553 | |
| 207 | E | B | -0.8235 | |
| 208 | F | B | 0.0000 | |
| 209 | K | B | -1.0944 | |
| 210 | V | B | -0.0972 | |
| 211 | K | B | -1.0825 | |
| 212 | I | B | 0.0000 | |
| 213 | D | B | -1.6883 | |
| 214 | Q | B | -1.5868 | |
| 215 | T | B | 0.0000 | |
| 216 | V | B | 0.0000 | |
| 217 | E | B | -2.5137 | |
| 218 | E | B | -2.4981 | |
| 219 | L | B | 0.0000 | |
| 220 | R | B | -2.2466 | |
| 221 | R | B | -2.5790 | |
| 222 | S | B | -1.7089 | |
| 223 | L | B | 0.0000 | |
| 224 | A | B | -1.4752 | |
| 225 | P | B | -1.0302 | |
| 226 | Y | B | -0.6952 | |
| 227 | A | B | 0.0000 | |
| 228 | Q | B | -2.4504 | |
| 229 | D | B | -2.9150 | |
| 230 | T | B | -2.5618 | |
| 231 | Q | B | -2.5319 | |
| 232 | E | B | -3.1282 | |
| 233 | K | B | -2.8716 | |
| 234 | L | B | 0.0000 | |
| 235 | N | B | -2.5743 | |
| 236 | H | B | -2.5162 | |
| 237 | Q | B | -1.3896 | |
| 238 | L | B | 0.0000 | |
| 239 | E | B | -2.4060 | |
| 240 | G | B | -0.8976 | |
| 241 | L | B | 0.0000 | |
| 242 | T | B | -1.0320 | |
| 243 | F | B | 0.0223 | |
| 244 | Q | B | -1.3545 | |
| 245 | M | B | 0.0000 | |
| 246 | K | B | -1.7425 | |
| 247 | K | B | -2.8549 | |
| 248 | N | B | -2.3241 | |
| 249 | A | B | 0.0000 | |
| 250 | E | B | -3.4628 | |
| 251 | E | B | -3.0442 | |
| 252 | L | B | 0.0000 | |
| 253 | K | B | -2.2274 | |
| 254 | A | B | -1.6701 | |
| 255 | R | B | -2.1584 | |
| 256 | I | B | 0.0000 | |
| 257 | S | B | -1.7311 | |
| 258 | A | B | -1.5761 | |
| 259 | S | B | 0.0000 | |
| 260 | A | B | 0.0000 | |
| 261 | E | B | -3.6910 | |
| 262 | E | B | -3.7541 | |
| 263 | L | B | 0.0000 | |
| 264 | R | B | -3.1968 | |
| 265 | Q | B | -3.4033 | |
| 266 | R | B | -3.5122 | |
| 267 | L | B | 0.0000 | |
| 268 | A | B | -2.0655 | |
| 269 | P | B | -2.2666 | |
| 270 | L | B | -1.9961 | |
| 271 | A | B | 0.0000 | |
| 272 | E | B | -3.3542 | |
| 273 | D | B | -3.1545 | |
| 274 | V | B | 0.0000 | |
| 275 | R | B | -3.2189 | |
| 276 | G | B | -2.5325 | |
| 277 | N | B | -2.7659 | |
| 278 | L | B | 0.0000 | |
| 279 | R | B | -2.3736 | |
| 280 | G | B | -1.9621 | |
| 281 | N | B | -2.6805 | |
| 282 | T | B | -2.6873 | |
| 283 | E | B | -3.1484 | |
| 284 | G | B | -2.6943 | |
| 285 | L | B | 0.0000 | |
| 286 | Q | B | -2.7493 | |
| 287 | K | B | -2.7557 | |
| 288 | S | B | -2.1995 | |
| 289 | L | B | 0.0000 | |
| 290 | A | B | -1.4290 | |
| 291 | E | B | -1.6417 | |
| 292 | L | B | 0.0000 | |
| 293 | G | B | -1.1125 | |
| 294 | G | B | -1.3836 | |
| 295 | H | B | -1.5787 | |
| 296 | L | B | 0.0000 | |
| 297 | D | B | -2.0307 | |
| 298 | Q | B | -2.1145 | |
| 299 | Q | B | -2.5481 | |
| 300 | V | B | 0.0000 | |
| 301 | E | B | -2.5908 | |
| 302 | E | B | -3.4294 | |
| 303 | F | B | 0.0000 | |
| 304 | R | B | -2.7613 | |
| 305 | R | B | -3.5715 | |
| 306 | R | B | -3.4201 | |
| 307 | V | B | 0.0000 | |
| 308 | E | B | -2.3053 | |
| 309 | P | B | -1.8018 | |
| 310 | Y | B | -1.8357 | |
| 311 | G | B | 0.0000 | |
| 312 | E | B | -3.1663 | |
| 313 | N | B | -2.2391 | |
| 314 | F | B | 0.0000 | |
| 315 | N | B | -2.1016 | |
| 316 | K | B | -2.7272 | |
| 317 | A | B | -1.7925 | |
| 318 | L | B | 0.0000 | |
| 319 | V | B | -1.7268 | |
| 320 | Q | B | -2.2303 | |
| 321 | Q | B | -1.8886 | |
| 322 | M | B | 0.0000 | |
| 323 | E | B | -2.5035 | |
| 324 | Q | B | -2.7059 | |
| 325 | L | B | 0.0000 | |
| 326 | R | B | -2.6489 | |
| 327 | Q | B | -2.7770 | |
| 328 | K | B | -2.5858 | |
| 329 | L | B | 0.0000 | |
| 330 | G | B | 0.0000 | |
| 331 | P | B | -1.3574 | |
| 332 | H | B | -1.5773 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine