Project name: 93c9d0d6db5746f

Chain sequence(s)	A: MEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.0129
• Maximal score value: 1.6357
• Average score: -0.915
• Total score value: -419.0771

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
8	M	A	-0.9083
9	E	A	-2.1109
10	A	A	-1.5384
11	A	A	-1.3948
12	K	A	-2.0044
13	K	A	-2.7393
14	E	A	-3.2482
15	K	A	0.0000
16	V	A	0.0000
17	E	A	-3.0131
18	Q	A	-2.2047
19	I	A	0.0000
20	L	A	-1.4819
21	A	A	-1.1465
22	E	A	-1.0789
23	F	A	0.0000
24	Q	A	-1.8361
25	L	A	0.0000
26	Q	A	-2.5627
27	E	A	-3.0898
28	E	A	-3.1380
29	D	A	-2.9351
30	L	A	0.0000
31	K	A	-2.6128
32	K	A	-2.8010
33	V	A	0.0000
34	M	A	0.0000
35	R	A	-2.8449
36	R	A	-2.0717
37	M	A	0.0000
38	Q	A	-1.8351
39	K	A	-2.4577
40	E	A	0.0000
41	M	A	0.0000
42	D	A	-2.1099
43	R	A	-1.8903
44	G	A	0.0000
45	L	A	-1.4139
46	R	A	-2.2212
47	L	A	-0.6112
48	E	A	-1.8042
49	T	A	-1.3376
50	H	A	-2.1563
51	E	A	-3.0392
52	E	A	-2.9219
53	A	A	-1.8535
54	S	A	-1.7262
55	V	A	0.0000
56	K	A	-0.9121
57	M	A	0.0000
58	L	A	-0.5210
59	P	A	-0.5420
60	T	A	0.0000
61	Y	A	-0.5028
62	V	A	0.0000
63	R	A	-1.0403
64	S	A	-0.8397
65	T	A	-0.7027
66	P	A	0.0000
67	E	A	-2.1714
68	G	A	0.0000
69	S	A	-0.9408
70	E	A	-0.3927
71	V	A	1.0679
72	G	A	0.2069
73	D	A	-0.5839
74	F	A	-0.0926
75	L	A	0.0000
76	S	A	0.0000
77	L	A	0.0000
78	D	A	-0.4528
79	L	A	0.0000
80	G	A	-0.7385
81	G	A	-1.0786
82	T	A	-0.9820
83	N	A	-0.7744
84	F	A	0.0000
85	R	A	-0.4900
86	V	A	0.0000
87	M	A	0.0000
88	L	A	-0.9152
89	V	A	0.0000
90	K	A	-1.4637
91	V	A	0.0000
92	G	A	0.0000
93	E	A	-1.7008
94	G	A	-2.0624
95	E	A	-3.1423
96	E	A	-3.1720
97	G	A	-1.8312
98	Q	A	-1.7571
99	W	A	-0.8687
100	S	A	-0.9890
101	V	A	-1.1167
102	K	A	-2.3325
103	T	A	-1.7302
104	K	A	-1.9287
105	H	A	-1.3386
106	Q	A	-0.7066
107	M	A	0.1306
108	Y	A	0.0619
109	S	A	-0.6014
110	I	A	0.0000
111	P	A	-1.6304
112	E	A	-2.8043
113	D	A	-2.6510
114	A	A	0.0000
115	M	A	-1.6520
116	T	A	-1.6770
117	G	A	-1.5115
118	T	A	-1.1376
119	A	A	0.0000
120	E	A	-1.7964
121	M	A	-0.6089
122	L	A	0.0000
123	F	A	0.0000
124	D	A	-1.5565
125	Y	A	-0.7656
126	I	A	0.0000
127	S	A	0.0000
128	E	A	-2.3394
129	C	A	-1.5908
130	I	A	0.0000
131	S	A	-2.7256
132	D	A	-3.3085
133	F	A	0.0000
134	L	A	0.0000
135	D	A	-3.5555
136	K	A	-3.2893
137	H	A	-2.3926
138	Q	A	-1.9188
139	M	A	-1.7617
140	K	A	-2.0170
141	H	A	-2.3293
142	K	A	-2.7377
143	K	A	-2.7463
144	L	A	0.0000
145	P	A	0.0000
146	L	A	0.0000
147	G	A	0.0000
148	F	A	0.0000
149	T	A	0.0000
150	F	A	0.0000
151	S	A	-0.4085
152	F	A	0.0000
153	P	A	-0.5021
154	V	A	0.0000
155	R	A	-1.7027
156	H	A	-1.7390
157	E	A	-2.5041
158	D	A	-2.0269
159	I	A	-0.9056
160	D	A	-1.0255
161	K	A	-1.8609
162	G	A	0.0000
163	I	A	-1.3633
164	L	A	0.0000
165	L	A	-0.8244
166	N	A	-1.7544
167	W	A	-1.3938
168	T	A	-1.1174
169	K	A	-1.5081
170	G	A	-1.3911
171	F	A	0.0000
172	K	A	-2.2802
173	A	A	0.0000
174	S	A	-1.3328
175	G	A	-1.3586
176	A	A	0.0000
177	E	A	-2.1722
178	G	A	-1.6059
179	N	A	-1.5947
180	N	A	-1.0650
181	V	A	0.0000
182	V	A	0.0000
183	G	A	-0.9236
184	L	A	-0.9320
185	L	A	0.0000
186	R	A	-2.1170
187	D	A	-3.3063
188	A	A	0.0000
189	I	A	0.0000
190	K	A	-4.0129
191	R	A	-3.8860
192	R	A	-3.1745
193	G	A	-2.6165
194	D	A	-2.9473
195	F	A	0.0000
196	E	A	-2.6359
197	M	A	0.0000
198	D	A	-1.1571
199	V	A	0.0000
200	V	A	0.0310
201	A	A	0.0000
202	M	A	0.0000
203	V	A	0.0000
204	N	A	0.0000
205	D	A	-0.5453
206	T	A	0.0000
207	V	A	0.0000
208	A	A	0.0000
209	T	A	0.0000
210	M	A	0.0000
211	I	A	0.0000
212	S	A	0.0000
213	C	A	0.0000
214	Y	A	-0.9854
215	Y	A	0.0000
216	E	A	-1.7132
217	D	A	-1.4320
218	H	A	-1.6559
219	Q	A	-1.6284
220	C	A	0.0000
221	E	A	-0.8491
222	V	A	0.0000
223	G	A	0.0000
224	M	A	0.0000
225	I	A	0.0582
226	V	A	0.0000
227	G	A	0.0000
228	T	A	-0.5958
229	G	A	-0.4955
230	C	A	0.0000
231	N	A	0.0000
232	A	A	0.0000
233	C	A	0.0000
234	Y	A	0.0000
235	M	A	-0.2519
236	E	A	0.0000
237	E	A	-1.7224
238	M	A	0.0000
239	Q	A	-1.8354
240	N	A	-1.5626
241	V	A	0.1262
242	E	A	-1.1274
243	L	A	0.2185
244	V	A	0.8436
245	E	A	-1.5304
246	G	A	-1.9183
247	D	A	-3.2221
248	E	A	-3.4375
249	G	A	-2.0522
250	R	A	-1.6295
251	M	A	0.0000
252	C	A	0.0000
253	V	A	0.0000
254	N	A	0.0000
255	T	A	0.0000
256	E	A	-0.5179
257	W	A	0.0000
258	G	A	0.0000
259	A	A	0.0000
260	F	A	0.0000
261	G	A	0.0000
262	D	A	-1.5781
263	S	A	-1.6521
264	G	A	-1.7882
265	E	A	-2.3725
266	L	A	-1.5846
267	D	A	-2.1937
268	E	A	-1.4190
269	F	A	-0.6140
270	L	A	-0.4112
271	L	A	-0.5947
272	E	A	-1.5659
273	Y	A	0.0000
274	D	A	0.0000
275	R	A	-1.1911
276	L	A	0.0363
277	V	A	-0.2850
278	D	A	0.0000
279	E	A	-1.9149
280	S	A	-1.1959
281	S	A	-1.0630
282	A	A	-1.0901
283	N	A	-2.0433
284	P	A	-1.9033
285	G	A	-1.7604
286	Q	A	-1.8933
287	Q	A	-1.2072
288	L	A	0.0000
289	Y	A	0.0000
290	E	A	-0.6156
291	K	A	-0.6492
292	L	A	-0.1193
293	I	A	0.0000
294	G	A	0.0000
295	G	A	0.0000
296	K	A	-2.3068
297	Y	A	-1.0134
298	M	A	0.0000
299	G	A	0.0000
300	E	A	-1.0805
301	L	A	0.0000
302	V	A	0.0000
303	R	A	0.0000
304	L	A	-0.4263
305	V	A	0.0000
306	L	A	0.0000
307	L	A	-1.0607
308	R	A	-1.2979
309	L	A	0.0000
310	V	A	-1.6960
311	D	A	-2.7160
312	E	A	-2.3150
313	N	A	-2.4467
314	L	A	-1.1536
315	L	A	0.0000
316	F	A	0.0000
317	H	A	-2.0001
318	G	A	-1.4214
319	E	A	-1.4817
320	A	A	-1.6129
321	S	A	-1.9604
322	E	A	-3.1050
323	Q	A	-2.9563
324	L	A	0.0000
325	R	A	-3.2269
326	T	A	-2.7019
327	R	A	-2.7195
328	G	A	-2.0734
329	A	A	-1.7072
330	F	A	0.0000
331	E	A	-2.3538
332	T	A	-2.1166
333	R	A	-2.5754
334	F	A	-1.3580
335	V	A	0.0000
336	S	A	-1.0881
337	Q	A	-1.4448
338	V	A	0.0000
339	E	A	-1.0917
340	S	A	-0.7319
341	D	A	0.0000
342	T	A	-0.8835
343	G	A	-1.0871
344	D	A	-1.5316
345	R	A	-2.0115
346	K	A	-1.3890
347	Q	A	0.0000
348	I	A	-0.4007
349	Y	A	0.4498
350	N	A	0.1107
351	I	A	0.0000
352	L	A	0.2334
353	S	A	0.0936
354	T	A	-0.1096
355	L	A	0.0000
356	G	A	-1.1090
357	L	A	0.0000
358	R	A	-1.8243
359	P	A	-1.0296
360	S	A	-0.6629
361	T	A	-0.5529
362	T	A	-0.6533
363	D	A	0.0000
364	C	A	0.0000
365	D	A	-1.2395
366	I	A	0.0000
367	V	A	0.0000
368	R	A	-1.4983
369	R	A	-1.6702
370	A	A	0.0000
371	C	A	0.0000
372	E	A	-0.9474
373	S	A	-0.8032
374	V	A	0.0000
375	S	A	0.0000
376	T	A	-0.9051
377	R	A	0.0000
378	A	A	0.0000
379	A	A	0.0000
380	H	A	-0.9801
381	M	A	0.0000
382	C	A	0.0000
383	S	A	0.0000
384	A	A	0.0000
385	G	A	0.0000
386	L	A	0.0000
387	A	A	0.0000
388	G	A	0.0000
389	V	A	0.0000
390	I	A	0.0000
391	N	A	0.0000
392	R	A	0.0000
393	M	A	-1.3446
394	R	A	-2.2852
395	E	A	-2.8722
396	S	A	-2.0653
397	R	A	-2.4611
398	S	A	-2.4697
399	E	A	-2.9046
400	D	A	-2.5611
401	V	A	-0.2565
402	M	A	-1.2317
403	R	A	-1.9690
404	I	A	0.0000
405	T	A	0.0000
406	V	A	0.0000
407	G	A	0.0000
408	V	A	0.0000
409	D	A	-0.7477
410	G	A	-0.3757
411	S	A	-0.0308
412	V	A	0.0000
413	Y	A	0.0000
414	K	A	-0.1507
415	L	A	1.0885
416	H	A	0.0000
417	P	A	-0.4524
418	S	A	-1.1500
419	F	A	0.0000
420	K	A	-1.7068
421	E	A	-2.8069
422	R	A	-2.4703
423	F	A	0.0000
424	H	A	-1.8539
425	A	A	-2.0534
426	S	A	0.0000
427	V	A	0.0000
428	R	A	-2.6858
429	R	A	-2.5952
430	L	A	0.0000
431	T	A	-1.3841
432	P	A	-1.6208
433	S	A	-1.1865
434	C	A	-1.5846
435	E	A	-2.3044
436	I	A	-1.3543
437	T	A	-0.4836
438	F	A	0.0000
439	I	A	0.1275
440	E	A	-1.0276
441	S	A	-0.9976
442	E	A	-1.2775
443	E	A	-1.2859
444	G	A	0.0000
445	S	A	-0.6253
446	G	A	0.0000
447	R	A	-0.7591
448	G	A	0.0000
449	A	A	0.0000
450	A	A	0.0000
451	L	A	0.0000
452	V	A	0.0000
453	S	A	0.0000
454	A	A	-0.0798
455	V	A	-0.3430
456	A	A	0.0000
457	C	A	-0.1071
458	K	A	-0.8829
459	K	A	-0.2346
460	A	A	0.5790
461	C	A	1.1116
462	M	A	1.6357
463	L	A	1.6245
464	G	A	0.1157
465	Q	A	-0.8413