Project name: badTAU

Chain sequence(s)	A: MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQARMVSKSKDGTGSDDKKAKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.2772
• Maximal score value: 2.0959
• Average score: -1.4347
• Total score value: -632.6878

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	M	A	-1.3942
2	A	A	-1.7050
3	E	A	-2.5634
4	P	A	-1.8659
5	R	A	-2.4636
6	Q	A	-2.4977
7	E	A	-2.1617
8	F	A	-1.5090
9	E	A	-2.6878
10	V	A	-1.5217
11	M	A	-1.0046
12	E	A	-2.9612
13	D	A	-3.4185
14	H	A	-2.3501
15	A	A	0.0000
16	G	A	-1.6875
17	T	A	-1.1577
18	Y	A	-1.3317
19	G	A	-0.9310
20	L	A	-0.2880
21	G	A	-1.9059
22	D	A	-3.3145
23	R	A	-3.6010
24	K	A	-3.7797
25	D	A	-2.9846
26	Q	A	-2.0814
27	G	A	-1.8742
28	G	A	-1.0753
29	Y	A	-0.2095
30	T	A	-0.4082
31	M	A	-0.3817
32	H	A	-1.6788
33	Q	A	-3.2379
34	D	A	-4.2146
35	Q	A	-3.8264
36	E	A	-4.1795
37	G	A	-4.1548
38	D	A	-4.1278
39	T	A	-2.8660
40	D	A	-2.6223
41	A	A	-2.7052
42	G	A	-1.8949
43	L	A	-0.7996
44	K	A	-2.7073
45	E	A	-2.4899
46	S	A	-1.2278
47	P	A	-0.3017
48	L	A	0.0908
49	Q	A	-1.1725
50	T	A	-0.4833
51	P	A	-1.0958
52	T	A	-1.3266
53	E	A	-2.6424
54	D	A	-3.2548
55	G	A	-3.1155
56	S	A	-2.9163
57	E	A	-3.4398
58	E	A	-3.6499
59	P	A	-2.6375
60	G	A	-1.9194
61	S	A	-1.8883
62	E	A	-2.5715
63	T	A	-2.2579
64	S	A	-1.9268
65	D	A	-2.6035
66	A	A	-2.1097
67	K	A	-2.5223
68	S	A	-1.6360
69	T	A	-1.5906
70	P	A	-1.8037
71	T	A	-1.0104
72	A	A	-1.5283
73	E	A	-2.0917
74	D	A	-1.5940
75	V	A	0.4478
76	T	A	0.0954
77	A	A	0.3479
78	P	A	0.2378
79	L	A	1.1131
80	V	A	-0.2969
81	D	A	-1.9477
82	E	A	-2.8178
83	G	A	-2.2311
84	A	A	-1.9257
85	P	A	-2.0167
86	G	A	-2.0292
87	K	A	-2.7659
88	Q	A	-2.1621
89	A	A	-1.4427
90	A	A	-1.6241
91	A	A	-1.2309
92	Q	A	-2.2760
93	P	A	-1.9593
94	H	A	-2.2120
95	T	A	-1.8441
96	E	A	-2.6727
97	I	A	-1.4721
98	P	A	-1.5988
99	E	A	-2.3625
100	G	A	-1.5268
101	T	A	-1.5092
102	T	A	-1.2986
103	A	A	-1.5784
104	E	A	-2.7119
105	E	A	-2.6851
106	A	A	-1.7449
107	G	A	-1.8032
108	I	A	-1.1599
109	G	A	-1.4327
110	D	A	-2.2517
111	T	A	-1.4171
112	P	A	-1.5428
113	S	A	-2.1158
114	L	A	-1.7303
115	E	A	-3.2416
116	D	A	-3.5411
117	E	A	-3.0647
118	A	A	-1.8872
119	A	A	-1.2606
120	G	A	-1.4044
121	H	A	-1.3894
122	V	A	-0.7196
123	T	A	-0.2148
124	Q	A	-0.5367
125	A	A	-0.5654
126	R	A	-1.7764
127	M	A	-0.5614
128	V	A	0.5875
129	S	A	-0.7857
130	K	A	-2.0534
131	S	A	-2.0081
132	K	A	-2.7002
133	D	A	-2.8900
134	G	A	-2.6757
135	T	A	-2.2403
136	G	A	-2.3630
137	S	A	-2.8934
138	D	A	-3.6135
139	D	A	-4.0057
140	K	A	-4.2772
141	K	A	-3.9732
142	A	A	-2.9582
143	K	A	-3.3876
144	G	A	-2.8449
145	A	A	-2.4036
146	D	A	-3.2855
147	G	A	-2.5643
148	K	A	-2.8256
149	T	A	-1.5349
150	K	A	-1.7479
151	I	A	0.6410
152	A	A	0.0787
153	T	A	-0.4672
154	P	A	-0.9917
155	R	A	-2.0911
156	G	A	-1.4976
157	A	A	-1.0794
158	A	A	-1.5677
159	P	A	-1.5629
160	P	A	-1.6459
161	G	A	-2.2278
162	Q	A	-3.0110
163	K	A	-3.3297
164	G	A	-2.5325
165	Q	A	-2.7171
166	A	A	-2.2965
167	N	A	-2.1911
168	A	A	-0.9807
169	T	A	-0.7308
170	R	A	-1.3481
171	I	A	0.3143
172	P	A	-0.3704
173	A	A	-0.6322
174	K	A	-1.5541
175	T	A	-0.8837
176	P	A	-0.8124
177	P	A	-0.9645
178	A	A	-1.1789
179	P	A	-1.3849
180	K	A	-2.1204
181	T	A	-1.2500
182	P	A	-1.0409
183	P	A	-0.9922
184	S	A	-1.4304
185	S	A	-1.2808
186	G	A	-1.6903
187	E	A	-2.5089
188	P	A	-1.7252
189	P	A	-1.6896
190	K	A	-1.6652
191	S	A	-1.3394
192	G	A	-1.2542
193	D	A	0.0000
194	R	A	-1.3601
195	S	A	-1.0239
196	G	A	-0.4099
197	Y	A	0.6503
198	S	A	-0.0297
199	S	A	-0.1442
200	P	A	-0.4728
201	G	A	-0.6331
202	S	A	-0.7937
203	P	A	-1.1196
204	G	A	-0.9393
205	T	A	-0.8335
206	P	A	-0.8593
207	G	A	0.0000
208	S	A	-1.3164
209	R	A	-1.9452
210	S	A	-1.5692
211	R	A	-2.2277
212	T	A	-1.2976
213	P	A	-0.5808
214	S	A	-0.4214
215	L	A	-0.2359
216	P	A	-0.2767
217	T	A	-0.3863
218	P	A	-0.5641
219	P	A	-1.1913
220	T	A	-1.4503
221	R	A	-2.5137
222	E	A	-3.1494
223	P	A	-2.5856
224	K	A	-2.9450
225	K	A	0.0000
226	V	A	0.0000
227	A	A	-0.9048
228	V	A	-0.5701
229	V	A	-0.9903
230	R	A	-2.1766
231	T	A	-1.5344
232	P	A	-1.3982
233	P	A	-1.5895
234	K	A	-2.3569
235	S	A	-1.8639
236	P	A	-1.2555
237	S	A	-1.4606
238	S	A	-1.7269
239	A	A	-1.9123
240	K	A	-2.7156
241	S	A	-2.2177
242	R	A	-2.8138
243	L	A	-1.9593
244	Q	A	-2.1268
245	T	A	-1.2617
246	A	A	-0.7609
247	P	A	-0.1622
248	V	A	-0.0812
249	P	A	-0.2726
250	M	A	-0.4070
251	P	A	-0.6503
252	D	A	-1.6525
253	L	A	-0.1916
254	K	A	-2.1616
255	N	A	-2.5507
256	V	A	-1.8310
257	K	A	-2.8591
258	S	A	-1.9523
259	K	A	-2.2701
260	I	A	-1.3737
261	G	A	-2.0500
262	S	A	-1.7179
263	T	A	-2.0590
264	E	A	-3.0916
265	N	A	-2.7309
266	L	A	-1.8233
267	K	A	-3.1887
268	H	A	-2.6507
269	Q	A	-2.3783
270	P	A	-1.5868
271	G	A	-1.8262
272	G	A	-1.3918
273	G	A	-1.5249
274	K	A	-2.3224
275	V	A	0.0000
276	Q	A	-1.3086
277	I	A	-0.3076
278	I	A	-1.4750
279	N	A	-2.3529
280	K	A	-3.2711
281	K	A	-3.2273
282	L	A	-2.1480
283	D	A	-2.7881
284	L	A	-1.4469
285	S	A	0.0000
286	N	A	-2.4693
287	V	A	-1.1957
288	Q	A	-2.0158
289	S	A	-1.4526
290	K	A	-2.0277
291	C	A	-1.5086
292	G	A	-1.7953
293	S	A	-2.2234
294	K	A	-2.8775
295	D	A	-2.9636
296	N	A	-2.4473
297	I	A	-0.5806
298	K	A	-0.7035
299	H	A	-0.8885
300	V	A	-0.2968
301	P	A	-0.8135
302	G	A	-0.9567
303	G	A	-0.8883
304	G	A	-0.9814
305	S	A	-0.6741
306	V	A	0.1670
307	Q	A	-0.0600
308	I	A	1.3132
309	V	A	2.0959
310	Y	A	1.1761
311	K	A	-0.4857
312	P	A	-0.0597
313	V	A	0.7324
314	D	A	-0.6132
315	L	A	0.8275
316	S	A	-0.2254
317	K	A	-0.6592
318	V	A	0.0861
319	T	A	-0.4268
320	S	A	-1.1737
321	K	A	-1.4806
322	C	A	-0.2449
323	G	A	-0.2983
324	S	A	0.0332
325	L	A	1.3529
326	G	A	0.0032
327	N	A	-0.6860
328	I	A	0.4815
329	H	A	-1.5291
330	H	A	-1.9937
331	K	A	-2.6499
332	P	A	-1.8198
333	G	A	-1.5575
334	G	A	-1.2973
335	G	A	-0.7641
336	Q	A	-0.8412
337	V	A	0.4187
338	E	A	-0.9425
339	V	A	0.0355
340	K	A	-1.8884
341	S	A	-1.6877
342	E	A	-2.7745
343	K	A	-2.2726
344	L	A	-0.3727
345	D	A	-0.9920
346	F	A	-0.1524
347	K	A	-2.1766
348	D	A	-2.9272
349	R	A	-2.6974
350	V	A	-1.4254
351	Q	A	-1.8347
352	S	A	-0.8827
353	K	A	-1.0994
354	I	A	0.9543
355	G	A	0.3457
356	S	A	0.0631
357	L	A	0.5710
358	D	A	-0.8767
359	N	A	-1.1213
360	I	A	0.8238
361	T	A	0.3060
362	H	A	0.1833
363	V	A	1.5808
364	P	A	-0.0344
365	G	A	-0.3407
366	G	A	-1.1593
367	G	A	-1.4246
368	N	A	-2.4617
369	K	A	-2.3442
370	K	A	-1.6036
371	I	A	-0.0582
372	E	A	-1.7837
373	T	A	-1.3182
374	H	A	-1.8044
375	K	A	-1.7496
376	L	A	-0.6166
377	T	A	-0.5505
378	F	A	-0.6311
379	R	A	-2.2931
380	E	A	-2.8359
381	N	A	-2.4970
382	A	A	-2.3936
383	K	A	-2.4717
384	A	A	-2.3174
385	K	A	-2.1801
386	T	A	0.0000
387	D	A	-3.0407
388	H	A	-2.1464
389	G	A	-1.9386
390	A	A	-1.3735
391	E	A	-1.7361
392	I	A	-1.3141
393	V	A	-0.1136
394	Y	A	-0.1232
395	K	A	-0.8079
396	S	A	-0.1376
397	P	A	-0.0462
398	V	A	0.3242
399	V	A	0.9714
400	S	A	-0.1274
401	G	A	-0.7710
402	D	A	-2.0681
403	T	A	-1.7643
404	S	A	-1.6627
405	P	A	-1.7687
406	R	A	-2.7804
407	H	A	-1.9138
408	L	A	0.0000
409	S	A	-0.8578
410	N	A	-0.7331
411	V	A	1.0061
412	S	A	0.2174
413	S	A	-0.2266
414	T	A	-0.3130
415	G	A	-0.9005
416	S	A	-1.2513
417	I	A	-0.4665
418	D	A	-0.9413
419	M	A	0.5052
420	V	A	0.7632
421	D	A	-1.3723
422	S	A	-0.8771
423	P	A	-1.0848
424	Q	A	-1.1795
425	L	A	0.0901
426	A	A	-0.4021
427	T	A	-0.2872
428	L	A	-0.2557
429	A	A	-1.1148
430	D	A	-2.4031
431	E	A	-2.2641
432	V	A	-0.4732
433	S	A	-0.7917
434	A	A	-1.0896
435	S	A	-0.6486
436	L	A	-0.3406
437	A	A	-0.9306
438	K	A	-2.0729
439	Q	A	-1.6296
440	G	A	-0.7747
441	L	A	0.7395