Project name: 4k3j:H

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAASGYTFTSYWLHWVRQAPGKGLEWVGMIDPSNSDTRFNPNFKDRFTISADTSKNTAYLQMNSLRAEDTAVYYCATYRSYVTPLDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKS
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.4171
• Maximal score value: 2.5287
• Average score: -0.6157
• Total score value: -136.0707

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.0843
2	V	H	-1.4725
3	Q	H	-1.3631
4	L	H	0.0000
5	V	H	0.6173
6	E	H	0.0000
7	S	H	-0.5001
8	G	H	-0.9083
9	G	H	-0.4996
10	G	H	-0.2896
11	L	H	0.0012
12	V	H	-0.6400
13	Q	H	-1.6289
14	P	H	-1.7549
15	G	H	-1.6576
16	G	H	-1.3713
17	S	H	-1.6215
18	L	H	-1.2924
19	R	H	-2.2067
20	L	H	0.0000
21	S	H	-0.4485
22	C	H	0.0000
23	A	H	-0.3625
24	A	H	-0.5595
25	S	H	-1.0405
26	G	H	-1.2275
27	Y	H	-0.7046
28	T	H	-0.1655
29	F	H	0.0000
30	T	H	-0.4594
31	S	H	-0.0907
32	Y	H	0.1646
33	W	H	-0.0581
34	L	H	0.0000
35	H	H	0.0545
36	W	H	0.0000
37	V	H	0.0000
38	R	H	0.0000
39	Q	H	-0.3924
40	A	H	-1.0820
41	P	H	-1.0478
42	G	H	-1.4057
43	K	H	-2.0394
44	G	H	-0.8872
45	L	H	0.6561
46	E	H	-0.0049
47	W	H	0.3375
48	V	H	0.0000
49	G	H	0.0000
50	M	H	-0.5735
51	I	H	0.0000
52	D	H	-1.1814
52A	P	H	0.0000
53	S	H	-1.1486
54	N	H	-1.8372
55	S	H	-1.4575
56	D	H	-1.8739
57	T	H	-1.7385
58	R	H	-2.2870
59	F	H	-1.8562
60	N	H	-1.6709
61	P	H	-2.0800
62	N	H	-2.2871
63	F	H	0.0000
64	K	H	-3.4171
65	D	H	-3.1905
66	R	H	-2.2622
67	F	H	0.0000
68	T	H	-1.3598
69	I	H	0.0000
70	S	H	-0.5639
71	A	H	-0.9452
72	D	H	-1.2381
73	T	H	-1.3021
74	S	H	-1.3472
75	K	H	-2.2056
76	N	H	-1.5692
77	T	H	0.0000
78	A	H	0.0000
79	Y	H	-0.5535
80	L	H	0.0000
81	Q	H	-1.4148
82	M	H	0.0000
82A	N	H	-2.2993
82B	S	H	-1.7762
82C	L	H	0.0000
83	R	H	-2.7060
84	A	H	-1.8748
85	E	H	-2.2776
86	D	H	0.0000
87	T	H	-0.8102
88	A	H	0.0000
89	V	H	0.3780
90	Y	H	0.0000
91	Y	H	0.2926
92	C	H	0.0000
93	A	H	0.0000
94	T	H	0.0000
95	Y	H	-0.0746
96	R	H	-1.1581
97	S	H	0.3085
98	Y	H	1.8285
99	V	H	2.0783
100	T	H	0.7551
100A	P	H	0.2149
100B	L	H	0.1889
101	D	H	-0.4974
102	Y	H	-0.2080
103	W	H	0.3723
104	G	H	-0.0993
105	Q	H	-0.8529
106	G	H	0.0000
107	T	H	-0.0398
108	L	H	0.0527
109	V	H	0.0000
110	T	H	-0.4551
111	V	H	0.0000
112	S	H	-0.7762
113	S	H	-0.6708
114	A	H	-0.5324
115	S	H	-0.7866
116	T	H	-1.1412
117	K	H	-2.0374
118	G	H	-1.8716
119	P	H	-0.7819
120	S	H	-0.1485
121	V	H	0.0000
122	F	H	1.2356
123	P	H	0.3309
124	L	H	0.4587
125	A	H	-0.8206
126	P	H	0.0000
127	S	H	-1.2877
128	S	H	-1.5141
129	K	H	-1.9489
130	S	H	-1.2159
131	T	H	-0.9763
132	S	H	-0.9246
133	G	H	-0.7823
134	G	H	-0.6011
135	T	H	-0.4283
136	A	H	0.0000
137	A	H	0.0991
138	L	H	0.0000
139	G	H	0.0000
140	C	H	0.0000
141	L	H	0.7282
142	V	H	0.0000
143	K	H	-0.1949
144	D	H	-0.8238
145	Y	H	0.0000
146	F	H	0.0000
147	P	H	0.0000
148	E	H	-0.6117
149	P	H	-0.7205
150	V	H	-0.6182
151	T	H	-0.5043
152	V	H	-0.1100
153	S	H	-0.4293
154	W	H	0.0000
155	N	H	-0.7583
156	S	H	-0.7029
157	G	H	-0.5999
158	A	H	-0.2617
159	L	H	-0.0184
160	T	H	-0.3000
161	S	H	-0.3607
162	G	H	-0.4426
163	V	H	0.0559
164	H	H	-0.3425
165	T	H	0.1853
166	F	H	0.9649
167	P	H	0.7425
168	A	H	1.2735
169	V	H	2.5287
170	L	H	2.2118
171	Q	H	0.6856
172	S	H	0.0772
173	S	H	-0.2125
174	G	H	0.2499
175	L	H	0.2636
176	Y	H	0.7564
177	S	H	0.0000
178	L	H	0.0000
179	S	H	0.6987
180	S	H	0.0000
181	V	H	0.5382
182	V	H	0.0000
183	T	H	-0.1887
184	V	H	0.0000
185	P	H	-0.5895
186	S	H	-0.8492
187	S	H	-0.6742
188	S	H	-0.6376
189	L	H	-0.8104
190	G	H	-1.0871
191	T	H	-0.9236
192	Q	H	-1.2891
193	T	H	-1.0714
194	Y	H	0.0000
195	I	H	-1.1993
196	C	H	0.0000
197	N	H	-1.5230
198	V	H	0.0000
199	N	H	-1.8411
200	H	H	0.0000
201	K	H	-2.7900
202	P	H	-1.7869
203	S	H	-2.0959
204	N	H	-2.7128
205	T	H	-2.1180
206	K	H	-2.6770
207	V	H	-1.5889
208	D	H	-2.5710
209	K	H	-1.9799
210	K	H	-1.9978
211	V	H	0.0000
212	E	H	-2.7807
213	P	H	-1.9660
214	K	H	-2.3905
215	S	H	-1.3009