| Chain sequence(s) |
A: SHHWGYGKHNGPEHWHKDFPIANGERQSPVDIDTKAVVQDPALKPLALVYGEATSRRMVNNGHSFNVEYDDSQDKAVLKDGPLTGTYRLVQFHFHWGSSDDQGSEHTVDRKKYAAELHLVHWNTKYGDFGTAAQQPDGLAVVGVFLKVGDANPALQKVLDALDSIKTKGKSTDFPNFDPGSLLPNVLDYWTYPGSLTTPPLLESVTWIVLKEPISVSSQQMLKFRTLNFNAEGEPELLMLANWRPAQPLKNRQVRGFPK B: SHHWGYGKHNGPEHWHKDFPIANGERQSPVDIDTKAVVQDPALKPLALVYGEATSRRMVNNGHSFNVEYDDSQDKAVLKDGPLTGTYRLVQFHFHWGSSDDQGSEHTVDRKKYAAELHLVHWNTKYGDFGTAAQQPDGLAVVGVFLKVGDANPALQKVLDALDSIKTKGKSTDFPNFDPGSLLPNVLDYWTYPGSLTTPPLLESVTWIVLKEPISVSSQQMLKFRTLNFNAEGEPELLMLANWRPAQPLKNRQVRGFPK |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | S | A | -0.5238 | |
| 2 | H | A | -0.7448 | |
| 3 | H | A | -1.3636 | |
| 4 | W | A | -1.0388 | |
| 5 | G | A | -0.7163 | |
| 6 | Y | A | -0.7655 | |
| 7 | G | A | -1.5474 | |
| 8 | K | A | -2.7447 | |
| 9 | H | A | -2.4403 | |
| 10 | N | A | -2.1040 | |
| 11 | G | A | 0.0000 | |
| 12 | P | A | -1.5302 | |
| 13 | E | A | -2.9488 | |
| 14 | H | A | -2.7041 | |
| 15 | W | A | 0.0000 | |
| 16 | H | A | -2.4797 | |
| 17 | K | A | -3.1604 | |
| 18 | D | A | -2.7586 | |
| 19 | F | A | -1.4294 | |
| 20 | P | A | -1.3596 | |
| 21 | I | A | -0.7892 | |
| 22 | A | A | 0.0000 | |
| 23 | N | A | -2.0977 | |
| 24 | G | A | -1.7084 | |
| 25 | E | A | -2.8147 | |
| 26 | R | A | -1.9172 | |
| 27 | Q | A | 0.0000 | |
| 28 | S | A | 0.0000 | |
| 29 | P | A | 0.0000 | |
| 30 | V | A | 0.0000 | |
| 31 | D | A | -1.7385 | |
| 32 | I | A | 0.0000 | |
| 33 | D | A | -2.4044 | |
| 34 | T | A | -1.6916 | |
| 35 | K | A | -1.9857 | |
| 36 | A | A | -1.2349 | |
| 37 | V | A | -1.2388 | |
| 38 | V | A | -1.0663 | |
| 39 | Q | A | -1.8603 | |
| 40 | D | A | -1.5010 | |
| 41 | P | A | -1.1254 | |
| 42 | A | A | -0.7639 | |
| 43 | L | A | 0.0000 | |
| 44 | K | A | -2.2544 | |
| 45 | P | A | -1.3575 | |
| 46 | L | A | 0.0000 | |
| 47 | A | A | -0.4149 | |
| 48 | L | A | 0.4316 | |
| 49 | V | A | 0.3746 | |
| 50 | Y | A | 0.0000 | |
| 51 | G | A | -1.3851 | |
| 52 | E | A | -2.6570 | |
| 53 | A | A | -2.1780 | |
| 54 | T | A | -2.0324 | |
| 55 | S | A | 0.0000 | |
| 56 | R | A | -2.7767 | |
| 57 | R | A | -2.5408 | |
| 58 | M | A | 0.0000 | |
| 59 | V | A | -1.1596 | |
| 60 | N | A | 0.0000 | |
| 61 | N | A | -0.6922 | |
| 62 | G | A | 0.0000 | |
| 63 | H | A | -0.1260 | |
| 64 | S | A | 0.0000 | |
| 65 | F | A | 0.0000 | |
| 66 | N | A | -0.5716 | |
| 67 | V | A | 0.0000 | |
| 68 | E | A | -1.9542 | |
| 69 | Y | A | 0.0000 | |
| 70 | D | A | -1.9038 | |
| 71 | D | A | -1.8644 | |
| 72 | S | A | -1.7786 | |
| 73 | Q | A | -2.5924 | |
| 74 | D | A | -2.9894 | |
| 75 | K | A | -2.5309 | |
| 76 | A | A | 0.0000 | |
| 77 | V | A | 0.0000 | |
| 78 | L | A | 0.0000 | |
| 79 | K | A | -1.3518 | |
| 80 | D | A | -2.1150 | |
| 81 | G | A | 0.0000 | |
| 82 | P | A | -0.9917 | |
| 83 | L | A | -0.9601 | |
| 84 | T | A | -0.7568 | |
| 85 | G | A | -1.2484 | |
| 86 | T | A | -1.2871 | |
| 87 | Y | A | 0.0000 | |
| 88 | R | A | -1.1709 | |
| 89 | L | A | 0.0000 | |
| 90 | V | A | -0.4620 | |
| 91 | Q | A | -0.8761 | |
| 92 | F | A | 0.0000 | |
| 93 | H | A | 0.0000 | |
| 94 | F | A | 0.0000 | |
| 95 | H | A | 0.0000 | |
| 96 | W | A | 0.0000 | |
| 97 | G | A | 0.0000 | |
| 98 | S | A | -0.0919 | |
| 99 | S | A | -0.7646 | |
| 100 | D | A | -1.6129 | |
| 101 | D | A | -2.6509 | |
| 102 | Q | A | -2.0187 | |
| 103 | G | A | 0.0000 | |
| 104 | S | A | 0.0000 | |
| 105 | E | A | 0.0000 | |
| 106 | H | A | 0.0000 | |
| 107 | T | A | 0.0000 | |
| 108 | V | A | 0.0000 | |
| 109 | D | A | -3.0689 | |
| 110 | R | A | -3.4826 | |
| 111 | K | A | -3.4953 | |
| 112 | K | A | -3.1006 | |
| 113 | Y | A | 0.0000 | |
| 114 | A | A | 0.0000 | |
| 115 | A | A | 0.0000 | |
| 116 | E | A | 0.0000 | |
| 117 | L | A | 0.0000 | |
| 118 | H | A | 0.0000 | |
| 119 | L | A | 0.0000 | |
| 120 | V | A | 0.0000 | |
| 121 | H | A | 0.0000 | |
| 122 | W | A | 0.0000 | |
| 123 | N | A | 0.0000 | |
| 124 | T | A | -1.6508 | |
| 125 | K | A | -2.0513 | |
| 126 | Y | A | -1.4055 | |
| 127 | G | A | -1.3040 | |
| 128 | D | A | -1.3865 | |
| 129 | F | A | -0.4008 | |
| 130 | G | A | -0.7337 | |
| 131 | T | A | -1.0532 | |
| 132 | A | A | 0.0000 | |
| 133 | A | A | 0.0000 | |
| 134 | Q | A | -1.5698 | |
| 135 | Q | A | -1.4851 | |
| 136 | P | A | -1.1618 | |
| 137 | D | A | -1.3209 | |
| 138 | G | A | 0.0000 | |
| 139 | L | A | 0.0000 | |
| 140 | A | A | 0.0000 | |
| 141 | V | A | 0.0000 | |
| 142 | V | A | 0.0000 | |
| 143 | G | A | 0.0000 | |
| 144 | V | A | 0.0000 | |
| 145 | F | A | 0.0000 | |
| 146 | L | A | 0.0000 | |
| 147 | K | A | -2.0074 | |
| 148 | V | A | -1.1698 | |
| 149 | G | A | -1.5666 | |
| 150 | D | A | -2.2896 | |
| 151 | A | A | -1.5508 | |
| 152 | N | A | -1.0164 | |
| 153 | P | A | -1.2027 | |
| 154 | A | A | -1.1287 | |
| 155 | L | A | 0.0000 | |
| 156 | Q | A | -2.4771 | |
| 157 | K | A | -2.7605 | |
| 158 | V | A | 0.0000 | |
| 159 | L | A | 0.0000 | |
| 160 | D | A | -3.1005 | |
| 161 | A | A | 0.0000 | |
| 162 | L | A | 0.0000 | |
| 163 | D | A | -2.4585 | |
| 164 | S | A | -1.7813 | |
| 165 | I | A | 0.0000 | |
| 166 | K | A | -1.5185 | |
| 167 | T | A | -1.8226 | |
| 168 | K | A | -1.6805 | |
| 169 | G | A | -1.5581 | |
| 170 | K | A | -1.8921 | |
| 171 | S | A | -1.3856 | |
| 172 | T | A | -1.7484 | |
| 173 | D | A | -2.5570 | |
| 174 | F | A | 0.0000 | |
| 175 | P | A | -2.1608 | |
| 176 | N | A | -2.3520 | |
| 177 | F | A | 0.0000 | |
| 178 | D | A | -2.5298 | |
| 179 | P | A | 0.0000 | |
| 180 | G | A | -0.7371 | |
| 181 | S | A | -0.8484 | |
| 182 | L | A | 0.0000 | |
| 183 | L | A | -0.2696 | |
| 184 | P | A | -0.5481 | |
| 185 | N | A | -0.8854 | |
| 186 | V | A | 0.2071 | |
| 187 | L | A | 0.1388 | |
| 188 | D | A | -0.6114 | |
| 189 | Y | A | 0.0000 | |
| 190 | W | A | 0.0000 | |
| 191 | T | A | 0.0000 | |
| 192 | Y | A | 0.0000 | |
| 193 | P | A | -0.8277 | |
| 194 | G | A | 0.0000 | |
| 195 | S | A | 0.0000 | |
| 196 | L | A | 0.1534 | |
| 197 | T | A | 0.0000 | |
| 198 | T | A | 0.1379 | |
| 199 | P | A | 0.0000 | |
| 200 | P | A | -0.1297 | |
| 201 | L | A | 0.0000 | |
| 202 | L | A | -0.0616 | |
| 203 | E | A | -0.8132 | |
| 204 | S | A | 0.0000 | |
| 205 | V | A | 0.0000 | |
| 206 | T | A | -0.2236 | |
| 207 | W | A | 0.0000 | |
| 208 | I | A | 0.0000 | |
| 209 | V | A | 0.0000 | |
| 210 | L | A | 0.0000 | |
| 211 | K | A | -0.6172 | |
| 212 | E | A | -1.2572 | |
| 213 | P | A | -0.8784 | |
| 214 | I | A | 0.0000 | |
| 215 | S | A | -1.2255 | |
| 216 | V | A | 0.0000 | |
| 217 | S | A | -1.2447 | |
| 218 | S | A | -1.0170 | |
| 219 | Q | A | -1.2719 | |
| 220 | Q | A | 0.0000 | |
| 221 | M | A | 0.0000 | |
| 222 | L | A | 0.2627 | |
| 223 | K | A | -0.8905 | |
| 224 | F | A | 0.0000 | |
| 225 | R | A | 0.0000 | |
| 226 | T | A | 0.1756 | |
| 227 | L | A | 0.0000 | |
| 228 | N | A | 0.0000 | |
| 229 | F | A | -0.0157 | |
| 230 | N | A | 0.0000 | |
| 231 | A | A | -2.1744 | |
| 232 | E | A | -3.2986 | |
| 233 | G | A | -2.5766 | |
| 234 | E | A | -3.0213 | |
| 235 | P | A | -1.9057 | |
| 236 | E | A | -1.7787 | |
| 237 | L | A | 0.8737 | |
| 238 | L | A | 1.3347 | |
| 239 | M | A | 0.0000 | |
| 240 | L | A | 1.2138 | |
| 241 | A | A | 0.3428 | |
| 242 | N | A | 0.0000 | |
| 243 | W | A | 0.1474 | |
| 244 | R | A | 0.0000 | |
| 245 | P | A | -0.4318 | |
| 246 | A | A | -0.4637 | |
| 247 | Q | A | -0.9283 | |
| 248 | P | A | -1.4046 | |
| 249 | L | A | -1.4811 | |
| 250 | K | A | -2.6844 | |
| 251 | N | A | -2.6345 | |
| 252 | R | A | -2.1788 | |
| 253 | Q | A | -1.7296 | |
| 254 | V | A | 0.0000 | |
| 255 | R | A | -1.4331 | |
| 256 | G | A | 0.0000 | |
| 257 | F | A | -1.4023 | |
| 258 | P | A | -1.5730 | |
| 259 | K | A | -2.2110 | |
| 1 | S | B | -0.6720 | |
| 2 | H | B | -0.9120 | |
| 3 | H | B | -1.4771 | |
| 4 | W | B | 0.0000 | |
| 5 | G | B | 0.0000 | |
| 6 | Y | B | -0.8110 | |
| 7 | G | B | -1.5724 | |
| 8 | K | B | -2.7226 | |
| 9 | H | B | -2.3667 | |
| 10 | N | B | -2.1672 | |
| 11 | G | B | 0.0000 | |
| 12 | P | B | -1.5219 | |
| 13 | E | B | -2.8869 | |
| 14 | H | B | -2.6367 | |
| 15 | W | B | 0.0000 | |
| 16 | H | B | -2.4455 | |
| 17 | K | B | -3.1422 | |
| 18 | D | B | -2.7600 | |
| 19 | F | B | -1.3771 | |
| 20 | P | B | -1.3534 | |
| 21 | I | B | -0.8338 | |
| 22 | A | B | 0.0000 | |
| 23 | N | B | -2.1260 | |
| 24 | G | B | -1.7950 | |
| 25 | E | B | -2.8856 | |
| 26 | R | B | -1.9447 | |
| 27 | Q | B | 0.0000 | |
| 28 | S | B | 0.0000 | |
| 29 | P | B | 0.0000 | |
| 30 | V | B | 0.0000 | |
| 31 | D | B | -1.7449 | |
| 32 | I | B | 0.0000 | |
| 33 | D | B | -2.6470 | |
| 34 | T | B | -1.7917 | |
| 35 | K | B | -2.0644 | |
| 36 | A | B | -1.3460 | |
| 37 | V | B | -1.2957 | |
| 38 | V | B | -1.0617 | |
| 39 | Q | B | -1.8447 | |
| 40 | D | B | -1.4633 | |
| 41 | P | B | -1.1333 | |
| 42 | A | B | -0.7023 | |
| 43 | L | B | 0.0000 | |
| 44 | K | B | -1.9680 | |
| 45 | P | B | -1.1899 | |
| 46 | L | B | 0.0000 | |
| 47 | A | B | -0.3240 | |
| 48 | L | B | 0.4909 | |
| 49 | V | B | 0.4542 | |
| 50 | Y | B | 0.0000 | |
| 51 | G | B | -1.3439 | |
| 52 | E | B | -2.6071 | |
| 53 | A | B | -2.1129 | |
| 54 | T | B | -1.9542 | |
| 55 | S | B | 0.0000 | |
| 56 | R | B | -2.4595 | |
| 57 | R | B | -2.5204 | |
| 58 | M | B | 0.0000 | |
| 59 | V | B | -1.0990 | |
| 60 | N | B | 0.0000 | |
| 61 | N | B | -0.7554 | |
| 62 | G | B | 0.0000 | |
| 63 | H | B | -0.2982 | |
| 64 | S | B | 0.0000 | |
| 65 | F | B | 0.0000 | |
| 66 | N | B | -0.4506 | |
| 67 | V | B | 0.0000 | |
| 68 | E | B | -1.4818 | |
| 69 | Y | B | 0.0000 | |
| 70 | D | B | -1.6637 | |
| 71 | D | B | -1.7023 | |
| 72 | S | B | -1.7407 | |
| 73 | Q | B | -2.5313 | |
| 74 | D | B | -2.9279 | |
| 75 | K | B | -2.4349 | |
| 76 | A | B | 0.0000 | |
| 77 | V | B | 0.0000 | |
| 78 | L | B | 0.0000 | |
| 79 | K | B | -1.2631 | |
| 80 | D | B | -1.9376 | |
| 81 | G | B | 0.0000 | |
| 82 | P | B | -0.9858 | |
| 83 | L | B | 0.0000 | |
| 84 | T | B | -0.9510 | |
| 85 | G | B | -1.2433 | |
| 86 | T | B | -1.2810 | |
| 87 | Y | B | 0.0000 | |
| 88 | R | B | -1.1341 | |
| 89 | L | B | 0.0000 | |
| 90 | V | B | -0.4164 | |
| 91 | Q | B | -0.7108 | |
| 92 | F | B | 0.0000 | |
| 93 | H | B | -0.2388 | |
| 94 | F | B | 0.0000 | |
| 95 | H | B | 0.0000 | |
| 96 | W | B | 0.0000 | |
| 97 | G | B | 0.0000 | |
| 98 | S | B | -0.1511 | |
| 99 | S | B | -0.7920 | |
| 100 | D | B | -1.4344 | |
| 101 | D | B | -2.5547 | |
| 102 | Q | B | -1.9874 | |
| 103 | G | B | 0.0000 | |
| 104 | S | B | 0.0000 | |
| 105 | E | B | 0.0000 | |
| 106 | H | B | 0.0000 | |
| 107 | T | B | 0.0000 | |
| 108 | V | B | -1.9936 | |
| 109 | D | B | -2.9546 | |
| 110 | R | B | -3.3762 | |
| 111 | K | B | -3.3311 | |
| 112 | K | B | -2.8229 | |
| 113 | Y | B | -1.6271 | |
| 114 | A | B | 0.0000 | |
| 115 | A | B | 0.0000 | |
| 116 | E | B | 0.0000 | |
| 117 | L | B | 0.0000 | |
| 118 | H | B | 0.0000 | |
| 119 | L | B | 0.0000 | |
| 120 | V | B | 0.0000 | |
| 121 | H | B | 0.0000 | |
| 122 | W | B | 0.0000 | |
| 123 | N | B | 0.0000 | |
| 124 | T | B | -1.6770 | |
| 125 | K | B | -2.0567 | |
| 126 | Y | B | -1.3939 | |
| 127 | G | B | -1.3127 | |
| 128 | D | B | -1.4510 | |
| 129 | F | B | -0.4098 | |
| 130 | G | B | -0.7325 | |
| 131 | T | B | -1.0533 | |
| 132 | A | B | 0.0000 | |
| 133 | A | B | 0.0000 | |
| 134 | Q | B | -1.5635 | |
| 135 | Q | B | -1.4654 | |
| 136 | P | B | -1.1624 | |
| 137 | D | B | -1.3630 | |
| 138 | G | B | 0.0000 | |
| 139 | L | B | 0.0000 | |
| 140 | A | B | 0.0000 | |
| 141 | V | B | 0.0000 | |
| 142 | V | B | 0.0000 | |
| 143 | G | B | 0.0000 | |
| 144 | V | B | 0.0000 | |
| 145 | F | B | 0.0000 | |
| 146 | L | B | 0.0000 | |
| 147 | K | B | -1.5293 | |
| 148 | V | B | -0.8408 | |
| 149 | G | B | -1.3936 | |
| 150 | D | B | -2.2139 | |
| 151 | A | B | -1.4014 | |
| 152 | N | B | -0.9919 | |
| 153 | P | B | -1.1556 | |
| 154 | A | B | -1.0626 | |
| 155 | L | B | 0.0000 | |
| 156 | Q | B | -2.3763 | |
| 157 | K | B | -2.5525 | |
| 158 | V | B | 0.0000 | |
| 159 | L | B | 0.0000 | |
| 160 | D | B | -3.0507 | |
| 161 | A | B | -2.2935 | |
| 162 | L | B | 0.0000 | |
| 163 | D | B | -2.5407 | |
| 164 | S | B | -1.8343 | |
| 165 | I | B | 0.0000 | |
| 166 | K | B | -1.6809 | |
| 167 | T | B | -2.0228 | |
| 168 | K | B | -1.6584 | |
| 169 | G | B | -1.6020 | |
| 170 | K | B | -1.8728 | |
| 171 | S | B | -1.3968 | |
| 172 | T | B | -1.7502 | |
| 173 | D | B | -2.6488 | |
| 174 | F | B | 0.0000 | |
| 175 | P | B | -2.2975 | |
| 176 | N | B | -2.6342 | |
| 177 | F | B | 0.0000 | |
| 178 | D | B | -2.5485 | |
| 179 | P | B | 0.0000 | |
| 180 | G | B | -0.5979 | |
| 181 | S | B | -0.8461 | |
| 182 | L | B | 0.0000 | |
| 183 | L | B | -0.2160 | |
| 184 | P | B | 0.0000 | |
| 185 | N | B | -0.9254 | |
| 186 | V | B | 0.0176 | |
| 187 | L | B | 0.1669 | |
| 188 | D | B | -0.5476 | |
| 189 | Y | B | 0.0000 | |
| 190 | W | B | 0.0000 | |
| 191 | T | B | 0.0000 | |
| 192 | Y | B | 0.0000 | |
| 193 | P | B | -0.7649 | |
| 194 | G | B | 0.0000 | |
| 195 | S | B | 0.0000 | |
| 196 | L | B | 0.1492 | |
| 197 | T | B | 0.0000 | |
| 198 | T | B | 0.0783 | |
| 199 | P | B | -0.2438 | |
| 200 | P | B | -0.1708 | |
| 201 | L | B | 0.0000 | |
| 202 | L | B | -0.1141 | |
| 203 | E | B | -0.8349 | |
| 204 | S | B | 0.0000 | |
| 205 | V | B | 0.0000 | |
| 206 | T | B | -0.2528 | |
| 207 | W | B | 0.0000 | |
| 208 | I | B | 0.0000 | |
| 209 | V | B | 0.0000 | |
| 210 | L | B | 0.0000 | |
| 211 | K | B | -0.4658 | |
| 212 | E | B | -0.8700 | |
| 213 | P | B | -0.5678 | |
| 214 | I | B | 0.0000 | |
| 215 | S | B | -0.9927 | |
| 216 | V | B | 0.0000 | |
| 217 | S | B | 0.0000 | |
| 218 | S | B | -0.8837 | |
| 219 | Q | B | -1.1696 | |
| 220 | Q | B | -0.8481 | |
| 221 | M | B | 0.0000 | |
| 222 | L | B | 0.5799 | |
| 223 | K | B | -0.9242 | |
| 224 | F | B | 0.0000 | |
| 225 | R | B | 0.3631 | |
| 226 | T | B | 0.0285 | |
| 227 | L | B | 0.0000 | |
| 228 | N | B | 0.0000 | |
| 229 | F | B | -0.3969 | |
| 230 | N | B | -1.6098 | |
| 231 | A | B | -2.3983 | |
| 232 | E | B | -3.3705 | |
| 233 | G | B | -2.6015 | |
| 234 | E | B | -3.1220 | |
| 235 | P | B | -2.1306 | |
| 236 | E | B | -2.1442 | |
| 237 | L | B | 0.1805 | |
| 238 | L | B | 0.7822 | |
| 239 | M | B | 0.0000 | |
| 240 | L | B | 1.0192 | |
| 241 | A | B | 0.2590 | |
| 242 | N | B | 0.0000 | |
| 243 | W | B | 0.1523 | |
| 244 | R | B | 0.0000 | |
| 245 | P | B | -0.4984 | |
| 246 | A | B | -0.4649 | |
| 247 | Q | B | -0.9766 | |
| 248 | P | B | -1.5339 | |
| 249 | L | B | -1.6328 | |
| 250 | K | B | -2.9007 | |
| 251 | N | B | -2.6925 | |
| 252 | R | B | -2.2118 | |
| 253 | Q | B | -1.7587 | |
| 254 | V | B | 0.0000 | |
| 255 | R | B | -1.3571 | |
| 256 | G | B | 0.0000 | |
| 257 | F | B | -1.2595 | |
| 258 | P | B | -1.4622 | |
| 259 | K | B | -2.1619 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine