Project name: cftr 3d

Chain sequence(s)	A: EVVMENVTAFWETPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSEGQQAKISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMSFDQFSAERRNSILTETLRRFSLEGDA
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -4.1899
• Maximal score value: 1.4245
• Average score: -0.8956
• Total score value: -220.3148

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
391	E	A	-4.0875
392	V	A	0.0000
393	V	A	0.0000
394	M	A	0.0000
395	E	A	-3.2545
396	N	A	-3.5461
397	V	A	0.0000
398	T	A	0.0000
399	A	A	0.0000
400	F	A	1.2197
401	W	A	0.2117
402	E	A	-1.2964
438	T	A	0.0648
439	P	A	0.4638
440	V	A	0.3869
441	L	A	0.0000
442	K	A	-2.4803
443	D	A	-3.2082
444	I	A	0.0000
445	N	A	-2.4696
446	F	A	0.0000
447	K	A	-2.7931
448	I	A	0.0000
449	E	A	-4.0121
450	R	A	-4.1899
451	G	A	-2.9224
452	Q	A	-2.4283
453	L	A	0.0000
454	L	A	0.0000
455	A	A	0.0000
456	V	A	0.0000
457	A	A	0.0000
458	G	A	0.0000
459	S	A	0.0000
460	T	A	-0.8638
461	G	A	-0.8934
462	A	A	0.0000
463	G	A	0.0000
464	K	A	-0.4704
465	T	A	-0.3480
466	S	A	0.0565
467	L	A	0.0000
468	L	A	0.0000
469	M	A	-0.6492
470	M	A	0.0000
471	I	A	0.0000
472	M	A	-0.6968
473	G	A	-1.5773
474	E	A	-2.2561
475	L	A	0.0000
476	E	A	-2.5314
477	P	A	-2.0442
478	S	A	-1.4697
479	E	A	-3.1989
480	G	A	-3.4223
481	K	A	-3.4159
482	I	A	-2.3696
483	K	A	-2.7110
484	H	A	-1.9069
485	S	A	-1.6263
486	G	A	-2.1203
487	R	A	-2.8687
488	I	A	-1.4173
489	S	A	0.0000
490	F	A	0.1953
491	C	A	0.0000
492	S	A	0.2509
493	Q	A	-0.2255
494	F	A	1.2860
495	S	A	0.0000
496	W	A	1.4245
497	I	A	0.9605
498	M	A	0.6369
499	P	A	-0.3209
500	G	A	-0.2217
501	T	A	-0.4879
502	I	A	0.0000
503	K	A	-0.8873
504	E	A	-0.7052
505	N	A	0.0000
506	I	A	0.0000
507	I	A	-0.3797
509	G	A	0.1089
510	V	A	1.4000
511	S	A	0.3685
512	Y	A	0.1891
513	D	A	-1.4250
514	E	A	-2.0188
515	Y	A	-0.5245
516	R	A	-1.4829
517	Y	A	0.0000
518	R	A	-2.5489
519	S	A	-1.3637
520	V	A	0.0000
521	I	A	0.0000
522	K	A	-2.8126
523	A	A	0.0000
524	C	A	0.0000
525	Q	A	-1.9010
526	L	A	0.0000
527	E	A	-3.5012
528	E	A	-3.4341
529	D	A	-2.3896
530	I	A	0.0000
531	S	A	-2.6593
532	K	A	-2.8939
533	F	A	-1.9192
534	A	A	-1.6727
535	E	A	-2.6598
536	K	A	-3.0349
537	D	A	-2.1307
538	N	A	-1.8565
539	I	A	0.0000
540	V	A	0.7669
541	L	A	0.0000
542	G	A	-0.7626
543	E	A	-1.9288
544	G	A	-0.9554
545	G	A	0.0928
546	I	A	1.4127
547	T	A	0.2169
548	L	A	-0.1690
549	S	A	-0.7735
550	E	A	-1.4184
551	G	A	-1.0241
552	Q	A	-0.8301
553	Q	A	-0.3083
554	A	A	0.0000
555	K	A	0.0000
556	I	A	0.0000
557	S	A	0.0000
558	L	A	0.0000
559	A	A	0.0000
560	R	A	-0.7347
561	A	A	0.0000
562	V	A	0.0000
563	Y	A	0.0000
564	K	A	-2.2462
565	D	A	-2.8950
566	A	A	0.0000
567	D	A	-3.6280
568	L	A	0.0000
569	Y	A	0.0000
570	L	A	0.0000
571	L	A	0.0000
572	D	A	0.0000
573	S	A	-0.3711
574	P	A	0.0000
575	F	A	0.0000
576	G	A	-0.3203
577	Y	A	0.2631
578	L	A	-0.1605
579	D	A	-0.4311
580	V	A	0.9391
581	L	A	0.8866
582	T	A	-0.2268
583	E	A	-0.5858
584	K	A	-1.5133
585	E	A	-1.5711
586	I	A	0.0000
587	F	A	0.0000
588	E	A	-2.0823
589	S	A	-1.6835
590	C	A	0.0000
591	V	A	0.0000
592	C	A	-1.3818
593	K	A	-1.7483
594	L	A	-0.7474
595	M	A	0.0000
596	A	A	-1.4199
597	N	A	-2.1956
598	K	A	-2.1794
599	T	A	0.0000
600	R	A	0.0000
601	I	A	0.0000
602	L	A	0.0000
603	V	A	0.0000
604	T	A	0.0000
605	S	A	-0.7547
606	K	A	0.0000
607	M	A	0.0000
608	E	A	-2.4879
609	H	A	0.0000
610	L	A	0.0000
611	K	A	-3.0871
612	K	A	-2.8886
613	A	A	-1.9925
614	D	A	-2.0874
615	K	A	-1.7798
616	I	A	0.0000
617	L	A	0.0000
618	I	A	0.0000
619	L	A	0.0000
620	H	A	0.0000
621	E	A	-2.2524
622	G	A	0.0000
623	S	A	-1.2658
624	S	A	-0.5323
625	Y	A	0.6161
626	F	A	0.0000
627	Y	A	0.0618
628	G	A	-0.4150
629	T	A	-1.4196
630	F	A	0.0000
631	S	A	-1.3140
632	E	A	-1.2817
633	L	A	0.0000
634	Q	A	-1.4912
635	N	A	-1.4824
636	L	A	0.1135
637	Q	A	-0.8270
638	P	A	-1.7371
639	D	A	-2.4364
640	F	A	0.0000
641	S	A	0.0000
642	S	A	-1.5424
643	K	A	-1.8022
644	L	A	0.0000
645	M	A	0.0132
649	S	A	-0.4325
650	F	A	0.0000
651	D	A	-0.9823
652	Q	A	-1.1350
653	F	A	-1.1169
654	S	A	-1.4083
655	A	A	-1.6450
656	E	A	-2.7888
657	R	A	-2.8479
658	R	A	-1.9905
659	N	A	-1.7973
660	S	A	-1.8282
661	I	A	-1.6077
662	L	A	0.0000
663	T	A	-1.9622
664	E	A	-3.0191
665	T	A	0.0000
666	L	A	0.0000
667	R	A	-3.8421
668	R	A	-3.4129
669	F	A	-1.1469
670	S	A	-0.8651
671	L	A	0.1429
672	E	A	-2.2295
673	G	A	-2.2002
674	D	A	-3.1233
675	A	A	-1.5095