Project name: 4x7s:H

Chain sequence(s)	H: EVQLVESGGGLVQPGGSLRLSCAVSGYSITSGYSWNWIRQAPGKGLEWVASITYDGSTNYNPSVKGRITISRDDSKNTFYLQMNSLRAEDTAVYYCARGSHYFGHWHFAVWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -2.8275
• Maximal score value: 2.4484
• Average score: -0.5479
• Total score value: -121.6316

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	E	H	-2.1634
2	V	H	-1.3600
3	Q	H	-1.3029
4	L	H	0.0000
5	V	H	1.0900
6	E	H	0.0000
7	S	H	-0.5002
8	G	H	-1.1664
9	G	H	-0.8668
10	G	H	-0.3562
11	L	H	-0.0361
12	V	H	-0.6083
13	Q	H	-1.5581
14	P	H	-1.5324
15	G	H	-1.5003
16	G	H	-1.2146
17	S	H	-1.5960
18	L	H	0.0000
19	R	H	-2.4098
20	L	H	0.0000
21	S	H	-0.4768
22	C	H	0.0000
23	A	H	-0.0632
24	V	H	0.0000
25	S	H	-0.7932
26	G	H	-1.3097
27	Y	H	-0.5718
28	S	H	-0.6195
29	I	H	0.0000
30	T	H	-0.4982
31	S	H	0.1081
32	G	H	0.0000
33	Y	H	0.2437
34	S	H	0.0000
35	W	H	0.0000
36	N	H	0.0000
37	W	H	0.0000
38	I	H	0.0000
39	R	H	0.0000
40	Q	H	-0.4007
41	A	H	-1.0607
42	P	H	-1.0703
43	G	H	-1.4247
44	K	H	-2.0589
45	G	H	-0.9151
46	L	H	0.6207
47	E	H	-0.0373
48	W	H	0.3380
49	V	H	0.0000
50	A	H	0.0000
51	S	H	0.0000
52	I	H	0.0000
53	T	H	-0.2576
54	Y	H	0.2994
55	D	H	-1.3066
56	G	H	-1.0085
57	S	H	-0.8856
58	T	H	-0.8740
59	N	H	-1.5623
60	Y	H	-1.2039
61	N	H	-1.1574
62	P	H	-1.3257
63	S	H	-0.9368
64	V	H	0.0000
65	K	H	-2.3710
66	G	H	-1.6247
67	R	H	-1.4523
68	I	H	0.0000
69	T	H	-1.1038
70	I	H	0.0000
71	S	H	-0.6720
72	R	H	-1.2154
73	D	H	-1.9375
74	D	H	-2.4993
75	S	H	-2.0006
76	K	H	-2.5722
77	N	H	-1.9338
78	T	H	0.0000
79	F	H	0.0000
80	Y	H	-0.7082
81	L	H	0.0000
82	Q	H	-1.5975
83	M	H	0.0000
84	N	H	-1.7986
85	S	H	-1.3922
86	L	H	0.0000
87	R	H	-2.6716
88	A	H	-1.8474
89	E	H	-2.3449
90	D	H	0.0000
91	T	H	-0.7803
92	A	H	0.0000
93	V	H	0.3514
94	Y	H	0.0000
95	Y	H	0.3922
96	C	H	0.0000
97	A	H	0.0000
98	R	H	-0.0819
99	G	H	0.0000
100	S	H	0.2901
101	H	H	0.2171
102	Y	H	1.7039
103	F	H	2.0866
104	G	H	0.6063
105	H	H	0.3843
106	W	H	0.2836
107	H	H	-0.2985
108	F	H	0.1497
109	A	H	0.2618
110	V	H	0.1309
111	W	H	0.3756
112	G	H	-0.0548
113	Q	H	-0.7848
114	G	H	-0.1690
115	T	H	-0.0585
116	L	H	0.1086
117	V	H	0.0000
118	T	H	-0.4232
119	V	H	0.0000
120	S	H	-0.7451
121	S	H	-0.6300
122	A	H	-0.4795
123	S	H	-0.6580
124	T	H	-1.1228
125	K	H	-1.6673
126	G	H	-1.7737
127	P	H	0.0000
128	S	H	-0.2229
129	V	H	0.0000
130	F	H	0.9496
131	P	H	-0.0055
132	L	H	0.3618
133	A	H	-0.9082
134	P	H	0.0000
135	S	H	-1.3513
136	S	H	-1.7885
137	K	H	-2.2148
138	S	H	-1.4077
139	T	H	-0.9009
140	S	H	-0.8234
141	G	H	-1.1526
142	G	H	-0.7692
143	T	H	-0.5375
144	A	H	0.0000
145	A	H	0.0803
146	L	H	0.0000
147	G	H	0.0000
148	C	H	0.0000
149	L	H	0.6930
150	V	H	0.0000
151	K	H	-0.3337
152	D	H	-0.8397
153	Y	H	0.0000
154	F	H	0.0000
155	P	H	0.0000
156	E	H	-0.3759
157	P	H	-0.6368
158	V	H	-0.6413
159	T	H	-0.5532
160	V	H	-0.3786
161	S	H	-0.4820
162	W	H	0.0000
163	N	H	-0.7902
164	S	H	-0.6747
165	G	H	-0.5424
166	A	H	-0.2653
167	L	H	-0.0587
168	T	H	-0.3246
169	S	H	-0.3833
170	G	H	-0.4871
171	V	H	-0.0285
172	H	H	-0.4642
173	T	H	0.1654
174	F	H	0.8985
175	P	H	0.6868
176	A	H	1.2406
177	V	H	2.4484
178	L	H	2.0377
179	Q	H	0.6366
180	S	H	0.0667
181	S	H	-0.2590
182	G	H	0.1344
183	L	H	0.1261
184	Y	H	0.6834
185	S	H	0.6794
186	L	H	0.0000
187	S	H	0.6426
188	S	H	0.0000
189	V	H	0.4228
190	V	H	0.0000
191	T	H	-0.2302
192	V	H	0.0000
193	P	H	-0.5809
194	S	H	-0.8584
195	S	H	-0.6595
196	S	H	-0.5509
197	L	H	-1.0420
198	G	H	-0.9674
199	T	H	-0.6529
200	Q	H	-1.0984
201	T	H	-1.0700
202	Y	H	0.0000
203	I	H	-1.3648
204	C	H	0.0000
205	N	H	-1.4959
206	V	H	0.0000
207	N	H	-1.9708
208	H	H	0.0000
209	K	H	-2.7871
210	P	H	-1.6736
211	S	H	-1.9618
212	N	H	-2.6610
213	T	H	-2.1635
214	K	H	-2.7044
215	V	H	-1.5955
216	D	H	-2.5154
217	K	H	-2.0443
218	K	H	-2.4745
219	V	H	0.0000
220	E	H	-2.8275
221	P	H	-2.1731
222	K	H	-2.4418