Project name: 9727cfd033ca6b6

Chain sequence(s)	A: DHHEGQPRSVCALEENAKRALISCVQTHLTADTTQKLSAVKDQLHCDDVYCVFVRICDRNNGTLEHPSNEFFSNAEKTDIRSAVVTCRENLQRQAEAAKTSGGGGSDHHEGTEEHHHGGHEHHHGHGHGHHASVCSFPPDALVTVVECVERNVTDQVRGKLAEVSQRLQCDTILCGIQKFCQMHGTLEGNRTDVFTREENIQLRNAFIGCKPQTLATTGDAAKGGGGSEFTNYMRKVQHQARMRHNHYRRLHGVPDLKESEELNRYAQAWAERLAKTGQFRHRSRSPYGENIYMSYNSDPNFKLKGRAPVDSWYSEIKYHNYNSNGFNPKTGHFTQVIWKGSRWLGTGVAKSRDGKIFVVSNYKPRGNMMGRFRENVPRPNSGGGGSSEIKYHNYNSNGFNPKGPGPGILFGDAFIPAIVQPVSQIFPGPGPGILFNSLQYTNVVKDYWGNDLGPGPGKETVLRVAVTAQHPKPASLMGPGPGYDAGIELAHLLAFNKYGPGPGHDKKQFAALMLYEEDGTLRVEGVGPGPGKRHGKRLRVTKVIPHAKYNEKSEAAAKFYPSYHSTPQRPGTP
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -3.4666
• Maximal score value: 1.5613
• Average score: -0.8431
• Total score value: -483.9314

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
1	D	A	-2.5921
2	H	A	-2.3785
3	H	A	-2.4645
4	E	A	-2.7954
5	G	A	-1.6848
6	Q	A	-1.2635
7	P	A	-0.8402
8	R	A	0.0000
9	S	A	0.0000
10	V	A	0.0000
11	C	A	0.0000
12	A	A	0.0000
13	L	A	0.0000
14	E	A	0.0000
15	E	A	0.0000
16	N	A	0.0000
17	A	A	0.0000
18	K	A	0.0000
19	R	A	0.0000
20	A	A	0.0000
21	L	A	0.0000
22	I	A	0.0000
23	S	A	0.0000
24	C	A	0.0000
25	V	A	0.0000
26	Q	A	0.0000
27	T	A	-0.3841
28	H	A	-0.9181
29	L	A	0.0000
30	T	A	-1.0328
31	A	A	-1.1909
32	D	A	-2.2660
33	T	A	0.0000
34	T	A	-1.2863
35	Q	A	-1.9898
36	K	A	-2.1194
37	L	A	0.0000
38	S	A	0.0000
39	A	A	-2.2122
40	V	A	0.0000
41	K	A	-2.7579
42	D	A	-3.0293
43	Q	A	-2.4242
44	L	A	0.0000
45	H	A	-2.4226
46	C	A	0.0000
47	D	A	-2.1836
48	D	A	-1.8244
49	V	A	0.0000
50	Y	A	0.0000
51	C	A	0.0000
52	V	A	0.0000
53	F	A	0.0000
54	V	A	0.0000
55	R	A	0.0000
56	I	A	0.0000
57	C	A	0.0000
58	D	A	-1.8330
59	R	A	-2.8721
60	N	A	-2.6721
61	N	A	-2.2573
62	G	A	-1.1628
63	T	A	-0.7154
64	L	A	0.1666
65	E	A	-0.9020
66	H	A	-1.0192
67	P	A	-1.2107
68	S	A	-1.1526
69	N	A	0.0000
70	E	A	-2.2345
71	F	A	-1.1372
72	F	A	0.0000
73	S	A	-1.5404
74	N	A	-1.7377
75	A	A	-1.1479
76	E	A	0.0000
77	K	A	0.0000
78	T	A	-0.9244
79	D	A	0.0000
80	I	A	0.0000
81	R	A	-1.8433
82	S	A	-0.9860
83	A	A	0.0000
84	V	A	0.0000
85	V	A	-1.0242
86	T	A	-0.6704
87	C	A	0.0000
88	R	A	-1.3883
89	E	A	-1.5728
90	N	A	-1.6370
91	L	A	0.0000
92	Q	A	-1.9950
93	R	A	-2.8512
94	Q	A	0.0000
95	A	A	-1.6375
96	E	A	-2.6147
97	A	A	0.0000
98	A	A	0.0000
99	K	A	-2.9324
100	T	A	-1.8965
101	S	A	-1.9601
102	G	A	-1.3946
103	G	A	-1.6468
104	G	A	-1.5326
105	G	A	0.0000
106	S	A	-1.2329
107	D	A	0.0000
108	H	A	0.0000
109	H	A	0.0000
110	E	A	-2.1419
111	G	A	-1.5826
112	T	A	0.0000
113	E	A	-2.8381
114	E	A	-2.7406
115	H	A	-2.2934
116	H	A	-2.2510
117	H	A	-2.0278
118	G	A	-1.5717
119	G	A	-1.7842
120	H	A	-2.4710
121	E	A	-3.1290
122	H	A	-2.7921
123	H	A	0.0000
124	H	A	-1.9960
125	G	A	-1.4528
126	H	A	0.0000
127	G	A	0.0000
128	H	A	-2.0702
129	G	A	-1.2852
130	H	A	-1.1021
131	H	A	-0.8408
132	A	A	0.0000
133	S	A	0.0000
134	V	A	0.0000
135	C	A	0.0000
136	S	A	-0.9009
137	F	A	0.0000
138	P	A	-1.0343
139	P	A	0.0000
140	D	A	-0.6856
141	A	A	0.0000
142	L	A	0.0000
143	V	A	0.0000
144	T	A	0.0000
145	V	A	0.0000
146	V	A	0.0000
147	E	A	0.0000
148	C	A	-0.8569
149	V	A	-1.0513
150	E	A	-1.5217
151	R	A	-2.3317
152	N	A	-1.8280
153	V	A	-1.1651
154	T	A	-1.5599
155	D	A	-2.4488
156	Q	A	-1.7073
157	V	A	0.0000
158	R	A	-2.3280
159	G	A	-1.7674
160	K	A	-1.3695
161	L	A	0.0000
162	A	A	-1.7493
163	E	A	-1.8699
164	V	A	0.0000
165	S	A	0.0000
166	Q	A	-2.0181
167	R	A	-2.3252
168	L	A	0.0000
169	Q	A	-0.5587
170	C	A	0.0101
171	D	A	-0.4342
172	T	A	0.0000
173	I	A	0.0000
174	L	A	0.2637
175	C	A	0.2104
176	G	A	0.0000
177	I	A	0.0000
178	Q	A	-0.0959
179	K	A	-0.3791
180	F	A	0.0000
181	C	A	0.0000
182	Q	A	-0.3319
183	M	A	-0.6325
184	H	A	-0.8109
185	G	A	-0.5899
186	T	A	-0.3415
187	L	A	0.1085
188	E	A	-1.4068
189	G	A	-1.3282
190	N	A	-1.5346
191	R	A	0.0000
192	T	A	-0.3839
193	D	A	0.2773
194	V	A	1.5613
195	F	A	0.3691
196	T	A	-0.7699
197	R	A	-1.8221
198	E	A	-2.4945
199	E	A	-1.7250
200	N	A	0.0000
201	I	A	0.0000
202	Q	A	-1.5151
203	L	A	0.0000
204	R	A	0.0000
205	N	A	0.0000
206	A	A	-0.7138
207	F	A	0.0000
208	I	A	0.0000
209	G	A	-0.8585
210	C	A	-0.5565
211	K	A	-1.2019
212	P	A	-1.1142
213	Q	A	-1.4306
214	T	A	-0.8521
215	L	A	-0.4634
216	A	A	-0.8714
217	T	A	-1.1289
218	T	A	-1.6494
219	G	A	-1.8192
220	D	A	-2.3198
221	A	A	-1.7061
222	A	A	-1.8567
223	K	A	-2.5544
224	G	A	-1.7368
225	G	A	-1.1750
226	G	A	-1.4527
227	G	A	0.0000
228	S	A	-1.6150
229	E	A	-1.6845
230	F	A	-0.1775
231	T	A	-0.7476
232	N	A	-1.2432
233	Y	A	-1.1045
234	M	A	-0.9490
235	R	A	-2.1078
236	K	A	-2.3161
237	V	A	0.0000
238	Q	A	-1.2883
239	H	A	-1.4366
240	Q	A	-1.5886
241	A	A	0.0000
242	R	A	0.0000
243	M	A	-0.3653
244	R	A	-1.0727
245	H	A	0.0000
246	N	A	0.0000
247	H	A	-0.9127
248	Y	A	0.0000
249	R	A	0.0000
250	R	A	-1.5498
251	L	A	0.2061
252	H	A	-0.6017
253	G	A	-1.0853
254	V	A	0.0000
255	P	A	-1.1874
256	D	A	0.0000
257	L	A	0.0000
258	K	A	0.0000
259	E	A	-0.9951
260	S	A	0.0000
261	E	A	-2.7593
262	E	A	-2.3235
263	L	A	0.0000
264	N	A	-2.1345
265	R	A	-2.6586
266	Y	A	-1.4166
267	A	A	0.0000
268	Q	A	-1.2800
269	A	A	-1.2555
270	W	A	0.0000
271	A	A	0.0000
272	E	A	-2.4355
273	R	A	-3.1570
274	L	A	0.0000
275	A	A	-3.0385
276	K	A	-3.3868
277	T	A	-2.0925
278	G	A	-2.1508
279	Q	A	-1.9187
280	F	A	-1.3119
281	R	A	-2.5170
282	H	A	-2.3705
283	R	A	-1.9218
284	S	A	-1.8375
285	R	A	-2.3492
286	S	A	-1.4407
287	P	A	-1.0241
288	Y	A	-0.8290
289	G	A	0.0000
290	E	A	-0.7573
291	N	A	0.0000
292	I	A	0.2620
293	Y	A	0.7262
294	M	A	0.8219
295	S	A	0.4502
296	Y	A	0.2766
297	N	A	-1.3356
298	S	A	-1.6940
299	D	A	-2.4004
300	P	A	-2.1870
301	N	A	-2.2686
302	F	A	-1.9487
303	K	A	-2.6951
304	L	A	0.0000
305	K	A	-2.6297
306	G	A	0.0000
307	R	A	-2.0444
308	A	A	-1.3235
309	P	A	0.0000
310	V	A	0.0000
311	D	A	-1.0727
312	S	A	-0.6421
313	W	A	0.0000
314	Y	A	-0.6859
315	S	A	-0.8019
316	E	A	-0.8921
317	I	A	0.0000
318	K	A	-1.4521
319	Y	A	-0.0819
320	H	A	-0.9945
321	N	A	-1.6695
322	Y	A	-0.5098
323	N	A	-1.6338
324	S	A	-1.6908
325	N	A	-2.0517
326	G	A	0.0000
327	F	A	-1.1165
328	N	A	-1.5996
329	P	A	0.0000
330	K	A	0.0000
331	T	A	-0.7275
332	G	A	-0.8025
333	H	A	-0.5944
334	F	A	0.0000
335	T	A	0.0000
336	Q	A	0.0000
337	V	A	0.0000
338	I	A	0.0000
339	W	A	0.0000
340	K	A	-1.3293
341	G	A	0.0000
342	S	A	-1.4162
343	R	A	-1.9736
344	W	A	-1.0399
345	L	A	0.0000
346	G	A	0.0000
347	T	A	0.0000
348	G	A	0.0000
349	V	A	-0.2954
350	A	A	0.0000
351	K	A	-2.7722
352	S	A	-3.0892
353	R	A	-3.4666
354	D	A	-2.8494
355	G	A	-2.3327
356	K	A	-1.5136
357	I	A	0.0000
358	F	A	0.0000
359	V	A	0.0000
360	V	A	0.0000
361	S	A	0.0000
362	N	A	0.0000
363	Y	A	0.0000
364	K	A	-1.2529
365	P	A	-1.0546
366	R	A	-0.8320
367	G	A	-0.6573
368	N	A	-0.3888
369	M	A	0.2297
370	M	A	0.4512
371	G	A	-0.7333
372	R	A	-1.3086
373	F	A	-0.6862
374	R	A	-0.7065
375	E	A	-0.8520
376	N	A	-0.9745
377	V	A	0.2313
378	P	A	-0.9002
379	R	A	-2.0028
380	P	A	-2.0016
381	N	A	-2.1520
382	S	A	-1.8533
383	G	A	-1.9151
384	G	A	-1.4168
385	G	A	-1.7007
386	G	A	-1.4887
387	S	A	-1.3142
388	S	A	-1.4159
389	E	A	-1.3295
390	I	A	-0.9616
391	K	A	-1.3365
392	Y	A	-1.0813
393	H	A	-1.3471
394	N	A	-0.9310
395	Y	A	0.0000
396	N	A	0.0000
397	S	A	-0.5152
398	N	A	-0.5843
399	G	A	-0.6666
400	F	A	-0.9375
401	N	A	-1.1832
402	P	A	-0.8195
403	K	A	-1.3201
404	G	A	-0.8062
405	P	A	-0.6323
406	G	A	0.0000
407	P	A	0.0000
408	G	A	0.0000
409	I	A	0.0000
410	L	A	0.0000
411	F	A	-0.6552
412	G	A	0.0000
413	D	A	-1.9486
414	A	A	0.0000
415	F	A	0.0000
416	I	A	-0.1561
417	P	A	0.0000
418	A	A	0.0000
419	I	A	0.0000
420	V	A	0.0000
421	Q	A	0.0000
422	P	A	0.0000
423	V	A	0.0000
424	S	A	-0.0221
425	Q	A	-0.1280
426	I	A	0.3678
427	F	A	0.0000
428	P	A	-0.1926
429	G	A	-0.4743
430	P	A	-0.8828
431	G	A	0.0000
432	P	A	-0.6367
433	G	A	-0.4940
434	I	A	0.0000
435	L	A	0.0000
436	F	A	0.0000
437	N	A	0.0000
438	S	A	0.0000
439	L	A	0.0000
440	Q	A	0.0000
441	Y	A	0.0000
442	T	A	0.0000
443	N	A	-0.5803
444	V	A	-0.3252
445	V	A	0.0000
446	K	A	-0.9192
447	D	A	-1.0252
448	Y	A	0.5059
449	W	A	-0.9766
450	G	A	-1.6870
451	N	A	-2.0554
452	D	A	-1.6024
453	L	A	0.4879
454	G	A	-0.5498
455	P	A	-1.3368
456	G	A	-1.0666
457	P	A	-1.4247
458	G	A	-2.1278
459	K	A	-3.0651
460	E	A	-2.8116
461	T	A	-1.7156
462	V	A	-0.8685
463	L	A	0.0000
464	R	A	0.0000
465	V	A	0.0000
466	A	A	0.0000
467	V	A	0.0000
468	T	A	0.0000
469	A	A	0.0000
470	Q	A	-1.8216
471	H	A	-1.9713
472	P	A	-1.3114
473	K	A	-0.7578
474	P	A	-0.3038
475	A	A	0.0000
476	S	A	-0.0303
477	L	A	0.7253
478	M	A	0.0000
479	G	A	-0.7938
480	P	A	-0.9040
481	G	A	0.0000
482	P	A	0.0000
483	G	A	0.0000
484	Y	A	0.0000
485	D	A	0.0000
486	A	A	0.0000
487	G	A	0.0000
488	I	A	0.0000
489	E	A	0.0000
490	L	A	0.0000
491	A	A	0.0000
492	H	A	0.0000
493	L	A	0.0000
494	L	A	0.0000
495	A	A	0.0000
496	F	A	0.0000
497	N	A	0.0000
498	K	A	0.0000
499	Y	A	0.0000
500	G	A	-1.4141
501	P	A	-1.5351
502	G	A	-1.7010
503	P	A	-1.5499
504	G	A	-1.5986
505	H	A	-1.9029
506	D	A	-1.9079
507	K	A	-1.8372
508	K	A	-1.5348
509	Q	A	0.0000
510	F	A	0.0000
511	A	A	0.0000
512	A	A	0.0000
513	L	A	0.0000
514	M	A	0.0000
515	L	A	0.0000
516	Y	A	0.0000
517	E	A	0.0000
518	E	A	-1.7675
519	D	A	-2.2285
520	G	A	0.0000
521	T	A	-1.2211
522	L	A	-0.4539
523	R	A	-0.1492
524	V	A	0.2867
525	E	A	-0.2479
526	G	A	0.0069
527	V	A	0.4009
528	G	A	-1.0306
529	P	A	-1.0154
530	G	A	-1.1209
531	P	A	-1.2417
532	G	A	-1.6931
533	K	A	-2.3634
534	R	A	-3.1760
535	H	A	-2.3923
536	G	A	0.0000
537	K	A	-1.7883
538	R	A	-1.2260
539	L	A	0.0000
540	R	A	-0.4168
541	V	A	0.0000
542	T	A	0.0000
543	K	A	-0.8966
544	V	A	0.0000
545	I	A	-0.2715
546	P	A	-0.5334
547	H	A	0.0000
548	A	A	-0.9657
549	K	A	-1.7492
550	Y	A	-1.5609
551	N	A	-2.5693
552	E	A	-3.2703
553	K	A	-3.0642
554	S	A	-2.2679
555	E	A	-2.6581
556	A	A	-1.7227
557	A	A	-1.0481
558	A	A	0.0000
559	K	A	-1.0584
560	F	A	0.9744
561	Y	A	0.3210
562	P	A	-0.3359
563	S	A	0.0000
564	Y	A	-0.1697
565	H	A	-0.7494
566	S	A	-0.6880
567	T	A	-0.6586
568	P	A	-1.1308
569	Q	A	-1.4665
570	R	A	-2.2059
571	P	A	-1.5302
572	G	A	-1.2326
573	T	A	-0.8632
574	P	A	-0.8455