Project name: 974d8221a60f82e
Status: done
submitted: 2019-04-03 01:36:46, status changed: 2019-04-03 01:45:43
Settings
|
Chain sequence(s)
|
A: VIHVTKEVKEVATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGEELNAINTTVSQDPETELYAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTA
|
| Distance of aggregation |
10 Å |
| Dynamic mode |
No
|
Drag cursor over the plot to display residue labels.
-
Minimal score value
-
-3.8422
-
Maximal score value
-
2.1275
-
Average score
-
-1.026
-
Total score value
-
-205.207
The table below lists A3D score for protein residues.
Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index |
residue name |
chain |
Aggrescan3D score |
mutation |
| residue index |
residue name |
chain |
Aggrescan3D score |
|
| 1 |
V |
A |
2.1275 |
|
| 2 |
I |
A |
2.0372 |
|
| 3 |
H |
A |
0.3802 |
|
| 4 |
V |
A |
0.2112 |
|
| 5 |
T |
A |
-1.3605 |
|
| 6 |
K |
A |
-2.3919 |
|
| 7 |
E |
A |
-3.3595 |
|
| 8 |
V |
A |
-2.4098 |
|
| 9 |
K |
A |
-2.4469 |
|
| 10 |
E |
A |
-1.9764 |
|
| 11 |
V |
A |
-0.1146 |
|
| 12 |
A |
A |
0.0000 |
|
| 13 |
T |
A |
0.2397 |
|
| 14 |
L |
A |
0.0000 |
|
| 15 |
S |
A |
-0.9369 |
|
| 16 |
C |
A |
0.0000 |
|
| 17 |
G |
A |
-1.1159 |
|
| 18 |
H |
A |
-1.4586 |
|
| 19 |
N |
A |
-1.8147 |
|
| 20 |
V |
A |
0.0000 |
|
| 21 |
S |
A |
-0.2903 |
|
| 22 |
V |
A |
0.4040 |
|
| 23 |
E |
A |
-1.5427 |
|
| 24 |
E |
A |
-1.5362 |
|
| 25 |
L |
A |
-1.0469 |
|
| 26 |
A |
A |
-1.3782 |
|
| 27 |
Q |
A |
-1.7472 |
|
| 28 |
T |
A |
0.0000 |
|
| 29 |
R |
A |
-1.1593 |
|
| 30 |
I |
A |
0.0000 |
|
| 31 |
Y |
A |
0.2845 |
|
| 32 |
W |
A |
0.0000 |
|
| 33 |
Q |
A |
-1.7173 |
|
| 34 |
K |
A |
-2.4693 |
|
| 35 |
E |
A |
-3.1237 |
|
| 36 |
K |
A |
-3.3293 |
|
| 37 |
K |
A |
-2.8188 |
|
| 38 |
M |
A |
-1.4490 |
|
| 39 |
V |
A |
0.0000 |
|
| 40 |
L |
A |
0.0000 |
|
| 41 |
T |
A |
0.0000 |
|
| 42 |
M |
A |
0.0000 |
|
| 43 |
M |
A |
-0.7955 |
|
| 44 |
S |
A |
-1.1988 |
|
| 45 |
G |
A |
-1.4848 |
|
| 46 |
D |
A |
-2.0153 |
|
| 47 |
M |
A |
-1.0184 |
|
| 48 |
N |
A |
-1.4087 |
|
| 49 |
I |
A |
-0.7820 |
|
| 50 |
W |
A |
-1.1599 |
|
| 51 |
P |
A |
-1.8383 |
|
| 52 |
E |
A |
-2.3899 |
|
| 53 |
Y |
A |
-1.7292 |
|
| 54 |
K |
A |
-2.6715 |
|
| 55 |
N |
A |
-2.2176 |
|
| 56 |
R |
A |
-0.9353 |
|
| 57 |
T |
A |
-0.0678 |
|
| 58 |
I |
A |
1.0570 |
|
| 59 |
F |
A |
0.6649 |
|
| 60 |
D |
A |
-0.2621 |
|
| 61 |
I |
A |
-0.1267 |
|
| 62 |
T |
A |
-0.7687 |
|
| 63 |
N |
A |
-1.9653 |
|
| 64 |
N |
A |
-2.0435 |
|
| 65 |
L |
A |
0.0000 |
|
| 66 |
S |
A |
0.0000 |
|
| 67 |
I |
A |
0.0000 |
|
| 68 |
V |
A |
0.9314 |
|
| 69 |
I |
A |
0.0000 |
|
| 70 |
L |
A |
0.3761 |
|
| 71 |
A |
A |
-1.0683 |
|
| 72 |
L |
A |
0.0000 |
|
| 73 |
R |
A |
-1.6504 |
|
| 74 |
P |
A |
0.0000 |
|
| 75 |
S |
A |
-0.7043 |
|
| 76 |
D |
A |
0.0000 |
|
| 77 |
E |
A |
-1.5740 |
|
| 78 |
G |
A |
-1.1490 |
|
| 79 |
T |
A |
-1.4358 |
|
| 80 |
Y |
A |
0.0000 |
|
| 81 |
E |
A |
-1.7787 |
|
| 82 |
C |
A |
0.0000 |
|
| 83 |
V |
A |
-0.5206 |
|
| 84 |
V |
A |
0.0000 |
|
| 85 |
L |
A |
-2.0294 |
|
| 86 |
K |
A |
-2.6318 |
|
| 87 |
Y |
A |
-2.5625 |
|
| 88 |
E |
A |
-3.8422 |
|
| 89 |
K |
A |
-3.4788 |
|
| 90 |
D |
A |
-3.0780 |
|
| 91 |
A |
A |
-2.2066 |
|
| 92 |
F |
A |
-2.1548 |
|
| 93 |
K |
A |
-3.6028 |
|
| 94 |
R |
A |
-3.2192 |
|
| 95 |
E |
A |
-2.4677 |
|
| 96 |
H |
A |
-1.3370 |
|
| 97 |
L |
A |
-0.4335 |
|
| 98 |
A |
A |
-0.3994 |
|
| 99 |
E |
A |
-1.3725 |
|
| 100 |
V |
A |
0.0000 |
|
| 101 |
T |
A |
-0.4849 |
|
| 102 |
L |
A |
0.0000 |
|
| 103 |
S |
A |
-1.3658 |
|
| 104 |
V |
A |
-2.0853 |
|
| 105 |
K |
A |
-2.4891 |
|
| 106 |
A |
A |
-1.7669 |
|
| 107 |
D |
A |
-1.6843 |
|
| 108 |
F |
A |
0.0000 |
|
| 109 |
P |
A |
-0.6706 |
|
| 110 |
T |
A |
-0.7553 |
|
| 111 |
P |
A |
0.0000 |
|
| 112 |
S |
A |
-0.2758 |
|
| 113 |
I |
A |
-0.0774 |
|
| 114 |
S |
A |
-0.2298 |
|
| 115 |
D |
A |
-0.8032 |
|
| 116 |
F |
A |
-0.2327 |
|
| 117 |
E |
A |
-1.6840 |
|
| 118 |
I |
A |
-0.8115 |
|
| 119 |
P |
A |
-0.7094 |
|
| 120 |
T |
A |
-0.8364 |
|
| 121 |
S |
A |
-1.1208 |
|
| 122 |
N |
A |
-1.7885 |
|
| 123 |
I |
A |
-1.1784 |
|
| 124 |
R |
A |
-1.3415 |
|
| 125 |
R |
A |
-0.8459 |
|
| 126 |
I |
A |
0.0000 |
|
| 127 |
I |
A |
-0.0736 |
|
| 128 |
C |
A |
0.0000 |
|
| 129 |
S |
A |
-0.1325 |
|
| 130 |
T |
A |
0.0000 |
|
| 131 |
S |
A |
-0.3063 |
|
| 132 |
G |
A |
-0.7560 |
|
| 133 |
G |
A |
0.0000 |
|
| 134 |
F |
A |
-0.6624 |
|
| 135 |
P |
A |
-1.0951 |
|
| 136 |
E |
A |
-1.6515 |
|
| 137 |
P |
A |
0.0000 |
|
| 138 |
H |
A |
-1.8575 |
|
| 139 |
L |
A |
-0.7394 |
|
| 140 |
S |
A |
-1.0561 |
|
| 141 |
W |
A |
0.0000 |
|
| 142 |
L |
A |
-1.6183 |
|
| 143 |
E |
A |
-1.9976 |
|
| 144 |
N |
A |
-2.4696 |
|
| 145 |
G |
A |
-2.3427 |
|
| 146 |
E |
A |
-3.4314 |
|
| 147 |
E |
A |
-3.0578 |
|
| 148 |
L |
A |
-1.6528 |
|
| 149 |
N |
A |
-1.6334 |
|
| 150 |
A |
A |
-0.7067 |
|
| 151 |
I |
A |
0.0896 |
|
| 152 |
N |
A |
-1.0527 |
|
| 153 |
T |
A |
-0.3887 |
|
| 154 |
T |
A |
-0.0246 |
|
| 155 |
V |
A |
0.3671 |
|
| 156 |
S |
A |
-0.4686 |
|
| 157 |
Q |
A |
-1.4591 |
|
| 158 |
D |
A |
-2.0386 |
|
| 159 |
P |
A |
-1.8309 |
|
| 160 |
E |
A |
-2.4615 |
|
| 161 |
T |
A |
-1.8925 |
|
| 162 |
E |
A |
-1.6913 |
|
| 163 |
L |
A |
0.0000 |
|
| 164 |
Y |
A |
-0.5971 |
|
| 165 |
A |
A |
-0.2371 |
|
| 166 |
V |
A |
0.0000 |
|
| 167 |
S |
A |
-0.1243 |
|
| 168 |
S |
A |
0.0000 |
|
| 169 |
K |
A |
-0.8032 |
|
| 170 |
L |
A |
0.0000 |
|
| 171 |
D |
A |
-0.9952 |
|
| 172 |
F |
A |
0.0000 |
|
| 173 |
N |
A |
-1.3822 |
|
| 174 |
M |
A |
-1.4440 |
|
| 175 |
T |
A |
-1.0105 |
|
| 176 |
T |
A |
-1.2441 |
|
| 177 |
N |
A |
-2.1574 |
|
| 178 |
H |
A |
-1.7667 |
|
| 179 |
S |
A |
-1.3651 |
|
| 180 |
F |
A |
0.0000 |
|
| 181 |
M |
A |
-0.5178 |
|
| 182 |
C |
A |
0.0000 |
|
| 183 |
L |
A |
-1.0391 |
|
| 184 |
I |
A |
0.0000 |
|
| 185 |
K |
A |
-2.7847 |
|
| 186 |
Y |
A |
0.0000 |
|
| 187 |
G |
A |
-1.6781 |
|
| 188 |
H |
A |
-1.5327 |
|
| 189 |
L |
A |
-1.2061 |
|
| 190 |
R |
A |
-2.5564 |
|
| 191 |
V |
A |
-1.3397 |
|
| 192 |
N |
A |
-1.2051 |
|
| 193 |
Q |
A |
-0.5718 |
|
| 194 |
T |
A |
-0.4280 |
|
| 195 |
F |
A |
-0.7408 |
|
| 196 |
N |
A |
-1.7269 |
|
| 197 |
W |
A |
-1.7557 |
|
| 198 |
N |
A |
-2.0432 |
|
| 199 |
T |
A |
-1.3042 |
|
| 200 |
A |
A |
-0.4630 |
|