| Chain sequence(s) |
A: VQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTF B: SHPSPQAKPSNPSNPRVFFDVDIGGERVGRIVLELFADIVPKTAENFRALCTGEKGIGPTTGKPLHFKGCPFHRIIKKFMIQGGDFSNQNGTGGESIYGEKFEDENFHYKHDKEGLLSMANAGSNTNGSQFFITTVPTPHLDGKHVVFGQVIKGMGVAKILENVEVKGEKPAKLCVIAECGELKEGDDWGIFPKDGSGDSHPDFPEDADVDLKDVDKILLISEDLKNIGNTFFKSQNWEMAIKKYTKVLRYVEGSRAAAEDADGAKLQPVALSCVLNIGACKLKMSDWQGAVDSCLEALEIDPSNTKALYRRAQGWQGLKEYDQALADLKKAQEIAPEDKAIQAELLKVKQKIKAQKDKEKAAY |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 306 | V | A | 1.5397 | |
| 307 | Q | A | 0.7793 | |
| 308 | I | A | 2.3142 | |
| 309 | V | A | 2.4119 | |
| 310 | Y | A | 1.9236 | |
| 311 | K | A | -0.3245 | |
| 312 | P | A | -0.0807 | |
| 313 | V | A | 0.8233 | |
| 314 | D | A | -0.6887 | |
| 315 | L | A | 0.7177 | |
| 316 | S | A | -0.4107 | |
| 317 | K | A | -1.1473 | |
| 318 | V | A | -0.1404 | |
| 319 | T | A | -0.5742 | |
| 320 | S | A | -1.2645 | |
| 321 | K | A | -1.7598 | |
| 322 | C | A | -0.3152 | |
| 323 | G | A | -0.4380 | |
| 324 | S | A | -0.0074 | |
| 325 | L | A | 1.2436 | |
| 326 | G | A | -0.1355 | |
| 327 | N | A | -0.7689 | |
| 328 | I | A | 0.0462 | |
| 329 | H | A | -1.6263 | |
| 330 | H | A | -2.0700 | |
| 331 | K | A | -2.9523 | |
| 332 | P | A | -2.1127 | |
| 333 | G | A | -1.5747 | |
| 334 | G | A | -1.2313 | |
| 335 | G | A | -0.8650 | |
| 336 | Q | A | -1.2539 | |
| 337 | V | A | -0.5391 | |
| 338 | E | A | -1.8977 | |
| 339 | V | A | -0.0832 | |
| 340 | K | A | -2.2550 | |
| 341 | S | A | -1.7684 | |
| 342 | E | A | -2.9568 | |
| 343 | K | A | -2.6071 | |
| 344 | L | A | -0.1205 | |
| 345 | D | A | -0.7965 | |
| 346 | F | A | -0.3238 | |
| 347 | K | A | -2.5559 | |
| 348 | D | A | -3.0893 | |
| 349 | R | A | -2.8068 | |
| 350 | V | A | -1.4792 | |
| 351 | Q | A | -1.6908 | |
| 352 | S | A | -0.7364 | |
| 353 | K | A | -1.1708 | |
| 354 | I | A | 0.9684 | |
| 355 | G | A | -0.1637 | |
| 356 | S | A | -0.7675 | |
| 357 | L | A | -0.5223 | |
| 358 | D | A | -1.5238 | |
| 359 | N | A | -1.4253 | |
| 360 | I | A | 0.7301 | |
| 361 | T | A | 0.3210 | |
| 362 | H | A | -0.1479 | |
| 363 | V | A | 0.9520 | |
| 364 | P | A | -0.3518 | |
| 365 | G | A | -0.7579 | |
| 366 | G | A | -1.5831 | |
| 367 | G | A | -2.0288 | |
| 368 | N | A | -2.4117 | |
| 369 | K | A | -2.7525 | |
| 370 | K | A | -2.2502 | |
| 371 | I | A | -0.3002 | |
| 372 | E | A | -1.8139 | |
| 373 | T | A | -1.4519 | |
| 374 | H | A | -2.1369 | |
| 375 | K | A | -1.9789 | |
| 376 | L | A | 0.3363 | |
| 377 | T | A | 0.9309 | |
| 378 | F | A | 2.0853 | |
| 2 | S | B | -1.0137 | |
| 3 | H | B | -1.3263 | |
| 4 | P | B | -1.2370 | |
| 5 | S | B | 0.0000 | |
| 6 | P | B | -1.2511 | |
| 7 | Q | B | -1.6235 | |
| 8 | A | B | -1.3403 | |
| 9 | K | B | -1.9034 | |
| 10 | P | B | -1.4430 | |
| 11 | S | B | -1.2879 | |
| 12 | N | B | -1.1726 | |
| 13 | P | B | -1.0304 | |
| 14 | S | B | -1.0056 | |
| 15 | N | B | 0.0000 | |
| 16 | P | B | -1.2609 | |
| 17 | R | B | -0.9234 | |
| 18 | V | B | 0.0000 | |
| 19 | F | B | -0.0396 | |
| 20 | F | B | 0.0000 | |
| 21 | D | B | 0.0000 | |
| 22 | V | B | 0.0000 | |
| 23 | D | B | 0.0000 | |
| 24 | I | B | -0.8941 | |
| 25 | G | B | -0.9201 | |
| 26 | G | B | -1.6206 | |
| 27 | E | B | -2.9271 | |
| 28 | R | B | -3.2214 | |
| 29 | V | B | -1.2398 | |
| 30 | G | B | -0.8711 | |
| 31 | R | B | -0.5520 | |
| 32 | I | B | 0.0000 | |
| 33 | V | B | 0.0000 | |
| 34 | L | B | 0.0000 | |
| 35 | E | B | 0.0000 | |
| 36 | L | B | 0.0000 | |
| 37 | F | B | 0.0000 | |
| 38 | A | B | -1.2016 | |
| 39 | D | B | -1.5834 | |
| 40 | I | B | -0.5699 | |
| 41 | V | B | 0.0000 | |
| 42 | P | B | -1.3263 | |
| 43 | K | B | -1.7303 | |
| 44 | T | B | 0.0000 | |
| 45 | A | B | 0.0000 | |
| 46 | E | B | -1.4245 | |
| 47 | N | B | 0.0000 | |
| 48 | F | B | 0.0000 | |
| 49 | R | B | -1.0706 | |
| 50 | A | B | 0.0000 | |
| 51 | L | B | 0.0000 | |
| 52 | C | B | 0.0000 | |
| 53 | T | B | -1.3683 | |
| 54 | G | B | -1.5801 | |
| 55 | E | B | -2.5652 | |
| 56 | K | B | -2.2535 | |
| 57 | G | B | -0.9417 | |
| 58 | I | B | 0.7047 | |
| 59 | G | B | 0.0000 | |
| 60 | P | B | -0.3628 | |
| 61 | T | B | -0.6694 | |
| 62 | T | B | -0.6295 | |
| 63 | G | B | -0.3831 | |
| 64 | K | B | -0.8373 | |
| 65 | P | B | -0.7380 | |
| 66 | L | B | 0.0000 | |
| 67 | H | B | -1.1371 | |
| 68 | F | B | 0.0000 | |
| 69 | K | B | -1.6941 | |
| 70 | G | B | 0.0000 | |
| 71 | C | B | 0.0000 | |
| 72 | P | B | 0.0000 | |
| 73 | F | B | 0.0000 | |
| 74 | H | B | 0.0000 | |
| 75 | R | B | -1.7429 | |
| 76 | I | B | 0.0000 | |
| 77 | I | B | -1.3872 | |
| 78 | K | B | -2.7891 | |
| 79 | K | B | -2.6687 | |
| 80 | F | B | -0.9831 | |
| 81 | M | B | 0.0000 | |
| 82 | I | B | 0.0000 | |
| 83 | Q | B | 0.0000 | |
| 84 | G | B | 0.0000 | |
| 85 | G | B | 0.0000 | |
| 86 | D | B | 0.0000 | |
| 87 | F | B | 0.0000 | |
| 88 | S | B | 0.0000 | |
| 89 | N | B | -1.8454 | |
| 90 | Q | B | -1.5279 | |
| 91 | N | B | -2.0537 | |
| 92 | G | B | -1.1349 | |
| 93 | T | B | -0.7070 | |
| 94 | G | B | -1.0358 | |
| 95 | G | B | -1.1749 | |
| 96 | E | B | 0.0000 | |
| 97 | S | B | 0.0000 | |
| 98 | I | B | -0.6368 | |
| 99 | Y | B | -0.3176 | |
| 100 | G | B | -1.2180 | |
| 101 | E | B | -2.6160 | |
| 102 | K | B | -3.0534 | |
| 103 | F | B | 0.0000 | |
| 104 | E | B | -2.8650 | |
| 105 | D | B | -2.2854 | |
| 106 | E | B | -1.5502 | |
| 107 | N | B | -0.9737 | |
| 108 | F | B | -0.6200 | |
| 109 | H | B | -0.7506 | |
| 110 | Y | B | -0.8185 | |
| 111 | K | B | -1.4541 | |
| 112 | H | B | 0.0000 | |
| 113 | D | B | -1.4704 | |
| 114 | K | B | -1.3600 | |
| 115 | E | B | -1.2845 | |
| 116 | G | B | 0.0000 | |
| 117 | L | B | 0.0000 | |
| 118 | L | B | 0.0000 | |
| 119 | S | B | 0.0000 | |
| 120 | M | B | 0.0000 | |
| 121 | A | B | -0.3797 | |
| 122 | N | B | -0.9244 | |
| 123 | A | B | -0.4506 | |
| 124 | G | B | -0.7671 | |
| 125 | S | B | -1.3542 | |
| 126 | N | B | -2.2911 | |
| 127 | T | B | -1.8626 | |
| 128 | N | B | 0.0000 | |
| 129 | G | B | -1.4486 | |
| 130 | S | B | 0.0000 | |
| 131 | Q | B | -0.2899 | |
| 132 | F | B | 0.0000 | |
| 133 | F | B | 0.0000 | |
| 134 | I | B | 0.0000 | |
| 135 | T | B | 0.0000 | |
| 136 | T | B | -1.2363 | |
| 137 | V | B | -0.9719 | |
| 138 | P | B | -1.1250 | |
| 139 | T | B | 0.0000 | |
| 140 | P | B | -1.3962 | |
| 141 | H | B | -1.6659 | |
| 142 | L | B | 0.0000 | |
| 143 | D | B | -1.7043 | |
| 144 | G | B | -1.6534 | |
| 145 | K | B | -2.1513 | |
| 146 | H | B | 0.0000 | |
| 147 | V | B | 0.0000 | |
| 148 | V | B | 0.0000 | |
| 149 | F | B | 0.0000 | |
| 150 | G | B | 0.0000 | |
| 151 | Q | B | 0.0000 | |
| 152 | V | B | 0.0000 | |
| 153 | I | B | 0.0000 | |
| 154 | K | B | -0.6559 | |
| 155 | G | B | 0.0000 | |
| 156 | M | B | -0.5340 | |
| 157 | G | B | -0.5679 | |
| 158 | V | B | 0.0000 | |
| 159 | A | B | 0.0000 | |
| 160 | K | B | -1.6112 | |
| 161 | I | B | -0.2952 | |
| 162 | L | B | 0.0000 | |
| 163 | E | B | -1.8953 | |
| 164 | N | B | -2.1625 | |
| 165 | V | B | -1.5606 | |
| 166 | E | B | -2.3073 | |
| 167 | V | B | -2.0000 | |
| 168 | K | B | -2.6747 | |
| 169 | G | B | -2.0767 | |
| 170 | E | B | -2.5693 | |
| 171 | K | B | -2.8920 | |
| 172 | P | B | 0.0000 | |
| 173 | A | B | -1.3612 | |
| 174 | K | B | -1.3176 | |
| 175 | L | B | -0.7622 | |
| 176 | C | B | 0.0000 | |
| 177 | V | B | 0.0000 | |
| 178 | I | B | 0.0000 | |
| 179 | A | B | 0.0000 | |
| 180 | E | B | -1.0614 | |
| 181 | C | B | 0.0000 | |
| 182 | G | B | -0.9026 | |
| 183 | E | B | -1.1902 | |
| 184 | L | B | 0.0000 | |
| 185 | K | B | -3.5563 | |
| 186 | E | B | -3.7016 | |
| 187 | G | B | -2.9349 | |
| 188 | D | B | -3.6962 | |
| 189 | D | B | -2.9098 | |
| 190 | W | B | -1.1201 | |
| 191 | G | B | -0.5825 | |
| 192 | I | B | 0.0263 | |
| 193 | F | B | 0.2073 | |
| 194 | P | B | -1.1770 | |
| 195 | K | B | -2.3295 | |
| 196 | D | B | -1.9598 | |
| 197 | G | B | -1.4464 | |
| 198 | S | B | -0.9442 | |
| 199 | G | B | -0.9054 | |
| 200 | D | B | 0.0000 | |
| 201 | S | B | -0.5557 | |
| 202 | H | B | -0.5034 | |
| 203 | P | B | -0.4660 | |
| 204 | D | B | -0.8179 | |
| 205 | F | B | -0.7768 | |
| 206 | P | B | 0.0000 | |
| 207 | E | B | -2.5546 | |
| 208 | D | B | -1.4539 | |
| 209 | A | B | -1.7404 | |
| 210 | D | B | -2.4499 | |
| 211 | V | B | -2.5559 | |
| 212 | D | B | -3.4356 | |
| 213 | L | B | -3.2854 | |
| 214 | K | B | -4.0317 | |
| 215 | D | B | -3.8270 | |
| 216 | V | B | 0.0000 | |
| 217 | D | B | -2.8896 | |
| 218 | K | B | -2.2520 | |
| 219 | I | B | 0.0000 | |
| 220 | L | B | -1.0758 | |
| 221 | L | B | -0.1614 | |
| 222 | I | B | 0.0000 | |
| 223 | S | B | 0.0000 | |
| 224 | E | B | -2.0168 | |
| 225 | D | B | -2.4757 | |
| 226 | L | B | 0.0000 | |
| 227 | K | B | -1.7839 | |
| 228 | N | B | -2.3454 | |
| 229 | I | B | -1.3713 | |
| 230 | G | B | 0.0000 | |
| 231 | N | B | -1.2592 | |
| 232 | T | B | -0.9924 | |
| 233 | F | B | -1.1078 | |
| 234 | F | B | -1.1000 | |
| 235 | K | B | -1.9155 | |
| 236 | S | B | -1.4476 | |
| 237 | Q | B | -1.9314 | |
| 238 | N | B | 0.0000 | |
| 239 | W | B | -1.4788 | |
| 240 | E | B | -1.8186 | |
| 241 | M | B | -1.3408 | |
| 242 | A | B | 0.0000 | |
| 243 | I | B | -0.9577 | |
| 244 | K | B | -1.7491 | |
| 245 | K | B | 0.0000 | |
| 246 | Y | B | 0.0000 | |
| 247 | T | B | -0.8236 | |
| 248 | K | B | 0.0000 | |
| 249 | V | B | 0.0000 | |
| 250 | L | B | -1.0012 | |
| 251 | R | B | -1.9639 | |
| 252 | Y | B | 0.0000 | |
| 253 | V | B | 0.0000 | |
| 254 | E | B | -2.6776 | |
| 255 | G | B | -2.3635 | |
| 256 | S | B | 0.0000 | |
| 257 | R | B | -3.9356 | |
| 258 | A | B | -2.0394 | |
| 259 | A | B | -2.4243 | |
| 260 | A | B | -3.3303 | |
| 261 | E | B | -3.8073 | |
| 262 | D | B | -3.5905 | |
| 263 | A | B | -2.5821 | |
| 264 | D | B | -4.0639 | |
| 265 | G | B | 0.0000 | |
| 266 | A | B | -2.1959 | |
| 267 | K | B | -2.3846 | |
| 268 | L | B | 0.0000 | |
| 269 | Q | B | -1.1051 | |
| 270 | P | B | -0.6569 | |
| 271 | V | B | 0.0000 | |
| 272 | A | B | 0.0000 | |
| 273 | L | B | -0.4661 | |
| 274 | S | B | -0.1612 | |
| 275 | C | B | 0.0000 | |
| 276 | V | B | 0.0000 | |
| 277 | L | B | -0.4072 | |
| 278 | N | B | -0.2049 | |
| 279 | I | B | 0.0000 | |
| 280 | G | B | 0.0000 | |
| 281 | A | B | -0.4384 | |
| 282 | C | B | 0.0000 | |
| 283 | K | B | -0.9397 | |
| 284 | L | B | -0.6979 | |
| 285 | K | B | -0.9733 | |
| 286 | M | B | -0.4537 | |
| 287 | S | B | -0.5503 | |
| 288 | D | B | -0.7258 | |
| 289 | W | B | -0.8915 | |
| 290 | Q | B | -1.2665 | |
| 291 | G | B | -0.9840 | |
| 292 | A | B | 0.0000 | |
| 293 | V | B | 0.0000 | |
| 294 | D | B | -1.5800 | |
| 295 | S | B | 0.0000 | |
| 296 | C | B | 0.0000 | |
| 297 | L | B | -0.7853 | |
| 298 | E | B | -2.0272 | |
| 299 | A | B | 0.0000 | |
| 300 | L | B | 0.0000 | |
| 301 | E | B | -2.0781 | |
| 302 | I | B | -0.9739 | |
| 303 | D | B | -1.1619 | |
| 304 | P | B | -1.0475 | |
| 305 | S | B | -0.9116 | |
| 306 | N | B | -0.7924 | |
| 307 | T | B | -1.1457 | |
| 308 | K | B | -1.5042 | |
| 309 | A | B | 0.0000 | |
| 310 | L | B | 0.0000 | |
| 311 | Y | B | -0.8208 | |
| 312 | R | B | -0.9199 | |
| 313 | R | B | -0.9009 | |
| 314 | A | B | 0.0000 | |
| 315 | Q | B | -0.7611 | |
| 316 | G | B | 0.0000 | |
| 317 | W | B | -1.1392 | |
| 318 | Q | B | 0.0000 | |
| 319 | G | B | -0.6928 | |
| 320 | L | B | -0.7523 | |
| 321 | K | B | -2.2465 | |
| 322 | E | B | -2.0680 | |
| 323 | Y | B | 0.0000 | |
| 324 | D | B | -2.5135 | |
| 325 | Q | B | -1.9985 | |
| 326 | A | B | 0.0000 | |
| 327 | L | B | -1.2097 | |
| 328 | A | B | -1.2009 | |
| 329 | D | B | 0.0000 | |
| 330 | L | B | 0.0000 | |
| 331 | K | B | -2.1411 | |
| 332 | K | B | -1.9135 | |
| 333 | A | B | 0.0000 | |
| 334 | Q | B | -2.3360 | |
| 335 | E | B | -2.4179 | |
| 336 | I | B | -0.6894 | |
| 337 | A | B | -1.5504 | |
| 338 | P | B | -2.2889 | |
| 339 | E | B | -2.8806 | |
| 340 | D | B | -2.5887 | |
| 341 | K | B | -2.7038 | |
| 342 | A | B | -1.3385 | |
| 343 | I | B | 0.0000 | |
| 344 | Q | B | -1.6732 | |
| 345 | A | B | -0.6405 | |
| 346 | E | B | 0.0000 | |
| 347 | L | B | -0.6920 | |
| 348 | L | B | -0.0833 | |
| 349 | K | B | -1.8421 | |
| 350 | V | B | 0.0000 | |
| 351 | K | B | -2.2429 | |
| 352 | Q | B | -2.8363 | |
| 353 | K | B | -3.2540 | |
| 354 | I | B | -3.5840 | |
| 355 | K | B | -4.1747 | |
| 356 | A | B | -3.6499 | |
| 357 | Q | B | -4.3292 | |
| 358 | K | B | -5.0881 | |
| 359 | D | B | -5.2794 | |
| 360 | K | B | -4.9040 | |
| 361 | E | B | -4.9552 | |
| 362 | K | B | -4.1722 | |
| 363 | A | B | -2.2947 | |
| 364 | A | B | -0.3826 | |
| 365 | Y | B | 1.3566 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine