| Chain sequence(s) |
A: SYSITTPSQFVFLSSAWADPIELINLCTNALGNQFQTQQARTVVQRQFSEVWKPSPQVTVRFPDSDFKVYRYNAVLDPLVTALLGAFDTRNRIIEVENQANPTTAETLDATRRVDDATVAIRSAINNLIVELIRGTGSYNRSSFESSSGLVWTSGPAT B: SYSITTPSQFVFLSSAWADPIELINLCTNALGNQFQTQQARTVVQRQFSEVWKPSPQVTVRFPDSDFKVYRYNAVLDPLVTALLGAFDTRNRIIEVENQANPTTAETLDATRRVDDATVAIRSAINNLIVELIRGTGSYNRSSFESSSGLVWTSGPAT |
| Distance of aggregation | 10 Å |
| Dynamic mode | No |
The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.
| residue index | residue name | chain | Aggrescan3D score | mutation |
|---|---|---|---|---|
| residue index | residue name | chain | Aggrescan3D score | |
| 1 | S | A | 0.3736 | |
| 2 | Y | A | 0.0000 | |
| 3 | S | A | 0.6905 | |
| 4 | I | A | 1.0625 | |
| 5 | T | A | 0.2767 | |
| 6 | T | A | 0.1660 | |
| 7 | P | A | 0.4061 | |
| 8 | S | A | 0.5693 | |
| 9 | Q | A | 0.0000 | |
| 10 | F | A | 2.1770 | |
| 11 | V | A | 1.7335 | |
| 12 | F | A | 1.0876 | |
| 13 | L | A | 0.0000 | |
| 14 | S | A | 0.1349 | |
| 15 | S | A | -1.2104 | |
| 16 | A | A | 0.0000 | |
| 17 | W | A | 0.0000 | |
| 18 | A | A | 0.0000 | |
| 19 | D | A | -1.3033 | |
| 20 | P | A | -0.0909 | |
| 21 | I | A | 0.8466 | |
| 22 | E | A | -1.2611 | |
| 23 | L | A | 0.0000 | |
| 24 | I | A | 0.1598 | |
| 25 | N | A | -1.2207 | |
| 26 | L | A | -0.7529 | |
| 27 | C | A | 0.0000 | |
| 28 | T | A | -1.1343 | |
| 29 | N | A | -1.5474 | |
| 30 | A | A | 0.0000 | |
| 31 | L | A | -0.7888 | |
| 32 | G | A | -1.1483 | |
| 33 | N | A | -1.6498 | |
| 34 | Q | A | -1.8957 | |
| 35 | F | A | 0.0000 | |
| 36 | Q | A | -1.9327 | |
| 37 | T | A | -1.5756 | |
| 38 | Q | A | -1.7587 | |
| 39 | Q | A | -1.5163 | |
| 40 | A | A | -1.0260 | |
| 41 | R | A | 0.0000 | |
| 42 | T | A | -0.9885 | |
| 43 | V | A | 0.0746 | |
| 44 | V | A | 0.0000 | |
| 45 | Q | A | -1.4290 | |
| 46 | R | A | -2.2829 | |
| 47 | Q | A | -1.7481 | |
| 48 | F | A | 0.0000 | |
| 49 | S | A | -2.0721 | |
| 50 | E | A | -2.9574 | |
| 51 | V | A | 0.0000 | |
| 52 | W | A | 0.0000 | |
| 53 | K | A | -2.4951 | |
| 54 | P | A | -1.2787 | |
| 55 | S | A | -0.7106 | |
| 56 | P | A | 0.0000 | |
| 57 | Q | A | 0.2766 | |
| 58 | V | A | 0.7962 | |
| 59 | T | A | 0.4547 | |
| 60 | V | A | 0.9917 | |
| 61 | R | A | -0.2219 | |
| 62 | F | A | 0.0000 | |
| 63 | P | A | -1.3139 | |
| 64 | D | A | -2.3662 | |
| 65 | S | A | -1.6161 | |
| 66 | D | A | -1.5636 | |
| 67 | F | A | -0.0417 | |
| 68 | K | A | -0.3949 | |
| 69 | V | A | 0.0000 | |
| 70 | Y | A | 0.0000 | |
| 71 | R | A | -0.2023 | |
| 72 | Y | A | 0.5280 | |
| 73 | N | A | 0.0277 | |
| 74 | A | A | -0.1819 | |
| 75 | V | A | 0.0000 | |
| 76 | L | A | 0.0000 | |
| 77 | D | A | -0.4072 | |
| 78 | P | A | -0.2998 | |
| 79 | L | A | -0.4709 | |
| 80 | V | A | 0.0000 | |
| 81 | T | A | -0.1818 | |
| 82 | A | A | -0.2447 | |
| 83 | L | A | 0.0000 | |
| 84 | L | A | -0.7294 | |
| 85 | G | A | -0.8860 | |
| 86 | A | A | -0.7770 | |
| 87 | F | A | 0.0000 | |
| 88 | D | A | -2.3579 | |
| 89 | T | A | -2.2625 | |
| 90 | R | A | -2.5448 | |
| 91 | N | A | -2.1921 | |
| 92 | R | A | -1.8273 | |
| 93 | I | A | 0.7532 | |
| 94 | I | A | 1.2204 | |
| 95 | E | A | -0.6069 | |
| 96 | V | A | -0.2132 | |
| 97 | E | A | -2.1644 | |
| 98 | N | A | -2.6868 | |
| 99 | Q | A | -2.2454 | |
| 100 | A | A | -1.5369 | |
| 101 | N | A | -2.1427 | |
| 102 | P | A | -1.1876 | |
| 103 | T | A | -0.9238 | |
| 104 | T | A | -0.5242 | |
| 105 | A | A | -0.7482 | |
| 106 | E | A | -2.4846 | |
| 107 | T | A | -1.3987 | |
| 108 | L | A | -0.2438 | |
| 109 | D | A | -2.2828 | |
| 110 | A | A | -2.1540 | |
| 111 | T | A | -1.9635 | |
| 112 | R | A | -2.9229 | |
| 113 | R | A | -2.9784 | |
| 114 | V | A | 0.0000 | |
| 115 | D | A | -2.4845 | |
| 116 | D | A | -2.3954 | |
| 117 | A | A | 0.0000 | |
| 118 | T | A | -0.8409 | |
| 119 | V | A | 0.6131 | |
| 120 | A | A | -0.0267 | |
| 121 | I | A | 0.0000 | |
| 122 | R | A | -0.4283 | |
| 123 | S | A | -0.5232 | |
| 124 | A | A | 0.0000 | |
| 125 | I | A | 0.0000 | |
| 126 | N | A | -1.3523 | |
| 127 | N | A | -1.3220 | |
| 128 | L | A | 0.0000 | |
| 129 | I | A | 0.2744 | |
| 130 | V | A | 0.2509 | |
| 131 | E | A | -0.0965 | |
| 132 | L | A | 0.6734 | |
| 133 | I | A | 1.3771 | |
| 134 | R | A | -0.8405 | |
| 135 | G | A | -0.3916 | |
| 136 | T | A | -0.3329 | |
| 137 | G | A | 0.0000 | |
| 138 | S | A | -0.4017 | |
| 139 | Y | A | -0.1662 | |
| 140 | N | A | -0.8612 | |
| 141 | R | A | -1.3401 | |
| 142 | S | A | -0.7585 | |
| 143 | S | A | -0.2929 | |
| 144 | F | A | 0.0000 | |
| 145 | E | A | -0.2194 | |
| 146 | S | A | -0.2797 | |
| 147 | S | A | -0.0300 | |
| 148 | S | A | 0.0000 | |
| 149 | G | A | 0.0835 | |
| 150 | L | A | 0.0000 | |
| 151 | V | A | 1.6434 | |
| 152 | W | A | 0.9933 | |
| 153 | T | A | 0.0907 | |
| 154 | S | A | -0.3242 | |
| 155 | G | A | -0.5995 | |
| 156 | P | A | -0.4995 | |
| 157 | A | A | -0.2149 | |
| 158 | T | A | -0.0983 | |
| 201 | S | B | 0.3969 | |
| 202 | Y | B | 0.0000 | |
| 203 | S | B | 0.7275 | |
| 204 | I | B | 1.0811 | |
| 205 | T | B | 0.2342 | |
| 206 | T | B | 0.1521 | |
| 207 | P | B | 0.4201 | |
| 208 | S | B | 0.5487 | |
| 209 | Q | B | 0.0000 | |
| 210 | F | B | 2.2759 | |
| 211 | V | B | 1.7146 | |
| 212 | F | B | 1.0731 | |
| 213 | L | B | 0.0000 | |
| 214 | S | B | 0.4547 | |
| 215 | S | B | -0.5132 | |
| 216 | A | B | 0.0000 | |
| 217 | W | B | 0.0000 | |
| 218 | A | B | 0.0000 | |
| 219 | D | B | -0.4241 | |
| 220 | P | B | 0.6309 | |
| 221 | I | B | 1.4755 | |
| 222 | E | B | -0.0213 | |
| 223 | L | B | 0.0000 | |
| 224 | I | B | 0.6055 | |
| 225 | N | B | -0.6785 | |
| 226 | L | B | -0.4237 | |
| 227 | C | B | 0.0000 | |
| 228 | T | B | -0.9212 | |
| 229 | N | B | -1.4887 | |
| 230 | A | B | 0.0000 | |
| 231 | L | B | -0.7617 | |
| 232 | G | B | -1.1058 | |
| 233 | N | B | -1.6211 | |
| 234 | Q | B | -2.0314 | |
| 235 | F | B | 0.0000 | |
| 236 | Q | B | -2.8036 | |
| 237 | T | B | -1.9066 | |
| 238 | Q | B | -1.8820 | |
| 239 | Q | B | -1.4923 | |
| 240 | A | B | 0.0000 | |
| 241 | R | B | 0.0000 | |
| 242 | T | B | -0.8042 | |
| 243 | V | B | 0.1857 | |
| 244 | V | B | 0.0000 | |
| 245 | Q | B | -1.5116 | |
| 246 | R | B | -2.2239 | |
| 247 | Q | B | -1.6977 | |
| 248 | F | B | 0.0000 | |
| 249 | S | B | -1.9273 | |
| 250 | E | B | -2.6670 | |
| 251 | V | B | 0.0000 | |
| 252 | W | B | 0.0000 | |
| 253 | K | B | -1.0011 | |
| 254 | P | B | -0.3608 | |
| 255 | S | B | -0.2486 | |
| 256 | P | B | 0.0000 | |
| 257 | Q | B | 0.6203 | |
| 258 | V | B | 1.4806 | |
| 259 | T | B | 0.5067 | |
| 260 | V | B | 0.7356 | |
| 261 | R | B | 0.0031 | |
| 262 | F | B | 0.0000 | |
| 263 | P | B | -1.2821 | |
| 264 | D | B | -2.2695 | |
| 265 | S | B | -1.5732 | |
| 266 | D | B | -1.4543 | |
| 267 | F | B | 0.0676 | |
| 268 | K | B | -0.0802 | |
| 269 | V | B | 0.0000 | |
| 270 | Y | B | 0.0000 | |
| 271 | R | B | 0.1615 | |
| 272 | Y | B | 0.8367 | |
| 273 | N | B | 0.4259 | |
| 274 | A | B | 0.5135 | |
| 275 | V | B | 0.8906 | |
| 276 | L | B | 0.0000 | |
| 277 | D | B | 0.0123 | |
| 278 | P | B | -0.0038 | |
| 279 | L | B | -0.2317 | |
| 280 | V | B | 0.0000 | |
| 281 | T | B | -0.1541 | |
| 282 | A | B | -0.2598 | |
| 283 | L | B | 0.0000 | |
| 284 | L | B | -0.7682 | |
| 285 | G | B | -0.9377 | |
| 286 | A | B | -0.6181 | |
| 287 | F | B | 0.0000 | |
| 288 | D | B | -2.4003 | |
| 289 | T | B | -2.1394 | |
| 290 | R | B | -2.2665 | |
| 291 | N | B | -1.7317 | |
| 292 | R | B | -0.3653 | |
| 293 | I | B | 1.5469 | |
| 294 | I | B | 1.5110 | |
| 295 | E | B | -0.6397 | |
| 296 | V | B | -0.3874 | |
| 297 | E | B | -1.9223 | |
| 298 | N | B | -2.5149 | |
| 299 | Q | B | -2.6578 | |
| 300 | A | B | -2.2285 | |
| 301 | N | B | -2.3339 | |
| 302 | P | B | -1.4108 | |
| 303 | T | B | -0.7975 | |
| 304 | T | B | -0.7781 | |
| 305 | A | B | -1.3831 | |
| 306 | E | B | -2.5062 | |
| 307 | T | B | -1.6888 | |
| 308 | L | B | -1.0136 | |
| 309 | D | B | -2.4556 | |
| 310 | A | B | -2.1949 | |
| 311 | T | B | -2.5628 | |
| 312 | R | B | -3.8974 | |
| 313 | R | B | -4.1508 | |
| 314 | V | B | -3.0952 | |
| 315 | D | B | -3.4272 | |
| 316 | D | B | -2.9934 | |
| 317 | A | B | -2.2956 | |
| 318 | T | B | -1.2207 | |
| 319 | V | B | 0.3034 | |
| 320 | A | B | -0.0748 | |
| 321 | I | B | 0.0000 | |
| 322 | R | B | -0.6776 | |
| 323 | S | B | -0.5345 | |
| 324 | A | B | -0.6311 | |
| 325 | I | B | 0.0000 | |
| 326 | N | B | -1.2363 | |
| 327 | N | B | -1.3287 | |
| 328 | L | B | 0.0000 | |
| 329 | I | B | 0.4709 | |
| 330 | V | B | 0.7470 | |
| 331 | E | B | 0.1417 | |
| 332 | L | B | 0.7641 | |
| 333 | I | B | 1.5043 | |
| 334 | R | B | -0.7724 | |
| 335 | G | B | -0.2668 | |
| 336 | T | B | -0.0837 | |
| 337 | G | B | -0.0669 | |
| 338 | S | B | -0.3534 | |
| 339 | Y | B | -0.1413 | |
| 340 | N | B | -0.8019 | |
| 341 | R | B | -1.2250 | |
| 342 | S | B | -0.7652 | |
| 343 | S | B | -0.4388 | |
| 344 | F | B | 0.0000 | |
| 345 | E | B | -0.2125 | |
| 346 | S | B | -0.4137 | |
| 347 | S | B | -0.5204 | |
| 348 | S | B | 0.0000 | |
| 349 | G | B | -0.0136 | |
| 350 | L | B | 0.0000 | |
| 351 | V | B | 1.6888 | |
| 352 | W | B | 0.8664 | |
| 353 | T | B | 0.0268 | |
| 354 | S | B | -0.4744 | |
| 355 | G | B | -0.5693 | |
| 356 | P | B | -0.1582 | |
| 357 | A | B | -0.2049 | |
| 358 | T | B | -0.0158 |
ALA alanine
ARG arginine
ASN asparagine
ASP aspartic acid
CYS cysteine
GLN glutamine
GLU glutamic acid
GLY glycine
HIS histidine
ILE isoleucine
LEU leucine
LYS lysine
MET methionine
PHE phenylalanine
PRO proline
SER serine
THR threonine
TRP tryptophan
TYR tyrosine
VAL valine