Project name: 6hre

Chain sequence(s)	A: GSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRE; C: GSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRE; B: GSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRE; E: GSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRE; D: GSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRE; F: GSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRE
Distance of aggregation	10 Å
Dynamic mode	No

• Minimal score value: -5.6473
• Maximal score value: 1.6264
• Average score: -1.1423
• Total score value: -527.7598

The table below lists A3D score for protein residues. Residues with A3D score > 0.0000 are marked by yellow rows.

residue index	residue name	chain	Aggrescan3D score	mutation
304	G	A	-0.7494
305	S	A	-0.8146
306	V	A	0.0000
307	Q	A	-0.3580
308	I	A	0.0000
309	V	A	0.7967
310	Y	A	0.0000
311	K	A	-0.7306
312	P	A	0.0000
313	V	A	0.3612
314	D	A	0.0000
315	L	A	0.7146
316	S	A	0.0000
317	K	A	-1.1119
318	V	A	0.0000
319	T	A	-1.4787
320	S	A	0.0000
321	K	A	-2.3691
322	C	A	-1.5525
323	G	A	-1.1279
324	S	A	-0.5237
325	L	A	0.0000
326	G	A	-1.0903
327	N	A	-1.5106
328	I	A	0.0000
329	H	A	-1.4624
330	H	A	0.0000
331	K	A	-1.7057
332	P	A	0.0000
333	G	A	0.0000
334	G	A	0.0000
335	G	A	0.0000
336	Q	A	0.0000
337	V	A	0.0000
338	E	A	-1.8351
339	V	A	0.0000
340	K	A	-3.2911
341	S	A	-3.4786
342	E	A	-3.8712
343	K	A	-3.5727
344	L	A	0.0000
345	D	A	-2.8376
346	F	A	0.0000
347	K	A	-4.9398
348	D	A	-5.1431
349	R	A	-5.6473
350	V	A	0.0000
351	Q	A	-3.4885
352	S	A	0.0000
353	K	A	-1.7528
354	I	A	0.0000
355	G	A	0.0000
356	S	A	0.0000
357	L	A	0.0000
358	D	A	-0.6522
359	N	A	0.0000
360	I	A	0.0476
361	T	A	0.0000
362	H	A	-0.2685
363	V	A	0.0000
364	P	A	0.0000
365	G	A	0.0000
366	G	A	0.0000
367	G	A	-1.2863
368	N	A	0.0000
369	K	A	-2.2872
370	K	A	0.0000
371	I	A	-0.5553
372	E	A	-0.6337
373	T	A	-1.2405
374	H	A	0.0000
375	K	A	-2.0585
376	L	A	0.0000
377	T	A	-1.1169
378	F	A	0.0000
379	R	A	-4.5389
380	E	A	-4.4745
304	G	B	-0.7311
305	S	B	-0.8156
306	V	B	0.0000
307	Q	B	-0.2731
308	I	B	0.0000
309	V	B	1.0983
310	Y	B	0.0000
311	K	B	-0.6942
312	P	B	0.0000
313	V	B	0.3200
314	D	B	0.0000
315	L	B	0.9463
316	S	B	0.0000
317	K	B	-1.0923
318	V	B	0.0000
319	T	B	0.0000
320	S	B	0.0000
321	K	B	-2.4505
322	C	B	0.0000
323	G	B	-1.1607
324	S	B	-0.5737
325	L	B	0.0000
326	G	B	-1.2366
327	N	B	-2.0095
328	I	B	0.0000
329	H	B	-1.6542
330	H	B	0.0000
331	K	B	0.0000
332	P	B	0.0000
333	G	B	0.0000
334	G	B	0.0000
335	G	B	0.0000
336	Q	B	-1.4753
337	V	B	0.0000
338	E	B	-2.6057
339	V	B	0.0000
340	K	B	-3.7063
341	S	B	0.0000
342	E	B	-4.0942
343	K	B	-3.6517
344	L	B	0.0000
345	D	B	-2.7215
346	F	B	0.0000
347	K	B	-4.8649
348	D	B	-5.0862
349	R	B	-5.4973
350	V	B	0.0000
351	Q	B	-2.9028
352	S	B	0.0000
353	K	B	-1.9757
354	I	B	0.0000
355	G	B	0.0000
356	S	B	0.0000
357	L	B	0.0000
358	D	B	-0.7713
359	N	B	0.0000
360	I	B	-0.0746
361	T	B	0.0000
362	H	B	-0.2806
363	V	B	0.0000
364	P	B	0.0000
365	G	B	0.0000
366	G	B	0.0000
367	G	B	-1.5384
368	N	B	0.0000
369	K	B	-2.4680
370	K	B	0.0000
371	I	B	-0.4660
372	E	B	-0.6482
373	T	B	-1.2552
374	H	B	0.0000
375	K	B	-2.0696
376	L	B	0.0000
377	T	B	-1.1777
378	F	B	0.0000
379	R	B	-4.6811
380	E	B	-4.6078
304	G	C	-0.5800
305	S	C	-0.5741
306	V	C	-0.2985
307	Q	C	-0.4135
308	I	C	0.9076
309	V	C	1.5017
310	Y	C	0.5928
311	K	C	-1.0003
312	P	C	-0.0433
313	V	C	1.2268
314	D	C	0.4525
315	L	C	1.3155
316	S	C	-0.2936
317	K	C	-1.5399
318	V	C	-0.7232
319	T	C	-0.9686
320	S	C	-1.1121
321	K	C	-2.2389
322	C	C	-0.9738
323	G	C	-0.9741
324	S	C	-0.5918
325	L	C	-0.3048
326	G	C	-1.0001
327	N	C	-1.6522
328	I	C	-0.8560
329	H	C	-1.4271
330	H	C	-1.0529
331	K	C	-1.8227
332	P	C	-1.1992
333	G	C	-0.9906
334	G	C	-0.8633
335	G	C	-0.5240
336	Q	C	-1.0528
337	V	C	-0.5692
338	E	C	-2.1943
339	V	C	-1.4112
340	K	C	-3.0013
341	S	C	-2.7758
342	E	C	-3.9279
343	K	C	-3.7034
344	L	C	0.0000
345	D	C	-3.1078
346	F	C	-3.0488
347	K	C	-4.5514
348	D	C	-4.3369
349	R	C	-4.4336
350	V	C	-3.0218
351	Q	C	-2.9835
352	S	C	-1.8076
353	K	C	-2.2332
354	I	C	-0.8457
355	G	C	-0.9683
356	S	C	-0.7175
357	L	C	-0.1361
358	D	C	-0.5964
359	N	C	-0.2709
360	I	C	0.8897
361	T	C	0.0000
362	H	C	-0.6970
363	V	C	-0.1640
364	P	C	-0.4236
365	G	C	0.0000
366	G	C	-0.9053
367	G	C	-1.1742
368	N	C	-1.2287
369	K	C	-2.0224
370	K	C	0.0000
371	I	C	0.9487
372	E	C	-0.0672
373	T	C	-0.5568
374	H	C	-1.3727
375	K	C	-2.2075
376	L	C	-0.7551
377	T	C	-1.1681
378	F	C	-1.7630
379	R	C	-3.8863
380	E	C	-3.8012
304	G	D	-0.5478
305	S	D	-0.5072
306	V	D	-0.1511
307	Q	D	-0.3157
308	I	D	1.0649
309	V	D	1.6264
310	Y	D	0.6452
311	K	D	-0.9541
312	P	D	-0.0234
313	V	D	1.2548
314	D	D	0.5220
315	L	D	1.4339
316	S	D	-0.2333
317	K	D	-1.5069
318	V	D	-0.7350
319	T	D	-0.9878
320	S	D	-1.1401
321	K	D	-2.2726
322	C	D	-1.0132
323	G	D	-1.0011
324	S	D	-0.5953
325	L	D	-0.3289
326	G	D	-1.0710
327	N	D	-1.8024
328	I	D	-0.9868
329	H	D	-1.8009
330	H	D	-1.1055
331	K	D	-1.7861
332	P	D	-1.1687
333	G	D	-0.9316
334	G	D	-1.0499
335	G	D	-1.0304
336	Q	D	-1.8751
337	V	D	-1.1424
338	E	D	-2.6903
339	V	D	-1.6542
340	K	D	-3.2021
341	S	D	-2.9366
342	E	D	-4.0839
343	K	D	-3.7587
344	L	D	0.0000
345	D	D	-3.0696
346	F	D	-2.8898
347	K	D	-4.4310
348	D	D	-4.0952
349	R	D	-4.1629
350	V	D	-2.7485
351	Q	D	-2.7706
352	S	D	-1.7528
353	K	D	-2.2880
354	I	D	-0.9801
355	G	D	-1.2793
356	S	D	-0.9962
357	L	D	-0.3343
358	D	D	-0.6765
359	N	D	-0.3073
360	I	D	0.7630
361	T	D	0.0000
362	H	D	-0.7004
363	V	D	-0.1407
364	P	D	-0.4256
365	G	D	0.0000
366	G	D	-0.9325
367	G	D	-1.2985
368	N	D	-1.3453
369	K	D	-2.0381
370	K	D	0.0000
371	I	D	0.8775
372	E	D	-0.1468
373	T	D	-0.5923
374	H	D	-1.3774
375	K	D	-2.1962
376	L	D	-0.7536
377	T	D	-1.1870
378	F	D	-1.8101
379	R	D	-3.9401
380	E	D	-3.8350
304	G	E	-0.6320
305	S	E	-0.5959
306	V	E	-0.6279
307	Q	E	-0.5147
308	I	E	0.7398
309	V	E	0.9278
310	Y	E	0.2592
311	K	E	-1.4899
312	P	E	-0.9646
313	V	E	0.1715
314	D	E	-0.1675
315	L	E	0.9929
316	S	E	-0.5694
317	K	E	-1.8753
318	V	E	-1.5132
319	T	E	-1.1607
320	S	E	-1.3893
321	K	E	-2.3890
322	C	E	-1.2444
323	G	E	-1.1544
324	S	E	-0.6846
325	L	E	-0.4004
326	G	E	-1.1464
327	N	E	-1.6904
328	I	E	-0.7164
329	H	E	-1.2175
330	H	E	-1.0613
331	K	E	-2.0327
332	P	E	-1.5411
333	G	E	-0.8979
334	G	E	-1.0778
335	G	E	-0.4892
336	Q	E	-0.7442
337	V	E	-0.1645
338	E	E	-1.4205
339	V	E	-1.0212
340	K	E	-2.8177
341	S	E	-2.7457
342	E	E	-3.2858
343	K	E	-2.4785
344	L	E	-1.1991
345	D	E	-2.0847
346	F	E	-1.9834
347	K	E	-3.8997
348	D	E	-4.3750
349	R	E	-4.4297
350	V	E	-3.6280
351	Q	E	-2.8591
352	S	E	-1.3799
353	K	E	-1.3843
354	I	E	-0.1435
355	G	E	-0.4269
356	S	E	-0.2977
357	L	E	-0.2188
358	D	E	-1.4156
359	N	E	-1.6506
360	I	E	-0.0267
361	T	E	-0.1798
362	H	E	-0.7699
363	V	E	0.0971
364	P	E	-0.4087
365	G	E	-0.7758
366	G	E	-0.7531
367	G	E	-1.0762
368	N	E	-2.0454
369	K	E	-3.1067
370	K	E	-3.0496
371	I	E	-1.0835
372	E	E	-2.0821
373	T	E	-1.4733
374	H	E	-1.7343
375	K	E	-1.8134
376	L	E	0.1919
377	T	E	-0.2339
378	F	E	-0.6565
379	R	E	-3.4709
380	E	E	-3.6024
304	G	F	-0.6424
305	S	F	-0.6612
306	V	F	-0.7645
307	Q	F	-0.5096
308	I	F	1.0888
309	V	F	1.6106
310	Y	F	0.5952
311	K	F	-1.3689
312	P	F	-0.9844
313	V	F	0.0547
314	D	F	-0.3683
315	L	F	0.9678
316	S	F	-0.5361
317	K	F	-1.8819
318	V	F	-1.7172
319	T	F	-1.2990
320	S	F	-1.5020
321	K	F	-2.3123
322	C	F	-1.2272
323	G	F	-1.1553
324	S	F	-0.6862
325	L	F	-0.4598
326	G	F	-1.3016
327	N	F	-1.9887
328	I	F	-1.0498
329	H	F	-1.5991
330	H	F	-0.8391
331	K	F	-1.2666
332	P	F	-1.0382
333	G	F	0.0000
334	G	F	-0.8879
335	G	F	0.0000
336	Q	F	-1.0176
337	V	F	-0.3388
338	E	F	-1.9175
339	V	F	-1.3148
340	K	F	-2.8499
341	S	F	-2.8040
342	E	F	-3.3126
343	K	F	-2.4526
344	L	F	-1.1468
345	D	F	-1.9912
346	F	F	-2.0399
347	K	F	-4.0965
348	D	F	-4.8222
349	R	F	-4.5586
350	V	F	-3.5755
351	Q	F	-2.7047
352	S	F	-1.2357
353	K	F	-1.2511
354	I	F	-0.1525
355	G	F	-0.4651
356	S	F	-0.2724
357	L	F	-0.0199
358	D	F	-1.5401
359	N	F	-1.6628
360	I	F	-0.2138
361	T	F	-0.2829
362	H	F	-0.7097
363	V	F	0.0681
364	P	F	-0.4865
365	G	F	-0.8335
366	G	F	-0.9092
367	G	F	-1.4148
368	N	F	-2.6830
369	K	F	-3.2505
370	K	F	-2.9595
371	I	F	-0.8898
372	E	F	-1.9705
373	T	F	-1.4569
374	H	F	-1.7933
375	K	F	-1.8564
376	L	F	0.1142
377	T	F	-0.3184
378	F	F	-0.7813
379	R	F	-3.5633
380	E	F	-3.6773